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Reducing breast cancer recurrence with weight loss, a vanguard trial: the Exercise and Nutrition to Enhance Recovery and Good Health for You (ENERGY) Trial.

Abstract：

:Breast cancer is the most common invasive cancer among women in developed countries. Obesity is a major risk factor for breast cancer recurrence and mortality in both pre- and postmenopausal women. Co-morbid medical conditions are common among breast cancer survivors. The Exercise and Nutrition to Enhance Recovery and Good Health for You (ENERGY) study is a 4-year randomized clinical trial of 693 overweight/obese women aged ≥21years diagnosed with any early stage breast cancer (stages I[≥1cm]-III) within the previous five years, designed to demonstrate the feasibility of achieving sustained weight loss and to examine the impact of weight loss on quality of life and co-morbidities, and to enable future exploration of biochemical mechanisms linking obesity to lower likelihood of disease-free survival. This trial is strategically designed as a vanguard for a fully-powered trial of women who will be evaluated for breast cancer recurrence and disease-free survival. Participants were recruited between 2010 and 2012 at four sites, had completed initial therapies, and had a body mass index between 25 and 45kg/m(2). The intervention featured a group-based cognitive-behavioral weight loss program with telephone counseling and tailored newsletters to support initial weight loss and subsequent maintenance, with the goal of 7% weight loss at two years. This study has high potential to have a major impact on clinical management and outcomes after a breast cancer diagnosis. This trial initiates the effort to establish weight loss support for overweight or obese breast cancer survivors as a new standard of clinical care.

journal_name

Contemp Clin Trials

journal_title

Contemporary clinical trials

authors

Rock CL,Byers TE,Colditz GA,Demark-Wahnefried W,Ganz PA,Wolin KY,Elias A,Krontiras H,Liu J,Naughton M,Pakiz B,Parker BA,Sedjo RL,Wyatt H,Exercise and Nutrition to Enhance Recovery and Good Health for You (ENERGY) Trial Group.

doi

10.1016/j.cct.2012.12.003

subject

Has Abstract

pub_date

2013-03-01 00:00:00

pages

282-95

issue

2

eissn

1551-7144

issn

1559-2030

pii

S1551-7144(12)00262-5

journal_volume

34

pub_type

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