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Antiviral activity of natural and synthetic β-carbolines against dengue virus.

Abstract：

:Dengue virus (DENV) is the most prevalent mosquito borne viral pathogen worldwide. In this work we first evaluated the antiviral activity of natural and synthetic β-carbolines against DENV-2 multiplication in cell cultures. We determined that the natural β-carboline harmol and a synthetic harmine derivative, 9N-methylharmine, exhibit inhibitory effect on DENV-2 production without virucidal activity. The active compounds were inhibitory of all DENV serotypes, being DENV-2 the more susceptible to their antiviral action. The mode of action of 9N-methylharmine against DENV-2 was further explored. We determined that the derivative neither affects viral adsorption-internalization events nor viral RNA synthesis. The quantification of intracellular and extracellular viral genomes and infectious virus particles indicated that 9N-methylharmine would impair the maturation and release of virus particles to the extracellular medium affecting the spreading of the infection. Furthermore, we also determined that 9N-methylharmine antiviral activity is not related to the ability of the compound to downregulate p38 MAPK phosphorylation.

journal_name

Antiviral Res

journal_title

Antiviral research

authors

Quintana VM,Piccini LE,Panozzo Zénere JD,Damonte EB,Ponce MA,Castilla V

doi

10.1016/j.antiviral.2016.08.018

subject

Has Abstract

pub_date

2016-10-01 00:00:00

pages

26-33

eissn

0166-3542

issn

1872-9096

pii

S0166-3542(16)30268-6

journal_volume

134

pub_type

杂志文章

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