Abstract：
:Development of efficient and safer vaccines against foot-and-mouth disease virus (FMDV) is a must. Previous results obtained in our laboratory have demonstrated that DNA vaccines encoding B and T cell epitopes from type C FMDV, efficiently controlled virus replication in mice, while they did not protect against FMDV challenge in pigs, one of the FMDV natural hosts. The main finding of this work is the ability to improve the protection afforded in swine using a new DNA-vaccine prototype (pCMV-APCH1BTT), encoding FMDV B and T-cell epitopes fused to the single-chain variable fragment of the 1F12 mouse monoclonal antibody that recognizes Class-II Swine Leukocyte antigens. Half of the DNA-immunized pigs were fully protected upon viral challenge, while the remaining animals were partially protected, showing a delayed, shorter and milder disease than control pigs. Full protection in a given vaccinated-pig correlated with the induction of specific IFNγ-secreting T-cells, detectable prior to FMDV-challenge, together with a rapid development of neutralizing antibodies after viral challenge, pointing towards the relevance that both arms of the immune response can play in protection. Our results open new avenues for developing future FMDV subunit vaccines.
journal_name
Antiviral Resjournal_title
Antiviral researchauthors
Borrego B,Argilaguet JM,Pérez-Martín E,Dominguez J,Pérez-Filgueira M,Escribano JM,Sobrino F,Rodriguez Fdoi
10.1016/j.antiviral.2011.07.017subject
Has Abstractpub_date
2011-11-01 00:00:00pages
359-63issue
2eissn
0166-3542issn
1872-9096pii
S0166-3542(11)00388-3journal_volume
92pub_type
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