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Can lifestyle modification improve neurocognition? Rationale and design of the ENLIGHTEN clinical trial.

Abstract：

BACKGROUND:Risk factors for cardiovascular disease (CVD) not only increase the risk for clinical CVD events, but also are associated with a cascade of neurophysiologic and neuroanatomic changes that increase the risk of cognitive impairment and dementia. Although epidemiological studies have shown that exercise and diet are associated with lower CVD risk and reduced incidence of dementia, no randomized controlled trial (RCT) has examined the independent effects of exercise and diet on neurocognitive function among individuals at risk for dementia. The ENLIGHTEN trial is a RCT of patients with CVD risk factors who also are characterized by subjective cognitive complaints and objective evidence of neurocognitive impairment without dementia (CIND) STUDY DESIGN: A 2 by 2 design will examine the independent and combined effects of diet and exercise on neurocognition. 160 participants diagnosed with CIND will be randomly assigned to 6 months of aerobic exercise, the DASH diet, or a combination of both exercise and diet; a (control) group will receive health education but otherwise will maintain their usual dietary and activity habits. Participants will complete comprehensive assessments of neurocognitive functioning along with biomarkers of CVD risk including measures of blood pressure, glucose, endothelial function, and arterial stiffness. CONCLUSION:The ENLIGHTEN trial will (a) evaluate the effectiveness of aerobic exercise and the DASH diet in improving neurocognitive functioning in CIND patients with CVD risk factors; (b) examine possible mechanisms by which exercise and diet improve neurocognition; and (c) consider potential moderators of treatment, including subclinical CVD.

journal_name

Contemp Clin Trials

journal_title

Contemporary clinical trials

authors

Blumenthal JA,Smith PJ,Welsh-Bohmer K,Babyak MA,Browndyke J,Lin PH,Doraiswamy PM,Burke J,Kraus W,Hinderliter A,Sherwood A

doi

10.1016/j.cct.2012.09.004

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

60-9

issue

1

eissn

1551-7144

issn

1559-2030

pii

S1551-7144(12)00211-X

journal_volume

34

pub_type

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