Role of trehalose dimycolate-induced interferon-alpha/beta in the restriction of encephalomyocarditis virus growth in vivo and in peritoneal macrophage cultures.

Abstract:

:Preventive intraperitoneal trehalose dimycolate (TDM) treatment of mice, inoculated with encephalomyocarditis (EMC) virus by the same route, caused restriction of virus growth in the peritoneum, which was correlated to IFN production in peritoneal fluids prior to infection. Peritoneal macrophages from TDM-treated mice (TDM-PM) spontaneously secreted IFN-alpha/beta in large amounts. By their supernatants, TDM-PM could transfer an antiviral state against EMC virus to permissive resident peritoneal macrophages from control mice. IFN-alpha/beta produced by TDM-PM was found to be involved in this transfer activity. TDM-PM also exerted a strong antiviral effect on EMC virus-infected L-929 cells, which increased with time and the macrophage-target cell ratio. This activity also occurred by an IFN-alpha/beta-dependent mechanism. These data point to the role of IFN-alpha/beta production prior to EMC virus infection in the antiviral activities of TDM-PM and, more generally, in the outcome of viral infection.

journal_name

Antiviral Res

journal_title

Antiviral research

authors

Guillemard E,Geniteau-Legendre M,Kergot R,Lemaire G,Petit JF,Labarre C,Quero AM

doi

10.1016/0166-3542(95)00047-p

subject

Has Abstract

pub_date

1995-10-01 00:00:00

pages

175-89

issue

2

eissn

0166-3542

issn

1872-9096

pii

0166-3542(95)00047-P

journal_volume

28

pub_type

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