Abstract：
:Osteoarthritis (OA) is the most common chronic condition and principal cause of disability among older adults. The current obesity epidemic has contributed to this high prevalence rate. Fortunately both OA symptoms and obesity can be ameliorated through lifestyle modifications. Physical activity (PA) combined with weight management improves physical function among obese persons with knee OA but evidence-based interventions that combine PA and weight management are limited for this population. This paper describes a comparative effectiveness trial testing an evidence-based PA program for adults with lower extremity (LE) OA, Fit and Strong!, against an enhanced version that also addresses weight management based on the evidence-based Obesity Reduction Black Intervention Trial (ORBIT). Adult participants (n=400) with LE OA, age 60+, overweight/obese, and not meeting PA requirements of ≥ 150 min per week, are randomized to one of the two programs. Both 8-week interventions meet 3 times per week and include 60 min of strength, flexibility, and aerobic exercise instruction followed by 30 min of education/group discussion. The Fit and Strong! education sessions focus on using PA to manage OA; whereas Fit and Strong! Plus addresses PA and weight loss management strategies. Maintenance of behavior change is reinforced in both groups during months 3-24 through telephone calls and mailed newsletters. Outcomes are assessed at baseline, and 2, 6, 12, 18, and 24 months. Primary outcomes are dietary change at 2 months followed by weight loss at 6 months that is maintained at 24 months. Secondary outcomes assess PA, physical performance, and anxiety/depression.
journal_name
Contemp Clin Trialsjournal_title
Contemporary clinical trialsauthors
Smith-Ray RL,Fitzgibbon ML,Tussing-Humphreys L,Schiffer L,Shah A,Huber GM,Braunschweig C,Campbell RT,Hughes SLdoi
10.1016/j.cct.2013.11.014subject
Has Abstractpub_date
2014-03-01 00:00:00pages
178-88issue
2eissn
1551-7144issn
1559-2030pii
S1551-7144(13)00196-1journal_volume
37pub_type
杂志文章,随机对照试验abstract：PURPOSE:By 2020, 70% of people living with HIV in the United States will be greater than 50 years of age. As many as 37% of sexually active older people living with HIV (OPLWH) engage in HIV transmission sexual behaviors. In spite of repeated calls for secondary prevention interventions to reduce condomless sex in OPLW...
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abstract：BACKGROUND:Currently, there is no consensus regarding the best treatment option in recurrent haemorrhoidal disease (HD), due to a lack of solid evidence. The Napoleon trial aims to provide high-level evidence on the comparative effectiveness and cost-effectiveness of repeat rubber band ligation (RBL) versus sutured muc...
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abstract：BACKGROUND:Colorectal cancer (CRC) screening by annual fecal immunochemical test (FIT) is an accessible and cost-effective strategy to lower CRC incidence and mortality. However, this mode of screening depends on follow-up colonoscopy after a positive FIT result. Unfortunately, nearly one-half of FIT-positive patients ...
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pub_type： 杂志文章,随机对照试验
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abstract：:Double-blinding is an important and widely implemented feature of clinical trials although its success is rarely assessed. In a randomized, placebo-controlled trial of tea tree oil, an aromatic essential oil, for the treatment of recurrent herpes labialis (RHL), or cold sores, deception was used to prevent volunteers ...
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journal_title：Contemporary clinical trials
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journal_title：Contemporary clinical trials
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更新日期：2013-01-01 00:00:00
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pub_type： 杂志文章,多中心研究
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更新日期：2009-09-01 00:00:00
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更新日期：2017-02-01 00:00:00
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journal_title：Contemporary clinical trials
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.cct.2011.10.013
更新日期：2012-03-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2012-07-01 00:00:00
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pub_type： 杂志文章,多中心研究,随机对照试验
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更新日期：2013-11-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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pub_type： 杂志文章,多中心研究,随机对照试验
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更新日期：2016-07-01 00:00:00
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pub_type： 杂志文章,随机对照试验
doi：10.1016/j.cct.2013.03.009
更新日期：2013-05-01 00:00:00
abstract：:While investigators designing clinical trials face the important issue of endpoint selection, an equally troublesome concern can be the a priori selection of the endpoint analysis. In this latter circumstance, there may be only one endpoint of interest in the clinical trial, but several competing endpoint analyses are...
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