Abstract：
:Respiratory syncytial virus (RSV) is the major cause for respiratory tract disease in infants and young children. Currently, no licensed vaccine or a selective antiviral drug against RSV infections are available. Here, we describe a structure-based drug design approach that led to the synthesis of a novel series of zinc-ejecting compounds active against RSV replication. 30 compounds, sharing a common dithiocarbamate moiety, were designed and prepared to target the zinc finger motif of the M2-1 protein. A library of ∼ 12,000 small fragments was docked to explore the area surrounding the zinc ion. Among these, seven ligands were selected and used for the preparation of the new derivatives. The results reported here may help the development of a lead compound for the treatment of RSV infections.
journal_name
Antiviral Resjournal_title
Antiviral researchauthors
Cancellieri M,Bassetto M,Widjaja I,van Kuppeveld F,de Haan CA,Brancale Adoi
10.1016/j.antiviral.2015.08.003subject
Has Abstractpub_date
2015-10-01 00:00:00pages
46-50eissn
0166-3542issn
1872-9096pii
S0166-3542(15)00189-8journal_volume
122pub_type
杂志文章abstract：:Synthetic flavans, isoflavans and isoflavenes substituted with chloro, cyano and amidino groups were tested for their in vitro activity against poliovirus type 2, Coxsackie virus B4, echovirus type 6 and enterovirus 71. Plaque-reduction assays showed that substituted 3-(2H)-isoflavenes, carrying a double bond in the o...
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pub_type： 杂志文章
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更新日期：1995-05-01 00:00:00
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pub_type： 杂志文章
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更新日期：1993-09-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2013.06.003
更新日期：2013-09-01 00:00:00
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pub_type： 历史文章,杂志文章,评审
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更新日期：2003-01-01 00:00:00
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journal_title：Antiviral research
pub_type： 杂志文章
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更新日期：2004-08-01 00:00:00
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更新日期：2018-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0166-3542(94)00064-f
更新日期：1995-01-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1016/j.antiviral.2015.08.009
更新日期：2015-10-01 00:00:00
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pub_type： 杂志文章,meta分析
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更新日期：2011-02-01 00:00:00
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pub_type： 杂志文章
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更新日期：1996-12-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0166-3542(96)06966-5
更新日期：1996-07-01 00:00:00
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pub_type： 杂志文章
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更新日期：2016-02-01 00:00:00
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pub_type： 杂志文章
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更新日期：2007-07-01 00:00:00
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更新日期：1991-01-01 00:00:00
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更新日期：1994-10-01 00:00:00
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pub_type： 杂志文章
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更新日期：2019-08-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2001-03-01 00:00:00
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pub_type： 杂志文章
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更新日期：2020-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：1993-07-01 00:00:00
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pub_type： 杂志文章
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更新日期：2002-12-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.antiviral.2004.02.006
更新日期：2004-07-01 00:00:00
