Evaluation of mHealth strategies to optimize adherence and efficacy of Option B+ prevention of mother-to-child HIV transmission: Rationale, design and methods of a 3-armed randomized controlled trial.

abstract：BACKGROUND:Although individuals with psychiatric disorders are disproportionately affected by cigarette smoking, few outpatient mental health treatment facilities offer smoking cessation services. In this paper, we describe the development of a smartphone-assisted mindfulness smoking cessation intervention with conting...

journal_title：Contemporary clinical trials

authors： Minami H,Brinkman HR,Nahvi S,Arnsten JH,Rivera-Mindt M,Wetter DW,Bloom EL,Price LH,Vieira C,Donnelly R,McClain LM,Kennedy KA,D'Aquila E,Fine M,McCarthy DE,Graham Thomas J,Hecht J,Brown RA

更新日期：2018-03-01 00:00:00

abstract：:We developed a novel diagram to depict patient flow and outcomes in clinical trials. In contrast to flow diagrams such as the CONSORT chart, our diagram enables individual patient histories to be traced and depicts important patterns of treatment administration and outcomes, such as response and adverse events. Also, ...

journal_title：Contemporary clinical trials

authors： Schuller JC,Mayer M,Lanz D,Schmitz SF,Brauchli P,Leupin N

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:Functional dyspepsia (FD) is a common problem affecting up to 10-25% of individuals. FD accounts for significant health care costs and affects quality of life but has no definitive treatment. OBJECTIVES:The Functional Dyspepsia Treatment Trial (FDTT) aims to test whether treatment with an antidepressant (am...

journal_title：Contemporary clinical trials

authors： Talley NJ,Locke GR 3rd,Herrick LM,Silvernail VM,Prather CM,Lacy BE,DiBaise JK,Howden CW,Brenner DM,Bouras EP,El-Serag HB,Abraham BP,Moayyedi P,Zinsmeister AR

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:The addition of specialty palliative care to standard oncology care improves outcomes for patients with advanced cancer and their caregivers, but many lack access to specialty care services. Primary palliative care-meaning basic palliative care services provided by clinicians who are not palliative care spec...

journal_title：Contemporary clinical trials

authors： Becker CL,Arnold RM,Park SY,Rosenzweig M,Smith TJ,White DB,Smith KJ,Schenker Y

更新日期：2017-03-01 00:00:00

abstract：:Phase IIA clinical trials are commonly conducted as pilot studies to evaluate efficacy and safety in selected populations of patients with the disease or condition to be treated or prevented. The efficacy objective is to find preliminarily evidence of the effectiveness or ineffectiveness of study treatments. Go/no-go ...

journal_title：Contemporary clinical trials

authors： Zhong B

更新日期：2012-11-01 00:00:00

abstract：INTRODUCTION:Focal therapy (FT) targets individual areas of cancer within the prostate, providing oncological control with minimal side-effects. Early evidence demonstrates encouraging short-medium-term outcomes. With no randomized controlled trials (RCT) comparing FT to radical therapies, Comparative Healthcare Resear...

journal_title：Contemporary clinical trials

authors： Reddy D,Shah TT,Dudderidge T,McCracken S,Arya M,Dobbs C,Emberton M,Fiorentino F,Day E,Prevost AT,Staffurth J,Sydes M,Winkler M,Ahmed HU

更新日期：2020-06-01 00:00:00

abstract：:Recruitment of patients for clinical trials is one of the major hurdles on the way to successful completion of any human research study. Direct comparison of recruitment activity in different sites and projects is not easy due to lack of a unified measure of recruitment efficacy. The author introduces a new variable, ...

journal_title：Contemporary clinical trials

authors： Rojavin MA

更新日期：2005-10-01 00:00:00

abstract：BACKGROUND:In a recent publication, the International Guidelines for Groin Hernia Management by the European Hernia Society (EHS) recognized the need to individualize and tailor the surgical approach for hernia repair. There may be different opportunities for optimization of the surgical technique for surgeons performi...

journal_title：Contemporary clinical trials

authors： LeBlanc KA

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Thousands of people die annually from prescription opioid overdoses; however there are few strategies to ensure patients receive medication risk information at the time of prescribing. OBJECTIVES:To compare the effectiveness of the Emergency Department (ED) Electronic Medication Complete Communication (EMC2...

journal_title：Contemporary clinical trials

authors： McCarthy DM,Courtney DM,Lank PM,Cameron KA,Russell AM,Curtis LM,Kim KA,Walton SM,Montague E,Lyden AL,Gravenor SJ,Wolf MS

更新日期：2017-08-01 00:00:00

abstract：:This paper proposes a method for balancing prognostic variables between treatment and control groups in design of clinical trials. It assumes that some of prognostic variables are continuous and others are categorical and that they are independently distributed. The proposed method uses the Kullback-Leibler divergence...

journal_title：Contemporary clinical trials

authors： Endo A,Nagatani F,Hamada C,Yoshimura I

更新日期：2006-10-01 00:00:00

abstract：:Upstream interventions - e.g. housing programs and community health worker interventions- address socioeconomic and behavioral factors that influence health outcomes across diseases. Studying these types of interventions in clinical trials raises a methodological challenge: how should researchers measure the effect of...

journal_title：Contemporary clinical trials

authors： Kangovi S,Mitra N,Turr L,Huo H,Grande D,Long JA

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:African American (AA) women perform low levels of physical activity (PA) and are disproportionally burdened by cardiometabolic disease conditions when compared to White women and the U.S. population as a whole. These disparities emphasize the need for innovative and effective interventions to increase PA and...

journal_title：Contemporary clinical trials

authors： Joseph RP,Ainsworth BE,Vega-López S,Adams MA,Hollingshead K,Hooker SP,Todd M,Gaesser GA,Keller C

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Currently, there is no consensus regarding the best treatment option in recurrent haemorrhoidal disease (HD), due to a lack of solid evidence. The Napoleon trial aims to provide high-level evidence on the comparative effectiveness and cost-effectiveness of repeat rubber band ligation (RBL) versus sutured muc...

journal_title：Contemporary clinical trials

authors： Kuiper SZ,Dirksen CD,Kimman ML,Van Kuijk SMJ,Van Tol RR,Muris JWM,Watson AJM,Maessen JMC,Melenhorst J,Breukink SO,Napoleon Trial Study Group.

更新日期：2020-12-01 00:00:00

abstract：:Pediatric primary care is an important setting in which to address obesity prevention, yet relatively few interventions have been evaluated and even fewer have been shown to be effective. The development and evaluation of cost-effective approaches to obesity prevention that leverage opportunities of direct access to f...

journal_title：Contemporary clinical trials

authors： Sherwood NE,Levy RL,Langer SL,Senso MM,Crain AL,Hayes MG,Anderson JD,Seburg EM,Jeffery RW

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Unlike conventional time-to-event analysis of composite endpoints in clinical trials, the "win ratio" method allows for flexibility in prioritizing their components. Here, we compare the EVOLVE trial findings using the win ratio with those from time-to-event analysis. METHODS: EXPOSURE:Randomization to cin...

journal_title：Contemporary clinical trials

authors： Abdalla S,Montez-Rath ME,Parfrey PS,Chertow GM

更新日期：2016-05-01 00:00:00

abstract：INTRODUCTION:Juvenile neuronal ceroid lipofuscinosis (JNCL; Batten disease) is a rare, inherited, fatal lysosomal storage childhood disorder. True for many rare diseases, there are no treatments that impact the course of JNCL. The University of Rochester Batten Center's (URBC) mission is to find treatments to slow, hal...

journal_title：Contemporary clinical trials

authors： de Blieck EA,Augustine EF,Marshall FJ,Adams H,Cialone J,Dure L,Kwon JM,Newhouse N,Rose K,Rothberg PG,Vierhile A,Mink JW,Batten Study Group.

更新日期：2013-07-01 00:00:00

abstract：:The prevalence of obesity is high resulting from chronic imbalances between energy intake and expenditure. On the expenditure side, regular exercise is associated with health benefits, including enhanced brain function. The benefits of exercise are not immediate and require persistence to be realized. Brain regions as...

journal_title：Contemporary clinical trials

authors： Herrmann SD,Martin LE,Breslin FJ,Honas JJ,Willis EA,Lepping RJ,Gibson CA,Befort CA,Lambourne K,Burns JM,Smith BK,Sullivan DK,Washburn RA,Yeh HW,Donnelly JE,Savage CR

更新日期：2014-01-01 00:00:00

abstract：:Modified Zelen's approach is a randomization technique useful in multi-center trials where balance in treatment assignments within a center is desired. It has great balancing properties in a study with equal allocation to several treatment arms. This technique can also be used in studies with unequal allocation, where...

journal_title：Contemporary clinical trials

authors： Kuznetsova OM,Tymofyeyev Y

更新日期：2011-11-01 00:00:00

abstract：:Chronic insomnia disorder is a prevalent condition and a significant proportion of these individuals also have obstructive sleep apnea (OSA). These two sleep disorders have distinct pathophysiology and are managed with different treatment approaches. High comorbidity rates have been a catalyst for emerging studies exa...

journal_title：Contemporary clinical trials

authors： Crawford MR,Turner AD,Wyatt JK,Fogg LF,Ong JC

更新日期：2016-03-01 00:00:00

abstract：INTRODUCTION:Youth in disadvantaged urban areas are frequently exposed to chronic stress and trauma, including housing instability, neighborhood violence, and other poverty-related adversities. These exposures increase risk for emotional, behavioral, and academic problems and ultimately, school dropout. Schools are a p...

journal_title：Contemporary clinical trials

authors： Mendelson T,Clary LK,Sibinga E,Tandon D,Musci R,Mmari K,Salkever D,Stuart EA,Ialongo N

更新日期：2020-03-01 00:00:00

abstract：:Double-blinded trials are often considered the gold standard for research, but significant bias may result from unblinding of participants and investigators. Although the CONSORT guidelines discuss the importance of reporting "evidence that blinding was successful", it is unclear what constitutes appropriate evidence....

journal_title：Contemporary clinical trials

authors： Rees JR,Wade TJ,Levy DA,Colford JM Jr,Hilton JF

更新日期：2005-02-01 00:00:00

abstract：:The COVID-19 pandemic has substantially impacted the conduct of clinical trials. While initially preparing for a period of time, where it would likely be impossible to supervise trials in the usual way and precautionary measures had to be implemented to care for medication supply and general safety of study participan...

journal_title：Contemporary clinical trials

authors： Großhennig A,Koch A

更新日期：2020-11-01 00:00:00

abstract：:Although colorectal cancer (CRC) is largely preventable through identification of pre-cancerous polyps through various screening modalities, morbidity and mortality rates remain a challenge, especially in African-American, Latino, low-income and uninsured/underinsured patients. Barriers to screening include cost, acce...

journal_title：Contemporary clinical trials

authors： Buscemi J,Miguel YS,Tussing-Humphreys L,Watts EA,Fitzgibbon ML,Watson K,Winn RA,Matthews KL,Molina Y

更新日期：2017-01-01 00:00:00

abstract：:The convention in clinical trials is to regard outcomes as independently distributed, possibly conditional on covariates, but in some situations they may be correlated. For example, in infectious diseases, correlation may be induced if participants have contact with a common infectious source, or share hygienic tips t...

journal_title：Contemporary clinical trials

authors： Follmann D,Proschan M

更新日期：2014-09-01 00:00:00

abstract：:Parents of young children with type 1 diabetes (T1D) experience unique, developmental challenges in managing their child's T1D, resulting in psychosocial distress. Only a small portion of young children reach glucose goals and adherence to diabetes devices that help improve T1D management have historically been low in...

journal_title：Contemporary clinical trials

authors： Berget C,Driscoll KA,Lagges A,Lange S,DiMeglio LA,Hannon TS,Woerner SE,Iturralde E,Barley RC,Hanes S,Hood KK,Buckingham BB,Toddler Diabetes Technology Study Group.

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVE:Maternal adiposity confers an increased risk of GDM in pregnancy. A low glycemic index (GI) dietary intervention has been found to improve glucose homeostasis and reduce gestational weight gain. Mobile Health (mHealth) Technology-assisted interventions are becoming commonplace as an aid to treating many chron...

journal_title：Contemporary clinical trials

authors： Kennelly MA,Ainscough K,Lindsay K,Gibney E,Mc Carthy M,McAuliffe FM

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Early pregnancy through the first year of life represents an important period for family health promotion and obesity prevention. Overall, preventive interventions in pregnancy and infancy have insufficiently engaged fathers. We describe the rationale and design of First Heroes, an intervention to improve pe...

journal_title：Contemporary clinical trials

authors： Whooten RC,Kwete GM,Farrar-Muir H,Cournoyer RN,Barth EA,Kotelchuck M,Taveras EM

更新日期：2020-12-17 00:00:00

abstract：INTRODUCTION:Robotic assistance during laparoscopic surgery for pelvic organ prolapse rapidly disseminated across the United States without level I data to support its benefit over traditional open and laparoscopic approaches [1]. This manuscript describes design and methodology of the Abdominal Colpopexy: Comparison o...

journal_title：Contemporary clinical trials

authors： Mueller ER,Kenton K,Tarnay C,Brubaker L,Rosenman A,Smith B,Stroupe K,Bresee C,Pantuck A,Schulam P,Anger JT

更新日期：2012-09-01 00:00:00

abstract：INTRODUCTION:Focal ablation therapy is playing an increasing role in oncology and may reduce the toxicity of current surgical treatments while achieving adequate oncological benefit. Irreversible electroporation (IRE) has been proposed to be tissue-selective with potential advantages compared with current thermal-ablat...

journal_title：Contemporary clinical trials

authors： Wendler JJ,Porsch M,Nitschke S,Köllermann J,Siedentopf S,Pech M,Fischbach F,Ricke J,Schostak M,Liehr UB

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Multiple sclerosis is a chronic progressive neurological disease. Evidence attests to the benefits of exercise, guidelines for exercise in multiple sclerosis are available. Remote-delivery of exercise adherence programmes based on the exercise guidelines require urgent testing. AIMS:The design, and outcomes...

journal_title：Contemporary clinical trials

authors： Learmonth YC,Kaur I,Baynton SL,Fairchild T,Paul L,van Rens F

更新日期：2021-01-12 00:00:00