Recent progress in henipavirus research: molecular biology, genetic diversity, animal models.

Abstract:

:Nipah and Hendra virus are members of a newly identified genus of emerging paramyxoviruses, the henipaviruses. Both viruses have the ability to cause severe pulmonary infection and severe acute encephalitis. Following their discovery in the 1990s, outbreaks caused by these zoonotic paramyxoviruses have been associated with high public health and especially economic threat potential. Currently, only geographic groupings in Asia and Australia have been described for the henipaviruses. However, while few viral isolates are available and more detailed characterization is necessary, there has been recent evidence that divergent henipaviruses might be present on the African continent. This review endeavours to capture recent advances in the field of henipavirus research, with a focus on genome structure and replication mechanisms, reservoir hosts, genetic diversity, pathogenesis and animal models.

journal_name

Antiviral Res

journal_title

Antiviral research

authors

Rockx B,Winegar R,Freiberg AN

doi

10.1016/j.antiviral.2012.05.008

subject

Has Abstract

pub_date

2012-08-01 00:00:00

pages

135-49

issue

2

eissn

0166-3542

issn

1872-9096

pii

S0166-3542(12)00123-4

journal_volume

95

pub_type

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