当前位置： SCI文献检索 > ANTIVIRAL RESEARCH期刊下所有文献 > Nuclear localization of dengue virus (DENV) 1-4 non-structural protein 5; protection against all 4 DENV serotypes by the inhibitor Ivermectin.

Nuclear localization of dengue virus (DENV) 1-4 non-structural protein 5; protection against all 4 DENV serotypes by the inhibitor Ivermectin.

Abstract：

:Infection by one of the 4 distinct serotypes of dengue virus (DENV) threatens >40% of the world's population, with no efficacious vaccine or antiviral agent currently available. DENV replication through the virus-encoded nonstructural protein (NS) 5 protein occurs in the infected cell cytoplasm, but NS5 from DENV2 has thus far been shown to localize strongly in the nucleus throughout infection. Here we use specific antibodies cross-reactive with NS5 from DENV1-4 to demonstrate nuclear localization of NS5 from all DENV serotypes for the first time in both infected as well as transfected cells, although to differing extents. The small-molecule inhibitor Ivermectin was inhibitory towards both DENV 1 and 2 NS5 interaction with its nuclear transporter importin α/β in vitro, and protected against infection from DENV1-4. Ivermectin thus has potential in the clinical setting as a dengue antiviral.

journal_name

Antiviral Res

journal_title

Antiviral research

authors

Tay MY,Fraser JE,Chan WK,Moreland NJ,Rathore AP,Wang C,Vasudevan SG,Jans DA

doi

10.1016/j.antiviral.2013.06.002

subject

Has Abstract

pub_date

2013-09-01 00:00:00

pages

301-6

issue

3

eissn

0166-3542

issn

1872-9096

pii

S0166-3542(13)00159-9

journal_volume

99

pub_type

杂志文章

相关文献

ANTIVIRAL RESEARCH文献大全
  • Genetic susceptibility in chronic viral hepatitis.

    abstract：:Infection with hepatitis B virus (HBV) or hepatitis C virus (HCV) may result in a number of different clinical outcomes. There is strong evidence in HBV infection that host genetic factors play a major role in determining the outcome of infection. A number of approaches may be used to determine the specific genetic fa...

    journal_title：Antiviral research

    pub_type： 杂志文章,评审

    doi：10.1016/s0166-3542(01)00175-9

    authors： Thursz M

    更新日期：2001-11-01 00:00:00

  • Down-regulation of suppressor of cytokine signaling 3 by miR-122 enhances interferon-mediated suppression of hepatitis B virus.

    abstract：:MicroRNA-122 (miR-122) is involved in the pathogenesis of several liver diseases, including chronic hepatitis B infection and hepatocellular carcinoma. This study aimed to explore the potential role of miR-122 in the interferon (IFN)-mediated suppression of hepatitis B virus (HBV) in hepatocytes. We found that elevate...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2015.03.001

    authors： Gao D,Zhai A,Qian J,Li A,Li Y,Song W,Zhao H,Yu X,Wu J,Zhang Q,Kao W,Wei L,Zhang F,Zhong Z

    更新日期：2015-06-01 00:00:00

  • Functional significance of amino acid residues within conserved hydrophilic regions in human interferons-alpha.

    abstract：:Site-directed in vitro mutagenesis was used to create analogs of human interferons (IFNs)-alpha 1 and -alpha 4. Analogs were expressed in vitro using SP6 RNA polymerase and a rabbit reticulocyte lysate cell-free protein synthesis system. Amino acid substitutions for the highly conserved residues at positions 33, 121, ...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/0166-3542(89)90066-1

    authors： Tymms MJ,McInnes B,Waine GJ,Cheetham BF,Linnane AW

    更新日期：1989-08-01 00:00:00

  • Ezetimibe inhibits dengue virus infection in Huh-7 cells by blocking the cholesterol transporter Niemann-Pick C1-like 1 receptor.

    abstract：:Despite the importance of Dengue virus (DENV) infection in human health, there is not a fully effective vaccine or antiviral treatment against the infection. Since lipids such as cholesterol are required during DENV infection, its uptake and synthesis are increased in infected cells. Ezetimibe is an FDA-approved drug ...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2018.10.024

    authors： Osuna-Ramos JF,Reyes-Ruiz JM,Bautista-Carbajal P,Cervantes-Salazar M,Farfan-Morales CN,De Jesús-González LA,Hurtado-Monzón AM,Del Ángel RM

    更新日期：2018-12-01 00:00:00

  • Identification of KX2-391 as an inhibitor of HBV transcription by a recombinant HBV-based screening assay.

    abstract：:Antiviral therapies for chronic hepatitis B virus (HBV) infection that are currently applicable for clinical use are limited to nucleos(t)ide analogs targeting HBV polymerase activity and pegylated interferon alpha (PEG-IFN). Towards establishing an effective therapy for HBV related diseases, it is important to develo...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2017.06.005

    authors： Harada K,Nishitsuji H,Ujino S,Shimotohno K

    更新日期：2017-08-01 00:00:00

  • Novel CCR5 monoclonal antibodies with potent and broad-spectrum anti-HIV activities.

    abstract：:To identify monoclonal antibodies (mAbs) with high potency and novel recognition sites, more than 25,000 of mouse hybridomas were screened and 4 novel anti-human CCR5 mAbs ROAb12, ROAb13, ROAb14, and ROAb18 showing potent activity in cell-cell fusion (CCF) assay were identified. These mAbs demonstrated potent antivira...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2006.11.003

    authors： Ji C,Brandt M,Dioszegi M,Jekle A,Schwoerer S,Challand S,Zhang J,Chen Y,Zautke L,Achhammer G,Baehner M,Kroetz S,Heilek-Snyder G,Schumacher R,Cammack N,Sankuratri S

    更新日期：2007-05-01 00:00:00

  • An engineered inhibitor RNA that efficiently interferes with hepatitis C virus translation and replication.

    abstract：:Hepatitis C virus (HCV) translation is mediated by a highly conserved internal ribosome entry site (IRES), mainly located at the 5'untranslatable region (5'UTR) of the viral genome. Viral protein synthesis clearly differs from that used by most cellular mRNAs, rendering the IRES an attractive target for novel antivira...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2012.02.015

    authors： Romero-López C,Berzal-Herranz B,Gómez J,Berzal-Herranz A

    更新日期：2012-05-01 00:00:00

  • Synthetic RNAi triggers and their use in chronic hepatitis B therapies with curative intent.

    abstract：:Current therapies for chronic hepatitis B virus infection (CHB) - nucleos(t)ide analogue reverse transcriptase inhibitors and interferons - result in low rates of functional cure defined as sustained off-therapy seroclearance of hepatitis B surface antigen (HBsAg). One likely reason is the inability of these therapies...

    journal_title：Antiviral research

    pub_type： 杂志文章,评审

    doi：10.1016/j.antiviral.2015.06.019

    authors： Gish RG,Yuen MF,Chan HL,Given BD,Lai CL,Locarnini SA,Lau JY,Wooddell CI,Schluep T,Lewis DL

    更新日期：2015-09-01 00:00:00

  • The efficacy of combined therapy of arsenic trioxide and alpha interferon in human T-cell leukemia virus type-1-infected squirrel monkeys (Saimiri sciureus).

    abstract：:Human T-cell lymphotropic virus type 1 (HTLV-1)-associated adult T-cell leukemia/lymphoma (ATLL) has a poor prognosis owing to its intrinsic resistance to chemotherapy. Although zidovudine (AZT) and alpha interferon (IFN-alpha) give rise to some response and improve the prognosis of ATLL, alternative therapies are nee...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2006.02.003

    authors： Heraud JM,Mortreux F,Merien F,Contamin H,Mahieux R,Pouliquen JF,Wattel E,Gessain A,de Thé H,Bazarbachi A,Hermine O,Kazanji M

    更新日期：2006-07-01 00:00:00

  • Inhibition of Japanese encephalitis virus entry into the cells by the envelope glycoprotein domain III (EDIII) and the loop3 peptide derived from EDIII.

    abstract：:Japanese encephalitis virus (JEV) infection is a major cause of acute viral encephalitis both in humans and animals. The domain III of virus envelope protein (EDIII) plays important roles in interacting with host cell receptors to facilitate virus entry. In this study, recombinant JEV EDIII was expressed and purified....

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2012.03.002

    authors： Li C,Zhang LY,Sun MX,Li PP,Huang L,Wei JC,Yao YL,Isahg H,Chen PY,Mao X

    更新日期：2012-05-01 00:00:00

  • Characterization of the binding affinities of peramivir and oseltamivir carboxylate to the neuraminidase enzyme.

    abstract：:With the continued threat of morbidity and mortality from influenza and the development of resistance to influenza antiviral drugs, there is increasing interest in new treatments, such as the investigational intravenous drug peramivir, and in combination treatments. In this study, we determined the impact of oseltamiv...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2011.06.010

    authors： Bantia S,Upshaw R,Babu YS

    更新日期：2011-09-01 00:00:00

  • Aprotinin aerosol treatment of influenza and paramyxovirus bronchopneumonia of mice.

    abstract：:The therapeutic efficacy of aerosolized aprotinin, a natural proteinase inhibitor, against influenza and paramyxovirus bronchopneumonia of mice is shown. Small-particle aerosol of aprotinin solution was generated by a Collison type nebulizer and infected mice were exposed to aerosol atmosphere by four 30-40 min incuba...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/0166-3542(94)90038-8

    authors： Ovcharenko AV,Zhirnov OP

    更新日期：1994-02-01 00:00:00

  • Meeting report: 27th International conference on antiviral research, in Raleigh, NC, USA.

    abstract：:The 27th International Conference on Antiviral Research (ICAR) was held in Raleigh, North Carolina, USA from May 12 to 16, 2014. This article summarizes the principal invited lectures. John Drach (Elion Award) described the early days of antiviral drugs and their novel modes of action. Piet Herdewijn (Holý Award) used...

    journal_title：Antiviral research

    pub_type：

    doi：10.1016/j.antiviral.2014.08.009

    authors： Vere Hodge RA

    更新日期：2014-11-01 00:00:00

  • A bacterial artificial chromosome (BAC)-vectored noninfectious replicon of SARS-CoV-2.

    abstract：:Vaccines and antiviral agents are in urgent need to stop the COVID-19 pandemic. To facilitate antiviral screening against SARS-CoV-2 without requirement for high biosafety level facility, we developed a bacterial artificial chromosome (BAC)-vectored replicon of SARS-CoV-2, nCoV-SH01 strain, in which secreted Gaussia l...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2020.104974

    authors： Zhang Y,Song W,Chen S,Yuan Z,Yi Z

    更新日期：2021-01-01 00:00:00

  • In vitro inhibition of the replication of classical swine fever virus by porcine Mx1 protein.

    abstract：:Classical swine fever virus (CSFV) is the causative pathogen of classical swine fever (CSF), a highly contagious disease of swine. Mx proteins are interferon-induced dynamin-like GTPases present in all vertebrates with a wide range of antiviral activities. Although Zhao et al. (2011) have reported that human MxA can i...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2014.01.020

    authors： He DN,Zhang XM,Liu K,Pang R,Zhao J,Zhou B,Chen PY

    更新日期：2014-04-01 00:00:00

  • Effects of apricitabine and other nucleoside reverse transcriptase inhibitors on replication of mitochondrial DNA in HepG2 cells.

    abstract：:Several nucleoside reverse transcriptase inhibitors are associated with mitochondrial toxicity resulting from inhibition of DNA polymerase-gamma. This study compared the effects on mitochondrial DNA of apricitabine (previously referred to as AVX754 or SPD754), a novel cytidine analogue under development for the treatm...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2007.05.004

    authors： de Baar MP,de Rooij ER,Smolders KG,van Schijndel HB,Timmermans EC,Bethell R

    更新日期：2007-10-01 00:00:00

  • Tumor suppressor ZHX2 restricts hepatitis B virus replication via epigenetic and non-epigenetic manners.

    abstract：:Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA), the stable genomic form as the template for viral transcription, plays a crucial role in viral persistence which remains a major global health problem. While accumulating evidence suggests the involvement of transcription factors and epigenetic machinery...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2018.03.008

    authors： Xu L,Wu Z,Tan S,Wang Z,Lin Q,Li X,Song X,Liu Y,Song Y,Zhang J,Peng J,Gao L,Gong Y,Liang X,Zuo X,Ma C

    更新日期：2018-05-01 00:00:00

  • Intravascular distribution of zidovudine: role of plasma proteins and whole blood components.

    abstract：:Knowledge of drug protein-binding and blood cell partitioning may be important for evaluating the pharmacokinetic parameters of zidovudine, particularly because of its intracellular site of action and potential to induce side effects. Equilibrium dialysis studies of zidovudine were performed over 2 h to identify the e...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/0166-3542(93)90032-e

    authors： Luzier A,Morse GD

    更新日期：1993-07-01 00:00:00

  • Transient inhibition of foot-and-mouth disease virus infection of BHK-21 cells by antisense oligonucleotides directed against the second functional initiator AUG.

    abstract：:The antiviral activity of antisense oligonucleotides corresponding to different regions of foot-and-mouth disease virus (FMDV) genome has been assessed in BHK-21 cells. The locations of the oligonucleotides used were: (i) two regions within the internal ribosome entry site (IRES), involved in the regulation of the tra...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/0166-3542(93)90082-t

    authors： Gutiérrez A,Rodríguez A,Pintado B,Sobrino F

    更新日期：1993-09-01 00:00:00

  • 4,6-dibenzamidopyrazolo[3,4-d]pyrimidine is a highly selective inhibitor of cytomegalovirus adsorption to cells.

    abstract：:The heterocycle, 4,6-dibenzamidopyrazolo[3,4-d]pyrimidine (DBAPP), inhibited cytopathology induced by human, mouse, and vervet monkey cytomegaloviruses (CMV) in vitro at 0.2 to 0.5 microM, but did not inhibit cell replication at less than or equal to 30 microM. Herpes simplex viruses were unaffected by the inhibitor. ...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/0166-3542(90)90040-e

    authors： Smee DF,Bartlett ML,Alaghamandan HA,Jones MM,Revankar GR,Robins RK

    更新日期：1990-01-01 00:00:00

  • Studies of rhinovirus resistant to an antiviral chalcone.

    abstract：:During studies of the antiviral activity of chalcone Ro-09-0410 on human rhinovirus type 9 (RV9) chalcone-resistant strains of RV9 were isolated and appeared with a frequency of about 10(-5) in chalcone sensitive stock. Chalcone-dependent viruses were found after further passage. Some characteristics of the resistant ...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/0166-3542(87)90085-4

    authors： Ahmad AL,Dowsett AB,Tyrrell DA

    更新日期：1987-08-01 00:00:00

  • Distinct patterns of cellular immune response elicited by influenza non-adjuvanted and AS03-adjuvanted monovalent H1N1(pdm09) vaccine.

    abstract：:The study aimed at identifying biomarkers of immune response elicited by non-adjuvanted-(NAV) and adjuvanted-(AV) H1N1(pdm09) vaccines. The results showed that despite both vaccines elicited similar levels of anti-H1N1 antibodies at day30 after vaccination, higher reactivity was observed in AV at day180. While AV indu...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2017.05.009

    authors： Giarola-Silva S,Coelho-Dos-Reis JGA,Mourão MM,Campi-Azevedo AC,Nakagaki Silva EE,Luiza-Silva M,Martins MA,Silveira-Cassette ACO,Batista MA,Peruhype-Magalhães V,Antonelli LRDV,Leite Ribeiro JG,Elói-Santos SM,Machado AV,Teixeir

    更新日期：2017-08-01 00:00:00

  • In vitro anti-influenza A activity of interferon (IFN)-λ1 combined with IFN-β or oseltamivir carboxylate.

    abstract：:Influenza viruses, which can cross species barriers and adapt to new hosts, pose a constant potential threat to human health. The influenza pandemic of 2009 highlighted the rapidity with which an influenza virus can spread worldwide. Currently available antivirals have a number of limitations against influenza, and no...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2014.09.008

    authors： Ilyushina NA,Donnelly RP

    更新日期：2014-11-01 00:00:00

  • Inhibition of adenovirus multiplication by short interfering RNAs directly or indirectly targeting the viral DNA replication machinery.

    abstract：:Human adenoviruses are a common threat to immunocompromised patients, e.g., HIV-positive individuals or solid-organ and, in particular, allogeneic stem cell transplant recipients. Antiviral drugs have a limited effect on adenoviruses, and existing treatment modalities often fail to prevent fatal outcome. Silencing of ...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2012.03.011

    authors： Kneidinger D,Ibrišimović M,Lion T,Klein R

    更新日期：2012-06-01 00:00:00

  • Effect of chloro-, cyano-, and amidino-substituted flavanoids on enterovirus infection in vitro.

    abstract：:Synthetic flavans, isoflavans and isoflavenes substituted with chloro, cyano and amidino groups were tested for their in vitro activity against poliovirus type 2, Coxsackie virus B4, echovirus type 6 and enterovirus 71. Plaque-reduction assays showed that substituted 3-(2H)-isoflavenes, carrying a double bond in the o...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/0166-3542(95)00088-4

    authors： Genovese D,Conti C,Tomao P,Desideri N,Stein ML,Catone S,Fiore L

    更新日期：1995-05-01 00:00:00

  • Human monoclonal anti-cytomegalovirus (CMV) antibody (MSL 109): enhancement of in vitro foscarnet- and ganciclovir-induced inhibition of CMV replication.

    abstract：:Human CMV causes a number of diseases that cause considerable morbidity and that can be life-threatening in immunocompromised patients, particularly those with AIDS. Ganciclovir (GCV) and Foscarnet (PFA) are currently the drugs of choice for management of CMV disease. Both are not without side effects and have a relat...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/0166-3542(94)90048-5

    authors： Nokta M,Tolpin MD,Nadler PI,Pollard RB

    更新日期：1994-05-01 00:00:00

  • Altered monocyte response to the dengue virus in those with varying severity of past dengue infection.

    abstract：OBJECTIVE:We sought to investigate the differences in monocyte immune responses to the dengue virus (DENV) in those who previously had either severe disease (past SD) or non-severe dengue (past NSD) following a secondary dengue infection. METHOD:Monocytes from healthy individuals who had either past SD (n = 6) or past...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2019.104554

    authors： Kamaladasa A,Gomes L,Wijesinghe A,Jeewandara C,Toh YX,Jayathilaka D,Ogg GS,Fink K,Malavige GN

    更新日期：2019-09-01 00:00:00

  • BacMam immunization partially protects pigs against sublethal challenge with African swine fever virus.

    abstract：:Lack of vaccines and efficient control measures complicate the control and eradication of African swine fever (ASF). Limitations of conventional inactivated and attenuated virus-based vaccines against African swine fever virus (ASFV) highlight the need to use new technologies to develop efficient and safe vaccines aga...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2013.02.005

    authors： Argilaguet JM,Pérez-Martín E,López S,Goethe M,Escribano JM,Giesow K,Keil GM,Rodríguez F

    更新日期：2013-04-01 00:00:00

  • Application of a gastric cancer cell line (MKN-28) for anti-adenovirus screening using the MTT method.

    abstract：:We established a sensitive and accurate method for screening of anti-adenovirus agents using the 3-(4,5-dimetylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. MKN-28 cells, which are well-differentiated stomach adenocarcinoma cells, were used for adenovirus (ADV) infection and examined for the anti-ADV act...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/0166-3542(96)06966-5

    authors： Kodama E,Shigeta S,Suzuki T,De Clercq E

    更新日期：1996-07-01 00:00:00

  • In silico study supports the efficacy of a reduced dose regimen for stavudine.

    abstract：:Stavudine (d4T) is used extensively as part of HAART in resource poor settings, despite its toxicities. The revised WHO guidelines specify replacement of d4T with less toxic but more expensive drugs when feasible, and that d4T doses be standardized to 30 mg twice daily (bid) (irrespective of body-weight), from the app...

    journal_title：Antiviral research

    pub_type： 杂志文章

    doi：10.1016/j.antiviral.2011.08.004

    authors： Hurwitz SJ,Schinazi RF

    更新日期：2011-11-01 00:00:00