Abstract:
:Double-stranded RNAs induce interferons and cause the development of antiviral and antiproliferative activities. Antiviral activity is related to the production of interferons and other proteins that stimulate various immunologic activities, which appear to contribute to their overall antiproliferative activity. The most active double-stranded RNA, polyI:polyC, was shown to be too toxic for therapeutic use. We conducted selective thiolation of the polyC strand at the five position of the cytosine bases, generating a partially thiolated polyC (MPC) which after annealing with a complimentary unmodified polyI, gave the thiolated double-stranded RNA, pI:MPC. We have explored antiviral and antiproliferative activities at various levels of thiolation and found that optimal responses can be obtained at 7.4% level of thiolation. This compound deserves further study of antiviral and antiproliferative responses in vivo, and eventually clinical exploration. Earlier studies have shown that this and related compounds are active against HIV-1, in human cells, and against DNA polymerases of DNA and RNA tumor viruses.
journal_name
Antiviral Resjournal_title
Antiviral researchauthors
Chadha KC,Dembinski WE,Dunn CB,Aradi J,Bardos TJ,Dunn JA,Ambrus JL Srdoi
10.1016/j.antiviral.2004.08.002subject
Has Abstractpub_date
2004-12-01 00:00:00pages
171-7issue
3eissn
0166-3542issn
1872-9096pii
S0166-3542(04)00165-2journal_volume
64pub_type
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pub_type: 杂志文章,评审
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2012.05.017
更新日期:2012-09-01 00:00:00
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journal_title:Antiviral research
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doi:10.1016/j.antiviral.2011.10.023
更新日期:2012-01-01 00:00:00
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pub_type: 杂志文章
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journal_title:Antiviral research
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1995-08-01 00:00:00
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journal_title:Antiviral research
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