Abstract：
:Our aim was to analyze the virological response to a combined antiretroviral therapy started after Maraviroc Clinical Test (MCT) in naïve HIV-infected patients. Forty-one patients were exposed to MCT, based on an 8-day MVC monotherapy. If undetectability or a viral load reduction >1 log10 HIV-RNA copies/ml was achieved, a MVC-containing cART was prescribed. Forty patients showed a positive MCT; undetectability after 48weeks on cART was achieved in 34/41 (82.9%) patients. The result of MCT was compared with a genotypic tropism method and with Trofile®, showing 10.7% and 18.75% discordance rates, respectively. MCT is a reliable tool to decide CCR5-antagonists prescription, also in the naïve scenario where most patients show a virological response to MVC independently the tropism result reported by genotypic or phenotypic methods.
journal_name
Antiviral Resjournal_title
Antiviral researchauthors
Genebat M,de Pablo-Bernal RS,Pulido I,Jiménez-Mejías ME,Martínez O,Pacheco YM,Raffi-El-Idrissi Benhia M,Abad MA,Ruiz-Mateos E,Leal Mdoi
10.1016/j.antiviral.2015.06.018subject
Has Abstractpub_date
2015-09-01 00:00:00pages
94-6eissn
0166-3542issn
1872-9096pii
S0166-3542(15)00149-7journal_volume
121pub_type
杂志文章abstract：:The 30th International Conference on Antiviral Research (ICAR) was held in Atlanta, GA, USA from May 18 to 21, 2017. This report provides an account of award lectures, invited keynote addresses and oral presentations during the meeting. The 2017 Gertrude Elion Memorial Lecture Award by Michael Sofia highlighted one of...
journal_title：Antiviral research
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abstract：:Upon screening synthetic small molecule libraries with the infectious hepatitis C virus (HCV) cell culture system, we identified a benzothiazepinecarboxamide (BTC) scaffold that inhibits HCV. A structure-activity relationship (SAR) study with BTCs was performed, and modifications that led to nanomolar antiviral activi...
journal_title：Antiviral research
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abstract：:Pseudorabies virus (PRV) infection was established in mice by means of inoculating the ear flap. The infection was universally fatal once clinical signs appeared. Bromovinyldeoxyuridine (BVDU) was a potent inhibitor of PRV in vitro, but this drug failed to protect mice and produced only marginal reductions in virus ti...
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journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2016.07.017
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abstract：:Several polyanionic compounds with potential for use as topically applied microbicides to prevent HIV-1 sexual transmission, such as PRO 2000, are currently in phase III clinical efficacy trials. Microbicidal formulations may well comprise combinations of inhibitors to increase potency, reduce dose and minimize proble...
journal_title：Antiviral research
pub_type： 杂志文章
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abstract：:The rapid spread of Zika virus (ZIKV) in recent years has highlighted the severe diseases associated with ZIKV infection, such as Guillain-Barré syndrome in adults and microcephaly in newborns; yet no vaccines or antivirals currently exist to prevent or treat ZIKV infection. We and others have previously identified N-...
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1016/j.antiviral.2008.03.001
更新日期：2008-08-01 00:00:00
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pub_type： 杂志文章
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journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2020.104867
更新日期：2020-11-01 00:00:00
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journal_title：Antiviral research
pub_type： 杂志文章
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journal_title：Antiviral research
pub_type： 临床试验,杂志文章
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更新日期：1982-08-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.antiviral.2020.104785
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journal_title：Antiviral research
pub_type： 杂志文章,评审
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更新日期：2004-02-01 00:00:00
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journal_title：Antiviral research
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journal_title：Antiviral research
pub_type： 杂志文章
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更新日期：2012-01-01 00:00:00
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journal_title：Antiviral research
pub_type： 杂志文章,评审
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doi：10.1016/s0166-3542(00)00063-2
更新日期：2000-02-01 00:00:00
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journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2006.02.003
更新日期：2006-07-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2012-05-01 00:00:00
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journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/0166-3542(92)90086-k
更新日期：1992-01-01 00:00:00
abstract：BACKGROUND:By modulating the antiviral immune response via vitamin D receptor, the active form of vitamin D (1,25-dihydroxyvitamin D, calcitriol) could play a central role in protection against respiratory virus infections. This in vitro study tested the hypothesis that respiratory viruses modulate vitamin D receptor e...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2016.11.004
更新日期：2017-01-01 00:00:00
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journal_title：Antiviral research
pub_type： 杂志文章
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更新日期：1996-08-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.antiviral.2012.04.010
更新日期：2012-07-01 00:00:00
abstract：:Citrusinine-I, a new acridone alkaloid isolated from the root bark of the citrus plant (Rutaceae), exhibited potent activity against herpes simplex virus (HSV) type 1 and type 2 at low concentrations relative to their cytotoxicity; 50% effective concentrations (ED50) of citrusinine-I were 0.56 micrograms/ml and 0.74 m...
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pub_type： 杂志文章
doi：10.1016/0166-3542(89)90065-x
更新日期：1989-08-01 00:00:00
abstract：:Coumarins and structurally related compounds have been recently shown to inhibit replication of human immunodeficiency virus (HIV) and thus, exhibit a therapeutic potential. In this study we report that mesuol and isomesuol, two 4-phenyl coumarins, isolated from the tree Marila pluricostata, suppress HIV-1 replication...
journal_title：Antiviral research
pub_type： 杂志文章
doi：10.1016/j.antiviral.2005.02.006
更新日期：2005-06-01 00:00:00
