Abstract：
:The antiviral effect of Hochu-ekki-to (TJ-41), a Japanese herbal medicine, was investigated using mice infected with influenza virus. TJ-41 was found to increase the survival rate, prolong the mean survival days, suppress viral growth in bronchoalveolar labage fluid (BALF) and inhibit the lung index (lung consolidation) on day 4 after infection in mice infected with influenza, after the agent had been administered orally once daily from day 7 to 2 before infection and from day 0 to 4 after infection. Administration of TJ-41 decreased the BALF concentrations of IL-1alpha, IL-6 and GM-CSF, but not TNF-alpha or interferon-gamma (IFN-gamma), on day 4 after infection. In addition, TJ-41 elevated the level of IFN-alpha in BALF on day 2 after infection. Yet, TJ-41 did not show any inhibitory effect on the growth of influenza virus in vitro. These results suggest that TJ-41 exerts its inhibitory effect on influenza virus infection via enhancement of the host immune responses in this experimental murine system.
journal_name
Antiviral Resjournal_title
Antiviral researchauthors
Mori K,Kido T,Daikuhara H,Sakakibara I,Sakata T,Shimizu K,Amagaya S,Sasaki H,Komatsu Ydoi
10.1016/s0166-3542(99)00048-0subject
Has Abstractpub_date
1999-12-15 00:00:00pages
103-11issue
2eissn
0166-3542issn
1872-9096pii
S0166-3542(99)00048-0journal_volume
44pub_type
杂志文章abstract：:Investments in the development of new drugs for orthopoxvirus infections have fostered new avenues of research, provided an improved understanding of orthopoxvirus biology and yielded new therapies that are currently progressing through clinical trials. These broad-based efforts have also resulted in the identificatio...
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pub_type： 临床试验,杂志文章,随机对照试验
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pub_type： 杂志文章
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journal_title：Antiviral research
pub_type： 杂志文章
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更新日期：2008-06-01 00:00:00
