Electronic medication complete communication strategy for opioid prescriptions in the emergency department: Rationale and design for a three-arm provider randomized trial.


BACKGROUND:Thousands of people die annually from prescription opioid overdoses; however there are few strategies to ensure patients receive medication risk information at the time of prescribing. OBJECTIVES:To compare the effectiveness of the Emergency Department (ED) Electronic Medication Complete Communication (EMC2) Opioid Strategy (with and without text messaging) to promote safe medication use and improved patient knowledge as compared to usual care. METHODS:The ED EMC2 Opioid Strategy consists of 5 automated components to promote safe medication use: 1) physician reminder to counsel, 2) inbox message sent on to the patient's primary care physician, 3) pharmacist message on the prescription to counsel, 4) MedSheet supporting prescription information, and 5) patient-centered Take-Wait-Stop wording of prescription instructions. This strategy will be assessed both with and without the addition of text messages via a three-arm randomized trial. The study will take place at an urban academic ED (annual volume>85,000) in Chicago, IL. Patients being discharged with a new prescription for hydrocodone-acetaminophen will be enrolled and randomized (based on their prescribing physician). The primary outcome of the study is medication safe use as measured by a demonstrated dosing task. Additionally actual safe use, patient knowledge and provider counseling will be measured. Implementation fidelity as well as costs will be reported. CONCLUSIONS:The ED EMC2 Opioid Strategy embeds a risk communication strategy into the electronic health record and promotes medication counseling with minimal workflow disruption. This trial will evaluate the strategy's effectiveness and implementation fidelity as compared to usual care. TRIAL REGISTRATION:This trial is registered on clinicaltrials.gov with identifier NCT02431793.


Contemp Clin Trials


McCarthy DM,Courtney DM,Lank PM,Cameron KA,Russell AM,Curtis LM,Kim KA,Walton SM,Montague E,Lyden AL,Gravenor SJ,Wolf MS




Has Abstract


2017-08-01 00:00:00












  • Randomized controlled trial protocol for project BRIDGE: A telephone-administered motivational interviewing intervention targeting risky sexual behavior in older people living with HIV.

    abstract:PURPOSE:By 2020, 70% of people living with HIV in the United States will be greater than 50 years of age. As many as 37% of sexually active older people living with HIV (OPLWH) engage in HIV transmission sexual behaviors. In spite of repeated calls for secondary prevention interventions to reduce condomless sex in OPLW...

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章


    authors: Kahler J,Heckman TG,Shen Y,Huckans MS,Feldstein Ewing SW,Parsons JT,Phelps A,Sutton M,Holloway J,Lovejoy TI

    更新日期:2020-08-01 00:00:00

  • Recombinant human hepatocyte growth factor for liver failure.

    abstract::The purpose of this paper is to evaluate the efficacy and safety of recombinant human hepatocyte growth factor (rh-HGF) for liver failure (LF) using meta-analysis of data from the literature involving available randomized controlled trials of rh-HGF plus comprehensive therapy (CT) compared with that of CT alone (Thera...

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章,meta分析


    authors: Cui YL,Meng MB,Tang H,Zheng MH,Wang YB,Han HX,Lei XZ

    更新日期:2008-09-01 00:00:00

  • A randomized controlled trial of the efficacy and cost-effectiveness of a brief intensified cognitive behavioral therapy and/or pharmacotherapy for mood and anxiety disorders: design and methods.

    abstract:BACKGROUND:Anxiety and mood disorders involve a high disease burden and are associated with high economic costs. A stepped-care approach intervention and abbreviated diagnostic method are assumed to increase effectiveness and efficiency of the mental healthcare and are expected to reduce economic costs. METHODS:Presen...

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章,随机对照试验


    authors: Meuldijk D,Carlier IV,van Vliet IM,van den Akker-Marle ME,Zitman FG

    更新日期:2012-09-01 00:00:00

  • Reducing breast cancer recurrence with weight loss, a vanguard trial: the Exercise and Nutrition to Enhance Recovery and Good Health for You (ENERGY) Trial.

    abstract::Breast cancer is the most common invasive cancer among women in developed countries. Obesity is a major risk factor for breast cancer recurrence and mortality in both pre- and postmenopausal women. Co-morbid medical conditions are common among breast cancer survivors. The Exercise and Nutrition to Enhance Recovery and...

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章,随机对照试验


    authors: Rock CL,Byers TE,Colditz GA,Demark-Wahnefried W,Ganz PA,Wolin KY,Elias A,Krontiras H,Liu J,Naughton M,Pakiz B,Parker BA,Sedjo RL,Wyatt H,Exercise and Nutrition to Enhance Recovery and Good Health for You (ENERGY) Trial Group.

    更新日期:2013-03-01 00:00:00

  • Evaluation of mHealth strategies to optimize adherence and efficacy of Option B+ prevention of mother-to-child HIV transmission: Rationale, design and methods of a 3-armed randomized controlled trial.

    abstract:BACKGROUND:Lifelong antiretroviral therapy (ART) (Option B+) is recommended for all HIV-infected pregnant/postpartum women, but high adherence is required to maximize HIV prevention potential and maintain maternal health. Mobile health (mHealth) interventions may provide treatment adherence support for women during, an...

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章,随机对照试验


    authors: Drake AL,Unger JA,Ronen K,Matemo D,Perrier T,DeRenzi B,Richardson BA,Kinuthia J,John-Stewart G

    更新日期:2017-06-01 00:00:00

  • Vitamin C to Decrease the Effects of Smoking in Pregnancy on Infant Lung Function (VCSIP): Rationale, design, and methods of a randomized, controlled trial of vitamin C supplementation in pregnancy for the primary prevention of effects of in utero tobacco

    abstract::Despite strong anti-smoking efforts, at least 12% of American women cannot quit smoking when pregnant resulting in >450,000 smoke-exposed infants born yearly. Smoking during pregnancy is the largest preventable cause of childhood respiratory illness including wheezing and asthma. Recent studies have shown a protective...

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章,随机对照试验


    authors: McEvoy CT,Milner KF,Scherman AJ,Schilling DG,Tiller CJ,Vuylsteke B,Shorey-Kendrick LE,Spindel ER,Schuff R,Mitchell J,Peters D,Metz J,Haas D,Jackson K,Tepper RS,Morris CD

    更新日期:2017-07-01 00:00:00

  • Participation in pediatric epidemiologic research: the SEARCH for Diabetes in Youth Study experience.

    abstract:BACKGROUND:We evaluated the association of demographic and clinical characteristics with participation in an epidemiologic study of diabetes mellitus among youth. METHODS:SEARCH for Diabetes in Youth is a multicenter study of physician-diagnosed diabetes in youth under the age of 20 comprising a surveillance and a coh...

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章,多中心研究


    authors: Liese AD,Liu L,Davis C,Standiford D,Waitzfelder B,Dabelea D,Bell R,Williams D,Imperatore G,Lawrence JM

    更新日期:2008-11-01 00:00:00

  • Patient randomized trial of a targeted navigation program to improve rates of follow-up colonoscopy in community health centers.

    abstract:BACKGROUND:Colorectal cancer (CRC) screening by annual fecal immunochemical test (FIT) is an accessible and cost-effective strategy to lower CRC incidence and mortality. However, this mode of screening depends on follow-up colonoscopy after a positive FIT result. Unfortunately, nearly one-half of FIT-positive patients ...

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章


    authors: Coronado GD,Johnson ES,Leo MC,Schneider JL,Smith D,Mummadi R,Petrik AF,Thompson JH,Jimenez R

    更新日期:2020-02-01 00:00:00

  • Rationale and design of a trial on the role of bosentan in Fontan patients: improvement of exercise capacity?

    abstract:BACKGROUND:The Fontan circulation is a palliative procedure performed in patients with complex congenital heart disease (CHD), making transpulmonary blood flow dependent on the systemic venous pressure. In a Fontan circulation a low pulmonary vascular resistance (PVR) is crucial, as is epitomized by the observation tha...

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Schuuring MJ,Vis JC,Bouma BJ,van Dijk AP,van Melle JP,Pieper PG,Vliegen HW,Sieswerda GT,Mulder BJ

    更新日期:2011-07-01 00:00:00

  • Competing events in patients with malignant disease who are at risk for recurrent venous thromboembolism.

    abstract::Patients with malignant disease enrolled in trials of thrombotic disorders may experience competing events such as death. The occurrence of a competing event may prevent the thrombotic event from being observed. Standard survival analysis techniques ignore competing risks, resulting in possible bias and distorted infe...

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章,随机对照试验


    authors: Parpia S,Julian JA,Thabane L,Lee AY,Rickles FR,Levine MN

    更新日期:2011-11-01 00:00:00

  • Analysis of duration of response in oncology trials.

    abstract::The fraction of patients who respond to treatment and the duration of response in the subset of responding patients are commonly evaluated in oncology trials of cytotoxic compounds. While formal, comparative analysis of the fraction of patients responding to treatment is straightforward in a randomised trial, analyses...

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章


    authors: Ellis S,Carroll KJ,Pemberton K

    更新日期:2008-07-01 00:00:00

  • Telephone-adapted Mindfulness-based Stress Reduction (tMBSR) for patients awaiting kidney transplantation.

    abstract:BACKGROUND:Patients with progressive kidney disease experience increasing physiologic and psychosocial stressors and declining health-related quality of life (HRQOL). METHODS:We conducted a randomized, active-controlled, open-label trial to test whether a Mindfulness-based Stress Reduction (MBSR) program delivered in ...

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章,随机对照试验


    authors: Gross CR,Reilly-Spong M,Park T,Zhao R,Gurvich OV,Ibrahim HN

    更新日期:2017-06-01 00:00:00

  • Development and implementation of a telehealth-enhanced intervention for pain and symptom management.

    abstract::Managing chronic pain effectively is often challenging for health care providers and patients. Telehealth technologies can bridge geographic distance and improve patients' quality of care in communities where access to pain specialists has previously been unavailable. This paper describes the development and evaluatio...

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章,随机对照试验


    authors: Eaton LH,Gordon DB,Wyant S,Theodore BR,Meins AR,Rue T,Towle C,Tauben D,Doorenbos AZ

    更新日期:2014-07-01 00:00:00

  • Does outpatient palliative care improve patient-centered outcomes in Parkinson's disease: Rationale, design, and implementation of a pragmatic comparative effectiveness trial.

    abstract::Patients with Parkinson's disease and related disorders (PDRD) and their families have considerable unmet needs including non-motor symptom management, caregiver support, spiritual wellbeing, advance care planning, and end-of-life care. There is increasing interest in applying palliative care (PC) models to better mee...

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Kluger BM,Katz M,Galifianakis N,Pantilat SZ,Kutner JS,Sillau S,Gritz M,Jones J,Fairclough D,Sumrall M,Hall K,Miyasaki J

    更新日期:2019-04-01 00:00:00

  • Efficacy of the tincture of jalapa in the treatment of functional constipation: a double-blind, randomized, placebo-controlled study.

    abstract:BACKGROUND:Laxatives are much utilized, but few clinical trials assessed the efficacy of phytotherapics in the functional constipation. AIM:The aim of this study was to evaluate the efficacy of the tincture of jalapa in the treatment of patients with functional constipation. METHODS:Double-blind, randomized, placebo-...

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章,随机对照试验


    authors: Cunha GH,Fechine FV,Santos LK,Pontes AV,Oliveira JC,Moraes MO,Bezerra FA,Moraes ME

    更新日期:2011-03-01 00:00:00

  • Paving the way to a more effective informed consent process: Recommendations from the Clinical Trials Transformation Initiative.

    abstract::Ethically sound clinical research requires that prospective study participants provide voluntary informed consent before any study procedures begin. The original intent was to provide the participant with clear, accurate information about study specifics (e.g., risks/benefits) to aid in the decision to participate. Br...

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章


    authors: Lentz J,Kennett M,Perlmutter J,Forrest A

    更新日期:2016-07-01 00:00:00

  • The medication Adherence and Blood Pressure Control (ABC) trial: a multi-site randomized controlled trial in a hypertensive, multi-cultural, economically disadvantaged population.

    abstract::The Medication Adherence and BP Control Trial (ABC Trial) is a randomized, controlled, multi-site, medication adherence and blood pressure (BP) control trial in an economically disadvantaged and multi-cultural population of hypertensive patients followed in primary care practices. To date, no other such trial has been...

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Gerin W,Tobin JN,Schwartz JE,Chaplin W,Rieckmann N,Davidson KW,Goyal TM,Jhalani J,Cassells A,Feliz K,Khalida C,Diaz-Gloster M,Ogedegbe G

    更新日期:2007-07-01 00:00:00

  • Rationale and design of Smart Walk: A randomized controlled pilot trial of a smartphone-delivered physical activity and cardiometabolic risk reduction intervention for African American women.

    abstract:BACKGROUND:African American (AA) women perform low levels of physical activity (PA) and are disproportionally burdened by cardiometabolic disease conditions when compared to White women and the U.S. population as a whole. These disparities emphasize the need for innovative and effective interventions to increase PA and...

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章,随机对照试验


    authors: Joseph RP,Ainsworth BE,Vega-López S,Adams MA,Hollingshead K,Hooker SP,Todd M,Gaesser GA,Keller C

    更新日期:2019-02-01 00:00:00

  • Digital training for non-specialist health workers to deliver a brief psychological treatment for depression in India: Protocol for a three-arm randomized controlled trial.

    abstract:BACKGROUND:Training non-specialist health workers (NSHWs) at scale is a major barrier to increasing the coverage of depression care in India. This trial will test the effectiveness of two forms of digital training compared to conventional face-to-face training in changing the competence of NSHWs to deliver a brief evid...

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章


    authors: Naslund JA,Tugnawat D,Anand A,Cooper Z,Dimidjian S,Fairburn CG,Hollon SD,Joshi U,Khan A,Lu C,Mitchell LM,Muke S,Nadkarni A,Ramaswamy R,Restivo JL,Shrivastava R,Singh A,Singla DR,Spiegelman D,Bhan A,Patel V

    更新日期:2021-01-06 00:00:00

  • Pain relief for osteoarthritis through combined treatment (PROACT): Protocol for a randomized controlled trial of mindfulness meditation combined with transcranial direct current stimulation in non-Hispanic black and white adults with knee osteoarthritis.

    abstract::Knee osteoarthritis (OA) is a leading cause of late life pain and disability, and non-Hispanic black (NHB) adults experience greater OA-related pain and disability than non-Hispanic whites (NHWs). Recent evidence implicates psychosocial stress, cognitive-attentional processes, and altered central pain processing as co...

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章


    authors: Fillingim RB,Woods AJ,Ahn H,Wu SS,Redden DT,Lai S,Deshpande H,Deutsch G,Sibille KT,Staud R,Zeidan F,Goodin BR

    更新日期:2020-11-01 00:00:00

  • Covid-19 pandemic research opportunity: Is the Middle East & North Africa (MENA) missing out?

    abstract:BACKGROUND:The Covid-19 pandemic has caused fear and panic worldwide, forcing healthcare systems to disregard conventional practices and adopt innovation to contain the infection and death. Globally, there has been a rapid proliferation of research studies and clinical trials assessing risks, infectivity and treatment....

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章,评审


    authors: Ibrahim H,Kamour AM,Harhara T,Gaba WH,Nair SC

    更新日期:2020-09-01 00:00:00

  • Design of a nurse-run, telephone-based intervention to improve lipids in diabetics.

    abstract::This randomized, controlled trial tested the effectiveness of a nurse-run, telephone-based intervention to improve lipid control in patients with diabetes. Our patient population is predominantly low-income and Latino. Using our diabetes registry, we randomly assigned 381 patients to continue with their usual care and...

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章


    authors: Fischer H,Mackenzie T,McCullen K,Everhart R,Estacio RO

    更新日期:2008-09-01 00:00:00

  • Sertraline vs. ELectrical Current Therapy for Treating Depression Clinical Trial--SELECT TDCS: design, rationale and objectives.

    abstract:BACKGROUND:Despite significant advancements in psychopharmacology, treating major depressive disorder (MDD) is still a challenge considering the efficacy, tolerability, safety, and economical costs of most antidepressant drugs. One approach that has been increasingly investigated is modulation of cortical activity with...

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章,随机对照试验


    authors: Brunoni AR,Valiengo L,Baccaro A,Zanao TA,de Oliveira JF,Vieira GP,Bueno VF,Goulart AC,Boggio PS,Lotufo PA,Bensenor IM,Fregni F

    更新日期:2011-01-01 00:00:00

  • The use of minimization in clinical trials.

    abstract::Since its introduction in 1974 the use of the term Minimization has been broadened to include other algorithms. All algorithms use patient characteristics to determine the assignment that produces the best overall balance between treatment groups. They differ in whether or not they use all of the data from each previo...

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章,meta分析,评审


    authors: Taves DR

    更新日期:2010-03-01 00:00:00

  • Healthy Living Partnerships to Prevent Diabetes (HELP PD): design and methods.

    abstract::Although the Diabetes Prevention Program (DPP) developed a lifestyle weight loss intervention that has been demonstrated to prevent type 2 diabetes in high-risk individuals, it has yet to be widely adopted at the community level. The Healthy Living Partnership to Prevent Diabetes study (HELP PD) was designed to transl...

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章,随机对照试验


    authors: Katula JA,Vitolins MZ,Rosenberger EL,Blackwell C,Espeland MA,Lawlor MS,Rejeski WJ,Goff DC

    更新日期:2010-01-01 00:00:00

  • Effect of sugar-sweetened beverages on body weight in children: design and baseline characteristics of the Double-blind, Randomized INtervention study in Kids.

    abstract:BACKGROUND:Intake of sugar-sweetened beverages is associated with overweight in observational studies. A possible explanation is that liquid sugars do not satiate and that their intake is not compensated by reduced caloric intake from other foods. However, evidence from intervention studies for this hypothesis is incon...

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: de Ruyter JC,Olthof MR,Kuijper LD,Katan MB

    更新日期:2012-01-01 00:00:00

  • Incentivizing healthy lifestyle behaviors to reduce cardiovascular risk in people with serious mental illness: An equipoise randomized controlled trial of the wellness incentives program.

    abstract:BACKGROUND:Medicaid recipients with serious mental illness die 25-30 years earlier than people in the general population due to health conditions that are modifiable through lifestyle changes. Cardiovascular diseases from excess weight, smoking, and sedentary lifestyle contribute substantially to this life expectancy d...

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章,随机对照试验


    authors: Pratt SI,Brunette MF,Wolfe R,Scherer EA,Xie H,Bartels S,Ferron JC,Capuchino K

    更新日期:2019-06-01 00:00:00

  • Lessons learned in the conduct of a global, large simple trial of treatments indicated for schizophrenia.

    abstract::Large, "practical" or streamlined trials (LSTs) are used to study the effectiveness and/or safety of medicines in real world settings with minimal study imposed interventions. While LSTs have benefits over traditional randomized clinical trials and observational studies, there are inherent challenges to their conduct....

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Kolitsopoulos FM,Strom BL,Faich G,Eng SM,Kane JM,Reynolds RF

    更新日期:2013-03-01 00:00:00

  • "Do you expect me to receive PTSD care in a setting where most of the other patients remind me of the perpetrator?": Home-based telemedicine to address barriers to care unique to military sexual trauma and veterans affairs hospitals.

    abstract::Home-based telemedicine (HBT) is a validated method of evidence-based treatment delivery for posttraumatic stress disorder (PTSD), and justification for its use has centered on closing gaps related to provider availability and distance to treatment centers. However, another potential use of HBT may be to overcome barr...

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章,随机对照试验


    authors: Gilmore AK,Davis MT,Grubaugh A,Resnick H,Birks A,Denier C,Muzzy W,Tuerk P,Acierno R

    更新日期:2016-05-01 00:00:00

  • Are current standards of reporting quality for clinical trials sufficient in addressing important sources of bias?

    abstract::Determining the quality of a randomized clinical trial (RCT) is necessary for decision-makers to determine the believability and applicability of the trial findings. Issues that are likely to affect the utility of RCT evidence include issues of bias, random error and applicability. In this article we focus primarily o...

    journal_title:Contemporary clinical trials

    pub_type: 杂志文章,评审


    authors: Mills EJ,Ayers D,Chou R,Thorlund K

    更新日期:2015-11-01 00:00:00