Abstract:
:The biological response modifier 7-thia-8-oxoguanosine was evaluated in mice against the hepatotropic Adames strain of Punta Toro virus. When administered intraperitoneally in divided doses, significant protection from death was conferred at doses of 50 and 100 mg/kg/day given 24 and 17 h pre-virus inoculation, 25-100 mg/kg/day administered 4 h pre- and 3 h post-virus challenge, and 12.5 to 100 mg/kg/day administered 24 and 31 h after virus inoculation. These doses preventing death reduced liver icterus scores, serum alanine aminotransferase and aspartate aminotransferase levels, and liver and serum virus titers relative to placebo controls. Full daily doses administered at 24 h were somewhat less protective to mice than divided daily doses starting at the same time. The initiation of treatment could be delayed as late as 36 h after virus inoculation, resulting in complete protection from mortality at 100 mg/kg/day. This prevention of death occurred despite the acute nature of the infection which resulted in deaths by 96 h in the placebo-treated controls. These results show that 7-thia-8-oxoguanosine has both prophylactic and therapeutic potential as an anti-Phlebovirus agent. Interferon induction appears to be the reason for antiviral activity in this model, since up to 10,000 units of interferon/ml were induced in mice 1 h after treatment with 100 mg 7-thia-8-oxoguanosine per kg, and antibody to interferon alpha/beta administered shortly after treatment with the nucleoside negated the antiviral effect.
journal_name
Antiviral Resjournal_title
Antiviral researchauthors
Smee DF,Huffman JH,Gessaman AC,Huggins JW,Sidwell RWdoi
10.1016/0166-3542(91)90069-4subject
Has Abstractpub_date
1991-03-01 00:00:00pages
229-39issue
3eissn
0166-3542issn
1872-9096pii
0166-3542(91)90069-4journal_volume
15pub_type
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journal_title:Antiviral research
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更新日期:1999-02-01 00:00:00
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更新日期:2017-01-01 00:00:00
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journal_title:Antiviral research
pub_type: 杂志文章
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journal_title:Antiviral research
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