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Participation in pediatric epidemiologic research: the SEARCH for Diabetes in Youth Study experience.

Abstract：

BACKGROUND:We evaluated the association of demographic and clinical characteristics with participation in an epidemiologic study of diabetes mellitus among youth. METHODS:SEARCH for Diabetes in Youth is a multicenter study of physician-diagnosed diabetes in youth under the age of 20 comprising a surveillance and a cohort component. At each center, we enumerated all prevalent cases of diabetes in 2001 (n=6266) and all incident cases between 2002 and 2004 (n=3668). After confirmation of eligibility and validation, we invited each case to complete a survey and participate in a study visit. Here we evaluate how age, sex, race, and diabetes type are associated with participation in the survey and study visit. RESULTS:Among prevalent cases, participation in the survey was 68% and 41% in the study visit. Among 2002 to 2004 incident cases, participation varied for the survey (76%, 81%, and 82%) and study visit (52%, 60%, and 60%). In multivariate logistic regression analyses among all incident cases, older age was associated with a lower odds of participation in the study visit (15-17 vs. <10 years: OR 0.5, 95% CI 0.4-0.7; 18-19 vs. <10 years: OR 0.3, 95% CI 0.2-0.5), as was having type 2 diabetes vs. type 1 diabetes (OR 0.5, 95% CI 0.4-0.7) and being of African American race vs. non-Hispanic White (OR 0.6, 95% CI 0.4-0.8). Results were very similar among prevalent cases. CONCLUSIONS:Elucidating the relationship between individual characteristics and participation is essential for evaluating nonresponse bias, correcting for it, and for planning and implementing recruitment strategies.

journal_name

Contemp Clin Trials

journal_title

Contemporary clinical trials

authors

Liese AD,Liu L,Davis C,Standiford D,Waitzfelder B,Dabelea D,Bell R,Williams D,Imperatore G,Lawrence JM

doi

10.1016/j.cct.2008.05.008

subject

Has Abstract

pub_date

2008-11-01 00:00:00

pages

829-36

issue

6

eissn

1551-7144

issn

1559-2030

pii

S1551-7144(08)00081-5

journal_volume

29

pub_type

杂志文章,多中心研究

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