Intestinal microbiota and its effect on the immune system--a nested case-cohort study on prevention of atopy among small children in Trondheim: the IMPACT study.

abstract：BACKGROUND:African American (AA) women perform low levels of physical activity (PA) and are disproportionally burdened by cardiometabolic disease conditions when compared to White women and the U.S. population as a whole. These disparities emphasize the need for innovative and effective interventions to increase PA and...

journal_title：Contemporary clinical trials

authors： Joseph RP,Ainsworth BE,Vega-López S,Adams MA,Hollingshead K,Hooker SP,Todd M,Gaesser GA,Keller C

更新日期：2019-02-01 00:00:00

abstract：:The Rare Diseases Clinical Research Network (RDCRN) Contact Registry has grown in size and scope since it was first reported in this journal in 2007. In this paper, we reflect on our seven years' experience developing and expanding the RDCRN Contact Registry to include many more rare diseases. We present the functiona...

journal_title：Contemporary clinical trials

authors： Richesson RL,Sutphen R,Shereff D,Krischer JP

更新日期：2012-07-01 00:00:00

abstract：:Although colorectal cancer (CRC) is largely preventable through identification of pre-cancerous polyps through various screening modalities, morbidity and mortality rates remain a challenge, especially in African-American, Latino, low-income and uninsured/underinsured patients. Barriers to screening include cost, acce...

journal_title：Contemporary clinical trials

authors： Buscemi J,Miguel YS,Tussing-Humphreys L,Watts EA,Fitzgibbon ML,Watson K,Winn RA,Matthews KL,Molina Y

更新日期：2017-01-01 00:00:00

abstract：:Interactive voice response (IVR) technology is a robust method of data collection that has been underutilized in behavioral medicine and clinical pharmacotherapy research. While it is clear that there is an increasing interest in this technology, published research in the medical field has not described its implementa...

journal_title：Contemporary clinical trials

authors： Abu-Hasaballah K,James A,Aseltine RH Jr

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:Suboptimal diet and inactive lifestyle are among the most prevalent preventable causes of premature death. Interventions that target multiple behaviors are potentially efficient; however the optimal way to initiate and maintain multiple health behavior changes is unknown. OBJECTIVE:The Make Better Choices 2...

journal_title：Contemporary clinical trials

authors： Pellegrini CA,Steglitz J,Johnston W,Warnick J,Adams T,McFadden HG,Siddique J,Hedeker D,Spring B

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:The addition of specialty palliative care to standard oncology care improves outcomes for patients with advanced cancer and their caregivers, but many lack access to specialty care services. Primary palliative care-meaning basic palliative care services provided by clinicians who are not palliative care spec...

journal_title：Contemporary clinical trials

authors： Becker CL,Arnold RM,Park SY,Rosenzweig M,Smith TJ,White DB,Smith KJ,Schenker Y

更新日期：2017-03-01 00:00:00

abstract：OBJECTIVE:To describe the study protocol of the Multimedia Self-Management (MSM) intervention to prepare patients and family caregivers (FCGs) for lung cancer surgery. DESIGN:The study is a five-year, single site, randomized controlled trial of 160 lung cancer surgery FCG and patient dyads (320 total participants), co...

journal_title：Contemporary clinical trials

authors： Sun V,Raz DJ,Erhunmwunsee L,Ruel N,Carranza J,Prieto R,Ferrell B,Krouse RS,McCorkle R,Kim JY

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Despite significant advancements in psychopharmacology, treating major depressive disorder (MDD) is still a challenge considering the efficacy, tolerability, safety, and economical costs of most antidepressant drugs. One approach that has been increasingly investigated is modulation of cortical activity with...

journal_title：Contemporary clinical trials

authors： Brunoni AR,Valiengo L,Baccaro A,Zanao TA,de Oliveira JF,Vieira GP,Bueno VF,Goulart AC,Boggio PS,Lotufo PA,Bensenor IM,Fregni F

更新日期：2011-01-01 00:00:00

abstract：:First-time blood donors are essential to the US donor pool, providing nearly a third of all donations. Unfortunately, there are a wide variety of obstacles to repeat donation and new donors are extremely difficult to retain. Because each donor experiences a unique set of deterrents, we developed a post-donation interv...

journal_title：Contemporary clinical trials

authors： France JL,France CR,Carlson BW,Kessler DA,Rebosa M,Shaz BH,Madden K,Carey PM

更新日期：2015-09-01 00:00:00

abstract：:If randomized controlled trials (RCTs) are to fulfill their potential to allow health care providers to make informed inferences about the validity of the trials upon which they base their clinical practice, then the reporting of key methodological factors must improve. The revised Consolidated Standards for Reporting...

journal_title：Contemporary clinical trials

authors： Mills EJ,Wu P,Gagnier J,Devereaux PJ

更新日期：2005-08-01 00:00:00

abstract：:The Medication Adherence and BP Control Trial (ABC Trial) is a randomized, controlled, multi-site, medication adherence and blood pressure (BP) control trial in an economically disadvantaged and multi-cultural population of hypertensive patients followed in primary care practices. To date, no other such trial has been...

journal_title：Contemporary clinical trials

authors： Gerin W,Tobin JN,Schwartz JE,Chaplin W,Rieckmann N,Davidson KW,Goyal TM,Jhalani J,Cassells A,Feliz K,Khalida C,Diaz-Gloster M,Ogedegbe G

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:Postmenopausal Latinas are a growing population group in the US who are at high risk for cardiovascular disease. Epidemiological studies have shown that excessive sitting is related to cardiovascular disease risk. Older women sit for prolonged periods and most individuals do not meet physical activity guidel...

journal_title：Contemporary clinical trials

authors： Takemoto M,Schechtman M,Villa N,Talavera G,Sears DD,Natarajan L,Owen N,Rosenberg DE,Dunstan D,Allison M,Kerr J

更新日期：2019-04-01 00:00:00

abstract：:Double-blinded trials are often considered the gold standard for research, but significant bias may result from unblinding of participants and investigators. Although the CONSORT guidelines discuss the importance of reporting "evidence that blinding was successful", it is unclear what constitutes appropriate evidence....

journal_title：Contemporary clinical trials

authors： Rees JR,Wade TJ,Levy DA,Colford JM Jr,Hilton JF

更新日期：2005-02-01 00:00:00

abstract：BACKGROUND:Despite widespread use of learning collaboratives in health care, few randomized trials have evaluated their effectiveness. The primary aim of this cluster randomized implementation trial is to evaluate the effectiveness of a virtual learning collaborative (VLC) in the implementation of a lifestyle intervent...

journal_title：Contemporary clinical trials

authors： Aschbrenner KA,Pratt SI,Bond GR,Zubkoff L,Naslund JA,Jue K,Williams G,Kinney A,Cohen MJ,Godfrey MM,Bartels SJ

更新日期：2019-09-01 00:00:00

abstract：:The prevalence of type 2 diabetes continues to increase in minority and underserved patients, who are also more likely to have poorer control of diabetes and related risk factors for complications. Although the Look AHEAD trial has demonstrated improved risk factor control among overweight or obese diabetes patients w...

journal_title：Contemporary clinical trials

authors： Katula JA,Kirk JK,Pedley CF,Savoca MR,Effoe VS,Bell RA,Bertoni AG,LIFT Diabetes Team.

更新日期：2017-02-01 00:00:00

abstract：:The convention in clinical trials is to regard outcomes as independently distributed, possibly conditional on covariates, but in some situations they may be correlated. For example, in infectious diseases, correlation may be induced if participants have contact with a common infectious source, or share hygienic tips t...

journal_title：Contemporary clinical trials

authors： Follmann D,Proschan M

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:Thousands of people die annually from prescription opioid overdoses; however there are few strategies to ensure patients receive medication risk information at the time of prescribing. OBJECTIVES:To compare the effectiveness of the Emergency Department (ED) Electronic Medication Complete Communication (EMC2...

journal_title：Contemporary clinical trials

authors： McCarthy DM,Courtney DM,Lank PM,Cameron KA,Russell AM,Curtis LM,Kim KA,Walton SM,Montague E,Lyden AL,Gravenor SJ,Wolf MS

更新日期：2017-08-01 00:00:00

abstract：:Patients with Parkinson's disease and related disorders (PDRD) and their families have considerable unmet needs including non-motor symptom management, caregiver support, spiritual wellbeing, advance care planning, and end-of-life care. There is increasing interest in applying palliative care (PC) models to better mee...

journal_title：Contemporary clinical trials

authors： Kluger BM,Katz M,Galifianakis N,Pantilat SZ,Kutner JS,Sillau S,Gritz M,Jones J,Fairclough D,Sumrall M,Hall K,Miyasaki J

更新日期：2019-04-01 00:00:00

abstract：:Assessing the probability that a Phase III clinical trial will demonstrate clinically relevant efficacy based on Phase II data is an important topic in clinical drug development. An accurate estimate of how likely a Phase III trial will succeed based on available data will inform the decision on whether to move an exp...

journal_title：Contemporary clinical trials

authors： Su Z

更新日期：2010-11-01 00:00:00

abstract：:Among children with asthma, black children are two to four times as likely to have an emergency department (ED) visit and die from asthma, respectively, compared to white children in the United States. Despite the availability of evidence-based asthma management guidelines, minority children are less likely than white...

journal_title：Contemporary clinical trials

authors： Krishnan JA,Martin MA,Lohff C,Mosnaim GS,Margellos-Anast H,DeLisa JA,McMahon K,Erwin K,Zun LS,Berbaum ML,McDermott M,Bracken NE,Kumar R,Margaret Paik S,Nyenhuis SM,Ignoffo S,Press VG,Pittsenbarger ZE,Thompson TM,CHI

更新日期：2017-06-01 00:00:00

abstract：:In order to evaluate strategies to reduce HIV transmission through breast milk and optimize both maternal and infant health among HIV-infected women and their infants, we designed and implemented a large, randomized clinical trial in Lilongwe, Malawi. The development of protocols for large, randomized clinical trials ...

journal_title：Contemporary clinical trials

authors： van der Horst C,Chasela C,Ahmed Y,Hoffman I,Hosseinipour M,Knight R,Fiscus S,Hudgens M,Kazembe P,Bentley M,Adair L,Piwoz E,Martinson F,Duerr A,Kourtis A,Loeliger AE,Tohill B,Ellington S,Jamieson D,Breastfeeding, Ant

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:Breast cancer survivors face dual challenges: long term sequelae of treatment, and risk of recurrent disease. Obesity and a sedentary lifestyle complicate both challenges. The WISER Survivor trial assessed the effects of exercise and/or weight-loss on lymphedema, biomarkers of breast cancer recurrence, and...

journal_title：Contemporary clinical trials

authors： Winkels RM,Sturgeon KM,Kallan MJ,Dean LT,Zhang Z,Evangelisti M,Brown JC,Sarwer DB,Troxel AB,Denlinger C,Laudermilk M,Fornash A,DeMichele A,Chodosh LA,Schmitz KH

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Risk factors for cardiovascular disease (CVD) not only increase the risk for clinical CVD events, but also are associated with a cascade of neurophysiologic and neuroanatomic changes that increase the risk of cognitive impairment and dementia. Although epidemiological studies have shown that exercise and die...

journal_title：Contemporary clinical trials

authors： Blumenthal JA,Smith PJ,Welsh-Bohmer K,Babyak MA,Browndyke J,Lin PH,Doraiswamy PM,Burke J,Kraus W,Hinderliter A,Sherwood A

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Research demonstrates a link between migraine and obesity. Obesity increases the risk of frequent migraines and is associated with migraine prevalence among reproductive-aged women. These findings are substantiated by several plausible mechanisms and emerging evidence of migraine improvements after surgical ...

journal_title：Contemporary clinical trials

authors： Bond DS,O'Leary KC,Thomas JG,Lipton RB,Papandonatos GD,Roth J,Rathier L,Daniello R,Wing RR

更新日期：2013-05-01 00:00:00

abstract：:Whole exome and whole genome sequencing are applications of next generation sequencing transforming clinical care, but there is little evidence whether these tests improve patient outcomes or if they are cost effective compared to current standard of care. These gaps in knowledge can be addressed by comparative effect...

journal_title：Contemporary clinical trials

authors： Gallego CJ,Bennette CS,Heagerty P,Comstock B,Horike-Pyne M,Hisama F,Amendola LM,Bennett RL,Dorschner MO,Tarczy-Hornoch P,Grady WM,Fullerton SM,Trinidad SB,Regier DA,Nickerson DA,Burke W,Patrick DL,Jarvik GP,Veenstra D

更新日期：2014-09-01 00:00:00

abstract：:Prostate cancer is a slow progressing cancer that affects millions of men in the US. Due to uncertainties in outcomes and treatment complications, it is important that patients engage in informed decision making to choose the "optimal treatment". Patient centered care that encompasses informed decision-making can impr...

journal_title：Contemporary clinical trials

authors： Jayadevappa R,Chhatre S,Gallo JJ,Wittink M,Morales KH,Bruce Malkowicz S,Lee D,Guzzo T,Caruso A,Van Arsdalen K,Wein AJ,Sanford Schwartz J

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:Training non-specialist health workers (NSHWs) at scale is a major barrier to increasing the coverage of depression care in India. This trial will test the effectiveness of two forms of digital training compared to conventional face-to-face training in changing the competence of NSHWs to deliver a brief evid...

journal_title：Contemporary clinical trials

authors： Naslund JA,Tugnawat D,Anand A,Cooper Z,Dimidjian S,Fairburn CG,Hollon SD,Joshi U,Khan A,Lu C,Mitchell LM,Muke S,Nadkarni A,Ramaswamy R,Restivo JL,Shrivastava R,Singh A,Singla DR,Spiegelman D,Bhan A,Patel V

更新日期：2021-01-06 00:00:00

abstract：:A response-adaptive randomization (RAR) design refers to the method in which the probability of treatment assignment changes according to how well the treatments are performing in the trial. Holding the promise of treating more patients with the better treatments, RARs have been successfully implemented in clinical tr...

journal_title：Contemporary clinical trials

authors： Du Y,Wang X,Jack Lee J

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:When the Centers for Medicare and Medicaid Services announced coverage for low dose CT lung cancer screening, they also mandated that imaging centers offer smoking cessation services. We designed the Optimizing Lung Screening (OaSiS) trial to evaluate strategies to implement the Public Health Service Guide...

journal_title：Contemporary clinical trials

authors： Foley KL,Miller DP Jr,Weaver K,Sutfin EL,Petty WJ,Bellinger C,Spangler J,Stone RJ,Lawler D,Davis W,Dressler E,Lesser G,Chiles C

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Chronic Obstructive Pulmonary Disease (COPD) frequently coexists with other diseases. Whereas COPD action plans are currently part of usual care, they are less suitable and potentially unsafe for use in the presence of comorbidities. This study evaluates whether an innovative treatment approach directed towa...

journal_title：Contemporary clinical trials

authors： Lenferink A,Frith P,van der Valk P,Buckman J,Sladek R,Cafarella P,van der Palen J,Effing T

更新日期：2013-09-01 00:00:00