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Deletion of the herpes simplex virus type 1 ribonucleotide reductase gene alters virulence and latency in vivo.

Abstract：

:The role of herpes simplex virus type 1 (HSV-1)-encoded ribonucleotide reductase (RR) has been investigated in mice and guinea pigs using a mutant from which 90% of the large subunit of the enzyme was deleted. The RR mutant was extremely impaired in its ability to induce external vaginal lesions or to cause death in mice following intracerebral, intraperitoneal, or intravaginal inoculation, or in guinea pigs following intraperitoneal or intravaginal inoculation. The RR mutant replicated poorly in the vagina of mice and guinea pigs when compared with the parental virus. Neither infectious nor latent virus was recovered from the trigeminal ganglia of mice or from the dorsal root ganglia of mice and guinea pigs after inoculation with the RR mutant. Using the polymerase chain reaction, RR mutant DNA was, nevertheless, detected in the dorsal root ganglia of guinea pigs. These studies suggest that HSV-1 RR is essential for virulence and may also play a role in the recovery of reactivatable latent virus from ganglia in both mice and guinea pigs.

journal_name

Antiviral Res

journal_title

Antiviral research

authors

Idowu AD,Fraser-Smith EB,Poffenberger KL,Herman RC

doi

10.1016/0166-3542(92)90048-a

subject

Has Abstract

pub_date

1992-02-01 00:00:00

pages

145-56

issue

2

eissn

0166-3542

issn

1872-9096

pii

0166-3542(92)90048-A

journal_volume

17

pub_type

杂志文章

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