abstract：BACKGROUND:Multiple sclerosis is a chronic progressive neurological disease. Evidence attests to the benefits of exercise, guidelines for exercise in multiple sclerosis are available. Remote-delivery of exercise adherence programmes based on the exercise guidelines require urgent testing. AIMS:The design, and outcomes...

journal_title：Contemporary clinical trials

authors： Learmonth YC,Kaur I,Baynton SL,Fairchild T,Paul L,van Rens F

更新日期：2021-01-12 00:00:00

abstract：BACKGROUND:Training non-specialist health workers (NSHWs) at scale is a major barrier to increasing the coverage of depression care in India. This trial will test the effectiveness of two forms of digital training compared to conventional face-to-face training in changing the competence of NSHWs to deliver a brief evid...

journal_title：Contemporary clinical trials

authors： Naslund JA,Tugnawat D,Anand A,Cooper Z,Dimidjian S,Fairburn CG,Hollon SD,Joshi U,Khan A,Lu C,Mitchell LM,Muke S,Nadkarni A,Ramaswamy R,Restivo JL,Shrivastava R,Singh A,Singla DR,Spiegelman D,Bhan A,Patel V

更新日期：2021-01-06 00:00:00

abstract：INTRODUCTION:Cognitive impairment (CI) and cardiovascular disease (CVD) disproportionately affect women compared to men, and CVD increases risk of CI. Physical activity and cognitive training can improve cognition in older adults and may have additive or synergistic effects. However, no combined intervention has target...

journal_title：Contemporary clinical trials

authors： Halloway S,Schoeny ME,Barnes LL,Arvanitakis Z,Pressler SJ,Braun LT,Volgman AS,Gamboa C,Wilbur J

更新日期：2020-12-29 00:00:00

abstract：BACKGROUND:Early pregnancy through the first year of life represents an important period for family health promotion and obesity prevention. Overall, preventive interventions in pregnancy and infancy have insufficiently engaged fathers. We describe the rationale and design of First Heroes, an intervention to improve pe...

journal_title：Contemporary clinical trials

authors： Whooten RC,Kwete GM,Farrar-Muir H,Cournoyer RN,Barth EA,Kotelchuck M,Taveras EM

更新日期：2020-12-17 00:00:00

abstract：:Low/no-income, African American men are disproportionally burdened by chronic disease resulting from a complex interplay of systemic, sociocultural, and individual factors. These disparities are related to poverty, racism, gender role strain, high levels of stress, low levels of physical activity, and malnutritious di...

journal_title：Contemporary clinical trials

authors： Valdez LA,Gubrium AC,Markham J,Scott L,Hubert A,Meyer J,Buchanan D

更新日期：2020-12-07 00:00:00

abstract：:The Ready Steady 3.0 trial is designed to test the main and interactive effects of two behavior change intervention components, within an 8-week physical activity intervention, on older adults' physical activity (PA). Each component is comprised of behavior change strategies that emphasize two different evidence-based...

journal_title：Contemporary clinical trials

authors： McMahon SK,Lewis BA,Guan W,Wyman JF,Rothman AJ

更新日期：2020-12-05 00:00:00

abstract：BACKGROUND:Currently, there is no consensus regarding the best treatment option in recurrent haemorrhoidal disease (HD), due to a lack of solid evidence. The Napoleon trial aims to provide high-level evidence on the comparative effectiveness and cost-effectiveness of repeat rubber band ligation (RBL) versus sutured muc...

journal_title：Contemporary clinical trials

authors： Kuiper SZ,Dirksen CD,Kimman ML,Van Kuijk SMJ,Van Tol RR,Muris JWM,Watson AJM,Maessen JMC,Melenhorst J,Breukink SO,Napoleon Trial Study Group.

更新日期：2020-12-01 00:00:00

abstract：:The usual development cycles are too slow for the development of vaccines, diagnostics and treatments in pandemics such as the ongoing SARS-CoV-2 pandemic. Given the pressure in such a situation, there is a risk that findings of early clinical trials are overinterpreted despite their limitations in terms of size and d...

journal_title：Contemporary clinical trials

authors： Friedrich S,Friede T

更新日期：2020-12-01 00:00:00

abstract：:Missing data is common in clinical trials. Depending on the volume and nature of missing data, it may reduce statistical power for detecting treatment difference, introduce potential bias and invalidate conclusions. Non-responder imputation (NRI), where patients with missing information to determine endpoint status ar...

journal_title：Contemporary clinical trials

authors： Chen J,Hunter S,Kisfalvi K,Lirio RA

更新日期：2020-11-22 00:00:00

abstract：:The combined use of cigarettes and alcohol is associated with an increased risk of morbidity and mortality. Yet, efficacious interventions that address both behaviors concurrently are lacking. Smoking cessation and alcohol modification not only garner health benefits, but there is also value in addressing alcohol use ...

journal_title：Contemporary clinical trials

authors： Hemenway M,Witkiewitz K,Unrod M,Brandon KO,Brandon TH,Wetter DW,Sutton SK,Vinci C

更新日期：2020-11-14 00:00:00

abstract：:Researchers have long sought to find combinations of cancer drugs that might achieve synergy. However, while observed in some preclinical tumor models, synergistic effects are rarely seen in clinical trials. In fact, growing evidence in clinical trial data shows that the treatment effect of most approved combination t...

journal_title：Contemporary clinical trials

authors： Chen C,Liu F,Ren Y,Suttner L,Sun Z,Shentu Y,Schmidt EV

更新日期：2020-11-01 00:00:00

abstract：:The COVID-19 pandemic has substantially impacted the conduct of clinical trials. While initially preparing for a period of time, where it would likely be impossible to supervise trials in the usual way and precautionary measures had to be implemented to care for medication supply and general safety of study participan...

journal_title：Contemporary clinical trials

authors： Großhennig A,Koch A

更新日期：2020-11-01 00:00:00

abstract：:Knee osteoarthritis (OA) is a leading cause of late life pain and disability, and non-Hispanic black (NHB) adults experience greater OA-related pain and disability than non-Hispanic whites (NHWs). Recent evidence implicates psychosocial stress, cognitive-attentional processes, and altered central pain processing as co...

journal_title：Contemporary clinical trials

authors： Fillingim RB,Woods AJ,Ahn H,Wu SS,Redden DT,Lai S,Deshpande H,Deutsch G,Sibille KT,Staud R,Zeidan F,Goodin BR

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:New approaches are needed to better monitor blood pressure (BP) between physician visits, especially for patients in rural areas or for those who lack transportation. We have developed a custom-built bi-directional texting platform for home BP measurements that can then be managed by clinical pharmacists loc...

journal_title：Contemporary clinical trials

authors： Polgreen LA,Carter BL,Polgreen PM,Snyder PM,Sewell DK,Bayman EO,Francis SL,Simmering JE,Parker C,Finkelstein R

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND/AIMS:Cocaine use disorder (CUD) persists as a major public health problem in the United States. Response to evidence-based behavioral treatment has been shown to be predicted by dopaminergic dysfunction. Amphetamine formulations modulate dopaminergic systems and are one of the few agents with positive clinic...

journal_title：Contemporary clinical trials

authors： Blevins D,Carpenter KM,Martinez D,Mariani JJ,Levin FR

更新日期：2020-11-01 00:00:00

abstract：:We describe an emergency department (ED)-based, Latino patient focused, unblinded, randomized controlled trial to empirically test if automated bilingual computerized alcohol screening and brief intervention (AB-CASI), a digital health tool, is superior to standard care (SC) on measures of alcohol consumption, alcohol...

journal_title：Contemporary clinical trials

authors： Vaca FE,Dziura J,Abujarad F,Pantalon MV,Hsiao A,Field CA,D'Onofrio G

更新日期：2020-10-01 00:00:00

abstract：:College student alcohol use and associated negative consequences are clear public health problems with consequences including damage to self, others, and institutions. This paper describes the protocol of a research study designed to answer a number of important questions in the development of an adaptive preventive i...

journal_title：Contemporary clinical trials

authors： Patrick ME,Boatman JA,Morrell N,Wagner AC,Lyden GR,Nahum-Shani I,King CA,Bonar EE,Lee CM,Larimer ME,Vock DM,Almirall D

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:The Covid-19 pandemic has caused fear and panic worldwide, forcing healthcare systems to disregard conventional practices and adopt innovation to contain the infection and death. Globally, there has been a rapid proliferation of research studies and clinical trials assessing risks, infectivity and treatment....

journal_title：Contemporary clinical trials

authors： Ibrahim H,Kamour AM,Harhara T,Gaba WH,Nair SC

更新日期：2020-09-01 00:00:00

abstract：PURPOSE:By 2020, 70% of people living with HIV in the United States will be greater than 50 years of age. As many as 37% of sexually active older people living with HIV (OPLWH) engage in HIV transmission sexual behaviors. In spite of repeated calls for secondary prevention interventions to reduce condomless sex in OPLW...

journal_title：Contemporary clinical trials

authors： Kahler J,Heckman TG,Shen Y,Huckans MS,Feldstein Ewing SW,Parsons JT,Phelps A,Sutton M,Holloway J,Lovejoy TI

更新日期：2020-08-01 00:00:00

abstract：:The 2-in-1 adaptive design [Chen et al. 2018] allows seamless expansion of an ongoing Phase 2 trial into a Phase 3 trial to expedite a drug development program. An intermediate endpoint can be used for the adaptive decision. Under a mild assumption that is expected to generally hold in practice, both the Phase 2 trial...

journal_title：Contemporary clinical trials

authors： Chen C,Li W,Deng Q

更新日期：2020-08-01 00:00:00

abstract：INTRODUCTION:Focal therapy (FT) targets individual areas of cancer within the prostate, providing oncological control with minimal side-effects. Early evidence demonstrates encouraging short-medium-term outcomes. With no randomized controlled trials (RCT) comparing FT to radical therapies, Comparative Healthcare Resear...

journal_title：Contemporary clinical trials

authors： Reddy D,Shah TT,Dudderidge T,McCracken S,Arya M,Dobbs C,Emberton M,Fiorentino F,Day E,Prevost AT,Staffurth J,Sydes M,Winkler M,Ahmed HU

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Despite efforts by the U.S. Department of Defense to train behavioral health (BH) providers in evidence-based psychotherapies (EBPs) for posttraumatic stress disorder (PTSD), numerous barriers limit EBP implementation. A context-tailored implementation approach called TACTICS (Targeted Assessment and Context...

journal_title：Contemporary clinical trials

authors： Rosen CS,Davis CA,Riggs D,Cook J,Peterson AL,Young-McCaughan S,Comtois KA,Haddock CK,Borah EV,Dondanville KA,Finley EP,Jahnke SA,Poston WSC,Wiltsey-Stirman S,Neitzer A,Broussard CR,Brzuchalski MA,Clayton MSP,Conforte

更新日期：2020-06-01 00:00:00

abstract：INTRODUCTION:When the Centers for Medicare and Medicaid Services announced coverage for low dose CT lung cancer screening, they also mandated that imaging centers offer smoking cessation services. We designed the Optimizing Lung Screening (OaSiS) trial to evaluate strategies to implement the Public Health Service Guide...

journal_title：Contemporary clinical trials

authors： Foley KL,Miller DP Jr,Weaver K,Sutfin EL,Petty WJ,Bellinger C,Spangler J,Stone RJ,Lawler D,Davis W,Dressler E,Lesser G,Chiles C

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Lower extremity peripheral arterial disease (PAD) is a public health problem and many patients with PAD experience claudication despite adequate medical and/or surgical management. Mobilization of endogenous progenitor cells using Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) is a novel therapeut...

journal_title：Contemporary clinical trials

authors： Mehta A,Mavromatis K,Ko YA,Rogers SC,Dhindsa DS,Goodwin C,Patel R,Martini MA,Prasad M,Mokhtari A,Hesaroieh IG,Frohwein SC,Kutner MH,Harzand A,Wells BJ,Duwayri Y,Alabi O,Rajani RR,Brewster LP,Waller EK,Quyyumi AA

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVE:Managing complex psychiatric disorders like PTSD and bipolar disorder is challenging in Federally Qualified Health Centers (FQHCs) delivering care to U.S residents living in underserved rural areas. This protocol paper describes SPIRIT, a pragmatic comparative effectiveness trial designed to compare two appro...

journal_title：Contemporary clinical trials

authors： Fortney JC,Heagerty PJ,Bauer AM,Cerimele JM,Kaysen D,Pfeiffer PN,Zielinski MJ,Pyne JM,Bowen D,Russo J,Ferro L,Moore D,Nolan JP,Fee FC,Heral T,Freyholtz-London J,McDonald B,Mullins J,Hafer E,Solberg L,Unützer J

更新日期：2020-03-01 00:00:00

abstract：INTRODUCTION:Youth in disadvantaged urban areas are frequently exposed to chronic stress and trauma, including housing instability, neighborhood violence, and other poverty-related adversities. These exposures increase risk for emotional, behavioral, and academic problems and ultimately, school dropout. Schools are a p...

journal_title：Contemporary clinical trials

authors： Mendelson T,Clary LK,Sibinga E,Tandon D,Musci R,Mmari K,Salkever D,Stuart EA,Ialongo N

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) screening by annual fecal immunochemical test (FIT) is an accessible and cost-effective strategy to lower CRC incidence and mortality. However, this mode of screening depends on follow-up colonoscopy after a positive FIT result. Unfortunately, nearly one-half of FIT-positive patients ...

journal_title：Contemporary clinical trials

authors： Coronado GD,Johnson ES,Leo MC,Schneider JL,Smith D,Mummadi R,Petrik AF,Thompson JH,Jimenez R

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Although people who inject drugs (PWID) having the highest incidence and prevalence of hepatitis C virus (HCV) in the US, HCV treatment is rarely provided to PWID due to assumptions about poor adherence and reinfection risk. As direct-acting antiviral agents (DAAs) have achieved sustained virologic response ...

journal_title：Contemporary clinical trials

authors： Litwin AH,Jost J,Wagner K,Heo M,Karasz A,Feinberg J,Kim AY,Lum PJ,Mehta SH,Taylor LE,Tsui JI,Pericot-Valverde I,Page K,HERO Study Group.

更新日期：2019-12-01 00:00:00

abstract：:Foundational elements of lifelong health are formed during the preschool years. Child care attendance has nearly doubled in the past 5 years making child care centers an ideal setting to establish healthy habits that prevent pediatric obesity. Despite the promising evidence of efficacy of child care-based obesity prev...

journal_title：Contemporary clinical trials

authors： Armstrong B,Trude ACB,Johnson C,Castelo RJ,Zemanick A,Haber-Sage S,Arbaiza R,Black MM

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:In a recent publication, the International Guidelines for Groin Hernia Management by the European Hernia Society (EHS) recognized the need to individualize and tailor the surgical approach for hernia repair. There may be different opportunities for optimization of the surgical technique for surgeons performi...

journal_title：Contemporary clinical trials

authors： LeBlanc KA

更新日期：2019-11-01 00:00:00

abstract：AIMS:To outline the study design, outcome measures, protocol and baseline characteristics of enrolled participants of Texas (TX) Sprouts, a one-year school-based gardening, nutrition, and cooking cluster randomized trial. METHODS:Eight schools were randomly assigned to the TX Sprouts intervention and eight schools to ...

journal_title：Contemporary clinical trials

authors： Davis J,Nikah K,Asigbee FM,Landry MJ,Vandyousefi S,Ghaddar R,Hoover A,Jeans M,Pont SJ,Richards D,Hoelscher DM,Van Den Berg AE,Bluestein M,Pérez A

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:Despite widespread use of learning collaboratives in health care, few randomized trials have evaluated their effectiveness. The primary aim of this cluster randomized implementation trial is to evaluate the effectiveness of a virtual learning collaborative (VLC) in the implementation of a lifestyle intervent...

journal_title：Contemporary clinical trials

authors： Aschbrenner KA,Pratt SI,Bond GR,Zubkoff L,Naslund JA,Jue K,Williams G,Kinney A,Cohen MJ,Godfrey MM,Bartels SJ

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Individuals with serious mental illness (SMI) smoke at disproportionately higher rates than those without SMI, have lifespans 25-32 years shorter, and thus bear an especially large burden of tobacco-related morbidity and mortality. Several recent studies demonstrate that smokers with SMI can successfully qui...

journal_title：Contemporary clinical trials

authors： Hecht J,Rigotti NA,Minami H,Kjome KL,Bloom EL,Kahler CW,Price LH,Levy DE,Carpenter KM,Brown RA

更新日期：2019-08-01 00:00:00

abstract：:Traditionally, children presenting with appendicitis are referred for urgent appendectomy. Recent improvements in the quality and availability of diagnostic imaging allow for better pre-operative characterization of appendicitis, including severity of inflammation; size of the appendix; and presence of extra-luminal i...

journal_title：Contemporary clinical trials

authors： Minneci PC,Hade EM,Lawrence AE,Saito JM,Mak GZ,Hirschl RB,Gadepalli S,Helmrath MA,Leys CM,Sato TT,Lal DR,Landman MP,Kabre R,Fallat ME,Fischer BA,Cooper JN,Deans KJ,Midwest Pediatric Surgery Consortium.

更新日期：2019-08-01 00:00:00

abstract：:In order to better characterize the safety profile of investigational new drugs (INDs) during clinical development, more interest and attention have been paid to ongoing safety monitoring and evaluation. The 2015 US FDA IND safety reporting draft guidance compels sponsors to periodically evaluate unblinded safety data...

journal_title：Contemporary clinical trials

authors： Lin LA,Zhan Y,Li H,Yuan SS,Ball G,Wang W

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVE:To describe the study protocol of the Multimedia Self-Management (MSM) intervention to prepare patients and family caregivers (FCGs) for lung cancer surgery. DESIGN:The study is a five-year, single site, randomized controlled trial of 160 lung cancer surgery FCG and patient dyads (320 total participants), co...

journal_title：Contemporary clinical trials

authors： Sun V,Raz DJ,Erhunmwunsee L,Ruel N,Carranza J,Prieto R,Ferrell B,Krouse RS,McCorkle R,Kim JY

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Current guidelines recommend behavioral intervention to achieve a modest weight loss (e.g., 3-5%) as a first-line obesity treatment. Online behavioral obesity treatment, delivered via the Rx Weight Loss (RxWL) program, produces clinically significant initial weight losses. However, the program's pragmatic ut...

journal_title：Contemporary clinical trials

authors： Espel-Huynh HM,Wing RR,Goldstein CM,Thomas JG

更新日期：2019-07-01 00:00:00

abstract：:Parents of young children with type 1 diabetes (T1D) experience unique, developmental challenges in managing their child's T1D, resulting in psychosocial distress. Only a small portion of young children reach glucose goals and adherence to diabetes devices that help improve T1D management have historically been low in...

journal_title：Contemporary clinical trials

authors： Berget C,Driscoll KA,Lagges A,Lange S,DiMeglio LA,Hannon TS,Woerner SE,Iturralde E,Barley RC,Hanes S,Hood KK,Buckingham BB,Toddler Diabetes Technology Study Group.

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVES:To review current publications to examine safety of tai chi (TC). DESIGN:Cochrane Library, EBSCO host and MEDLINE/PubMed were searched for randomized controlled trials (RCTs) including TC as the core intervention and reporting adverse events (AEs). Data were extracted considering active vs. inactive control...

journal_title：Contemporary clinical trials

authors： Cui H,Wang Q,Pedersen M,Wang Q,Lv S,James D,Larkey L

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Medicaid recipients with serious mental illness die 25-30 years earlier than people in the general population due to health conditions that are modifiable through lifestyle changes. Cardiovascular diseases from excess weight, smoking, and sedentary lifestyle contribute substantially to this life expectancy d...

journal_title：Contemporary clinical trials

authors： Pratt SI,Brunette MF,Wolfe R,Scherer EA,Xie H,Bartels S,Ferron JC,Capuchino K

更新日期：2019-06-01 00:00:00