当前位置： SCI文献检索 > ANTIVIRAL RESEARCH期刊下所有文献 > Inhibitory effect of Ephedrae herba, an oriental traditional medicine, on the growth of influenza A/PR/8 virus in MDCK cells.

Inhibitory effect of Ephedrae herba, an oriental traditional medicine, on the growth of influenza A/PR/8 virus in MDCK cells.

Abstract：

:Using several herbal extracts, we investigated whether certain Kampo medicines exert an inhibitory effect on the acidification of intracellular compartments such as endosomes and lysosomes (referred to as ELS), and thereby inhibit the growth of influenza A virus in Madin-Darby canine kidney cells. The vital fluorescence microscopic study showed that the extract of Ephedrae herba (EHext) among five herbal extracts inhibited acidification of endosomes and lysosomes in a concentration-dependent manner (100-400 microg/ml). Moreover the growth of influenza A/PR/8/34 (H1N1) (PR8) virus was inhibited when the cells were treated with EHext for 1 h immediately after infection, or treated as early as 5-10 min after infection. Conversely, virus growth resumed concomitantly with the reappearance of acidified ELS after removal of EHext. The fact that the inhibitory effect of EHext was completely or partially reversed by FeCl3, a tannin-reactive agent, strongly suggests that tannin is one of the active components in the extract.

journal_name

Antiviral Res

journal_title

Antiviral research

authors

Mantani N,Andoh T,Kawamata H,Terasawa K,Ochiai H

doi

10.1016/s0166-3542(99)00067-4

subject

Has Abstract

pub_date

1999-12-31 00:00:00

pages

193-200

issue

3

eissn

0166-3542

issn

1872-9096

pii

S0166354299000674

journal_volume

44

pub_type

杂志文章

相关文献

ANTIVIRAL RESEARCH文献大全
  • Adefovir dipivoxil efficiently inhibits the proliferation of pseudorabies virus in vitro and in vivo.

    abstract：:Since 2011, highly pathogenic pseudorabies virus (PRV) variants that emerged on many farms in China have posed major economic burdens to the animal industry and have even recently caused several human cases of viral encephalitis. Currently, there are no approved effective drugs to treat PRV associated diseases in huma...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2021.105014

    authors： Wang G,Chen R,Huang P,Hong J,Cao J,Wu Q,Zheng W,Lin L,Han Q,Chen Y,Xia N

    更新日期：2021-01-07 00:00:00

  • Natural killer cell activity and function in chronic HCV-infected patients during peg interferon and ribavirin: early effects of active substance use.

    abstract：:In Western countries, chronic hepatitis C virus (HCV)-infection mostly affects former and active substance users. The effect of active substance use on interferon (IFN)-responsiveness and therapy efficacy is not well understood. In this study, we compared natural killer (NK) cell activity and function in healthy contr...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2012.12.025

    authors： Hotho DM,Kreefft K,Groothuismink ZM,Janssen HL,de Knegt RJ,Boonstra A

    更新日期：2013-03-01 00:00:00

  • Genetic analysis of a ganciclovir-resistant human cytomegalovirus mutant.

    abstract：:We isolated a ganciclovir (GCV)-resistant human cytomegalovirus (HCMV) from a laboratory strain, AD169, and analysed the mutant. Attempts were also made to identify directly the mutated gene. The 50% inhibitory concentration (IC50) of GCV for the mutant strain was five times higher than that of the wild-type strain. T...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/s0166-3542(98)00051-5

    authors： Faizi Khan R,Mori S,Eizuru Y,Kumura Ishii K,Minamishima Y

    更新日期：1998-12-01 00:00:00

  • Effective inhibition of infectious bursal disease virus replication in vitro by DNA vector-based RNA interference.

    abstract：:Infectious bursal disease (IBD) leads to considerable economic losses for the poultry industry by inducing severe immunosuppression and high mortality in chickens. The objective of this study was to determine if RNA interference (RNAi) could be utilized to inhibit IBDV replication in vitro. We selected 3 short interfe...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2007.11.007

    authors： Gao Y,Liu W,Gao H,Qi X,Lin H,Wang X,Shen R

    更新日期：2008-08-01 00:00:00

  • Orthopoxvirus targets for the development of new antiviral agents.

    abstract：:Investments in the development of new drugs for orthopoxvirus infections have fostered new avenues of research, provided an improved understanding of orthopoxvirus biology and yielded new therapies that are currently progressing through clinical trials. These broad-based efforts have also resulted in the identificatio...

    journal_title：Antiviral research

    pub_type： 杂志文章,评审

    doi：10.1016/j.antiviral.2012.02.012

    authors： Prichard MN,Kern ER

    更新日期：2012-05-01 00:00:00

  • Treatment of Venezuelan equine encephalitis virus infection with (-)-carbodine.

    abstract：:Venezuelan equine encephalitis virus (VEEV) may cause encephalitis in humans, for which no FDA-approved antiviral treatment is available. Carbocyclic cytosine (carbodine) has broad-spectrum activity but toxicity has limited its utility. It was anticipated that one of the enantiomers of carbodine would show enhanced ac...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2008.07.002

    authors： Julander JG,Bowen RA,Rao JR,Day C,Shafer K,Smee DF,Morrey JD,Chu CK

    更新日期：2008-12-01 00:00:00

  • A randomized, double-blind trial of parenteral low dose versus high dose interferon-beta in combination with cryotherapy for treatment of condyloma acuminatum.

    abstract：:Forty-nine subjects were enrolled in a study comparing two dosages of parenterally administered interferon (IFN)-beta in combination with cryotherapy for the treatment of anogenital warts. Subjects were randomized to receive subcutaneous injections of either 2 x 10(6) or 4 x 10(6) IU/m2 of IFN-beta (Biogen) three time...

    journal_title：Antiviral research

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/s0166-3542(97)01037-1

    authors： Bonnez W,Oakes D,Bailey-Farchione A,Choi A,Hallahan D,Corey L,Barnum G,Pappas PG,Halloway M,Stoler MH,Reichman RC

    更新日期：1997-06-01 00:00:00

  • Preferential selection of heterologous G3-VP7 gene in the genetic background of simian rotavirus SA11 detected by using a homotypic single-VP7 gene-substitution reassortant.

    abstract：:Introduction of segmented genomes into virion is an important process in viral replication of rotavirus. We previously studied the assortment of the VP7 gene segment (encoding outer capsid protein VP7) in the genetic background of simian rotavirus SA11 (G serotype 3, G3) and found the preferential selection of homolog...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/s0166-3542(98)00006-0

    authors： Okada J,Kobayashi N,Taniguchi K,Urasawa S

    更新日期：1998-04-01 00:00:00

  • Combined antiviral options for the treatment of chronic hepatitis C.

    abstract：:In the absence of antiviral treatment, chronic hepatitis C virus (HCV) infection is a liver disease characterized by the development of necroinflammatory changes and progressive liver fibrosis, leading to cirrhosis, end-stage liver disease and hepatocellular carcinoma (HCC). The approval of ribavirin in combination th...

    journal_title：Antiviral research

    pub_type： 杂志文章,评审

    doi：10.1016/j.antiviral.2003.08.009

    authors： Medina J,García-Buey L,Moreno-Monteagudo JA,Trapero-Marugán M,Moreno-Otero R

    更新日期：2003-10-01 00:00:00

  • Design of clinical trials for drug combinations: cytomegalovirus retinitis--foscarnet and ganciclovir. The CMV retinitis retreatment trial.

    abstract：:The Cytomegalovirus Retinitis Retreatment Trial was a multicenter clinical trial designed to evaluate three treatments for the treatment of relapsed CMV retinitis; (1) foscarnet; (2) 'high-dose' ganciclovir, and (3) combination foscarnet and ganciclovir. Two hundred seventy-nine patients were enrolled and randomly ass...

    journal_title：Antiviral research

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0166-3542(95)00921-3

    authors： Jabs DA

    更新日期：1996-01-01 00:00:00

  • Safety, pharmacokinetics, and antiviral activity of the cyclophilin inhibitor NIM811 alone or in combination with pegylated interferon in HCV-infected patients receiving 14 days of therapy.

    abstract：BACKGROUND:Cyclophilin inhibitors have shown activity against a variety of viruses, including HCV. NIM811, a novel, non-immunosuppressive cyclophilin inhibitor was studied in ascending doses in a randomized, double-blind, placebo-controlled 14-day trial in genotype 1 HCV patients. Doses of 10 up to 600 mg were given or...

    journal_title：Antiviral research

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.antiviral.2011.01.003

    authors： Lawitz E,Godofsky E,Rouzier R,Marbury T,Nguyen T,Ke J,Huang M,Praestgaard J,Serra D,Evans TG

    更新日期：2011-03-01 00:00:00

  • Comparative therapeutic effect of aerosolized and oral rimantadine HCl in experimental human influenza A virus infection.

    abstract：:Thirty-six adult volunteers were inoculated intranasally with 7.2 log10 egg infectious doses 50% of an attenuated A/Khabarovsk/77/H1N1 virus. Twenty-four hours later volunteers were begun on both aerosol treatments (rimantadine HCl 25 mg in saline or saline, 10 min exposure twice daily) and oral medications (rimantadi...

    journal_title：Antiviral research

    pub_type： 临床试验,杂志文章

    doi：10.1016/0166-3542(82)90016-x

    authors： Hayden FG,Zylidnikov DM,Iljenko VI,Padolka YV

    更新日期：1982-08-01 00:00:00

  • Anthraquinones as a new class of antiviral agents against human immunodeficiency virus.

    abstract：:Various anthraquinones substituted with hydroxyl, amino, halogen, carboxylic acid, substituted aromatic group, and sulfonate were tested to determine their activity against human immunodeficiency virus type 1 (HIV-1) in primary human lymphocytes. Among the compounds tested, polyphenolic and/or polysulfonate substitute...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/0166-3542(90)90071-e

    authors： Schinazi RF,Chu CK,Babu JR,Oswald BJ,Saalmann V,Cannon DL,Eriksson BF,Nasr M

    更新日期：1990-05-01 00:00:00

  • Persistent primary cytomegalovirus infection in a kidney transplant recipient: Multi-drug resistant and compartmentalized infection leading to graft loss.

    abstract：:Cytomegalovirus (CMV) is one of the most common opportunistic infections after transplantation. To prevent CMV infections, universal prophylaxis and pre-emptive therapy with ganciclovir or its prodrug valganciclovir is applied. However, prolonged antiviral therapy may result in drug-resistance emergence. We describe a...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2019.06.004

    authors： Andrei G,Van Loon E,Lerut E,Victoor J,Meijers B,Bammens B,Sprangers B,Gillemot S,Fiten P,Opdenakker G,Lagrou K,Kuypers D,Snoeck R,Naesens M

    更新日期：2019-08-01 00:00:00

  • Helper T cell cytokine response to ribavirin priming before combined treatment with interferon alpha and ribavirin for patients with chronic hepatitis C.

    abstract：:The viral genotype and serum viral level influence the response to interferon (IFN) treatment in patients with chronic hepatitis C virus (HCV) viremia. The aim of this study was to investigate a possible relationship between early virological response and helper T (Th) cell cytokine expansion by 4 weeks of ribavirin (...

    journal_title：Antiviral research

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.antiviral.2005.04.001

    authors： Furusyo N,Kubo N,Toyoda K,Takeoka H,Nabeshima S,Murata M,Nakamuta M,Hayashi J

    更新日期：2005-07-01 00:00:00

  • Derivatives of amphotericin inhibit infection with human immunodeficiency virus in vitro by different modes of action.

    abstract：:Three water-soluble derivatives of amphotericin B were tested for inhibition of HIV infection in vitro. The compounds amphotericin B methyl ester (AME) and N-(N'-(2-(4'-methylmorpholinio)ethyl)N"-cyclohexyl guanyl) amphotericin B methyl ester (MCG) inhibited HIV infection by 50% at 1 microgram/ml; N-(N'-(3-dimethylami...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/0166-3542(90)90031-2

    authors： Hansen JE,Witzke NM,Nielsen C,Mathiesen LR,Teglbjaerg LS,Nielsen CM,Nielsen JO

    更新日期：1990-09-01 00:00:00

  • New pleconaril and [(biphenyloxy)propyl]isoxazole derivatives with substitutions in the central ring exhibit antiviral activity against pleconaril-resistant coxsackievirus B3.

    abstract：:Amino acid 1092 (AA1092) in capsid protein 1 of coxsackievirus B3 (CVB3) is located in close vicinity to the central phenoxy group of capsid binders (i.e. pleconaril). Whereas isoleucine is associated with drug susceptibility, leucine and methionine confer resistance to pleconaril. In the present study, novel analogue...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2008.09.002

    authors： Schmidtke M,Wutzler P,Zieger R,Riabova OB,Makarov VA

    更新日期：2009-01-01 00:00:00

  • Vmw65 phosphorothioate oligonucleotides inhibit HSV KOS replication and Vmw65 protein synthesis.

    abstract：:Phosphorothioate-modified oligomers have been shown to be more stable than natural oligomers to serum and cellular nucleases. For this reason we used these analogs to explore the utility of antisense molecules as potential antiviral agents. The oligomers we studied are complementary to the initiation region of the Vmw...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/0166-3542(91)90023-k

    authors： Kmetz ME,Ceruzzi M,Schwartz J

    更新日期：1991-09-01 00:00:00

  • A reporter cell line for rapid and sensitive evaluation of hepatitis C virus infectivity and replication.

    abstract：:The human pathogen hepatitis C virus (HCV) is associated with chronic liver disease. The recent development of the cell culture infectious HCV (HCVcc) system has opened up avenues for detailed studies on the life cycle of the virus and its interaction with the host cell. Current methods to quantitate virus infectivity...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2009.04.007

    authors： Iro M,Witteveldt J,Angus AG,Woerz I,Kaul A,Bartenschlager R,Patel AH

    更新日期：2009-08-01 00:00:00

  • Peptidomimetic furin inhibitor MI-701 in combination with oseltamivir and ribavirin efficiently blocks propagation of highly pathogenic avian influenza viruses and delays high level oseltamivir resistance in MDCK cells.

    abstract：:Antiviral medication is used for the treatment of severe influenza infections, of which the neuraminidase inhibitors (NAIs) are the most effective drugs, approved so far. Here, we investigated the antiviral efficacy of the peptidomimetic furin inhibitor MI-701 in combination with oseltamivir carboxylate and ribavirin ...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2015.05.006

    authors： Lu Y,Hardes K,Dahms SO,Böttcher-Friebertshäuser E,Steinmetzer T,Than ME,Klenk HD,Garten W

    更新日期：2015-08-01 00:00:00

  • Recent progress in henipavirus research: molecular biology, genetic diversity, animal models.

    abstract：:Nipah and Hendra virus are members of a newly identified genus of emerging paramyxoviruses, the henipaviruses. Both viruses have the ability to cause severe pulmonary infection and severe acute encephalitis. Following their discovery in the 1990s, outbreaks caused by these zoonotic paramyxoviruses have been associated...

    journal_title：Antiviral research

    pub_type： 杂志文章,评审

    doi：10.1016/j.antiviral.2012.05.008

    authors： Rockx B,Winegar R,Freiberg AN

    更新日期：2012-08-01 00:00:00

  • Using high-throughput genomics to study hepatitis C: what determines the outcome of infection?

    abstract：:High-throughput genomic methods are now being used to study a wide variety of viral diseases, in an effort to understand how host responses to infection can lead either to efficient elimination of the pathogen or the development of severe disease. This article reviews how gene expression studies are addressing importa...

    journal_title：Antiviral research

    pub_type： 杂志文章,评审

    doi：10.1016/j.antiviral.2008.12.005

    authors： Walters KA,Katze MG

    更新日期：2009-03-01 00:00:00

  • Dextran sulfate-resistant A/Puerto Rico/8/34 influenza virus is associated with the emergence of specific mutations in the neuraminidase glycoprotein.

    abstract：:Dextran sulfate (DS) is a negatively charged sulfated polysaccharide that suppresses the replication of influenza A viruses. The suppression was thought to be associated with inhibition of the hemagglutinin-dependent fusion activity. However, we previously showed that suppression by DS was observed not only at the ini...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2014.09.002

    authors： Yamada H,Nagao C,Haredy AM,Mori Y,Mizuguchi K,Yamanishi K,Okamoto S

    更新日期：2014-11-01 00:00:00

  • Activated interferon system in healthy homosexual men.

    abstract：:More than 50% of a group of healthy homosexuals in Israel were found to have an activated interferon (IFN) system as evidenced by markedly elevated blood IFN levels, increased in vitro production of IFN by unstimulated peripheral blood mononuclear cells and HuIFN-alpha and HuIFN-gamma production by appropriately stimu...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/0166-3542(85)90027-0

    authors： Levin S,Hahn T,Handzel ZT,Galili-Wiesstub E,Bregman V,Myer R,Tinowitz M,Altman Y,Barzilai N,Brenner Y

    更新日期：1985-08-01 00:00:00

  • Successful strategies implemented towards the elimination of canine rabies in the Western Hemisphere.

    abstract：:Almost all cases of human rabies result from dog bites, making the elimination of canine rabies a global priority. During recent decades, many countries in the Western Hemisphere have carried out large-scale dog vaccination campaigns, controlled their free-ranging dog populations and enforced legislation for responsib...

    journal_title：Antiviral research

    pub_type： 历史文章,杂志文章,评审

    doi：10.1016/j.antiviral.2017.03.023

    authors： Velasco-Villa A,Escobar LE,Sanchez A,Shi M,Streicker DG,Gallardo-Romero NF,Vargas-Pino F,Gutierrez-Cedillo V,Damon I,Emerson G

    更新日期：2017-07-01 00:00:00

  • Natural killer cell inhibits human immunodeficiency virus replication in chronically infected immune cells.

    abstract：:Natural killer (NK) cells are a crucial component of the host innate immune system. We investigated the noncytolytic anti-human immunodeficiency virus (HIV) activity of NK cells in chronically HIV-infected immune cells. Supernatants collected from NK cell cultures (both primary NK cells and NK cell lines, YTS and NK 9...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2006.08.006

    authors： Zhang T,Li Y,Wang YJ,Wang X,Young M,Douglas SD,Ho WZ

    更新日期：2007-02-01 00:00:00

  • Inhibition of Sendai virus replication by delta 12-prostaglandin J2: induction of heat shock protein synthesis and alteration of protein glycosylation.

    abstract：:delta 12-Prostaglandin J2 (delta 12-PGJ2), a natural dehydration product of prostaglandin D2 present in human body fluids, was shown to suppress Sendai virus replication in monkey kidney cells, at doses non-toxic to uninfected cells. Dramatic inhibition of virus production could be obtained at doses of delta 12-PGJ2 w...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/0166-3542(92)90072-d

    authors： Amici C,Palamara AT,Garaci E,Santoro MG

    更新日期：1992-08-01 00:00:00

  • Broad spectrum anti-flavivirus pyridobenzothiazolones leading to less infective virions.

    abstract：:We report the design, synthesis, and biological evaluation of a class of 1H-pyrido[2,1-b][1,3]benzothiazol-1-ones originated from compound 1, previously identified as anti-flavivirus agent. Some of the new compounds showed activity in low μM range with reasonable selectivity against Dengue 2, Yellow fever (Bolivia str...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2019.03.004

    authors： Cannalire R,Tarantino D,Piorkowski G,Carletti T,Massari S,Felicetti T,Barreca ML,Sabatini S,Tabarrini O,Marcello A,Milani M,Cecchetti V,Mastrangelo E,Manfroni G,Querat G

    更新日期：2019-07-01 00:00:00

  • Novel dengue virus inhibitor 4-HPR activates ATF4 independent of protein kinase R-like Endoplasmic Reticulum Kinase and elevates levels of eIF2α phosphorylation in virus infected cells.

    abstract：:Infections by dengue virus (DENV) are increasing worldwide, with an urgent need for effective anti-DENV agents. We recently identified N-(4-hydroxyphenyl) retinamide (4-HPR), an anti-DENV agent effective against all 4 serotypes of DENV in cell culture, and in a lethal mouse model for DENV infection (Fraser et al., 201...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2016.03.006

    authors： Fraser JE,Wang C,Chan KW,Vasudevan SG,Jans DA

    更新日期：2016-06-01 00:00:00

  • Antiviral activity of Viracea against acyclovir susceptible and acyclovir resistant strains of herpes simplex virus.

    abstract：:Viracea, a topical microbicide, is a blend of benzalkonium chloride and phytochemicals derived from Echinacea purpurea and is a proprietary formula from Destiny BioMediX Corp. Viracea was tested against 40 strains of herpes simplex virus (HSV): 15 strains (five HSV-1 and ten HSV-2) were resistant to acyclovir (ACV-R) ...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/s0166-3542(98)00027-8

    authors： Thompson KD

    更新日期：1998-07-01 00:00:00