Effectiveness and cost-effectiveness of rubber band ligation versus sutured mucopexy versus haemorrhoidectomy in patients with recurrent haemorrhoidal disease (Napoleon trial): Study protocol for a multicentre randomized controlled trial.

abstract：:Large, "practical" or streamlined trials (LSTs) are used to study the effectiveness and/or safety of medicines in real world settings with minimal study imposed interventions. While LSTs have benefits over traditional randomized clinical trials and observational studies, there are inherent challenges to their conduct....

journal_title：Contemporary clinical trials

authors： Kolitsopoulos FM,Strom BL,Faich G,Eng SM,Kane JM,Reynolds RF

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Chronic Obstructive Pulmonary Disease (COPD) frequently coexists with other diseases. Whereas COPD action plans are currently part of usual care, they are less suitable and potentially unsafe for use in the presence of comorbidities. This study evaluates whether an innovative treatment approach directed towa...

journal_title：Contemporary clinical trials

authors： Lenferink A,Frith P,van der Valk P,Buckman J,Sladek R,Cafarella P,van der Palen J,Effing T

更新日期：2013-09-01 00:00:00

abstract：:An instrumental variable (IV) estimator has been widely used to estimate causal effects among compliers in randomized trials with noncompliance. The estimator of complier average treatment effect can be expressed as a ratio of two unbiased estimators but the ratio estimator is not unbiased. The bias of IV estimator ca...

journal_title：Contemporary clinical trials

authors： Chan KC

更新日期：2012-07-01 00:00:00

abstract：INTRODUCTION:Youth in disadvantaged urban areas are frequently exposed to chronic stress and trauma, including housing instability, neighborhood violence, and other poverty-related adversities. These exposures increase risk for emotional, behavioral, and academic problems and ultimately, school dropout. Schools are a p...

journal_title：Contemporary clinical trials

authors： Mendelson T,Clary LK,Sibinga E,Tandon D,Musci R,Mmari K,Salkever D,Stuart EA,Ialongo N

更新日期：2020-03-01 00:00:00

abstract：:Ethically sound clinical research requires that prospective study participants provide voluntary informed consent before any study procedures begin. The original intent was to provide the participant with clear, accurate information about study specifics (e.g., risks/benefits) to aid in the decision to participate. Br...

journal_title：Contemporary clinical trials

authors： Lentz J,Kennett M,Perlmutter J,Forrest A

更新日期：2016-07-01 00:00:00

abstract：:Numerous studies have attempted to identify successful dietary strategies for weight loss, and many have focused on Low-Fat vs. Low-Carbohydrate comparisons. Despite relatively small between-group differences in weight loss found in most previous studies, researchers have consistently observed relatively large between...

journal_title：Contemporary clinical trials

authors： Stanton MV,Robinson JL,Kirkpatrick SM,Farzinkhou S,Avery EC,Rigdon J,Offringa LC,Trepanowski JF,Hauser ME,Hartle JC,Cherin RJ,King AC,Ioannidis JP,Desai M,Gardner CD

更新日期：2017-02-01 00:00:00

abstract：OBJECTIVE:To assess parental decision making and experiences in an autologous umbilical cord blood infusion study in young children with type 1 diabetes (T1D). METHODS:Surveys were completed with 22 parents of children with T1D who received infusion and 22 parents who declined infusion. RESULTS:Parents who stored umb...

journal_title：Contemporary clinical trials

authors： Driscoll KA,Johnson SB,Schatz DA,Haller MJ

更新日期：2011-07-01 00:00:00

abstract：:In order to better characterize the safety profile of investigational new drugs (INDs) during clinical development, more interest and attention have been paid to ongoing safety monitoring and evaluation. The 2015 US FDA IND safety reporting draft guidance compels sponsors to periodically evaluate unblinded safety data...

journal_title：Contemporary clinical trials

authors： Lin LA,Zhan Y,Li H,Yuan SS,Ball G,Wang W

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Evaluation of new therapies for cancer has suffered a paradigm shift in the last years. The use of innovative and more efficient designs is a priority for the scientific community; nevertheless, the use of this kind of design is not yet wide spread. PURPOSE:In this paper will examine the effectiveness of ad...

journal_title：Contemporary clinical trials

authors： López MF,Dupuy JF,Gonzalez CV

更新日期：2012-01-01 00:00:00

abstract：:The Medication Adherence and BP Control Trial (ABC Trial) is a randomized, controlled, multi-site, medication adherence and blood pressure (BP) control trial in an economically disadvantaged and multi-cultural population of hypertensive patients followed in primary care practices. To date, no other such trial has been...

journal_title：Contemporary clinical trials

authors： Gerin W,Tobin JN,Schwartz JE,Chaplin W,Rieckmann N,Davidson KW,Goyal TM,Jhalani J,Cassells A,Feliz K,Khalida C,Diaz-Gloster M,Ogedegbe G

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:Intake of sugar-sweetened beverages is associated with overweight in observational studies. A possible explanation is that liquid sugars do not satiate and that their intake is not compensated by reduced caloric intake from other foods. However, evidence from intervention studies for this hypothesis is incon...

journal_title：Contemporary clinical trials

authors： de Ruyter JC,Olthof MR,Kuijper LD,Katan MB

更新日期：2012-01-01 00:00:00

abstract：INTRODUCTION:Focal therapy offers the possibility of cancer control, without the side effect profile of radical therapies. Early single centre prospective development studies using high intensity focused ultrasound (HIFU) have demonstrated encouraging genitourinary functional preservation and short-term cancer control....

journal_title：Contemporary clinical trials

authors： Dickinson L,Ahmed HU,Kirkham AP,Allen C,Freeman A,Barber J,Hindley RG,Leslie T,Ogden C,Persad R,Winkler MH,Emberton M,INDEX Study Group.

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Lifelong antiretroviral therapy (ART) (Option B+) is recommended for all HIV-infected pregnant/postpartum women, but high adherence is required to maximize HIV prevention potential and maintain maternal health. Mobile health (mHealth) interventions may provide treatment adherence support for women during, an...

journal_title：Contemporary clinical trials

authors： Drake AL,Unger JA,Ronen K,Matemo D,Perrier T,DeRenzi B,Richardson BA,Kinuthia J,John-Stewart G

更新日期：2017-06-01 00:00:00

abstract：:College student alcohol use and associated negative consequences are clear public health problems with consequences including damage to self, others, and institutions. This paper describes the protocol of a research study designed to answer a number of important questions in the development of an adaptive preventive i...

journal_title：Contemporary clinical trials

authors： Patrick ME,Boatman JA,Morrell N,Wagner AC,Lyden GR,Nahum-Shani I,King CA,Bonar EE,Lee CM,Larimer ME,Vock DM,Almirall D

更新日期：2020-09-01 00:00:00

abstract：UNLABELLED:Latinos bear a disproportionate burden of the dual pandemic of obesity and diabetes. However, successful interventions addressing this disparity through primary care are lacking. To address this gap, the 5-year Vida Sana (Healthy Life) study tests a culturally adapted and technology-enhanced group-based Diab...

journal_title：Contemporary clinical trials

authors： Rosas LG,Lv N,Xiao L,Lewis MA,Zavella P,Kramer MK,Luna V,Ma J

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Evidence suggests that periodontitis is associated with prevalent and incident type 2 diabetes mellitus (T2DM), raising the question of whether periodontitis treatment may improve glycemic control in patients with T2DM. Meta-analyses of mostly small clinical trials suggest that periodontitis treatment result...

journal_title：Contemporary clinical trials

authors： DPTT study group.,Engebretson S,Gelato M,Hyman L,Michalowicz BS,Schoenfeld E

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Multiple sclerosis is a chronic progressive neurological disease. Evidence attests to the benefits of exercise, guidelines for exercise in multiple sclerosis are available. Remote-delivery of exercise adherence programmes based on the exercise guidelines require urgent testing. AIMS:The design, and outcomes...

journal_title：Contemporary clinical trials

authors： Learmonth YC,Kaur I,Baynton SL,Fairchild T,Paul L,van Rens F

更新日期：2021-01-12 00:00:00

abstract：BACKGROUND:The translation of research evidence into practice is facilitated by clinical trials such as those sponsored by the National Cancer Institute's Community Clinical Oncology Program (CCOP) that help disseminate cancer care innovations to community-based physicians and provider organizations. However, CCOP part...

journal_title：Contemporary clinical trials

authors： McAlearney AS,Song PH,Reiter KL

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Women have higher rates of depression and often experience depression symptoms during critical reproductive periods, including adolescence, pregnancy, postpartum, and menopause. Collaborative care intervention models for mood disorders in patients receiving care in an OB-GYN clinic setting have not been eval...

journal_title：Contemporary clinical trials

authors： LaRocco-Cockburn A,Reed SD,Melville J,Croicu C,Russo JE,Inspektor M,Edmondson E,Katon W

更新日期：2013-11-01 00:00:00

abstract：:Cancer related cognitive impairments (CRCI) are frequently reported by patients prior to, during and after medical treatment. Although this cognitive decline severely affects patients' quality of life, little is known about effective treatments. Exercise programs represent a promising supportive strategy in this field...

journal_title：Contemporary clinical trials

authors： Zimmer P,Oberste M,Bloch W,Schenk A,Joisten N,Hartig P,Wolf F,Baumann FT,Garthe A,Hallek M,Elter T

更新日期：2016-07-01 00:00:00

abstract：:This study was set up to test an ecological intervention using a pragmatic cluster randomised controlled design (RCT) aimed at increasing physical activity (PA) within the community in a deprived inner-city area in the UK. The research will provide a detailed mapping (using Graphical Information Systems GIS) of the en...

journal_title：Contemporary clinical trials

authors： Davey RC,Cochrane T,Gidlow C,Fairburn J,Smith G

更新日期：2008-09-01 00:00:00

abstract：:Patients with malignant disease enrolled in trials of thrombotic disorders may experience competing events such as death. The occurrence of a competing event may prevent the thrombotic event from being observed. Standard survival analysis techniques ignore competing risks, resulting in possible bias and distorted infe...

journal_title：Contemporary clinical trials

authors： Parpia S,Julian JA,Thabane L,Lee AY,Rickles FR,Levine MN

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:African American (AA) women perform low levels of physical activity (PA) and are disproportionally burdened by cardiometabolic disease conditions when compared to White women and the U.S. population as a whole. These disparities emphasize the need for innovative and effective interventions to increase PA and...

journal_title：Contemporary clinical trials

authors： Joseph RP,Ainsworth BE,Vega-López S,Adams MA,Hollingshead K,Hooker SP,Todd M,Gaesser GA,Keller C

更新日期：2019-02-01 00:00:00

abstract：:Thirty percent of all military personnel smoke cigarettes. Because of the negative health consequences and their impact on physical fitness, overall health, and military readiness, the Department of Defense has identified the reduction of tobacco use as a priority of US military forces. This study aims to evaluate the...

journal_title：Contemporary clinical trials

authors： Richey PA,Klesges RC,Talcott GW,Debon M,Womack C,Thomas F,Hryshko-Mullen A

更新日期：2012-09-01 00:00:00

abstract：PURPOSE:This article describes the protocol for a Hybrid Type I cost-effectiveness and implementation study of interpersonal psychotherapy (IPT) for men and women prisoners with major depressive disorder (MDD). The goal is to promote uptake of evidence-based treatments in criminal justice settings by conducting a rando...

journal_title：Contemporary clinical trials

authors： Johnson JE,Miller TR,Stout RL,Zlotnick C,Cerbo LA,Andrade JT,Wiltsey-Stirman S

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:In the past 20-30 years, the prevalence of atopic diseases, particularly among children in the Western world, has increased. It has been suggested that Western lifestyle may have reduced the overall exposure to microbial stimulation early in life. The role of the gut flora in this connection has been studied...

journal_title：Contemporary clinical trials

authors： Øien T,Storrø O,Johnsen R

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND:Despite evidence that palliative care increases quality and length of life, many patients and families remain uninformed about its nature and benefits. The purpose of this study is to test a psycho-educational intervention, Managing Cancer Care: A Personal Guide (MCC), intended to improve breast cancer patie...

journal_title：Contemporary clinical trials

authors： Schulman-Green D,Linsky S,Jeon S,Kapo J,Blatt L,Chagpar A

更新日期：2016-05-01 00:00:00

abstract：:Managing chronic pain effectively is often challenging for health care providers and patients. Telehealth technologies can bridge geographic distance and improve patients' quality of care in communities where access to pain specialists has previously been unavailable. This paper describes the development and evaluatio...

journal_title：Contemporary clinical trials

authors： Eaton LH,Gordon DB,Wyant S,Theodore BR,Meins AR,Rue T,Towle C,Tauben D,Doorenbos AZ

更新日期：2014-07-01 00:00:00

abstract：:The combined use of cigarettes and alcohol is associated with an increased risk of morbidity and mortality. Yet, efficacious interventions that address both behaviors concurrently are lacking. Smoking cessation and alcohol modification not only garner health benefits, but there is also value in addressing alcohol use ...

journal_title：Contemporary clinical trials

authors： Hemenway M,Witkiewitz K,Unrod M,Brandon KO,Brandon TH,Wetter DW,Sutton SK,Vinci C

更新日期：2020-11-14 00:00:00

abstract：BACKGROUND:Despite controversy about paying research subjects, little is known about actual practices in the U.S., including what type of studies offer payment, to what type of subjects, and how amounts are determined. OBJECTIVE:To document current U.S. practices regarding payment to research subjects. METHODS:The pr...

journal_title：Contemporary clinical trials

authors： Grady C,Dickert N,Jawetz T,Gensler G,Emanuel E

更新日期：2005-06-01 00:00:00