Abstract:
:Chikungunya virus (CHIKV) is an arbovirus transmitted to humans by mosquito bite. A decade ago, the virus caused a major outbreak in the islands of the Indian Ocean, then reached India and Southeast Asia. More recently, CHIKV has emerged in the Americas, first reaching the Caribbean and now extending to Central, South and North America. It is therefore considered a major public health and economic threat. CHIKV causes febrile illness typically associated with debilitating joint pains. In rare cases, it may also cause central nervous system disease, notably in neonates. Joint symptoms may persist for months to years, and lead to arthritis. This review focuses on the spectrum of signs and symptoms associated with CHIKV infection in humans. It also illustrates how the analysis of clinical and biological data from human cohorts and the development of animal and cellular models of infection has helped to identify the tissue and cell tropisms of the virus and to decipher host responses in benign, severe or persistent disease. This article forms part of a symposium in Antiviral Research on "Chikungunya discovers the New World".
journal_name
Antiviral Resjournal_title
Antiviral researchauthors
Couderc T,Lecuit Mdoi
10.1016/j.antiviral.2015.07.002subject
Has Abstractpub_date
2015-09-01 00:00:00pages
120-31eissn
0166-3542issn
1872-9096pii
S0166-3542(15)00165-5journal_volume
121pub_type
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journal_title:Antiviral research
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pub_type: 杂志文章
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journal_title:Antiviral research
pub_type: 杂志文章
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journal_title:Antiviral research
pub_type: 杂志文章
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journal_title:Antiviral research
pub_type: 杂志文章
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journal_title:Antiviral research
pub_type: 杂志文章,评审
doi:10.1016/j.antiviral.2012.02.012
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2008.05.012
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journal_title:Antiviral research
pub_type: 杂志文章
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更新日期:2018-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.antiviral.2008.06.011
更新日期:2008-12-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2012.04.010
更新日期:2012-07-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2013.09.021
更新日期:2013-12-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章,评审
doi:10.1016/j.antiviral.2006.02.004
更新日期:2006-09-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2010.08.004
更新日期:2010-10-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/0166-3542(90)90069-j
更新日期:1990-05-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2015.08.003
更新日期:2015-10-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2005.11.001
更新日期:2006-02-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章,评审
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journal_title:Antiviral research
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2007.03.004
更新日期:2007-09-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2003.11.008
更新日期:2004-04-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/s0166-3542(96)01004-2
更新日期:1997-01-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2006.03.010
更新日期:2006-10-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2019.104650
更新日期:2020-01-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2017.06.005
更新日期:2017-08-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2012.05.017
更新日期:2012-09-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2011.05.013
更新日期:2011-08-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/0166-3542(88)90003-4
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