Abstract:
:Cats infected with molecularly cloned FeLV-FAIDS develop an immunodeficiency syndrome characterized by persistent antigenemia, decline in circulating CD4+ T lymphocytes, and impaired T-cell-dependent immune responses and opportunistic infection. We evaluated the capacity of PMEA to inhibit the replication of FeLV-FAIDS in vitro and to inhibit the progression of FeLV-FAIDS infection in vivo. We found that PMEA inhibited replication of FeLV-FAIDS by greater than or equal to 50% at concentrations of greater than or equal to 0.5 microgram/ml (1.63 microM) in feline fibroblasts and prevented T lymphocyte killing at concentrations of 3 micrograms/ml. PMEA administered to cats at dosages of greater than or equal to 6.25 mg/kg/day from 0 to 49 days after FeLV-FAIDS infection prevented the development of persistent antigenemia and the induction of immunodeficiency disease. In contrast to placebo treated controls, cats successfully treated with PMEA contained viral infection, developed neutralizing antibody, and resisted a second virulent virus challenge without further therapy. Manifestations of PMEA toxicity produced by higher dosages (25 or 12.5 mg/kg/day) were anemia, leukopenia, and diarrhea. These results indicate PMEA to be a potent antiretroviral agent effective in aborting fatal progression of FeLV-FAIDS infection when therapy is initiated at the time of virus exposure.
journal_name
Antiviral Resjournal_title
Antiviral researchauthors
Hoover EA,Ebner JP,Zeidner NS,Mullins JIdoi
10.1016/0166-3542(91)90060-5subject
Has Abstractpub_date
1991-07-01 00:00:00pages
77-92issue
1eissn
0166-3542issn
1872-9096pii
0166-3542(91)90060-5journal_volume
16pub_type
杂志文章abstract::Several mammarenaviruses, chiefly Lassa virus (LASV) in Western Africa and Junín virus (JUNV) in the Argentine Pampas, cause severe disease in humans and pose important public health problems in their endemic regions. Moreover, mounting evidence indicates that the worldwide-distributed mammarenavirus lymphocytic chori...
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journal_title:Antiviral research
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journal_title:Antiviral research
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pub_type: 历史文章,杂志文章,评审
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journal_title:Antiviral research
pub_type: 杂志文章
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journal_title:Antiviral research
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journal_title:Antiviral research
pub_type: 杂志文章
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更新日期:2015-04-01 00:00:00
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journal_title:Antiviral research
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journal_title:Antiviral research
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更新日期:2015-09-01 00:00:00