Abstract：
:This study describes the extent of cross-resistance and interactions for selected inhibitors of human cytomegalovirus (HCMV) DNA synthesis and DNA processing. HCMV isolates resistant to the benzimidazole D-ribonucleoside viral DNA processing inhibitors TCRB and BDCRB were sensitive to BAY 38-4766, a non-nucleoside inhibitor of viral DNA processing. This indicates that these two drug types have distinct interactions with the products of HCMV genes UL56 and UL89 required for viral DNA cleavage and packaging. These virus isolates also were sensitive to ganciclovir (GCV) but slightly resistant to the L-benzimidazole ribonucleoside viral DNA synthesis inhibitor 1263W94. Virus resistant to 1263W94 remained sensitive to BDCRB, GCV, and BAY 38-4766. Examination of drug-drug interactions in cell culture assays measuring inhibition of HCMV replication revealed strong synergism for the combination of BDCRB with 1263W94, and for combinations of 1263W94 with cidofovir (CDV) and foscarnet (PFA), but not with GCV. Combinations of GCV with CDV and PFA were synergistic as well. The combination of GCV with 1263W94 showed additive antiviral interactions, whereas, a combination of BAY 38-4766 with GCV showed antagonism. Interaction of BDCRB with BAY 38-4766 showed a mixed pattern of synergy and antagonism. The antiviral synergy observed between GCV and PFA or CDV serves to validate clinical combination therapies for these drugs. Antagonism seen for BAY 38-4766 with GCV indicates that these two drugs are unlikely to be useful for combination therapies. Notably, 1263W94 demonstrated greater synergy in combination with PFA or CDV than did GCV, suggesting some promise for this benzimidazole L-riboside in such combination therapies.
journal_name
Antiviral Resjournal_title
Antiviral researchauthors
Evers DL,Komazin G,Shin D,Hwang DD,Townsend LB,Drach JCdoi
10.1016/s0166-3542(02)00094-3subject
Has Abstractpub_date
2002-10-01 00:00:00pages
61-72issue
1eissn
0166-3542issn
1872-9096pii
S0166354202000943journal_volume
56pub_type
杂志文章abstract：:Efavirenz (EFV), a first generation non-nucleoside analogue reverse transcriptase inhibitor widely employed in combination antiretroviral therapy regimens over the last 20 years, has been associated with a wide range of neuropsychiatric effects and has also been linked with HIV-associated neurocognitive disorder (HAND...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2019.04.015
更新日期：2019-08-01 00:00:00
abstract：:Coxsackievirus A16 (CA16) is one of the main causative agents of hand, foot and mouth disease (HFMD), which is a common infectious disease in children. CA16 infection may lead to severe nervous system damage and even death in humans. However, study of the pathogenesis of CA16 infection and development of vaccines and ...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2014.02.015
更新日期：2014-05-01 00:00:00
abstract：:Novel L-lyxo-TSAO-T analogs with an inverted configuration at the C-4'-position of the sugar moiety and 5'-deoxy-5'-modified TSAO-T derivatives have been prepared and evaluated for their inhibitory effect on human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) replication in cell culture. None of the compoun...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/s0166-3542(95)00989-2
更新日期：1996-11-01 00:00:00
abstract：:Salvage therapy with ritonavir (RTV) and saquinavir (SQV) failed to achieve virological and immunological improvement in 24 HIV-infected patients who discontinued triple therapy with RTV or indinavir (IDV) because of failure or intolerance to treatment. Changes in the HIV-1 protease gene sequence were analyzed prospec...
journal_title：Antiviral research
pub_type： 临床试验,杂志文章
doi：10.1016/s0166-3542(00)00110-8
更新日期：2000-09-01 00:00:00
abstract：:Oxyresveratrol, a major compound purified from Artocarpus lakoocha, a Thai traditional medicinal plant, was evaluated for its mechanism of action and therapeutic efficacy on cutaneous herpes simplex virus (HSV) infection in mice. The inhibitory concentrations for 50% HSV-1 plaque formation of oxyresveratrol, three cli...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2008.05.002
更新日期：2008-10-01 00:00:00
abstract：:The therapeutic efficacy of aerosolized aprotinin, a natural proteinase inhibitor, against influenza and paramyxovirus bronchopneumonia of mice is shown. Small-particle aerosol of aprotinin solution was generated by a Collison type nebulizer and infected mice were exposed to aerosol atmosphere by four 30-40 min incuba...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/0166-3542(94)90038-8
更新日期：1994-02-01 00:00:00
abstract：:Enterovirus-71 (EV71) is one of the major causative reagents for hand-foot-and-mouth disease. In particular, EV71 causes severe central nervous system infections and leads to numerous dead cases. Although several inactivated whole-virus vaccines have entered in clinical trials, no antiviral agent has been provided for...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2013.12.008
更新日期：2014-03-01 00:00:00
abstract：:Tea is the second most consumed drink in the world. The beneficial effects of tea have been mostly attributed to its catechin content. Black tea is derived from the leaves of Camellia sinensis plant, and it is rich in theaflavin polyphenols, in particular theaflavin (TF1), theaflavin-3-monogallate (TF2A), theaflavin-3...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2015.03.009
更新日期：2015-06-01 00:00:00
abstract：:(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, HPMPC, and two HPMPC-related nucleoside analogs, (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine, HPMPA, and (2-phosphonylmethoxyethyl)guanine, PMEG, were evaluated for their antiviral activities against guinea pig cytomegalovirus (GPCMV) infection in guinea pig ...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/0166-3542(90)90069-j
更新日期：1990-05-01 00:00:00
abstract：:In 1989, a new type of antibody was identified, first in the sera of dromedaries and later also in all other species of the Camelidae family. These antibodies do not contain a light chain and also lack the first constant heavy domain. Today it is still unclear what the evolutionary advantage of such heavy chain-only a...
journal_title：Antiviral research
pub_type： 杂志文章,评审
doi：10.1016/j.antiviral.2011.09.002
更新日期：2011-12-01 00:00:00
abstract：:Heparan sulfate (HS) is a ubiquitous glycosaminoglycan that serves as a cellular attachment site for a number of significant human pathogens, including respiratory syncytial virus (RSV), human parainfluenza virus 3 (hPIV3), and herpes simplex virus (HSV). Decoy receptors can target pathogens by binding to the receptor...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2015.01.008
更新日期：2015-04-01 00:00:00
abstract：:Treatment of the chronic hepatitis C virus (HCV) infection is an unmet medical need, and the HCV NS3 serine protease (NS3-SP) has been used as an attractive target of antiviral screening against HCV. To find naturally chemical entities as lead compounds from which novel anti-HCV agents could be developed, bioassay-gui...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2007.06.001
更新日期：2007-10-01 00:00:00
abstract：:Twenty-four patients with chronic non-A non-B hepatitis were randomly assigned to receive either human fibroblast interferon (HuIFN-beta) at doses of 1 or 3 million international units (MIU) per day for 4 or 12 weeks (12 patients) or to receive no therapy (12 patients), and were then compared with 5 patients with chro...
journal_title：Antiviral research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0166-3542(89)90048-x
更新日期：1989-10-01 00:00:00
abstract：:IRES-driven translation plays an essential role in picornavirus infection. However, there are seldom reports of compounds targeting this pathway with effective protection in animal models. Here, we identified emetine, an antiprotozoal drug, which inhibits EV-A71 with an EC50 value of 0.04 μM and a CC50 value of 10 μM ...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2019.104650
更新日期：2020-01-01 00:00:00
abstract：:Prostaglandins are potentially useful antiviral agents, however their mechanism of action is unclear. Recent evidence suggests that RNA transcription of vesicular stomatitis virus (VSV) is inhibited by prostaglandins (Bader and Ankel, J. Gen. Virol. 71, 2823-2832, 1990). Prostaglandins are known to have multiple effec...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/0166-3542(94)00067-i
更新日期：1995-01-01 00:00:00
abstract：:The hepatitis B virus nucleocapsid or core antigen is extremely immunogenic during infection and after immunization. This review summarizes several features of the nucleocapsid which explain this exceptionally high immunogenicity: a unique three-dimensional folding, the presence of a region that interacts with immunog...
journal_title：Antiviral research
pub_type： 杂志文章,评审
doi：10.1016/j.antiviral.2003.08.011
更新日期：2003-10-01 00:00:00
abstract：:This study aimed to investigate anti-HBV effect and major active compounds of Su-duxing, a medicine extracted from Chinese herbs. HBV-replicating cell lines HepG2.2.15 (wild-type) and HepG2.A64 (entecavir-resistant) were used for in vitro test. C57BL/6 mice infected by adeno-associated virus carrying 1.3 mer wild-type...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2018.04.017
更新日期：2018-07-01 00:00:00
abstract：:Emergence of drug-resistant human cytomegalovirus (HCMV) strains is a substantial problem during treatment of HCMV infections in immunocompromised patients. The Z-isomers of 2-hydroxymethylcyclopropylidenemethyl adenine (synadenol) and guanine (synguanol) were previously shown to be potent inhibitors of AD169 and Town...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/s0166-3542(02)00129-8
更新日期：2002-12-01 00:00:00
abstract：:We have investigated viral breakthrough during a long-term culture of HIV-1-infected cells with the non-nucleoside reverse transcriptase inhibitors (NNRTIs) 6-benzyl-1-ethoxymethyl-5-isopropyluracil (MKC-442), nevirapine and loviride (alpha-APA). When the compounds were examined for their inhibitory effects on HIV-1 (...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/0166-3542(96)00946-1
更新日期：1996-06-01 00:00:00
abstract：:Previous studies have demonstrated that cyclopentenone prostaglandins (cyPGs) inhibit the replication of a wide variety of DNA and RNA viruses in different mammalian cell types. We investigated a new role for prostaglandin A1 (PGA1) in the inhibition of hepatitis C virus (HCV)-IRES-mediated translation. PGA1 exhibited...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2015.01.013
更新日期：2015-05-01 00:00:00
abstract：:Investments in the development of new drugs for orthopoxvirus infections have fostered new avenues of research, provided an improved understanding of orthopoxvirus biology and yielded new therapies that are currently progressing through clinical trials. These broad-based efforts have also resulted in the identificatio...
journal_title：Antiviral research
pub_type： 杂志文章,评审
doi：10.1016/j.antiviral.2012.02.012
更新日期：2012-05-01 00:00:00
abstract：:Trimming of the N-glycans attached to the envelope proteins of hepatitis B virus (HBV) is required in different steps of the viral life cycle. Inhibition of the host enzymes alpha-glucosidases, involved in the endoplasmic reticulum (ER)-associated processing of the N-linked glycans, results in misfolding of the HBV en...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2007.04.004
更新日期：2007-10-01 00:00:00
abstract：:The effects of HIV-1 protease inhibitors on proteolytic processing and infectivity of virions produced from lymphocytes chronically infected with the virus were studied. Protease inhibition was detected by the accumulation of the polyprotein precursors Pr55gag and Pr160gag-pol and their cleavage intermediates. Immunob...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/s0166-3542(99)00074-1
更新日期：2000-01-01 00:00:00
abstract：:EV71 is a major causative agent of hand, foot and mouth disease (HFMD) and is responsible for large outbreaks in various Asian Pacific countries. In the present study, we generated the recombinant baculovirus (Bac-VP1) encoding VP1 in a novel expression cassette. The transmembrane domain of hemagglutinin of the H3N2 i...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2012.05.017
更新日期：2012-09-01 00:00:00
abstract：:Ebola virus (EBOV), a negative-sense RNA virus in the family Filoviridae, is known to cause severe hemorrhagic fever in humans and other primates. Infection with EBOV causes a high mortality rate and currently there is no FDA-licensed vaccine or therapeutic treatment available. Recently, heat-shock protein 90 (Hsp90),...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2010.04.015
更新日期：2010-08-01 00:00:00
abstract：:Although highly active anti-retroviral therapy (HAART) is successful in the treatment of HIV infection, problems with toxicity, drug-resistant variants, and therapeutic failures have compromised the long-term utility of existing combination regimens. Mismatched double-stranded RNA (polyI-polyC(12)U) is an immune modul...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/s0166-3542(01)00150-4
更新日期：2001-09-01 00:00:00
abstract：:Novel analogues of the anti-HIV-1 agent TSAO-T, [1-[2',5'-bis-O-(tert- butyldimethylsilyl)-beta-D-ribofuranosyl]thymine]-3'-spiro-5"-(4"-amino- 1",2"-oxathiole-2",2"-dioxide) and its 3-methyl counterpart TSAO-m3T were obtained by modifications at positions 2' or 5' of the sugar moiety. These compounds were evaluated f...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/0166-3542(95)00012-b
更新日期：1995-06-01 00:00:00
abstract：:Amantadine and rimantadine hydrochloride were tested for stability after storage at different temperatures and under different conditions for extended periods of time. Both compounds were quite stable after storage for at least 25 years at ambient temperature; they both retained full antiviral activity after long-term...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/s0166-3542(98)00015-1
更新日期：1998-06-01 00:00:00
abstract：:Enterovirus D68 (EV-D68) is a member of the Picornavirus family and a causative agent of respiratory diseases in children. The incidence of EV-D68 infection has increased worldwide in recent years. Thus far, there are no approved antiviral agents or vaccines for EV-D68. Here, we show that methyl-β-cyclodextrin (MβCD),...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2020.104752
更新日期：2020-04-01 00:00:00
abstract：:Because encapsulation of antiviral drugs in liposomes resulted generally in improved activity against retroviral replication in vivo, the antiviral effects of free-SPC3 and liposome-associated SPC3 were compared in cultured human lymphocytes infected with HIV-1. SPC3 was entrapped in various liposomal formulations, ei...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/s0166-3542(02)00002-5
更新日期：2002-06-01 00:00:00
