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Hepatitis delta virus: From biological and medical aspects to current and investigational therapeutic options.

Abstract：

:An estimated 15-20 million individuals are co-infected by hepatitis B and hepatitis D virus worldwide and are at high risk of developing end-stage liver disease, including hepatocellular carcinoma. While HBV viremia can now be controlled in the vast majority of individuals by nucleoside analogs, leading to a delay of disease progression, HDV treatment has for long relied on the relatively inefficient and not well-tolerated interferon-alpha. While the epidemiology and pathogenesis of the disease remain to be precisely determined, using adequate diagnostic tools and well-designed cohort studies, basic research efforts have led to interesting progress in the understanding of HDV biology, which is not yet sufficient to identify specific antiviral targets. More resources now need to be devoted to the HDV field to achieve therapeutic breakthroughs. In this manuscript, we carefully review the literature regarding the biology of hepatitis D virus, the disease, its prevention, current treatments and investigational strategies. This article forms part of a symposium in Antiviral Research on "An unfinished story: from the discovery of the Australia antigen to the development of new curative therapies for chronic hepatitis B."

journal_name

Antiviral Res

journal_title

Antiviral research

authors

Alfaiate D,Dény P,Durantel D

doi

10.1016/j.antiviral.2015.08.009

subject

Has Abstract

pub_date

2015-10-01 00:00:00

pages

112-29

eissn

0166-3542

issn

1872-9096

pii

S0166-3542(15)00195-3

journal_volume

122

pub_type

杂志文章,评审

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