A randomized control trial to determine the effectiveness and physiological effects of spinal manipulation and spinal mobilization compared to each other and a sham condition in patients with chronic low back pain: Study protocol for The RELIEF Study.

abstract：:Phase IIA clinical trials are commonly conducted as pilot studies to evaluate efficacy and safety in selected populations of patients with the disease or condition to be treated or prevented. The efficacy objective is to find preliminarily evidence of the effectiveness or ineffectiveness of study treatments. Go/no-go ...

journal_title：Contemporary clinical trials

authors： Zhong B

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND/AIMS:Cocaine use disorder (CUD) persists as a major public health problem in the United States. Response to evidence-based behavioral treatment has been shown to be predicted by dopaminergic dysfunction. Amphetamine formulations modulate dopaminergic systems and are one of the few agents with positive clinic...

journal_title：Contemporary clinical trials

authors： Blevins D,Carpenter KM,Martinez D,Mariani JJ,Levin FR

更新日期：2020-11-01 00:00:00

abstract：:Transitional care programs have been widely used to reduce readmissions and improve the quality and safety of the handoff process between hospital and outpatient providers. Very little is known about effective transitional care interventions among patients who are uninsured or with Medicaid. This paper describes the d...

journal_title：Contemporary clinical trials

authors： Schaeffer C,Teter C,Finch EA,Hurt C,Keeter MK,Liss DT,Rogers A,Sheth A,Ackermann R

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Children with sickle cell anemia (SCA) have an 11% risk of stroke by the age of 18. Chronic transfusion applied in patients detected to be at risk by transcranial Doppler allows a significant reduction of stroke risk. However, chronic transfusion exposes to several adverse events, including alloimmunization ...

journal_title：Contemporary clinical trials

authors： Chevret S,Verlhac S,Ducros-Miralles E,Dalle JH,de Latour RP,de Montalembert M,Benkerrou M,Pondarré C,Thuret I,Guitton C,Lesprit E,Etienne-Julan M,Elana G,Vannier JP,Lutz P,Neven B,Galambrun C,Paillard C,Runel C,Jube

更新日期：2017-11-01 00:00:00

abstract：:Physical therapy (PT) is a key component of treatment for knee osteoarthritis (OA) and can decrease pain and improve function. Given the expected rise in prevalence of knee OA and the associated demand for treatment, there is a need for models of care that cost-effectively extend PT services for patients with this con...

journal_title：Contemporary clinical trials

authors： Allen KD,Bongiorni D,Walker TA,Bartle J,Bosworth HB,Coffman CJ,Datta SK,Edelman D,Hall KS,Hansen G,Jennings C,Lindquist JH,Oddone EZ,Senick MJ,Sizemore JC,St John J,Hoenig H

更新日期：2013-03-01 00:00:00

abstract：INTRODUCTION:In rural America cigarette smoking is prevalent, few cessation services are available, and healthcare providers lack the time and resources to help smokers quit. This paper describes the design and participant characteristics of Connect2Quit (C2Q), a randomized control trial (RCT) that tests the effectiven...

journal_title：Contemporary clinical trials

authors： Mussulman L,Ellerbeck EF,Cupertino AP,Preacher KJ,Spaulding R,Catley D,Cox LS,Lambart L,Hunt JJ,Nazir N,Shireman T,Richter KP

更新日期：2014-07-01 00:00:00

abstract：:A response-adaptive randomization (RAR) design refers to the method in which the probability of treatment assignment changes according to how well the treatments are performing in the trial. Holding the promise of treating more patients with the better treatments, RARs have been successfully implemented in clinical tr...

journal_title：Contemporary clinical trials

authors： Du Y,Wang X,Jack Lee J

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Individuals with serious mental illness (SMI) smoke at disproportionately higher rates than those without SMI, have lifespans 25-32 years shorter, and thus bear an especially large burden of tobacco-related morbidity and mortality. Several recent studies demonstrate that smokers with SMI can successfully qui...

journal_title：Contemporary clinical trials

authors： Hecht J,Rigotti NA,Minami H,Kjome KL,Bloom EL,Kahler CW,Price LH,Levy DE,Carpenter KM,Brown RA

更新日期：2019-08-01 00:00:00

abstract：:This randomized, controlled trial tested the effectiveness of a nurse-run, telephone-based intervention to improve lipid control in patients with diabetes. Our patient population is predominantly low-income and Latino. Using our diabetes registry, we randomly assigned 381 patients to continue with their usual care and...

journal_title：Contemporary clinical trials

authors： Fischer H,Mackenzie T,McCullen K,Everhart R,Estacio RO

更新日期：2008-09-01 00:00:00

abstract：INTRODUCTION:Focal therapy (FT) targets individual areas of cancer within the prostate, providing oncological control with minimal side-effects. Early evidence demonstrates encouraging short-medium-term outcomes. With no randomized controlled trials (RCT) comparing FT to radical therapies, Comparative Healthcare Resear...

journal_title：Contemporary clinical trials

authors： Reddy D,Shah TT,Dudderidge T,McCracken S,Arya M,Dobbs C,Emberton M,Fiorentino F,Day E,Prevost AT,Staffurth J,Sydes M,Winkler M,Ahmed HU

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Bipolar Disorder (BD) is a common and severe form of mental illness. Pharmacotherapy is the main treatment offered, but has limited effectiveness, and there is increasing evidence that people with BD respond well to psychological interventions. Inequalities in access to face-to-face psychological interventio...

journal_title：Contemporary clinical trials

authors： Todd NJ,Solis-Trapala I,Jones SH,Lobban FA

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:Evidence suggests that periodontitis is associated with prevalent and incident type 2 diabetes mellitus (T2DM), raising the question of whether periodontitis treatment may improve glycemic control in patients with T2DM. Meta-analyses of mostly small clinical trials suggest that periodontitis treatment result...

journal_title：Contemporary clinical trials

authors： DPTT study group.,Engebretson S,Gelato M,Hyman L,Michalowicz BS,Schoenfeld E

更新日期：2013-11-01 00:00:00

abstract：:This paper proposes a method for balancing prognostic variables between treatment and control groups in design of clinical trials. It assumes that some of prognostic variables are continuous and others are categorical and that they are independently distributed. The proposed method uses the Kullback-Leibler divergence...

journal_title：Contemporary clinical trials

authors： Endo A,Nagatani F,Hamada C,Yoshimura I

更新日期：2006-10-01 00:00:00

abstract：:Obesity prevalence is higher in rural compared to urban residents. Rural health clinics offer a potential venue for delivery of weight management. However, traditional programs require travel to attend on-site meetings which is impractical or inconvenient for rural residents. Clinic staff in most rural settings are un...

journal_title：Contemporary clinical trials

authors： Gorczyca AM,Washburn RA,Ptomey L,Mayo MS,Sullivan DK,Gibson CA,Lee R,Stolte S,Donnelly JE

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Basic research suggests that rapid increases in circulating inflammatory and hemostatic blood markers may trigger or indicate impending plaque rupture and coronary thrombosis, resulting in acute ischemic heart disease (IHD) events. However, these associations are not established in humans. METHODS AND RESUL...

journal_title：Contemporary clinical trials

authors： McDermott MM,Greenland P,Liu K,Tian L,Green D,Shah SJ,Huffman M,Wilkins J,Kibbe M,Liao Y,Huang CC,Skelly C,Jacobs C,McCarthy W,Auerbach A,Lloyd-Jones D

更新日期：2014-05-01 00:00:00

abstract：UNLABELLED:Latinos bear a disproportionate burden of the dual pandemic of obesity and diabetes. However, successful interventions addressing this disparity through primary care are lacking. To address this gap, the 5-year Vida Sana (Healthy Life) study tests a culturally adapted and technology-enhanced group-based Diab...

journal_title：Contemporary clinical trials

authors： Rosas LG,Lv N,Xiao L,Lewis MA,Zavella P,Kramer MK,Luna V,Ma J

更新日期：2016-05-01 00:00:00

abstract：:Slow or insufficient enrollment in clinical research and a high demand for research participants raises questions about the need for and use of incentives to participate, including payment. Much of the available literature on payment to research participants focuses on ethical concerns, and rarely addresses guidelines...

journal_title：Contemporary clinical trials

authors： Dominguez D,Jawara M,Martino N,Sinaii N,Grady C

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:The addition of specialty palliative care to standard oncology care improves outcomes for patients with advanced cancer and their caregivers, but many lack access to specialty care services. Primary palliative care-meaning basic palliative care services provided by clinicians who are not palliative care spec...

journal_title：Contemporary clinical trials

authors： Becker CL,Arnold RM,Park SY,Rosenzweig M,Smith TJ,White DB,Smith KJ,Schenker Y

更新日期：2017-03-01 00:00:00

abstract：:The ability to recruit qualified subjects who are willing to adhere to the study protocol in clinical trials is an essential component of translational research. Such tasks can be particularly challenging for chemoprevention studies when the targeted study population is healthy, at risk individuals who do not have sig...

journal_title：Contemporary clinical trials

authors： Kye SH,Tashkin DP,Roth MD,Adams B,Nie WX,Mao JT

更新日期：2009-09-01 00:00:00

abstract：:Clinical trial research is the cornerstone for successful advancement of medicine that provides hope for millions of people in the future. Full transparency in clinical trials may allow independent investigators to evaluate study designs, perform additional analysis of data, and potentially eliminate duplicate studies...

journal_title：Contemporary clinical trials

authors： Logvinov I

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Despite controversy about paying research subjects, little is known about actual practices in the U.S., including what type of studies offer payment, to what type of subjects, and how amounts are determined. OBJECTIVE:To document current U.S. practices regarding payment to research subjects. METHODS:The pr...

journal_title：Contemporary clinical trials

authors： Grady C,Dickert N,Jawetz T,Gensler G,Emanuel E

更新日期：2005-06-01 00:00:00

abstract：OBJECTIVE:Feasibility of a clinical-trial comparing a low-glycaemic diet with a low-calorie healthy eating approach at achieving weight loss and reducing the risk of endometrial cancer in women with PCOS. DESIGN:A pilot Randomised-Controlled-Trial using different recruitment strategies. SETTING:A University Hospital ...

journal_title：Contemporary clinical trials

authors： Atiomo W,Read A,Golding M,Silcocks P,Razali N,Sarkar S,Hardiman P,Thornton J

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:Suboptimal diet and inactive lifestyle are among the most prevalent preventable causes of premature death. Interventions that target multiple behaviors are potentially efficient; however the optimal way to initiate and maintain multiple health behavior changes is unknown. OBJECTIVE:The Make Better Choices 2...

journal_title：Contemporary clinical trials

authors： Pellegrini CA,Steglitz J,Johnston W,Warnick J,Adams T,McFadden HG,Siddique J,Hedeker D,Spring B

更新日期：2015-03-01 00:00:00

abstract：:Parents of young children with type 1 diabetes (T1D) experience unique, developmental challenges in managing their child's T1D, resulting in psychosocial distress. Only a small portion of young children reach glucose goals and adherence to diabetes devices that help improve T1D management have historically been low in...

journal_title：Contemporary clinical trials

authors： Berget C,Driscoll KA,Lagges A,Lange S,DiMeglio LA,Hannon TS,Woerner SE,Iturralde E,Barley RC,Hanes S,Hood KK,Buckingham BB,Toddler Diabetes Technology Study Group.

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Hypertension disproportionately affects African Americans compared to whites, and it is the single most common explanation for the disparity in mortality between African Americans and whites. Adherence with antihypertensive medications can help reduce risk of negative hypertension-related outcomes. Motivatio...

journal_title：Contemporary clinical trials

authors： Ogedegbe G,Schoenthaler A,Richardson T,Lewis L,Belue R,Espinosa E,Spencer J,Allegrante JP,Charlson ME

更新日期：2007-02-01 00:00:00

abstract：:Hepatitis C virus (HCV) is a leading cause of chronic liver disease. The natural history of HCV infection is heterogeneous, and a person infected with HCV can clear the virus or progress to a chronic infection. The chronic infection can remain asymptomatic for decades before the development of liver cirrhosis and/or c...

journal_title：Contemporary clinical trials

authors： Kang M,Nicolay U

更新日期：2008-09-01 00:00:00

abstract：:In order to better characterize the safety profile of investigational new drugs (INDs) during clinical development, more interest and attention have been paid to ongoing safety monitoring and evaluation. The 2015 US FDA IND safety reporting draft guidance compels sponsors to periodically evaluate unblinded safety data...

journal_title：Contemporary clinical trials

authors： Lin LA,Zhan Y,Li H,Yuan SS,Ball G,Wang W

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Many studies on the health effects of the glycemic index (GI) are confounded by differences in the intakes of other macronutrients and fibre. Little data exist about the within- and between-subject variability of the GI. OBJECTIVE:Our objectives were therefore (i) to calculate the GI of eight commonly used ...

journal_title：Contemporary clinical trials

authors： Vrolix R,Mensink RP

更新日期：2010-01-01 00:00:00

abstract：:Behavioral weight loss programs help people achieve clinically meaningful weight losses (8-10% of starting body weight). Despite data showing that only half of participants achieve this goal, a "one size fits all" approach is normative. This weight loss intervention science gap calls for adaptive interventions that pr...

journal_title：Contemporary clinical trials

authors： Sherwood NE,Butryn ML,Forman EM,Almirall D,Seburg EM,Lauren Crain A,Kunin-Batson AS,Hayes MG,Levy RL,Jeffery RW

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Despite significant advancements in psychopharmacology, treating major depressive disorder (MDD) is still a challenge considering the efficacy, tolerability, safety, and economical costs of most antidepressant drugs. One approach that has been increasingly investigated is modulation of cortical activity with...

journal_title：Contemporary clinical trials

authors： Brunoni AR,Valiengo L,Baccaro A,Zanao TA,de Oliveira JF,Vieira GP,Bueno VF,Goulart AC,Boggio PS,Lotufo PA,Bensenor IM,Fregni F

更新日期：2011-01-01 00:00:00