Effect of tiazofurin on tomato plants infected with tomato spotted wilt virus.

abstract：:Several mammarenaviruses, chiefly Lassa virus (LASV) in Western Africa and Junín virus (JUNV) in the Argentine Pampas, cause severe disease in humans and pose important public health problems in their endemic regions. Moreover, mounting evidence indicates that the worldwide-distributed mammarenavirus lymphocytic chori...

journal_title：Antiviral research

authors： Kim YJ,Cubitt B,Chen E,Hull MV,Chatterjee AK,Cai Y,Kuhn JH,de la Torre JC

更新日期：2019-09-01 00:00:00

abstract：:Zika virus (ZIKV) is a mosquito-borne flavivirus associated with severe neonatal birth defects, but the causative mechanism is incompletely understood. ZIKV shares sequence homology and early clinical manifestations with yellow fever virus (YFV) and dengue virus (DENV) and are all transmitted in urban cycles by the sa...

journal_title：Antiviral research

authors： Luo H,Winkelmann ER,Fernandez-Salas I,Li L,Mayer SV,Danis-Lozano R,Sanchez-Casas RM,Vasilakis N,Tesh R,Barrett AD,Weaver SC,Wang T

更新日期：2018-03-01 00:00:00

abstract：:In vitro studies of HBV core promoter mutations in hepatoma cell lines suggest that some mutations in core promoter transcription factor binding sites result in reduced core promoter activity and viral replication. We sought to validate this hypothesis using clinical samples with viral load differences before and afte...

journal_title：Antiviral research

authors： Cheng Y,Seet BL,Ong CS,Wasser S,Tan TM,Peter FJ,Lim SG

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:Cyclophilin inhibitors have shown activity against a variety of viruses, including HCV. NIM811, a novel, non-immunosuppressive cyclophilin inhibitor was studied in ascending doses in a randomized, double-blind, placebo-controlled 14-day trial in genotype 1 HCV patients. Doses of 10 up to 600 mg were given or...

journal_title：Antiviral research

authors： Lawitz E,Godofsky E,Rouzier R,Marbury T,Nguyen T,Ke J,Huang M,Praestgaard J,Serra D,Evans TG

更新日期：2011-03-01 00:00:00

abstract：:In the scope of the search for new anti-HIV agents interacting with a new target, we developed a high-throughput screening system to detect the interactions between Nef and Hck. Nef is an accessory protein of HIV, which is involved in the pathogenicity of the acquired immunodeficiency syndrome (AIDS). Nef is also a si...

journal_title：Antiviral research

authors： Murakami Y,Fukazawa H,Kobatake T,Yamagoe S,Takebe Y,Tobiume M,Matsuda M,Uehara Y

更新日期：2002-07-01 00:00:00

abstract：:Wedelolactone (WDL) is a coumestan present in the plants Eclipta prostrata and Wedelia calendulacea which are used for treatment of a multitude of health problems in traditional medicine. It has previously been shown that WDL exerts antiviral activity against human immunodeficiency virus and hepatitis C virus. In this...

journal_title：Antiviral research

authors： Svrlanska A,Ruhland A,Marschall M,Reuter N,Stamminger T

更新日期：2020-02-01 00:00:00

abstract：:Many flaviviruses, such as Zika virus (ZIKV), Dengue virus (DENV1-4) and yellow fever virus (YFV), are significant human pathogens. Infection with ZIKV, an emerging mosquito-borne flavivirus, is associated with increased risk of microcephaly in newborns and Guillain-Barré syndrome and other complications in adults. Cu...

journal_title：Antiviral research

authors： Li Z,Sakamuru S,Huang R,Brecher M,Koetzner CA,Zhang J,Chen H,Qin CF,Zhang QY,Zhou J,Kramer LD,Xia M,Li H

更新日期：2018-02-01 00:00:00

abstract：:The reverse transcriptase (RT) of HIV which has been inhibited by the incorporation of AZT into the primer strand is subject to a deblocking reaction by cellular ATP. This reaction yields unblocked primer plus the dinucleoside tetraphosphate, AZTp(4)A. In the present study, we report that AZTp(4)A is an excellent subs...

journal_title：Antiviral research

authors： Pitcher WH 3rd,Kirby TW,DeRose EF,London RE

更新日期：2003-05-01 00:00:00

abstract：:The model of simian immunodeficiency virus (SIV) infection in rhesus macaques was used to evaluate the effects of recombinant human interferon alpha, Hu IFN-alpha 2b and Hu IFN-gamma B,D, at two doses. Administration began 1 day prior to infection and was continued for 90 days postinfection. Both interferons suppresse...

journal_title：Antiviral research

authors： Schellekens H,Niphuis H,Buijs L,Douw van der Krap P,Hochkeppel HK,Heeney JL

更新日期：1996-08-01 00:00:00

abstract：:Transcriptional activation of HIV-1 gene expression is partially controlled by the interaction between viral and cellular transcription factors acting at HIV-1 long terminal repeat (LTR) sequences. HIV-1 subtyping at LTR region and nucleotide LTR variability from clinical samples in 48 subjects carrying different HIV-...

journal_title：Antiviral research

authors： de Arellano ER,Alcamí J,López M,Soriano V,Holguín A

更新日期：2010-11-01 00:00:00

abstract：:In March and April 2009, an entirely novel influenza A (H1N1) virus (NIAV) emerged in Mexico and the USA. During the subsequent months, the virus rapidly spread all over the world by person-to-person transmission. In this report, RNA interference (RNAi) was used as an antiviral agent to inhibit NIAV replication in A54...

journal_title：Antiviral research

authors： Zhiqiang W,Yaowu Y,Fan Y,Jian Y,Yongfeng H,Lina Z,Jianwei W,Qi J

更新日期：2010-03-01 00:00:00

abstract：:The creatine kinase/creatine phosphate (CK/CrP) system plays an important role in cellular energy homeostasis. CK isoenzymes, which reversibly generate ATP from CrP, are compartmentalized at cellular sites where energy is produced or utilized. It has been noted that the expression of CK is induced in cells infected by...

journal_title：Antiviral research

authors： Lillie JW,Smee DF,Huffman JH,Hansen LJ,Sidwell RW,Kaddurah-Daouk R

更新日期：1994-04-01 00:00:00

abstract：:Human parainfluenza virus type 3 (HPIV3) is an important respiratory tract pathogen of infants and children. There are no vaccines or antivirals currently approved for prevention or treatment of HPIV3 infection. Towards developing an antiviral therapy to combat HPIV3 infection, we have established a green fluorescent ...

journal_title：Antiviral research

authors： Mao H,Thakur CS,Chattopadhyay S,Silverman RH,Gudkov A,Banerjee AK

更新日期：2008-02-01 00:00:00

abstract：:We have analyzed a panel of protein kinase inhibitors (PKIs) and found that some indolocarbazoles (Gö6976, K252a, K252c) proved to be highly effective inhibitors of GCV-sensitive and -resistant human cytomegalovirus (HCMV) strains, but did not show any effect against herpes simplex virus. Antiviral activity was determ...

journal_title：Antiviral research

authors： Zimmermann A,Wilts H,Lenhardt M,Hahn M,Mertens T

更新日期：2000-10-01 00:00:00

abstract：:Innate, non-specific, resistance mechanisms are important barriers to pathogens, particularly delaying virus multiplication at the onset of infections. These innate defense mechanisms include a series of mechanical barriers, pre-existing inhibitory molecules, and cellular responses with antimicrobial activity. The ant...

journal_title：Antiviral research

authors： Baron S,Singh I,Chopra A,Coppenhaver D,Pan J

更新日期：2000-11-01 00:00:00

abstract：:Prostratin, a non-tumor-promoting phorbol ester, inhibited human immunodeficiency virus (HIV)-induced cell killing and viral replication in a variety of acutely-infected cell systems. The potency and degree of cytoprotection was dependent on both viral strain and host cell type. Prostratin activated viral expression i...

journal_title：Antiviral research

authors： Gulakowski RJ,McMahon JB,Buckheit RW Jr,Gustafson KR,Boyd MR

更新日期：1997-01-01 00:00:00

abstract：:The present study was undertaken to examine the potential of rectal route of immunization for induction of protective immunity in the female genital tract against genital herpes infection in mice. A single rectal immunization of female C57Bl/6 mice with live attenuated herpes simplex virus type 2 lacking thymidine kin...

journal_title：Antiviral research

authors： Tengvall S,O'Hagan D,Harandi AM

更新日期：2008-06-01 00:00:00

abstract：:The immune evasion of wild-type (wt) rabies virus (RABV) has been attributed to its glycoprotein (G), particularly to their inefficiency to bind/enter into dendritic cells (DCs). However, the domain responsible for G-mediated DC activation is not clear. In the present study, attempts were made to map the domain(s) on ...

journal_title：Antiviral research

authors： Huang J,Zhang Y,Huang Y,Gnanadurai CW,Zhou M,Zhao L,Fu ZF

更新日期：2017-05-01 00:00:00

abstract：:Natural products provide a large reservoir of potentially active agents with anti-hepatitis B virus (HBV) activity. We examined the effect of the polyphenolic extract from Geranium carolinianum L. (PPGC) on HBV replication both in vitro and in vivo. In the human HBV-transfected liver cell line HepG(2) 2.2.15, PPGC eff...

journal_title：Antiviral research

authors： Li J,Huang H,Feng M,Zhou W,Shi X,Zhou P

更新日期：2008-08-01 00:00:00

abstract：:Drug resistance resulting from reverse transcriptase (RT) mutations is one of the main obstacles to successful hepatitis B virus (HBV) therapy. Indeed, HBV treatment guidelines recommend HBV genotypic resistance testing for patients receiving nucleos(t)ide RT inhibitors (N(t)RTIs) who develop virological failure. N(t)...

journal_title：Antiviral research

authors： Rhee SY,Margeridon-Thermet S,Nguyen MH,Liu TF,Kagan RM,Beggel B,Verheyen J,Kaiser R,Shafer RW

更新日期：2010-12-01 00:00:00

abstract：:Infection with the oncogenic γ-herpesviruses Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV) cause several severe malignancies in humans. Inhibition of the lytic replication of EBV and KSHV eliminates the reservoir of persistent infection and transmission, consequently preventing the occurr...

journal_title：Antiviral research

authors： Huang L,Yang M,Yuan Y,Li X,Kuang E

更新日期：2017-02-01 00:00:00

abstract：:The biological evaluation of mononucleotide prodrugs (pronucleotides) of various nucleoside reverse transcriptase inhibitors (NRTIs) such as zidovudine (AZT), zalcitabine (ddC) and lamivudine (3TC) was reported in human T-lymphoid MOLT-4/8 cells which were grown continuously for more than 1 year in a medium containing...

journal_title：Antiviral research

authors： Gröschel B,Cinatl J,Périgaud C,Gosselin G,Imbach JL,Doerr HW,Cinatl J Jr

更新日期：2002-02-01 00:00:00

abstract：:PMEA [9-[2-(phosphonomethoxy)ethyl]adenine; adefovir] has shown anti-cytomegalovirus activity in animal models and in preliminary human trials. PMEA diphosphate (PMEApp), the active antiviral metabolite of PMEA, is a potent inhibitor of human cytomegalovirus (HCMV) DNA polymerase. PMEA is efficiently taken up and phos...

journal_title：Antiviral research

authors： Xiong X,Flores C,Fuller MD,Mendel DB,Mulato AS,Moon K,Chen MS,Cherrington JM

更新日期：1997-11-01 00:00:00

abstract：:A new adamantane derivative N,N'-bis (ethylene)P(1-adamantyl)-phosphonis diamide, was found to inhibit Rous sarcoma virus replication in much the same manner as reported for the parent compound, 1-adamantanamine hydrochloride. ...

journal_title：Antiviral research

authors： McGraw TL,Cates LA,Daley LS,Chen YC

更新日期：1981-11-01 00:00:00

abstract：:This study aimed to investigate anti-HBV effect and major active compounds of Su-duxing, a medicine extracted from Chinese herbs. HBV-replicating cell lines HepG2.2.15 (wild-type) and HepG2.A64 (entecavir-resistant) were used for in vitro test. C57BL/6 mice infected by adeno-associated virus carrying 1.3 mer wild-type...

journal_title：Antiviral research

authors： Liu Y,Yao W,Si L,Hou J,Wang J,Xu Z,Li W,Chen J,Li R,Li P,Bo L,Xiao X,Lan J,Xu D

更新日期：2018-07-01 00:00:00

abstract：:The study aimed at identifying biomarkers of immune response elicited by non-adjuvanted-(NAV) and adjuvanted-(AV) H1N1(pdm09) vaccines. The results showed that despite both vaccines elicited similar levels of anti-H1N1 antibodies at day30 after vaccination, higher reactivity was observed in AV at day180. While AV indu...

journal_title：Antiviral research

authors： Giarola-Silva S,Coelho-Dos-Reis JGA,Mourão MM,Campi-Azevedo AC,Nakagaki Silva EE,Luiza-Silva M,Martins MA,Silveira-Cassette ACO,Batista MA,Peruhype-Magalhães V,Antonelli LRDV,Leite Ribeiro JG,Elói-Santos SM,Machado AV,Teixeir

更新日期：2017-08-01 00:00:00

abstract：:Previous studies have demonstrated that cyclopentenone prostaglandins (cyPGs) inhibit the replication of a wide variety of DNA and RNA viruses in different mammalian cell types. We investigated a new role for prostaglandin A1 (PGA1) in the inhibition of hepatitis C virus (HCV)-IRES-mediated translation. PGA1 exhibited...

journal_title：Antiviral research

authors： Tsukimoto A,Sugiyama R,Abe M,Nishitsuji H,Shimizu Y,Shimotohno K,Kawai G,Takaku H

更新日期：2015-05-01 00:00:00

abstract：:Dengue virus (DENV) infection is the most prevalent mosquito-borne viral infection of which there is no licensed therapeutic drug available. Previous studies have shown that minocycline, an antibiotic, can inhibit DENV infection in vitro. However, the mechanism is not fully understood. It is known that macrophage migr...

journal_title：Antiviral research

authors： Lai YC,Chuang YC,Chang CP,Lin YS,Perng GC,Wu HC,Hsieh SL,Yeh TM

更新日期：2018-07-01 00:00:00

abstract：:Antiviral medication is used for the treatment of severe influenza infections, of which the neuraminidase inhibitors (NAIs) are the most effective drugs, approved so far. Here, we investigated the antiviral efficacy of the peptidomimetic furin inhibitor MI-701 in combination with oseltamivir carboxylate and ribavirin ...

journal_title：Antiviral research

authors： Lu Y,Hardes K,Dahms SO,Böttcher-Friebertshäuser E,Steinmetzer T,Than ME,Klenk HD,Garten W

更新日期：2015-08-01 00:00:00

abstract：:Infection with hepatitis B virus (HBV) or hepatitis C virus (HCV) may result in a number of different clinical outcomes. There is strong evidence in HBV infection that host genetic factors play a major role in determining the outcome of infection. A number of approaches may be used to determine the specific genetic fa...

journal_title：Antiviral research

authors： Thursz M

更新日期：2001-11-01 00:00:00