Abstract:
:Distamycin-A hydrochloride, a synthetic antibiotic, and 2,3-dihydroxy-6-bromo-pyrazino (2,3-beta) pyrazine derivative, were used against tomato spotted wilt virus (TSWV) in tobacco plants. The drugs were applied to the leaves at concentrations of 200 and 400 mg/l. The results showed that both drugs delayed virus spread within the plant, retarding the appearance of systemic symptoms. A virus recovery test, carried out on primary leaves of Phaseolus vulgaris cv. Manteiga, showed that TSWV replication was markedly inhibited by the pyrazino-pyrazine derivative at concentrations of 200 and 400 mg/l and, to a lower extent, by Dystamycin-A at 400 mg/l.
journal_name
Antiviral Resjournal_title
Antiviral researchauthors
De Fazio G,Kudamatsu Mdoi
10.1016/0166-3542(83)90032-3subject
Has Abstractpub_date
1983-08-01 00:00:00pages
109-13issue
2eissn
0166-3542issn
1872-9096pii
0166-3542(83)90032-3journal_volume
3pub_type
杂志文章abstract::The hepatitis B virus nucleocapsid or core antigen is extremely immunogenic during infection and after immunization. This review summarizes several features of the nucleocapsid which explain this exceptionally high immunogenicity: a unique three-dimensional folding, the presence of a region that interacts with immunog...
journal_title:Antiviral research
pub_type: 杂志文章,评审
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abstract::The bicyclams represent a new class of highly potent and selective HIV inhibitors. Time-of-addition experiments have previously shown that these compounds interfere with an early event in the viral replicative cycle. Additional experiments have now been carried out in order to investigate in more detail the mechanism ...
journal_title:Antiviral research
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abstract::Despite an urgent medical need, a broadly effective anti-viral therapy for the treatment of infections with hepatitis C viruses (HCVs) has yet to be developed. One of the approaches to anti-HCV drug discovery is the design and development of specific small molecule drugs to inhibit the proteolytic processing of the HC...
journal_title:Antiviral research
pub_type: 杂志文章,评审
doi:
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abstract::While combination antiretroviral therapy (cART) has successfully converted HIV to a chronic but manageable infection in many parts of the world, HIV continues to persist within latent cellular reservoirs, which can become reactivated at any time to produce infectious virus. New therapies are therefore needed not only ...
journal_title:Antiviral research
pub_type: 杂志文章,评审
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abstract::Zika virus (ZIKV) is a mosquito-borne flavivirus that mostly causes asymptomatic infections or mild disease characterized by low-grade fever, rash, conjunctivitis, and malaise. However, the recent massive ZIKV epidemics in the Americas have also linked ZIKV infection to fetal malformations like microcephaly and Guilla...
journal_title:Antiviral research
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journal_title:Antiviral research
pub_type: 杂志文章
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更新日期:2018-12-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2017.09.016
更新日期:2018-01-01 00:00:00
abstract::Drug resistance resulting from reverse transcriptase (RT) mutations is one of the main obstacles to successful hepatitis B virus (HBV) therapy. Indeed, HBV treatment guidelines recommend HBV genotypic resistance testing for patients receiving nucleos(t)ide RT inhibitors (N(t)RTIs) who develop virological failure. N(t)...
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pub_type: 杂志文章
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abstract::The EIAV (equine infectious anemia virus) multi-species attenuated vaccine EIAV(DLV121) successfully prevented the spread of equine infectious anemia (EIA) in China in the 1970s and provided an excellent model for the study of protective immunity to lentiviruses. In this study, we compared immune responses induced by ...
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2011.08.016
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journal_title:Antiviral research
pub_type: 杂志文章
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更新日期:2017-01-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2016.01.010
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abstract::For the routine manufacture of live virus vaccines, virus is diluted into a formulation buffer to stabilize it for long-term storage, and to facilitate vaccine administration. The characteristics of this buffer are dependent on the storage temperature of the vaccine, as well as the desired characteristics of the produ...
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2005.11.001
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abstract::Conventional treatment of severe viral disease is limited by the narrow choice as well as the often-significant side effects or lack of clear efficacy of antiviral chemotherapy. At the same time, however, it is known that a reduction in viral load leads to significant clinical improvement in a number of important vira...
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2010.05.007
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abstract::Introduction of segmented genomes into virion is an important process in viral replication of rotavirus. We previously studied the assortment of the VP7 gene segment (encoding outer capsid protein VP7) in the genetic background of simian rotavirus SA11 (G serotype 3, G3) and found the preferential selection of homolog...
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/s0166-3542(98)00006-0
更新日期:1998-04-01 00:00:00
abstract::Emergence of drug-resistant human cytomegalovirus (HCMV) strains is a substantial problem during treatment of HCMV infections in immunocompromised patients. The Z-isomers of 2-hydroxymethylcyclopropylidenemethyl adenine (synadenol) and guanine (synguanol) were previously shown to be potent inhibitors of AD169 and Town...
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/s0166-3542(02)00129-8
更新日期:2002-12-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章,评审
doi:10.1016/j.antiviral.2019.104569
更新日期:2019-10-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2020.104785
更新日期:2020-06-01 00:00:00
abstract::Natural products provide a large reservoir of potentially active agents with anti-hepatitis B virus (HBV) activity. We examined the effect of the polyphenolic extract from Geranium carolinianum L. (PPGC) on HBV replication both in vitro and in vivo. In the human HBV-transfected liver cell line HepG(2) 2.2.15, PPGC eff...
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2008.03.001
更新日期:2008-08-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2013.09.011
更新日期:2013-11-01 00:00:00
abstract::Isolation of rhinoviruses from nasal secretions may be delayed or prevented by exogenously applied interferon which is carried over into nasal wash specimens. In studies of interferon-alpha 2 treated volunteers with experimental rhinovirus infection, we determined that incorporation of antiinterferon antibody into col...
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/0166-3542(83)90016-5
更新日期:1983-03-01 00:00:00
abstract::We studied susceptibility to herpes labialis by exposing 20 volunteers to experimental ultraviolet radiation (UVR) on three occasions at 3- to 4-month intervals. The number of patients who developed lesions after each session was 9/20 (45%), 9/20 (45%) and 14/20 (70%). Herpes simplex virus (HSV) was isolated from 21/2...
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pub_type: 杂志文章
doi:10.1016/0166-3542(95)00038-n
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/0166-3542(96)00946-1
更新日期:1996-06-01 00:00:00
abstract::Natural compounds provide a large reservoir of potentially active anti-hepatitis B virus (HBV) agents. We examined the direct effects of protocatechuic aldehyde (PA; derived from the Chinese herb, Salvia miltiorrhiza) on HBV replication in HepG2 2.2.15 cell line and duck hepatitis B virus (DHBV) replication in ducklin...
journal_title:Antiviral research
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doi:10.1016/j.antiviral.2006.12.005
更新日期:2007-04-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2016.11.025
更新日期:2017-02-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2006.10.007
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/s0166-3542(99)00067-4
更新日期:1999-12-31 00:00:00
abstract::Tea is the second most consumed drink in the world. The beneficial effects of tea have been mostly attributed to its catechin content. Black tea is derived from the leaves of Camellia sinensis plant, and it is rich in theaflavin polyphenols, in particular theaflavin (TF1), theaflavin-3-monogallate (TF2A), theaflavin-3...
journal_title:Antiviral research
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journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/0166-3542(93)90082-t
更新日期:1993-09-01 00:00:00
abstract::Development of efficient and safer vaccines against foot-and-mouth disease virus (FMDV) is a must. Previous results obtained in our laboratory have demonstrated that DNA vaccines encoding B and T cell epitopes from type C FMDV, efficiently controlled virus replication in mice, while they did not protect against FMDV c...
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2011.07.017
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abstract::Transcriptional activation of HIV-1 gene expression is partially controlled by the interaction between viral and cellular transcription factors acting at HIV-1 long terminal repeat (LTR) sequences. HIV-1 subtyping at LTR region and nucleotide LTR variability from clinical samples in 48 subjects carrying different HIV-...
journal_title:Antiviral research
pub_type: 杂志文章
doi:10.1016/j.antiviral.2010.08.007
更新日期:2010-11-01 00:00:00