Abstract:
:Nipah and Hendra virus are members of a newly identified genus of emerging paramyxoviruses, the henipaviruses. Both viruses have the ability to cause severe pulmonary infection and severe acute encephalitis. Following their discovery in the 1990s, outbreaks caused by these zoonotic paramyxoviruses have been associated with high public health and especially economic threat potential. Currently, only geographic groupings in Asia and Australia have been described for the henipaviruses. However, while few viral isolates are available and more detailed characterization is necessary, there has been recent evidence that divergent henipaviruses might be present on the African continent. This review endeavours to capture recent advances in the field of henipavirus research, with a focus on genome structure and replication mechanisms, reservoir hosts, genetic diversity, pathogenesis and animal models.
journal_name
Antiviral Resjournal_title
Antiviral researchauthors
Rockx B,Winegar R,Freiberg ANdoi
10.1016/j.antiviral.2012.05.008subject
Has Abstractpub_date
2012-08-01 00:00:00pages
135-49issue
2eissn
0166-3542issn
1872-9096pii
S0166-3542(12)00123-4journal_volume
95pub_type
杂志文章,评审abstract::Filoviruses, which include Ebola virus (EBOV) and Marburg virus, are negative-sense RNA viruses associated with sporadic outbreaks of severe viral hemorrhagic fever characterized by uncontrolled virus replication. The extreme virulence and emerging nature of these zoonotic pathogens make them a significant threat to h...
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journal_title:Antiviral research
pub_type: 杂志文章,评审
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journal_title:Antiviral research
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更新日期:2009-09-01 00:00:00
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更新日期:2007-09-01 00:00:00
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pub_type: 杂志文章
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2016.03.005
更新日期:2016-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2002-12-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
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更新日期:2017-06-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2013.08.004
更新日期:2013-10-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章,评审
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更新日期:2006-09-01 00:00:00
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pub_type: 杂志文章
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journal_title:Antiviral research
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pub_type: 临床试验,杂志文章
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journal_title:Antiviral research
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doi:10.1016/j.antiviral.2016.08.020
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更新日期:2018-04-01 00:00:00
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journal_title:Antiviral research
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doi:10.1016/j.antiviral.2004.09.005
更新日期:2005-01-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2003.11.008
更新日期:2004-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:1995-05-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1992-07-01 00:00:00