Abstract:
PURPOSE:By 2020, 70% of people living with HIV in the United States will be greater than 50 years of age. As many as 37% of sexually active older people living with HIV (OPLWH) engage in HIV transmission sexual behaviors. In spite of repeated calls for secondary prevention interventions to reduce condomless sex in OPLWH, no age-appropriate, evidence-based secondary prevention interventions exist for this group. Furthermore, many OPLWH face barriers to engaging in face-to-face secondary prevention services because of HIV- and age-related stigma, comorbid mental and physical health conditions that complicate travel, or geographic isolation. High rates of depression in OPLWH may further complicate engagement in interventions intended to reduce HIV transmissions. Telephone-administered motivational interviewing may be a feasible and efficacious intervention for this population. METHODS:This randomized controlled trial will test the efficacy of a 5-session telephone-administered motivational interviewing plus behavioral skills training (teleMI+BST) intervention versus a 5-session telephone-administered coping effectiveness training (teleCET) control intervention to reduce condomless sex in OPLWH. A diverse sample of 336 OPLWH will be recruited across the U.S. The primary analysis will test the efficacy of teleMI+BST to reduce occasions of non-condom protected anal and vaginal intercourse with HIV serodiscordant sex partners. Secondary analyses will examine the efficacy of teleMI+BST to reduce depressive symptoms in mildly depressed OPLWH. CONCLUSION:This is the first large-scale RCT intended to reduce HIV sexual transmission risk behavior in OPLWH and will add to the literature on secondary prevention telehealth interventions for people living with HIV. ClinicalTrials.gov Identifier: NCT03004170. This trial has been conducted by the approval of the Institutional Review Board. Participants provided verbal consent to participate in this trial.
journal_name
Contemp Clin Trialsjournal_title
Contemporary clinical trialsauthors
Kahler J,Heckman TG,Shen Y,Huckans MS,Feldstein Ewing SW,Parsons JT,Phelps A,Sutton M,Holloway J,Lovejoy TIdoi
10.1016/j.cct.2020.106047subject
Has Abstractpub_date
2020-08-01 00:00:00pages
106047eissn
1551-7144issn
1559-2030pii
S1551-7144(20)30125-7journal_volume
95pub_type
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journal_title:Contemporary clinical trials
pub_type: 杂志文章,随机对照试验
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abstract:PURPOSE:African-American women (AAW) are more likely to be metabolically unhealthy than White women (WW). Metabolic syndrome (MetS) is associated with increased breast cancer risk and mortality from breast cancer is greater in AAW compared to WW. Data show MetS affects health-related quality of life (HRQoL). Exercise s...
journal_title:Contemporary clinical trials
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abstract::Pediatric primary care is an important setting in which to address obesity prevention, yet relatively few interventions have been evaluated and even fewer have been shown to be effective. The development and evaluation of cost-effective approaches to obesity prevention that leverage opportunities of direct access to f...
journal_title:Contemporary clinical trials
pub_type: 杂志文章,随机对照试验
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journal_title:Contemporary clinical trials
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journal_title:Contemporary clinical trials
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journal_title:Contemporary clinical trials
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journal_title:Contemporary clinical trials
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journal_title:Contemporary clinical trials
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journal_title:Contemporary clinical trials
pub_type: 杂志文章,随机对照试验
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pub_type: 临床试验,杂志文章
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journal_title:Contemporary clinical trials
pub_type: 杂志文章,随机对照试验
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journal_title:Contemporary clinical trials
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Contemporary clinical trials
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journal_title:Contemporary clinical trials
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journal_title:Contemporary clinical trials
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journal_title:Contemporary clinical trials
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journal_title:Contemporary clinical trials
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pub_type: 杂志文章,评审
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journal_title:Contemporary clinical trials
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journal_title:Contemporary clinical trials
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更新日期:2017-06-01 00:00:00
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journal_title:Contemporary clinical trials
pub_type: 杂志文章,meta分析,评审
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abstract::An instrumental variable (IV) estimator has been widely used to estimate causal effects among compliers in randomized trials with noncompliance. The estimator of complier average treatment effect can be expressed as a ratio of two unbiased estimators but the ratio estimator is not unbiased. The bias of IV estimator ca...
journal_title:Contemporary clinical trials
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doi:10.1016/j.cct.2012.03.013
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