Rationale and Design for a Randomized Comparison of Efficacy and Safety between Aspirin and Clopidogrel in Atrial Fibrillation Patients with Low Stroke Risk: CESAC-AF trial.

abstract：:This study was set up to test an ecological intervention using a pragmatic cluster randomised controlled design (RCT) aimed at increasing physical activity (PA) within the community in a deprived inner-city area in the UK. The research will provide a detailed mapping (using Graphical Information Systems GIS) of the en...

journal_title：Contemporary clinical trials

authors： Davey RC,Cochrane T,Gidlow C,Fairburn J,Smith G

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:Multiple sclerosis is a chronic progressive neurological disease. Evidence attests to the benefits of exercise, guidelines for exercise in multiple sclerosis are available. Remote-delivery of exercise adherence programmes based on the exercise guidelines require urgent testing. AIMS:The design, and outcomes...

journal_title：Contemporary clinical trials

authors： Learmonth YC,Kaur I,Baynton SL,Fairchild T,Paul L,van Rens F

更新日期：2021-01-12 00:00:00

abstract：:Researchers have long sought to find combinations of cancer drugs that might achieve synergy. However, while observed in some preclinical tumor models, synergistic effects are rarely seen in clinical trials. In fact, growing evidence in clinical trial data shows that the treatment effect of most approved combination t...

journal_title：Contemporary clinical trials

authors： Chen C,Liu F,Ren Y,Suttner L,Sun Z,Shentu Y,Schmidt EV

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Many of the health behaviors known to contribute to cardiometabolic risk and disease (CMRD), including physical activity, diet, sleep, and screen time, begin during childhood. Given the population-wide burden of CMRD, novel ways of assessing risk and providing feedback to support behavior change are needed. ...

journal_title：Contemporary clinical trials

authors： Oreskovic NM,Fletcher R,Sharifi M,Knutsen JD,Chilingirian A,Taveras EM

更新日期：2016-07-01 00:00:00

abstract：:Home-based telemedicine (HBT) is a validated method of evidence-based treatment delivery for posttraumatic stress disorder (PTSD), and justification for its use has centered on closing gaps related to provider availability and distance to treatment centers. However, another potential use of HBT may be to overcome barr...

journal_title：Contemporary clinical trials

authors： Gilmore AK,Davis MT,Grubaugh A,Resnick H,Birks A,Denier C,Muzzy W,Tuerk P,Acierno R

更新日期：2016-05-01 00:00:00

abstract：:Large, "practical" or streamlined trials (LSTs) are used to study the effectiveness and/or safety of medicines in real world settings with minimal study imposed interventions. While LSTs have benefits over traditional randomized clinical trials and observational studies, there are inherent challenges to their conduct....

journal_title：Contemporary clinical trials

authors： Kolitsopoulos FM,Strom BL,Faich G,Eng SM,Kane JM,Reynolds RF

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Suboptimal diet and inactive lifestyle are among the most prevalent preventable causes of premature death. Interventions that target multiple behaviors are potentially efficient; however the optimal way to initiate and maintain multiple health behavior changes is unknown. OBJECTIVE:The Make Better Choices 2...

journal_title：Contemporary clinical trials

authors： Pellegrini CA,Steglitz J,Johnston W,Warnick J,Adams T,McFadden HG,Siddique J,Hedeker D,Spring B

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Training non-specialist health workers (NSHWs) at scale is a major barrier to increasing the coverage of depression care in India. This trial will test the effectiveness of two forms of digital training compared to conventional face-to-face training in changing the competence of NSHWs to deliver a brief evid...

journal_title：Contemporary clinical trials

authors： Naslund JA,Tugnawat D,Anand A,Cooper Z,Dimidjian S,Fairburn CG,Hollon SD,Joshi U,Khan A,Lu C,Mitchell LM,Muke S,Nadkarni A,Ramaswamy R,Restivo JL,Shrivastava R,Singh A,Singla DR,Spiegelman D,Bhan A,Patel V

更新日期：2021-01-06 00:00:00

abstract：:Clinical trial is considered a breakthrough method in medicine and essential to the development of new drugs. Clinical trials that comply with international and national regulations require an appropriate infrastructure and team qualification. The goal of this study was to evaluate clinical trial groups in Brazil: pro...

journal_title：Contemporary clinical trials

authors： Paschoale HS,Barbosa FR,Nita ME,Carrilho FJ,Ono-Nita SK

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Patients with progressive kidney disease experience increasing physiologic and psychosocial stressors and declining health-related quality of life (HRQOL). METHODS:We conducted a randomized, active-controlled, open-label trial to test whether a Mindfulness-based Stress Reduction (MBSR) program delivered in ...

journal_title：Contemporary clinical trials

authors： Gross CR,Reilly-Spong M,Park T,Zhao R,Gurvich OV,Ibrahim HN

更新日期：2017-06-01 00:00:00

abstract：:Upstream interventions - e.g. housing programs and community health worker interventions- address socioeconomic and behavioral factors that influence health outcomes across diseases. Studying these types of interventions in clinical trials raises a methodological challenge: how should researchers measure the effect of...

journal_title：Contemporary clinical trials

authors： Kangovi S,Mitra N,Turr L,Huo H,Grande D,Long JA

更新日期：2017-02-01 00:00:00

abstract：:Caregivers for a family member with dementia experience chronic long-term stress that may benefit from new complementary therapies such as mindfulness-based stress reduction. Little is known however, about the challenges of recruiting and retaining family caregivers to research on mind-body based complementary therapi...

journal_title：Contemporary clinical trials

authors： Whitebird RR,Kreitzer MJ,Lewis BA,Hanson LR,Crain AL,Enstad CJ,Mehta A

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:In 2007, we commenced the Healthy Beginnings Trial (HBT) Phase 1 study, which is the first randomised controlled trial (RCT) to test the effectiveness of an early childhood obesity intervention in children aged up to 2 years. The results were promising with significant improvements in infant feeding practice...

journal_title：Contemporary clinical trials

authors： Wen LM,Baur LA,Rissel C,Flood V,Simpson JM,Hayes A,Hardy LL,Wardle K

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:Mammographic breast density is one of the strongest risk factors for breast cancer after age and family history. Mandatory breast density disclosure policies are increasing nationally without clear guidance on how to communicate density status to women. Coupling density disclosure with personalized risk coun...

journal_title：Contemporary clinical trials

authors： Knerr S,Wernli KJ,Leppig K,Ehrlich K,Graham AL,Farrell D,Evans C,Luta G,Schwartz MD,O'Neill SC

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Mindfulness-based relapse prevention (MBRP) is a method that combines cognitive behavioral relapse prevention with mindfulness practice. Research suggests that MBRP can effectively reduce withdrawal/craving in people with substance use disorder (SUD). An important part of MBRP is to practice mindfulness medi...

journal_title：Contemporary clinical trials

authors： Chen XJ,Wang DM,Zhou LD,Winkler M,Pauli P,Sui N,Li YH

更新日期：2018-07-01 00:00:00

abstract：PURPOSE:To describe the strategies-based on the social triad concept of a partnership of researchers, school personnel and community-employed to recruit low-income, minority parent/caregivers of kindergarten children into a school-based tooth decay prevention trial in the United States. METHODS:The study site was an u...

journal_title：Contemporary clinical trials

authors： Nelson S,Milgrom P

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Bipolar Disorder (BD) is a common and severe form of mental illness. Pharmacotherapy is the main treatment offered, but has limited effectiveness, and there is increasing evidence that people with BD respond well to psychological interventions. Inequalities in access to face-to-face psychological interventio...

journal_title：Contemporary clinical trials

authors： Todd NJ,Solis-Trapala I,Jones SH,Lobban FA

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:African American (AA) women perform low levels of physical activity (PA) and are disproportionally burdened by cardiometabolic disease conditions when compared to White women and the U.S. population as a whole. These disparities emphasize the need for innovative and effective interventions to increase PA and...

journal_title：Contemporary clinical trials

authors： Joseph RP,Ainsworth BE,Vega-López S,Adams MA,Hollingshead K,Hooker SP,Todd M,Gaesser GA,Keller C

更新日期：2019-02-01 00:00:00

abstract：:It is of vital importance to the success of a randomized clinical trial to maintain the balance of baseline characteristics (covariates) that could potentially confound the outcomes of the trial. Various randomization methods have been proposed to increase the likelihood of having balanced covariates at the end of a t...

journal_title：Contemporary clinical trials

authors： Su Z

更新日期：2011-07-01 00:00:00

abstract：:Cancer related cognitive impairments (CRCI) are frequently reported by patients prior to, during and after medical treatment. Although this cognitive decline severely affects patients' quality of life, little is known about effective treatments. Exercise programs represent a promising supportive strategy in this field...

journal_title：Contemporary clinical trials

authors： Zimmer P,Oberste M,Bloch W,Schenk A,Joisten N,Hartig P,Wolf F,Baumann FT,Garthe A,Hallek M,Elter T

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Patients with high blood pressure (BP) visit a physician an average of 4 times or more per year in the U.S., yet BP is controlled in fewer than half. Practical, robust and sustainable models are needed to improve BP in patients with uncontrolled hypertension. OBJECTIVES:The Home Blood Pressure Telemonitorin...

journal_title：Contemporary clinical trials

authors： Margolis KL,Kerby TJ,Asche SE,Bergdall AR,Maciosek MV,O'Connor PJ,Sperl-Hillen JM

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:Despite widespread use of learning collaboratives in health care, few randomized trials have evaluated their effectiveness. The primary aim of this cluster randomized implementation trial is to evaluate the effectiveness of a virtual learning collaborative (VLC) in the implementation of a lifestyle intervent...

journal_title：Contemporary clinical trials

authors： Aschbrenner KA,Pratt SI,Bond GR,Zubkoff L,Naslund JA,Jue K,Williams G,Kinney A,Cohen MJ,Godfrey MM,Bartels SJ

更新日期：2019-09-01 00:00:00

abstract：:Despite strong anti-smoking efforts, at least 12% of American women cannot quit smoking when pregnant resulting in >450,000 smoke-exposed infants born yearly. Smoking during pregnancy is the largest preventable cause of childhood respiratory illness including wheezing and asthma. Recent studies have shown a protective...

journal_title：Contemporary clinical trials

authors： McEvoy CT,Milner KF,Scherman AJ,Schilling DG,Tiller CJ,Vuylsteke B,Shorey-Kendrick LE,Spindel ER,Schuff R,Mitchell J,Peters D,Metz J,Haas D,Jackson K,Tepper RS,Morris CD

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Despite significant advancements in psychopharmacology, treating major depressive disorder (MDD) is still a challenge considering the efficacy, tolerability, safety, and economical costs of most antidepressant drugs. One approach that has been increasingly investigated is modulation of cortical activity with...

journal_title：Contemporary clinical trials

authors： Brunoni AR,Valiengo L,Baccaro A,Zanao TA,de Oliveira JF,Vieira GP,Bueno VF,Goulart AC,Boggio PS,Lotufo PA,Bensenor IM,Fregni F

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Currently, there is no consensus regarding the best treatment option in recurrent haemorrhoidal disease (HD), due to a lack of solid evidence. The Napoleon trial aims to provide high-level evidence on the comparative effectiveness and cost-effectiveness of repeat rubber band ligation (RBL) versus sutured muc...

journal_title：Contemporary clinical trials

authors： Kuiper SZ,Dirksen CD,Kimman ML,Van Kuijk SMJ,Van Tol RR,Muris JWM,Watson AJM,Maessen JMC,Melenhorst J,Breukink SO,Napoleon Trial Study Group.

更新日期：2020-12-01 00:00:00

abstract：:The Rare Diseases Clinical Research Network (RDCRN) Contact Registry has grown in size and scope since it was first reported in this journal in 2007. In this paper, we reflect on our seven years' experience developing and expanding the RDCRN Contact Registry to include many more rare diseases. We present the functiona...

journal_title：Contemporary clinical trials

authors： Richesson RL,Sutphen R,Shereff D,Krischer JP

更新日期：2012-07-01 00:00:00

abstract：AIMS:To outline the study design, outcome measures, protocol and baseline characteristics of enrolled participants of Texas (TX) Sprouts, a one-year school-based gardening, nutrition, and cooking cluster randomized trial. METHODS:Eight schools were randomly assigned to the TX Sprouts intervention and eight schools to ...

journal_title：Contemporary clinical trials

authors： Davis J,Nikah K,Asigbee FM,Landry MJ,Vandyousefi S,Ghaddar R,Hoover A,Jeans M,Pont SJ,Richards D,Hoelscher DM,Van Den Berg AE,Bluestein M,Pérez A

更新日期：2019-10-01 00:00:00

abstract：:Illustrated is the use of a patient enrichment adaptive design in a randomized phase II trial which allows the evaluation of treatment benefits by the biomarker expression level and makes interim adjustment according to the pre-specified rules. The design was applied to an actual phase II metastatic hepatocellular car...

journal_title：Contemporary clinical trials

authors： Song JX

更新日期：2014-01-01 00:00:00

abstract：:College student alcohol use and associated negative consequences are clear public health problems with consequences including damage to self, others, and institutions. This paper describes the protocol of a research study designed to answer a number of important questions in the development of an adaptive preventive i...

journal_title：Contemporary clinical trials

authors： Patrick ME,Boatman JA,Morrell N,Wagner AC,Lyden GR,Nahum-Shani I,King CA,Bonar EE,Lee CM,Larimer ME,Vock DM,Almirall D

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:New approaches are needed to better monitor blood pressure (BP) between physician visits, especially for patients in rural areas or for those who lack transportation. We have developed a custom-built bi-directional texting platform for home BP measurements that can then be managed by clinical pharmacists loc...

journal_title：Contemporary clinical trials

authors： Polgreen LA,Carter BL,Polgreen PM,Snyder PM,Sewell DK,Bayman EO,Francis SL,Simmering JE,Parker C,Finkelstein R

更新日期：2020-11-01 00:00:00