A randomized, double-blind trial of parenteral low dose versus high dose interferon-beta in combination with cryotherapy for treatment of condyloma acuminatum.

abstract：:Several polyanionic compounds with potential for use as topically applied microbicides to prevent HIV-1 sexual transmission, such as PRO 2000, are currently in phase III clinical efficacy trials. Microbicidal formulations may well comprise combinations of inhibitors to increase potency, reduce dose and minimize proble...

journal_title：Antiviral research

authors： Gantlett KE,Weber JN,Sattentau QJ

更新日期：2007-09-01 00:00:00

abstract：:We established a sensitive and accurate method for screening of anti-adenovirus agents using the 3-(4,5-dimetylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. MKN-28 cells, which are well-differentiated stomach adenocarcinoma cells, were used for adenovirus (ADV) infection and examined for the anti-ADV act...

journal_title：Antiviral research

authors： Kodama E,Shigeta S,Suzuki T,De Clercq E

更新日期：1996-07-01 00:00:00

abstract：:The model of simian immunodeficiency virus (SIV) infection in rhesus macaques was used to evaluate the effects of recombinant human interferon alpha, Hu IFN-alpha 2b and Hu IFN-gamma B,D, at two doses. Administration began 1 day prior to infection and was continued for 90 days postinfection. Both interferons suppresse...

journal_title：Antiviral research

authors： Schellekens H,Niphuis H,Buijs L,Douw van der Krap P,Hochkeppel HK,Heeney JL

更新日期：1996-08-01 00:00:00

abstract：:Lactoferrin (LF) is an iron binding glycoprotein that is present in several mucosal secretions. Many biological functions have been ascribed to LF. One of the functions of LF is the transport of metals, but LF is also an important component of the non-specific immune system, since LF has antimicrobial properties again...

journal_title：Antiviral research

authors： van der Strate BW,Beljaars L,Molema G,Harmsen MC,Meijer DK

更新日期：2001-12-01 00:00:00

abstract：:Chikungunya virus (CHIKV) is an arbovirus transmitted to humans by mosquito bite. A decade ago, the virus caused a major outbreak in the islands of the Indian Ocean, then reached India and Southeast Asia. More recently, CHIKV has emerged in the Americas, first reaching the Caribbean and now extending to Central, South...

journal_title：Antiviral research

authors： Couderc T,Lecuit M

更新日期：2015-09-01 00:00:00

abstract：:Antiviral therapies for chronic hepatitis B virus (HBV) infection that are currently applicable for clinical use are limited to nucleos(t)ide analogs targeting HBV polymerase activity and pegylated interferon alpha (PEG-IFN). Towards establishing an effective therapy for HBV related diseases, it is important to develo...

journal_title：Antiviral research

authors： Harada K,Nishitsuji H,Ujino S,Shimotohno K

更新日期：2017-08-01 00:00:00

abstract：:Novel L-lyxo-TSAO-T analogs with an inverted configuration at the C-4'-position of the sugar moiety and 5'-deoxy-5'-modified TSAO-T derivatives have been prepared and evaluated for their inhibitory effect on human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) replication in cell culture. None of the compoun...

journal_title：Antiviral research

authors： Ingate S,De Clercq E,Balzarini J,Camarasa MJ

更新日期：1996-11-01 00:00:00

abstract：:Ampligen, a known immunomodulator and interferon inducer, was used alone and in combination with other antiviral agents to treat ducks congenitally-infected with duck hepatitis B virus. These antiviral agents included the conventional nucleoside analogue ganciclovir and the prokaryotic DNA gyrase B inhibitor coumermyc...

journal_title：Antiviral research

authors： Niu J,Wang Y,Dixon R,Bowden S,Qiao M,Einck L,Locarnini S

更新日期：1993-06-01 00:00:00

abstract：:Favipiravir (T-705) is a broad spectrum antiviral which has been approved in Japan for the treatment of severe influenza virus infections. We reported earlier that favipiravir inhibits the in vitro replication of CHIKV and protects against disease progression in CHIKV-infected immunodeficient mice. We here explored wh...

journal_title：Antiviral research

authors： Abdelnabi R,Jochmans D,Verbeken E,Neyts J,Delang L

更新日期：2018-01-01 00:00:00

abstract：:The reverse transcriptase (RT) of HIV which has been inhibited by the incorporation of AZT into the primer strand is subject to a deblocking reaction by cellular ATP. This reaction yields unblocked primer plus the dinucleoside tetraphosphate, AZTp(4)A. In the present study, we report that AZTp(4)A is an excellent subs...

journal_title：Antiviral research

authors： Pitcher WH 3rd,Kirby TW,DeRose EF,London RE

更新日期：2003-05-01 00:00:00

abstract：:Antiviral medication is used for the treatment of severe influenza infections, of which the neuraminidase inhibitors (NAIs) are the most effective drugs, approved so far. Here, we investigated the antiviral efficacy of the peptidomimetic furin inhibitor MI-701 in combination with oseltamivir carboxylate and ribavirin ...

journal_title：Antiviral research

authors： Lu Y,Hardes K,Dahms SO,Böttcher-Friebertshäuser E,Steinmetzer T,Than ME,Klenk HD,Garten W

更新日期：2015-08-01 00:00:00

abstract：:Interferon alpha-2b (IFN) alone or in combination with Ribavirin is approved in the United States for the treatment of chronic hepatitis C virus (HCV) infection. We have previously reported that the glucosidase inhibitor, n-butyl deoxynojirimycin (nB-DNJ) inhibits the production of infectious bovine diarrhea virus (BV...

journal_title：Antiviral research

authors： Ouzounov S,Mehta A,Dwek RA,Block TM,Jordan R

更新日期：2002-09-01 00:00:00

abstract：:Rotavirus infection has emerged as an important cause of complications in organ transplantation recipients. Immunosuppressants used to prevent alloreactivity can also interfere with virus infection, but the direct effects of the specific type of immunosuppressants on rotavirus infection are still unclear. Here we prof...

journal_title：Antiviral research

authors： Yin Y,Wang Y,Dang W,Xu L,Su J,Zhou X,Wang W,Felczak K,van der Laan LJ,Pankiewicz KW,van der Eijk AA,Bijvelds M,Sprengers D,de Jonge H,Koopmans MP,Metselaar HJ,Peppelenbosch MP,Pan Q

更新日期：2016-09-01 00:00:00

abstract：:We studied the effects of two antiviral agents, human interferon-alpha (IFN-alpha) and ribavirin, on subacute sclerosing panencephalitis (SSPE) virus infections in hamsters. By intracranial administration, IFN-alpha alone improved the survival of infected hamsters by 20% at a dose of 6 x 10(4) IU/kg every other day fo...

journal_title：Antiviral research

authors： Takahashi T,Hosoya M,Kimura K,Ohno K,Mori S,Takahashi K,Shigeta S

更新日期：1998-01-01 00:00:00

abstract：:Twenty-five years after the discovery of the therapeutic activity of azidothymidine (AZT), the first antiretroviral drug used in the clinic, infection with the human immunodeficiency virus (HIV) has become, at least in the industrialized world, a manageable chronic disease with a significant improvement in life expect...

journal_title：Antiviral research

authors： Esté JA,Cihlar T

更新日期：2010-01-01 00:00:00

abstract：:Itraconazole (ITZ) is a well-known, FDA-approved antifungal drug that is also in clinical trials for its anticancer activity. ITZ exerts its anticancer activity through several disparate targets and pathways. ITZ inhibits angiogenesis by hampering the functioning of the vascular endothelial growth receptor 2 (VEGFR2) ...

journal_title：Antiviral research

authors： Bauer L,Ferla S,Head SA,Bhat S,Pasunooti KK,Shi WQ,Albulescu L,Liu JO,Brancale A,van Kuppeveld FJM,Strating JRPM

更新日期：2018-08-01 00:00:00

abstract：:Oxymatrine (OMTR) is an anti-hepatitis drug used in China. Its mechanism of action is unknown. Recently, we found that OMTR inhibits hepatitis B virus (HBV) via down-regulating the expression of heat-stress cognate 70 (Hsc70), a host protein required for HBV DNA replication. Goal of this study was to assess the effect...

journal_title：Antiviral research

authors： Wang YP,Zhao W,Xue R,Zhou ZX,Liu F,Han YX,Ren G,Peng ZG,Cen S,Chen HS,Li YH,Jiang JD

更新日期：2011-03-01 00:00:00

abstract：UNLABELLED:This paper presents the public health rationale for multipurpose prevention technologies (MPTs) for sexual and reproductive health (SRH) based on regional trends in demographic and SRH indicators. It then distils important lessons gleaned from the introduction of contraceptive and reproductive health product...

journal_title：Antiviral research

authors： Brady M,Manning J

更新日期：2013-12-01 00:00:00

abstract：:Pseudorabies virus (PRV) infection was established in mice by means of inoculating the ear flap. The infection was universally fatal once clinical signs appeared. Bromovinyldeoxyuridine (BVDU) was a potent inhibitor of PRV in vitro, but this drug failed to protect mice and produced only marginal reductions in virus ti...

journal_title：Antiviral research

authors： Field HJ

更新日期：1985-06-01 00:00:00

abstract：:Pritelivir, a helicase-primase inhibitor, has excellent in vitro and in vivo activity against human herpes simplex virus (HSV). Mice lethally infected with HSV type 1 or 2, including acyclovir-resistant strains, were treated 72 h after infection for 7 days with pritelivir or acyclovir. Both drugs were administered ora...

journal_title：Antiviral research

authors： Quenelle DC,Birkmann A,Goldner T,Pfaff T,Zimmermann H,Bonsmann S,Collins DJ,Rice TL,Prichard MN

更新日期：2018-01-01 00:00:00

abstract：:Because encapsulation of antiviral drugs in liposomes resulted generally in improved activity against retroviral replication in vivo, the antiviral effects of free-SPC3 and liposome-associated SPC3 were compared in cultured human lymphocytes infected with HIV-1. SPC3 was entrapped in various liposomal formulations, ei...

journal_title：Antiviral research

authors： de Mareuil J,Mabrouk K,Doria E,Moulard M,de Chasteigner S,Oughideni R,van Rietschoten J,Rochat H,De Waard M,Sabatier JM

更新日期：2002-06-01 00:00:00

abstract：:Influenza viruses (IV) continue to pose an imminent threat to human welfare. Yearly re-occurring seasonal epidemic outbreaks and pandemics with high mortality can occur. Besides vaccination against a limited number of viral strains only a few antiviral drugs are available, which are losing their effectiveness as more ...

journal_title：Antiviral research

authors： Haasbach E,Müller C,Ehrhardt C,Schreiber A,Pleschka S,Ludwig S,Planz O

更新日期：2017-06-01 00:00:00

abstract：:The essential role of SMAR1 in HIV-1 transcription and LTR driven gene expression suggests SMAR1 as an HIV dependency factor (HDF) and a potential anti-HIV therapeutic target. Here, we report for the first time, anti-HIV activity of 8 novel isothiocyanate (ITC) derivatives that differentially stabilise SMAR1. Out of 8...

journal_title：Antiviral research

authors： Trivedi J,Alam A,Joshi S,Kumar TP,Chippala V,Mainkar PS,Chandrasekhar S,Chattopadhyay S,Mitra D

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND AND AIMS:The combination of tenofovir disoproxil fumarate (TDF) plus emtricitabine (FTC) is used extensively to treat HIV infection and also has potent activity against hepatitis B virus (HBV) infection. The aim of this study was to assess the efficacy and tolerance of TDF + FTC in patients with chronic hepa...

journal_title：Antiviral research

authors： Si-Ahmed SN,Pradat P,Zoutendijk R,Buti M,Mallet V,Cruiziat C,Deterding K,Dumortier J,Bailly F,Esteban R,Wedemeyer H,Janssen HL,Zoulim F

更新日期：2011-10-01 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiologic agent of Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. In immunocompromised patients, KSHV infection is capable of causing severe and fatal diseases. Current antiviral treatments for KSHV infections consist mostly of n...

journal_title：Antiviral research

authors： Chen J,Zhang H,Chen X

更新日期：2020-08-01 00:00:00

abstract：:RNA interference, mediated by short interfering RNAs (siRNAs), has been shown to have activity against a wide range of viruses and is a promising new antiviral therapy. Using multiple siRNAs that target conserved areas of the genome allows for increased chances of antiviral activity against different viral strains and...

journal_title：Antiviral research

authors： O'Brien L

更新日期：2007-07-01 00:00:00

abstract：:Commercial vaccines against human papillomavirus (HPV) have low uptake due to parental autonomy, dosing regimen, cost, and cold chain storage requirements. Carrageenan (CG)-based formulations prevent HPV infection in vitro and in vivo but data are needed on the durability of anti-HPV activity and the effect of seminal...

journal_title：Antiviral research

authors： Rodríguez A,Kleinbeck K,Mizenina O,Kizima L,Levendosky K,Jean-Pierre N,Villegas G,Ford BE,Cooney ML,Teleshova N,Robbiani M,Herold BC,Zydowsky T,Fernández Romero JA

更新日期：2014-08-01 00:00:00

abstract：:Previously, we found that a ganciclovir (GCV)-resistant clinical human cytomegalovirus (HCMV) isolate had an amino acid substitution at codon 501 (Leu --> Phe) in the delta-region C of the DNA polymerase gene. DNA polymerases have now been (partially) purified from both the GCV-resistant and sensitive parental strains...

journal_title：Antiviral research

authors： Kariya M,Mori S,Eizuru Y

更新日期：2000-02-01 00:00:00

abstract：:Prevention of HIV infection and unintended pregnancies are public health priorities. In sub-Saharan Africa, where HIV prevalence is highest, depot medroxyprogesterone acetate (DMPA) is widely used as contraception. Therefore, understanding potential interactions between DMPA and antiretrovirals is critical. Here, we u...

journal_title：Antiviral research

authors： Daly MB,Sterling M,Holder A,Dinh C,Nishiura K,Khalil G,García-Lerma JG,Dobard C

更新日期：2020-12-29 00:00:00

abstract：:Flavivirus methyltransferase is a genetically-validated antiviral target. Crystal structures of almost all available flavivirus methyltransferases contain S-adenosyl-L-methionine (SAM), the methyl donor molecule that co-purifies with the enzymes. This raises a possibility that SAM is an integral structural component r...

journal_title：Antiviral research

authors： Noble CG,Li SH,Dong H,Chew SH,Shi PY

更新日期：2014-11-01 00:00:00