The OaSiS trial: A hybrid type II, national cluster randomized trial to implement smoking cessation during CT screening for lung cancer.

abstract：:Although colorectal cancer (CRC) is largely preventable through identification of pre-cancerous polyps through various screening modalities, morbidity and mortality rates remain a challenge, especially in African-American, Latino, low-income and uninsured/underinsured patients. Barriers to screening include cost, acce...

journal_title：Contemporary clinical trials

authors： Buscemi J,Miguel YS,Tussing-Humphreys L,Watts EA,Fitzgibbon ML,Watson K,Winn RA,Matthews KL,Molina Y

更新日期：2017-01-01 00:00:00

abstract：:Clinical trial research is the cornerstone for successful advancement of medicine that provides hope for millions of people in the future. Full transparency in clinical trials may allow independent investigators to evaluate study designs, perform additional analysis of data, and potentially eliminate duplicate studies...

journal_title：Contemporary clinical trials

authors： Logvinov I

更新日期：2014-03-01 00:00:00

abstract：:Recruitment of patients for clinical trials is one of the major hurdles on the way to successful completion of any human research study. Direct comparison of recruitment activity in different sites and projects is not easy due to lack of a unified measure of recruitment efficacy. The author introduces a new variable, ...

journal_title：Contemporary clinical trials

authors： Rojavin MA

更新日期：2005-10-01 00:00:00

abstract：INTRODUCTION:Focal ablation therapy is playing an increasing role in oncology and may reduce the toxicity of current surgical treatments while achieving adequate oncological benefit. Irreversible electroporation (IRE) has been proposed to be tissue-selective with potential advantages compared with current thermal-ablat...

journal_title：Contemporary clinical trials

authors： Wendler JJ,Porsch M,Nitschke S,Köllermann J,Siedentopf S,Pech M,Fischbach F,Ricke J,Schostak M,Liehr UB

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:There are numerous potential sources of problems when performing complex clinical research trials. These issues are compounded when studies are multi-site and multiple personnel from different sites are responsible for varying actions from case report form design to primary data collection and data entry. M...

journal_title：Contemporary clinical trials

authors： Brandt CA,Argraves S,Money R,Ananth G,Trocky NM,Nadkarni PM

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND:Low back pain (LBP) is one of the most common reasons for seeking medical care. Manipulative therapies are a common treatment for LBP. Few studies have compared the effectiveness of different types of manipulative therapies. Moreover, the physiologic mechanisms underlying these treatments are not fully under...

journal_title：Contemporary clinical trials

authors： Clark BC,Russ DW,Nakazawa M,France CR,Walkowski S,Law TD,Applegate M,Mahato N,Lietkam S,Odenthal J,Corcos D,Hain S,Sindelar B,Ploutz-Snyder RJ,Thomas JS

更新日期：2018-07-01 00:00:00

abstract：:Recruiting sufficient patients within an acceptable time horizon is an issue for most clinical trials and is especially challenging in the field of rare diseases. It is therefore an attractive option to include historical data from previous (pilot) trials in the current study thus reducing the recruitment burden. In c...

journal_title：Contemporary clinical trials

authors： Hees K,Kieser M

更新日期：2017-12-01 00:00:00

abstract：PURPOSE:This article describes the protocol for a Hybrid Type I cost-effectiveness and implementation study of interpersonal psychotherapy (IPT) for men and women prisoners with major depressive disorder (MDD). The goal is to promote uptake of evidence-based treatments in criminal justice settings by conducting a rando...

journal_title：Contemporary clinical trials

authors： Johnson JE,Miller TR,Stout RL,Zlotnick C,Cerbo LA,Andrade JT,Wiltsey-Stirman S

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Low-wage workers suffer disproportionately high rates of chronic disease and are important targets for workplace health and safety interventions. Child care centers offer an ideal opportunity to reach some of the lowest paid workers, but these settings have been ignored in workplace intervention studies. ME...

journal_title：Contemporary clinical trials

authors： Ward DS,Vaughn AE,Hales D,Viera AJ,Gizlice Z,Bateman LA,Grummon AH,Arandia G,Linnan LA

更新日期：2018-05-01 00:00:00

abstract：:The COVID-19 pandemic has substantially impacted the conduct of clinical trials. While initially preparing for a period of time, where it would likely be impossible to supervise trials in the usual way and precautionary measures had to be implemented to care for medication supply and general safety of study participan...

journal_title：Contemporary clinical trials

authors： Großhennig A,Koch A

更新日期：2020-11-01 00:00:00

abstract：:The prevalence of type 2 diabetes continues to increase in minority and underserved patients, who are also more likely to have poorer control of diabetes and related risk factors for complications. Although the Look AHEAD trial has demonstrated improved risk factor control among overweight or obese diabetes patients w...

journal_title：Contemporary clinical trials

authors： Katula JA,Kirk JK,Pedley CF,Savoca MR,Effoe VS,Bell RA,Bertoni AG,LIFT Diabetes Team.

更新日期：2017-02-01 00:00:00

abstract：:Dosing is potentially the most important decision that must be made when building or refining behavioral interventions. In this paper, we propose standardized terminology and reporting of dosing information, which would inform intervention development, refinement for dissemination, and systematic reviews of dose-respo...

journal_title：Contemporary clinical trials

authors： Voils CI,Chang Y,Crandell J,Leeman J,Sandelowski M,Maciejewski ML

更新日期：2012-11-01 00:00:00

abstract：INTRODUCTION:Juvenile neuronal ceroid lipofuscinosis (JNCL; Batten disease) is a rare, inherited, fatal lysosomal storage childhood disorder. True for many rare diseases, there are no treatments that impact the course of JNCL. The University of Rochester Batten Center's (URBC) mission is to find treatments to slow, hal...

journal_title：Contemporary clinical trials

authors： de Blieck EA,Augustine EF,Marshall FJ,Adams H,Cialone J,Dure L,Kwon JM,Newhouse N,Rose K,Rothberg PG,Vierhile A,Mink JW,Batten Study Group.

更新日期：2013-07-01 00:00:00

abstract：:Parents of young children with type 1 diabetes (T1D) experience unique, developmental challenges in managing their child's T1D, resulting in psychosocial distress. Only a small portion of young children reach glucose goals and adherence to diabetes devices that help improve T1D management have historically been low in...

journal_title：Contemporary clinical trials

authors： Berget C,Driscoll KA,Lagges A,Lange S,DiMeglio LA,Hannon TS,Woerner SE,Iturralde E,Barley RC,Hanes S,Hood KK,Buckingham BB,Toddler Diabetes Technology Study Group.

更新日期：2019-07-01 00:00:00

abstract：:Clinical trial is considered a breakthrough method in medicine and essential to the development of new drugs. Clinical trials that comply with international and national regulations require an appropriate infrastructure and team qualification. The goal of this study was to evaluate clinical trial groups in Brazil: pro...

journal_title：Contemporary clinical trials

authors： Paschoale HS,Barbosa FR,Nita ME,Carrilho FJ,Ono-Nita SK

更新日期：2010-09-01 00:00:00

abstract：:The convention in clinical trials is to regard outcomes as independently distributed, possibly conditional on covariates, but in some situations they may be correlated. For example, in infectious diseases, correlation may be induced if participants have contact with a common infectious source, or share hygienic tips t...

journal_title：Contemporary clinical trials

authors： Follmann D,Proschan M

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:Obesity, a disorder associated with a myriad of comorbidities, is increasing at an alarming rate around the world. Given that pharmacotherapy has limited available options and that bariatric surgery is reserved for those who are morbidly obese or who have significant comorbidities, the most common approach t...

journal_title：Contemporary clinical trials

authors： Burke LE,Choo J,Music E,Warziski M,Styn MA,Kim Y,Sevick MA

更新日期：2006-02-01 00:00:00

abstract：:Since its introduction in 1974 the use of the term Minimization has been broadened to include other algorithms. All algorithms use patient characteristics to determine the assignment that produces the best overall balance between treatment groups. They differ in whether or not they use all of the data from each previo...

journal_title：Contemporary clinical trials

authors： Taves DR

更新日期：2010-03-01 00:00:00

abstract：INTRODUCTION:Excessive recreational screen time (i.e., screen use for entertainment) is a global public health issue associated with adverse mental and physical health outcomes. Considering the growing popularity of screen-based recreation in adolescents, there is a need to identify effective strategies for reducing sc...

journal_title：Contemporary clinical trials

authors： Babic MJ,Morgan PJ,Plotnikoff RC,Lonsdale C,Eather N,Skinner G,Baker AL,Pollock E,Lubans DR

更新日期：2015-01-01 00:00:00

abstract：:Assessing the probability that a Phase III clinical trial will demonstrate clinically relevant efficacy based on Phase II data is an important topic in clinical drug development. An accurate estimate of how likely a Phase III trial will succeed based on available data will inform the decision on whether to move an exp...

journal_title：Contemporary clinical trials

authors： Su Z

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:Training non-specialist health workers (NSHWs) at scale is a major barrier to increasing the coverage of depression care in India. This trial will test the effectiveness of two forms of digital training compared to conventional face-to-face training in changing the competence of NSHWs to deliver a brief evid...

journal_title：Contemporary clinical trials

authors： Naslund JA,Tugnawat D,Anand A,Cooper Z,Dimidjian S,Fairburn CG,Hollon SD,Joshi U,Khan A,Lu C,Mitchell LM,Muke S,Nadkarni A,Ramaswamy R,Restivo JL,Shrivastava R,Singh A,Singla DR,Spiegelman D,Bhan A,Patel V

更新日期：2021-01-06 00:00:00

abstract：:While investigators designing clinical trials face the important issue of endpoint selection, an equally troublesome concern can be the a priori selection of the endpoint analysis. In this latter circumstance, there may be only one endpoint of interest in the clinical trial, but several competing endpoint analyses are...

journal_title：Contemporary clinical trials

authors： Moyé LA,Baraniuk S

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Evidence suggests that periodontitis is associated with prevalent and incident type 2 diabetes mellitus (T2DM), raising the question of whether periodontitis treatment may improve glycemic control in patients with T2DM. Meta-analyses of mostly small clinical trials suggest that periodontitis treatment result...

journal_title：Contemporary clinical trials

authors： DPTT study group.,Engebretson S,Gelato M,Hyman L,Michalowicz BS,Schoenfeld E

更新日期：2013-11-01 00:00:00

abstract：:Osteoarthritis (OA) is the most common chronic condition and principal cause of disability among older adults. The current obesity epidemic has contributed to this high prevalence rate. Fortunately both OA symptoms and obesity can be ameliorated through lifestyle modifications. Physical activity (PA) combined with wei...

journal_title：Contemporary clinical trials

authors： Smith-Ray RL,Fitzgibbon ML,Tussing-Humphreys L,Schiffer L,Shah A,Huber GM,Braunschweig C,Campbell RT,Hughes SL

更新日期：2014-03-01 00:00:00

abstract：OBJECTIVE:To describe the methodology of a 2-arm randomized controlled trial that compared the effects of a narrative and didactic version of the Witness CARES (Community Awareness, Reach, & Empowerment for Screening) intervention on colorectal cancer screening behavior among African Americans, as well as the cognitive...

journal_title：Contemporary clinical trials

authors： Ellis EM,Erwin DO,Jandorf L,Saad-Harfouche F,Sriphanlop P,Clark N,Dauphin C,Johnson D,Klasko-Foster LB,Martinez C,Sly J,White D,Winkel G,Kiviniemi MT

更新日期：2018-02-01 00:00:00

abstract：:Traditionally, children presenting with appendicitis are referred for urgent appendectomy. Recent improvements in the quality and availability of diagnostic imaging allow for better pre-operative characterization of appendicitis, including severity of inflammation; size of the appendix; and presence of extra-luminal i...

journal_title：Contemporary clinical trials

authors： Minneci PC,Hade EM,Lawrence AE,Saito JM,Mak GZ,Hirschl RB,Gadepalli S,Helmrath MA,Leys CM,Sato TT,Lal DR,Landman MP,Kabre R,Fallat ME,Fischer BA,Cooper JN,Deans KJ,Midwest Pediatric Surgery Consortium.

更新日期：2019-08-01 00:00:00

abstract：INTRODUCTION:Many low-income parent/caregivers do not understand the importance of cavity-free primary (baby) teeth and the chronic nature of dental caries (tooth decay). As a consequence, dental preventive and treatment utilization is low even when children are screened in schools and referred for care. This study aim...

journal_title：Contemporary clinical trials

authors： Nelson S,Riedy C,Albert JM,Lee W,Slusar MB,Curtan S,Ferretti G,Cunha-Cruz J,Milgrom P

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:Individuals with serious mental illness (SMI) smoke at disproportionately higher rates than those without SMI, have lifespans 25-32 years shorter, and thus bear an especially large burden of tobacco-related morbidity and mortality. Several recent studies demonstrate that smokers with SMI can successfully qui...

journal_title：Contemporary clinical trials

authors： Hecht J,Rigotti NA,Minami H,Kjome KL,Bloom EL,Kahler CW,Price LH,Levy DE,Carpenter KM,Brown RA

更新日期：2019-08-01 00:00:00

abstract：:Behavioral weight loss programs help people achieve clinically meaningful weight losses (8-10% of starting body weight). Despite data showing that only half of participants achieve this goal, a "one size fits all" approach is normative. This weight loss intervention science gap calls for adaptive interventions that pr...

journal_title：Contemporary clinical trials

authors： Sherwood NE,Butryn ML,Forman EM,Almirall D,Seburg EM,Lauren Crain A,Kunin-Batson AS,Hayes MG,Levy RL,Jeffery RW

更新日期：2016-03-01 00:00:00

abstract：:The Rare Diseases Clinical Research Network (RDCRN) Contact Registry has grown in size and scope since it was first reported in this journal in 2007. In this paper, we reflect on our seven years' experience developing and expanding the RDCRN Contact Registry to include many more rare diseases. We present the functiona...

journal_title：Contemporary clinical trials

authors： Richesson RL,Sutphen R,Shereff D,Krischer JP

更新日期：2012-07-01 00:00:00