Abstract：
:Human CMV causes a number of diseases that cause considerable morbidity and that can be life-threatening in immunocompromised patients, particularly those with AIDS. Ganciclovir (GCV) and Foscarnet (PFA) are currently the drugs of choice for management of CMV disease. Both are not without side effects and have a relatively narrow margin of safety. In this report the effects of a human IgG1 neutralizing monoclonal antibody MSL-109 (MSL, Sandoz Pharmaceuticals) on CMV replication was examined both alone or in combination with either GCV or PFA. Human embryonic lung fibroblasts were infected with CMV strain AD169 with a multiplicity of infection of 3 plaque forming units/cell for 1 h. Prior to infection the virus was incubated for 30 min at 37 degrees C with serial concentrations of the MSL Ab (0.1-3.0 micrograms/ml). Concentrations of GCV (0.3 to 30 microM) or PFA (50-400 microM) were added to CMV-infected cells that had been either previously incubated with MSL or not. Four days after infection CMV replication was measured by DNA/DNA probe hybridization using the Hybriwix system. MSL in combination with GCV had an additive effect that was observed at concentrations of GCV of 3-10 microM and MSL of 1-10 micrograms/ml. On the other hand, MSL (3-10 micrograms/ml) together with PFA (100-400 microM) produced a synergistic effect on CMV replication. The data suggest that MSL at doses achievable in humans, enhanced GCV- and PFA-induced antiviral effect in a dose-dependent manner and that the combination might be clinically useful in the treatment of CMV disease.
journal_name
Antiviral Resjournal_title
Antiviral researchauthors
Nokta M,Tolpin MD,Nadler PI,Pollard RBdoi
10.1016/0166-3542(94)90048-5subject
Has Abstractpub_date
1994-05-01 00:00:00pages
17-26issue
1eissn
0166-3542issn
1872-9096pii
0166-3542(94)90048-5journal_volume
24pub_type
杂志文章abstract：:Lack of vaccines and efficient control measures complicate the control and eradication of African swine fever (ASF). Limitations of conventional inactivated and attenuated virus-based vaccines against African swine fever virus (ASFV) highlight the need to use new technologies to develop efficient and safe vaccines aga...
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更新日期：2017-08-01 00:00:00
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doi：10.1016/s0166-3542(97)00039-9
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更新日期：2001-03-01 00:00:00
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pub_type： 杂志文章
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pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期：1997-06-01 00:00:00
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更新日期：2018-08-01 00:00:00
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更新日期：2008-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：2010-10-01 00:00:00
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