Abstract:
:High-throughput genomic methods are now being used to study a wide variety of viral diseases, in an effort to understand how host responses to infection can lead either to efficient elimination of the pathogen or the development of severe disease. This article reviews how gene expression studies are addressing important clinical issues related to hepatitis C virus infection, in which some 15-25% of infected individuals are able to clear the virus without treatment, while the remainder progress to chronic liver disease that can lead to cirrhosis and death. Similar methods are also being used in an effort to identify the mechanisms underlying the failure of some hepatitis C patients to respond to interferon-alpha/ribavirin therapy. By providing a detailed picture of virus-host interactions, high-throughput genomics could potentially lead to the identification of novel cellular targets for the treatment of hepatitis C.
journal_name
Antiviral Resjournal_title
Antiviral researchauthors
Walters KA,Katze MGdoi
10.1016/j.antiviral.2008.12.005subject
Has Abstractpub_date
2009-03-01 00:00:00pages
198-208issue
3eissn
0166-3542issn
1872-9096pii
S0166-3542(08)00486-5journal_volume
81pub_type
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pub_type: 杂志文章
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journal_title:Antiviral research
pub_type: 杂志文章
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2006.02.003
更新日期:2006-07-01 00:00:00
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pub_type: 杂志文章
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2017.06.005
更新日期:2017-08-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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更新日期:2009-04-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2015.12.004
更新日期:2016-02-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1988-04-01 00:00:00
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更新日期:2007-10-01 00:00:00
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更新日期:2005-01-01 00:00:00
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更新日期:2007-02-01 00:00:00
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更新日期:2018-02-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2013.02.005
更新日期:2013-04-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
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更新日期:2020-04-01 00:00:00