Abstract：
:Behavioral weight loss programs help people achieve clinically meaningful weight losses (8-10% of starting body weight). Despite data showing that only half of participants achieve this goal, a "one size fits all" approach is normative. This weight loss intervention science gap calls for adaptive interventions that provide the "right treatment at the right time for the right person." Sequential Multiple Assignment Randomized Trials (SMART), use experimental design principles to answer questions for building adaptive interventions including whether, how, or when to alter treatment intensity, type, or delivery. This paper describes the rationale and design of the BestFIT study, a SMART designed to evaluate the optimal timing for intervening with sub-optimal responders to weight loss treatment and relative efficacy of two treatments that address self-regulation challenges which impede weight loss: 1) augmenting treatment with portion-controlled meals (PCM) which decrease the need for self-regulation; and 2) switching to acceptance-based behavior treatment (ABT) which boosts capacity for self-regulation. The primary aim is to evaluate the benefit of changing treatment with PCM versus ABT. The secondary aim is to evaluate the best time to intervene with sub-optimal responders. BestFIT results will lead to the empirically-supported construction of an adaptive intervention that will optimize weight loss outcomes and associated health benefits.
journal_name
Contemp Clin Trialsjournal_title
Contemporary clinical trialsauthors
Sherwood NE,Butryn ML,Forman EM,Almirall D,Seburg EM,Lauren Crain A,Kunin-Batson AS,Hayes MG,Levy RL,Jeffery RWdoi
10.1016/j.cct.2016.01.011subject
Has Abstractpub_date
2016-03-01 00:00:00pages
209-16eissn
1551-7144issn
1559-2030pii
S1551-7144(16)30012-Xjournal_volume
47pub_type
杂志文章,随机对照试验abstract：BACKGROUND:Despite evidence that palliative care increases quality and length of life, many patients and families remain uninformed about its nature and benefits. The purpose of this study is to test a psycho-educational intervention, Managing Cancer Care: A Personal Guide (MCC), intended to improve breast cancer patie...
journal_title：Contemporary clinical trials
pub_type： 杂志文章,随机对照试验
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journal_title：Contemporary clinical trials
pub_type： 杂志文章,多中心研究,随机对照试验
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journal_title：Contemporary clinical trials
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journal_title：Contemporary clinical trials
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