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Therapy of chronic hepatitis B virus infection: inhibition of the viral polymerase and other antiviral strategies.

Abstract：

:Chronic hepatitis B infection remains a major public health problem worldwide. The hepatitis B virus belongs to the family of hepadnaviruses that replicate their DNA genome via a reverse transcription pathway. The chronicity of infection in infected hepatocytes is maintained by the persistence of the viral covalently closed circular DNA. The main strategies to combat chronic HBV infection rely on the stimulation of the specific antiviral immune response and on the inhibition of viral replication. While the prolonged administration of reverse transcriptase inhibitors is most often associated with a control of viral replication rather than eradication, it may select for resistant mutants. The search for new viral targets is therefore mandatory to design combination strategies to prevent the emergence of resistant mutants and eventually clear viral infection.

journal_name

Antiviral Res

journal_title

Antiviral research

authors

Zoulim F

doi

10.1016/s0166-3542(99)00056-x

subject

Has Abstract

pub_date

1999-11-01 00:00:00

pages

1-30

issue

1

eissn

0166-3542

issn

1872-9096

pii

S0166-3542(99)00056-X

journal_volume

44

pub_type

杂志文章,评审

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