Efficacy of (E)-5-(2-bromovinyl)-2'-deoxyuridine in the treatment of experimental herpes simplex virus encephalitis in mice.

abstract：:The era of antiviral chemotherapy started more than 50 years with the findings by Domagk and his colleagues that thiosemicarbazones showed activity against vaccinia virus. One of the derivatives, methisazone, was even investigated in the prophylaxis of smallpox. With the successful implementation of the smallpox vacci...

journal_title：Antiviral research

authors： Neyts J,De Clercq E

更新日期：2003-01-01 00:00:00

abstract：:In the absence of antiviral treatment, chronic hepatitis C virus (HCV) infection is a liver disease characterized by the development of necroinflammatory changes and progressive liver fibrosis, leading to cirrhosis, end-stage liver disease and hepatocellular carcinoma (HCC). The approval of ribavirin in combination th...

journal_title：Antiviral research

authors： Medina J,García-Buey L,Moreno-Monteagudo JA,Trapero-Marugán M,Moreno-Otero R

更新日期：2003-10-01 00:00:00

abstract：:Derivatives of beta-lactam antibiotics of the cephalosporin type at 0.02-1 mM concentrations interfered with in vitro replication of two DNA-containing viruses, herpes simplex I and vaccinia, but showed no effects on two RNA-viruses, lymphocytic choriomeningitis virus and vesicular stomatitis virus, or on cell viabili...

journal_title：Antiviral research

authors： Cottagnoud P,Neftel KA,Hany M,Zinkernagel RM

更新日期：1988-11-01 00:00:00

abstract：:Despite the importance of Dengue virus (DENV) infection in human health, there is not a fully effective vaccine or antiviral treatment against the infection. Since lipids such as cholesterol are required during DENV infection, its uptake and synthesis are increased in infected cells. Ezetimibe is an FDA-approved drug ...

journal_title：Antiviral research

authors： Osuna-Ramos JF,Reyes-Ruiz JM,Bautista-Carbajal P,Cervantes-Salazar M,Farfan-Morales CN,De Jesús-González LA,Hurtado-Monzón AM,Del Ángel RM

更新日期：2018-12-01 00:00:00

abstract：:Global eradication of hepatitis C virus (HCV) infection will require an efficacious vaccine capable of eliciting protective immunity against genetically diverse HCV strains. Natural spontaneous resolution of HCV infection is associated with production of broadly-neutralizing antibodies targeting the HCV glycoproteins ...

journal_title：Antiviral research

authors： Tarr AW,Backx M,Hamed MR,Urbanowicz RA,McClure CP,Brown RJP,Ball JK

更新日期：2018-12-01 00:00:00

abstract：:Everolimus is an inhibitor of mammalian target of rapamycin (mTOR) and reduces the risk of cytomegalovirus (CMV) infection in transplant recipients. Everolimus inhibits mTOR complex 1, which regulates factors involved in several crucial cellular functions and is required for CMV replication. However, it is not clear h...

journal_title：Antiviral research

authors： Tan L,Sato N,Shiraki A,Yanagita M,Yoshida Y,Takemura Y,Shiraki K

更新日期：2019-02-01 00:00:00

abstract：:Respiratory syncytial virus (RSV), which presents the primary cause of bronchiolitis and pneumonia among infants and causes significant morbidity and mortality in immunodeficient patients, remains a health problem worldwide. Unfortunately, an effective vaccine is currently unavailable and pharmacologic treatment needs...

journal_title：Antiviral research

authors： Xie YY,Zhao XD,Jiang LP,Liu HL,Wang LJ,Fang P,Shen KL,Xie ZD,Wu YP,Yang XQ

更新日期：2006-08-01 00:00:00

abstract：:Interleukin (IL)28-B polymorphism has been related to interferon response in the treatment of hepatitis C, but its role in chronic hepatitis B (CHB) therapy is still poorly understood. We aimed to investigate the effect of IL28-B polymorphisms in the treatment with pegylated-interferon (PEG-IFN) of patients with CHB. ...

journal_title：Antiviral research

authors： Boglione L,Cusato J,Allegra S,Esposito I,Patti F,Cariti G,Di Perri G,D'Avolio A

更新日期：2014-02-01 00:00:00

abstract：:Serum from wild alligators was collected and tested for antibiotic activity against three enveloped viruses using cell-based assays. Alligator serum demonstrated antiviral activities against human immunodeficiency virus type 1 (HIV-1; IC50=0.9%), West Nile virus (WNV; IC50=4.3%), and Herpes simplex virus type 1 (HSV-1...

journal_title：Antiviral research

authors： Merchant ME,Pallansch M,Paulman RL,Wells JB,Nalca A,Ptak R

更新日期：2005-04-01 00:00:00

abstract：:In the event of an influenza pandemic, the use of oseltamivir (OTV) will undoubtedly increase and therefore it is more likely that OTV-resistant influenza strains will also arise. OTV-resistance genotyping using sequence-based testing on viruses isolated in cell culture is time consuming and less likely to detect the ...

journal_title：Antiviral research

authors： Steain MC,Dwyer DE,Hurt AC,Kol C,Saksena NK,Cunningham AL,Wang B

更新日期：2009-12-01 00:00:00

abstract：:There are no drugs approved specifically to treat disseminated adenovirus (Ad) infections in humans. Cidofovir is active against Ad in cell culture, and it is used frequently in the clinic with disseminated infection in pediatric transplant patients; however, controlled clinical studies have not been conducted to prov...

journal_title：Antiviral research

authors： Tollefson AE,Spencer JF,Ying B,Buller RM,Wold WS,Toth K

更新日期：2014-12-01 00:00:00

abstract：:RNA interference, mediated by short interfering RNAs (siRNAs), has been shown to have activity against a wide range of viruses and is a promising new antiviral therapy. Using multiple siRNAs that target conserved areas of the genome allows for increased chances of antiviral activity against different viral strains and...

journal_title：Antiviral research

authors： O'Brien L

更新日期：2007-07-01 00:00:00

abstract：:Almost all cases of human rabies result from dog bites, making the elimination of canine rabies a global priority. During recent decades, many countries in the Western Hemisphere have carried out large-scale dog vaccination campaigns, controlled their free-ranging dog populations and enforced legislation for responsib...

journal_title：Antiviral research

authors： Velasco-Villa A,Escobar LE,Sanchez A,Shi M,Streicker DG,Gallardo-Romero NF,Vargas-Pino F,Gutierrez-Cedillo V,Damon I,Emerson G

更新日期：2017-07-01 00:00:00

abstract：:Pseudorabies virus (PRV) infection was established in mice by means of inoculating the ear flap. The infection was universally fatal once clinical signs appeared. Bromovinyldeoxyuridine (BVDU) was a potent inhibitor of PRV in vitro, but this drug failed to protect mice and produced only marginal reductions in virus ti...

journal_title：Antiviral research

authors： Field HJ

更新日期：1985-06-01 00:00:00

abstract：:The human pathogen hepatitis C virus (HCV) is associated with chronic liver disease. The recent development of the cell culture infectious HCV (HCVcc) system has opened up avenues for detailed studies on the life cycle of the virus and its interaction with the host cell. Current methods to quantitate virus infectivity...

journal_title：Antiviral research

authors： Iro M,Witteveldt J,Angus AG,Woerz I,Kaul A,Bartenschlager R,Patel AH

更新日期：2009-08-01 00:00:00

abstract：:Prostratin, a non-tumor-promoting phorbol ester, inhibited human immunodeficiency virus (HIV)-induced cell killing and viral replication in a variety of acutely-infected cell systems. The potency and degree of cytoprotection was dependent on both viral strain and host cell type. Prostratin activated viral expression i...

journal_title：Antiviral research

authors： Gulakowski RJ,McMahon JB,Buckheit RW Jr,Gustafson KR,Boyd MR

更新日期：1997-01-01 00:00:00

abstract：:Because encapsulation of antiviral drugs in liposomes resulted generally in improved activity against retroviral replication in vivo, the antiviral effects of free-SPC3 and liposome-associated SPC3 were compared in cultured human lymphocytes infected with HIV-1. SPC3 was entrapped in various liposomal formulations, ei...

journal_title：Antiviral research

authors： de Mareuil J,Mabrouk K,Doria E,Moulard M,de Chasteigner S,Oughideni R,van Rietschoten J,Rochat H,De Waard M,Sabatier JM

更新日期：2002-06-01 00:00:00

abstract：:Twenty-four patients with chronic non-A non-B hepatitis were randomly assigned to receive either human fibroblast interferon (HuIFN-beta) at doses of 1 or 3 million international units (MIU) per day for 4 or 12 weeks (12 patients) or to receive no therapy (12 patients), and were then compared with 5 patients with chro...

journal_title：Antiviral research

authors： Kiyosawa K,Sodeyama T,Nakano Y,Yoda H,Tanaka E,Hayata T,Tsuchiya K,Yousuf M,Furuta S

更新日期：1989-10-01 00:00:00

abstract：:Human parainfluenza virus type 3 (HPIV3) is an important respiratory tract pathogen of infants and children. There are no vaccines or antivirals currently approved for prevention or treatment of HPIV3 infection. Towards developing an antiviral therapy to combat HPIV3 infection, we have established a green fluorescent ...

journal_title：Antiviral research

authors： Mao H,Thakur CS,Chattopadhyay S,Silverman RH,Gudkov A,Banerjee AK

更新日期：2008-02-01 00:00:00

abstract：:Since 2011, highly pathogenic pseudorabies virus (PRV) variants that emerged on many farms in China have posed major economic burdens to the animal industry and have even recently caused several human cases of viral encephalitis. Currently, there are no approved effective drugs to treat PRV associated diseases in huma...

journal_title：Antiviral research

authors： Wang G,Chen R,Huang P,Hong J,Cao J,Wu Q,Zheng W,Lin L,Han Q,Chen Y,Xia N

更新日期：2021-01-07 00:00:00

abstract：:Nucleoside analogues have been the most successful antiviral compounds. Likewise, they are the most intriguing antiviral compounds, because of their structural relationship to natural nucleosides. This is also the reason why the design process of a potential selective antiviral nucleoside is so difficult. Too many nat...

journal_title：Antiviral research

authors： Herdewijn P

更新日期：2006-09-01 00:00:00

abstract：:Two new influenza virus neuraminidase inhibitors (NAIs), peramivir and laninamivir, were approved in 2010 which resulted to four NAIs that were used during the 2010-2011 influenza season in Japan. This study aims to monitor the susceptibility of influenza virus isolates in 2009-2010 and 2010-2011 influenza seasons in ...

journal_title：Antiviral research

authors： Dapat C,Kondo H,Dapat IC,Baranovich T,Suzuki Y,Shobugawa Y,Saito K,Saito R,Suzuki H

更新日期：2013-09-01 00:00:00

abstract：:Highly pathogenic influenza viruses pose a serious public health threat to humans. Although vaccines are available, antivirals are needed to efficiently control disease progression and virus transmission due to the emergence of drug-resistant viral strains. In this study, germacrone, which is a major component of the ...

journal_title：Antiviral research

authors： Liao Q,Qian Z,Liu R,An L,Chen X

更新日期：2013-12-01 00:00:00

abstract：:The prevention and control of disease caused by seasonal and potential pandemic influenza viruses is currently managed by the use influenza vaccines and antivirals. The adamantanes (amantadine and rimantadine) were the first antivirals licensed for use against influenza A viruses and have been used extensively in some...

journal_title：Antiviral research

authors： Barr IG,Hurt AC,Iannello P,Tomasov C,Deed N,Komadina N

更新日期：2007-02-01 00:00:00

abstract：:The immune evasion of wild-type (wt) rabies virus (RABV) has been attributed to its glycoprotein (G), particularly to their inefficiency to bind/enter into dendritic cells (DCs). However, the domain responsible for G-mediated DC activation is not clear. In the present study, attempts were made to map the domain(s) on ...

journal_title：Antiviral research

authors： Huang J,Zhang Y,Huang Y,Gnanadurai CW,Zhou M,Zhao L,Fu ZF

更新日期：2017-05-01 00:00:00

abstract：:Due to diverse pathogenic potentials, there is a growing need for anti-HCMV agents. In this study, we show that treatment with DAPT, a γ-secretase inhibitor (GSI), impairs HCMV replication as assessed by a progeny assay based on immunostaining. This effect is not limited to DAPT because other GSIs with different struc...

journal_title：Antiviral research

authors： Lee SM,Han D,Kwon M,Noh H,Lee JH,Yoon Y,Cho JY,Ahn JH,Yoon K

更新日期：2020-11-01 00:00:00

abstract：:Approximately 170 million people worldwide are chronic carriers of Hepatitis C virus (HCV). To date, there is no prophylactic vaccine available against HCV. The standard-of-care therapy for HCV infection involves a combination of pegylated interferon-α and ribavirin. This therapy, which is commonly associated with sid...

journal_title：Antiviral research

authors： Ip PP,Nijman HW,Wilschut J,Daemen T

更新日期：2012-10-01 00:00:00

abstract：:Anti-herpes simplex virus (HSV) activities of oxyresveratrol in vitro and topical administration in cutaneous HSV-1 infection in mice were examined. The inhibitory concentrations for 50% plaque formation (IC(50)) of oxyresveratrol against HSV-1 clinical isolates and HSV-2 clinical isolates were 20.9-29.5 and 22.2-27.5...

journal_title：Antiviral research

authors： Lipipun V,Sasivimolphan P,Yoshida Y,Daikoku T,Sritularak B,Ritthidej G,Likhitwitayawuid K,Pramyothin P,Hattori M,Shiraki K

更新日期：2011-08-01 00:00:00

abstract：:Novel L-lyxo-TSAO-T analogs with an inverted configuration at the C-4'-position of the sugar moiety and 5'-deoxy-5'-modified TSAO-T derivatives have been prepared and evaluated for their inhibitory effect on human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) replication in cell culture. None of the compoun...

journal_title：Antiviral research

authors： Ingate S,De Clercq E,Balzarini J,Camarasa MJ

更新日期：1996-11-01 00:00:00

abstract：:Dengue virus (DENV) is the most prevalent mosquito borne viral pathogen worldwide. In this work we first evaluated the antiviral activity of natural and synthetic β-carbolines against DENV-2 multiplication in cell cultures. We determined that the natural β-carboline harmol and a synthetic harmine derivative, 9N-methyl...

journal_title：Antiviral research

authors： Quintana VM,Piccini LE,Panozzo Zénere JD,Damonte EB,Ponce MA,Castilla V

更新日期：2016-10-01 00:00:00