Abstract：
BACKGROUND:Basic research suggests that rapid increases in circulating inflammatory and hemostatic blood markers may trigger or indicate impending plaque rupture and coronary thrombosis, resulting in acute ischemic heart disease (IHD) events. However, these associations are not established in humans. METHODS AND RESULTS:The Biomarker Risk Assessment in Vulnerable Outpatients (BRAVO) Study will determine whether levels of inflammatory and hemostatic biomarkers rapidly increase during the weeks prior to an acute IHD event in people with lower extremity peripheral artery disease (PAD). The BRAVO Study will determine whether biomarker levels measured immediately prior to an IHD event are higher than levels not preceding an IHD event; whether participants who experience an IHD event (cases) have higher biomarker levels immediately prior to the event and higher biomarker levels at each time point leading up to the IHD event than participants without an IHD event (controls); and whether case participants have greater increases in biomarkers during the months leading up to the event than controls. BRAVO enrolled 595 patients with PAD, a population at high risk for acute IHD events. After a baseline visit, participants returned every two months for blood collection, underwent an electrocardiogram to identify new silent myocardial infarctions, and were queried about new hospitalizations since their prior study visit. Mortality data were also collected. Participants were followed prospectively for up to three years. CONCLUSIONS:BRAVO results will provide important information about the pathophysiology of IHD events and may lead to improved therapies for preventing IHD events in high-risk patients.
journal_name
Contemp Clin Trialsjournal_title
Contemporary clinical trialsauthors
McDermott MM,Greenland P,Liu K,Tian L,Green D,Shah SJ,Huffman M,Wilkins J,Kibbe M,Liao Y,Huang CC,Skelly C,Jacobs C,McCarthy W,Auerbach A,Lloyd-Jones Ddoi
10.1016/j.cct.2014.03.009subject
Has Abstractpub_date
2014-05-01 00:00:00pages
121-9issue
1eissn
1551-7144issn
1559-2030pii
S1551-7144(14)00048-2journal_volume
38pub_type
杂志文章abstract：:We report here on the use of interactive telephone technology for collecting longitudinal data in a large randomized non-blinded parallel trial. Data were primarily collected via an automated interactive telephone system which enabled data to be downloaded by researchers periodically via a secure website. Alternative ...
journal_title：Contemporary clinical trials
pub_type： 杂志文章,多中心研究,随机对照试验
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journal_title：Contemporary clinical trials
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journal_title：Contemporary clinical trials
pub_type： 杂志文章,随机对照试验
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journal_title：Contemporary clinical trials
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doi：10.1016/j.cct.2018.12.009
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abstract：BACKGROUND:Lower extremity peripheral arterial disease (PAD) is a public health problem and many patients with PAD experience claudication despite adequate medical and/or surgical management. Mobilization of endogenous progenitor cells using Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) is a novel therapeut...
journal_title：Contemporary clinical trials
pub_type： 杂志文章
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abstract：PURPOSE:By 2020, 70% of people living with HIV in the United States will be greater than 50 years of age. As many as 37% of sexually active older people living with HIV (OPLWH) engage in HIV transmission sexual behaviors. In spite of repeated calls for secondary prevention interventions to reduce condomless sex in OPLW...
journal_title：Contemporary clinical trials
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journal_title：Contemporary clinical trials
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journal_title：Contemporary clinical trials
pub_type： 杂志文章,随机对照试验
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abstract：BACKGROUND:Chronic Obstructive Pulmonary Disease (COPD) frequently coexists with other diseases. Whereas COPD action plans are currently part of usual care, they are less suitable and potentially unsafe for use in the presence of comorbidities. This study evaluates whether an innovative treatment approach directed towa...
journal_title：Contemporary clinical trials
pub_type： 杂志文章,多中心研究,随机对照试验
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journal_title：Contemporary clinical trials
pub_type： 杂志文章
doi：10.1016/j.cct.2015.07.020
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journal_title：Contemporary clinical trials
pub_type： 杂志文章,随机对照试验
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journal_title：Contemporary clinical trials
pub_type： 杂志文章
doi：10.1016/j.cct.2020.106053
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journal_title：Contemporary clinical trials
pub_type： 杂志文章,随机对照试验
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journal_title：Contemporary clinical trials
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.cct.2009.05.004
更新日期：2009-09-01 00:00:00
abstract：BACKGROUND:Extended-release naltrexone (XR-NTX, Vivitrol; Alkermes Inc.) is an injectable monthly sustained-release mu opioid receptor antagonist. XR-NTX is a potentially effective intervention for opioid use disorders and as relapse prevention among criminal justice system (CJS) populations. METHODS:This 5-site open-...
journal_title：Contemporary clinical trials
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.cct.2015.01.005
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abstract：OBJECTIVE:Managing complex psychiatric disorders like PTSD and bipolar disorder is challenging in Federally Qualified Health Centers (FQHCs) delivering care to U.S residents living in underserved rural areas. This protocol paper describes SPIRIT, a pragmatic comparative effectiveness trial designed to compare two appro...
journal_title：Contemporary clinical trials
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abstract：:Traditionally, children presenting with appendicitis are referred for urgent appendectomy. Recent improvements in the quality and availability of diagnostic imaging allow for better pre-operative characterization of appendicitis, including severity of inflammation; size of the appendix; and presence of extra-luminal i...
journal_title：Contemporary clinical trials
pub_type： 杂志文章
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journal_title：Contemporary clinical trials
pub_type： 杂志文章,随机对照试验
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journal_title：Contemporary clinical trials
pub_type： 杂志文章,随机对照试验
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更新日期：2016-09-01 00:00:00
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journal_title：Contemporary clinical trials
pub_type： 杂志文章,随机对照试验
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更新日期：2009-09-01 00:00:00
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journal_title：Contemporary clinical trials
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journal_title：Contemporary clinical trials
pub_type： 杂志文章,随机对照试验
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更新日期：2013-01-01 00:00:00
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journal_title：Contemporary clinical trials
pub_type： 杂志文章,多中心研究,随机对照试验
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abstract：BACKGROUND:Laxatives are much utilized, but few clinical trials assessed the efficacy of phytotherapics in the functional constipation. AIM:The aim of this study was to evaluate the efficacy of the tincture of jalapa in the treatment of patients with functional constipation. METHODS:Double-blind, randomized, placebo-...
journal_title：Contemporary clinical trials
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journal_title：Contemporary clinical trials
pub_type： 杂志文章,随机对照试验
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更新日期：2015-03-01 00:00:00
abstract：BACKGROUND:Training non-specialist health workers (NSHWs) at scale is a major barrier to increasing the coverage of depression care in India. This trial will test the effectiveness of two forms of digital training compared to conventional face-to-face training in changing the competence of NSHWs to deliver a brief evid...
journal_title：Contemporary clinical trials
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journal_title：Contemporary clinical trials
pub_type： 杂志文章,随机对照试验
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