A multi-centre prospective development study evaluating focal therapy using high intensity focused ultrasound for localised prostate cancer: The INDEX study.

abstract：BACKGROUND:Unlike conventional time-to-event analysis of composite endpoints in clinical trials, the "win ratio" method allows for flexibility in prioritizing their components. Here, we compare the EVOLVE trial findings using the win ratio with those from time-to-event analysis. METHODS: EXPOSURE:Randomization to cin...

journal_title：Contemporary clinical trials

authors： Abdalla S,Montez-Rath ME,Parfrey PS,Chertow GM

更新日期：2016-05-01 00:00:00

abstract：:Evaluation of time to event outcomes usually is examined by the Kaplan-Meier method and Cox proportional hazards models. We developed a modified statistical model based on histologic grade and other variables to describe the time-dependent outcome for autologous stem cell transplant (autotransplant) performed for non-...

journal_title：Contemporary clinical trials

authors： Fu P,van Heeckeren WJ,Wadhwa PD,Bajor DJ,Creger RJ,Xu Z,Cooper BW,Laughlin MJ,Gerson SL,Koç ON,Lazarus HM

更新日期：2008-03-01 00:00:00

abstract：:There are few effective obesity interventions directed towards younger children, particularly young minority children. This paper describes the design, intervention, recruitment methods, and baseline data of the ongoing Positive Lifestyles for Active Youngsters (Team PLAY) study. This randomized controlled trial is de...

journal_title：Contemporary clinical trials

authors： Hare ME,Coday M,Williams NA,Richey PA,Tylavsky FA,Bush AJ

更新日期：2012-05-01 00:00:00

abstract：:An instrumental variable (IV) estimator has been widely used to estimate causal effects among compliers in randomized trials with noncompliance. The estimator of complier average treatment effect can be expressed as a ratio of two unbiased estimators but the ratio estimator is not unbiased. The bias of IV estimator ca...

journal_title：Contemporary clinical trials

authors： Chan KC

更新日期：2012-07-01 00:00:00

abstract：:Hepatitis C virus (HCV) is a leading cause of chronic liver disease. The natural history of HCV infection is heterogeneous, and a person infected with HCV can clear the virus or progress to a chronic infection. The chronic infection can remain asymptomatic for decades before the development of liver cirrhosis and/or c...

journal_title：Contemporary clinical trials

authors： Kang M,Nicolay U

更新日期：2008-09-01 00:00:00

abstract：:Caregivers for a family member with dementia experience chronic long-term stress that may benefit from new complementary therapies such as mindfulness-based stress reduction. Little is known however, about the challenges of recruiting and retaining family caregivers to research on mind-body based complementary therapi...

journal_title：Contemporary clinical trials

authors： Whitebird RR,Kreitzer MJ,Lewis BA,Hanson LR,Crain AL,Enstad CJ,Mehta A

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:Evaluation of new therapies for cancer has suffered a paradigm shift in the last years. The use of innovative and more efficient designs is a priority for the scientific community; nevertheless, the use of this kind of design is not yet wide spread. PURPOSE:In this paper will examine the effectiveness of ad...

journal_title：Contemporary clinical trials

authors： López MF,Dupuy JF,Gonzalez CV

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:Feasibility of a clinical-trial comparing a low-glycaemic diet with a low-calorie healthy eating approach at achieving weight loss and reducing the risk of endometrial cancer in women with PCOS. DESIGN:A pilot Randomised-Controlled-Trial using different recruitment strategies. SETTING:A University Hospital ...

journal_title：Contemporary clinical trials

authors： Atiomo W,Read A,Golding M,Silcocks P,Razali N,Sarkar S,Hardiman P,Thornton J

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:Extant obesity efforts have had a limited impact among low-income underserved children, in part because existing programs are limited in terms of their short duration and low dosage, limited accessibility and sustainability; and failure to address barriers faced by diverse low-income families. METHODS:This ...

journal_title：Contemporary clinical trials

authors： de la Haye K,Fluke M,Laney PC,Goran M,Galama T,Chou CP,Salvy SJ

更新日期：2019-02-01 00:00:00

abstract：:Dosing is potentially the most important decision that must be made when building or refining behavioral interventions. In this paper, we propose standardized terminology and reporting of dosing information, which would inform intervention development, refinement for dissemination, and systematic reviews of dose-respo...

journal_title：Contemporary clinical trials

authors： Voils CI,Chang Y,Crandell J,Leeman J,Sandelowski M,Maciejewski ML

更新日期：2012-11-01 00:00:00

abstract：:The use of blinding strengthens the credibility of randomized controlled trials (RCTs) by minimizing bias. However, there is confusion surrounding the definition of blinding as well as the terms single, double, and triple blind. It has been suggested that these terms should be discontinued due to their broad misinterp...

journal_title：Contemporary clinical trials

authors： Miller LE,Stewart ME

更新日期：2011-03-01 00:00:00

abstract：:The Ready Steady 3.0 trial is designed to test the main and interactive effects of two behavior change intervention components, within an 8-week physical activity intervention, on older adults' physical activity (PA). Each component is comprised of behavior change strategies that emphasize two different evidence-based...

journal_title：Contemporary clinical trials

authors： McMahon SK,Lewis BA,Guan W,Wyman JF,Rothman AJ

更新日期：2020-12-05 00:00:00

abstract：BACKGROUND:Individuals with serious mental illness (SMI) smoke at disproportionately higher rates than those without SMI, have lifespans 25-32 years shorter, and thus bear an especially large burden of tobacco-related morbidity and mortality. Several recent studies demonstrate that smokers with SMI can successfully qui...

journal_title：Contemporary clinical trials

authors： Hecht J,Rigotti NA,Minami H,Kjome KL,Bloom EL,Kahler CW,Price LH,Levy DE,Carpenter KM,Brown RA

更新日期：2019-08-01 00:00:00

abstract：INTRODUCTION:In promoting the health of chronically ill children, the hospital should help children cope both medically and psychosocially with their disease. The University Children's Hospital of Nancy proposes adapted physical activity for hospitalized children, but the practice during hospitalization is not well dev...

journal_title：Contemporary clinical trials

authors： Speyer E,Vuillemin A,Herbinet A,Chastagner P,Briançon S

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:Many of the health behaviors known to contribute to cardiometabolic risk and disease (CMRD), including physical activity, diet, sleep, and screen time, begin during childhood. Given the population-wide burden of CMRD, novel ways of assessing risk and providing feedback to support behavior change are needed. ...

journal_title：Contemporary clinical trials

authors： Oreskovic NM,Fletcher R,Sharifi M,Knutsen JD,Chilingirian A,Taveras EM

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Women have higher rates of depression and often experience depression symptoms during critical reproductive periods, including adolescence, pregnancy, postpartum, and menopause. Collaborative care intervention models for mood disorders in patients receiving care in an OB-GYN clinic setting have not been eval...

journal_title：Contemporary clinical trials

authors： LaRocco-Cockburn A,Reed SD,Melville J,Croicu C,Russo JE,Inspektor M,Edmondson E,Katon W

更新日期：2013-11-01 00:00:00

abstract：:Home-based telemedicine (HBT) is a validated method of evidence-based treatment delivery for posttraumatic stress disorder (PTSD), and justification for its use has centered on closing gaps related to provider availability and distance to treatment centers. However, another potential use of HBT may be to overcome barr...

journal_title：Contemporary clinical trials

authors： Gilmore AK,Davis MT,Grubaugh A,Resnick H,Birks A,Denier C,Muzzy W,Tuerk P,Acierno R

更新日期：2016-05-01 00:00:00

abstract：:Osteoarthritis (OA) is the most common chronic condition and principal cause of disability among older adults. The current obesity epidemic has contributed to this high prevalence rate. Fortunately both OA symptoms and obesity can be ameliorated through lifestyle modifications. Physical activity (PA) combined with wei...

journal_title：Contemporary clinical trials

authors： Smith-Ray RL,Fitzgibbon ML,Tussing-Humphreys L,Schiffer L,Shah A,Huber GM,Braunschweig C,Campbell RT,Hughes SL

更新日期：2014-03-01 00:00:00

abstract：:Researchers have long sought to find combinations of cancer drugs that might achieve synergy. However, while observed in some preclinical tumor models, synergistic effects are rarely seen in clinical trials. In fact, growing evidence in clinical trial data shows that the treatment effect of most approved combination t...

journal_title：Contemporary clinical trials

authors： Chen C,Liu F,Ren Y,Suttner L,Sun Z,Shentu Y,Schmidt EV

更新日期：2020-11-01 00:00:00

abstract：:In order to better characterize the safety profile of investigational new drugs (INDs) during clinical development, more interest and attention have been paid to ongoing safety monitoring and evaluation. The 2015 US FDA IND safety reporting draft guidance compels sponsors to periodically evaluate unblinded safety data...

journal_title：Contemporary clinical trials

authors： Lin LA,Zhan Y,Li H,Yuan SS,Ball G,Wang W

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Patients with high blood pressure (BP) visit a physician an average of 4 times or more per year in the U.S., yet BP is controlled in fewer than half. Practical, robust and sustainable models are needed to improve BP in patients with uncontrolled hypertension. OBJECTIVES:The Home Blood Pressure Telemonitorin...

journal_title：Contemporary clinical trials

authors： Margolis KL,Kerby TJ,Asche SE,Bergdall AR,Maciosek MV,O'Connor PJ,Sperl-Hillen JM

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:Functional dyspepsia (FD) is a common problem affecting up to 10-25% of individuals. FD accounts for significant health care costs and affects quality of life but has no definitive treatment. OBJECTIVES:The Functional Dyspepsia Treatment Trial (FDTT) aims to test whether treatment with an antidepressant (am...

journal_title：Contemporary clinical trials

authors： Talley NJ,Locke GR 3rd,Herrick LM,Silvernail VM,Prather CM,Lacy BE,DiBaise JK,Howden CW,Brenner DM,Bouras EP,El-Serag HB,Abraham BP,Moayyedi P,Zinsmeister AR

更新日期：2012-05-01 00:00:00

abstract：:Ethically sound clinical research requires that prospective study participants provide voluntary informed consent before any study procedures begin. The original intent was to provide the participant with clear, accurate information about study specifics (e.g., risks/benefits) to aid in the decision to participate. Br...

journal_title：Contemporary clinical trials

authors： Lentz J,Kennett M,Perlmutter J,Forrest A

更新日期：2016-07-01 00:00:00

abstract：INTRODUCTION:Breast cancer survivors face dual challenges: long term sequelae of treatment, and risk of recurrent disease. Obesity and a sedentary lifestyle complicate both challenges. The WISER Survivor trial assessed the effects of exercise and/or weight-loss on lymphedema, biomarkers of breast cancer recurrence, and...

journal_title：Contemporary clinical trials

authors： Winkels RM,Sturgeon KM,Kallan MJ,Dean LT,Zhang Z,Evangelisti M,Brown JC,Sarwer DB,Troxel AB,Denlinger C,Laudermilk M,Fornash A,DeMichele A,Chodosh LA,Schmitz KH

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Children with sickle cell anemia (SCA) have an 11% risk of stroke by the age of 18. Chronic transfusion applied in patients detected to be at risk by transcranial Doppler allows a significant reduction of stroke risk. However, chronic transfusion exposes to several adverse events, including alloimmunization ...

journal_title：Contemporary clinical trials

authors： Chevret S,Verlhac S,Ducros-Miralles E,Dalle JH,de Latour RP,de Montalembert M,Benkerrou M,Pondarré C,Thuret I,Guitton C,Lesprit E,Etienne-Julan M,Elana G,Vannier JP,Lutz P,Neven B,Galambrun C,Paillard C,Runel C,Jube

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:This paper reports the protocol of a randomised, double-blind, placebo-controlled study to test the efficacy, safety, and tolerability of lubiprostone (LUB) vs. placebo on suppressing gut permeability in non-alcoholic fatty liver disease (NAFLD) patients with constipation. NAFLD, including non-alcoholic stea...

journal_title：Contemporary clinical trials

authors： Kessoku T,Imajo K,Kobayashi T,Honda Y,Kato T,Ogawa Y,Tomeno W,Kato S,Higurashi T,Yoneda M,Kirikoshi H,Kubota K,Taguri M,Yamanaka T,Usuda H,Wada K,Saito S,Nakajima A

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Risk factors for cardiovascular disease (CVD) not only increase the risk for clinical CVD events, but also are associated with a cascade of neurophysiologic and neuroanatomic changes that increase the risk of cognitive impairment and dementia. Although epidemiological studies have shown that exercise and die...

journal_title：Contemporary clinical trials

authors： Blumenthal JA,Smith PJ,Welsh-Bohmer K,Babyak MA,Browndyke J,Lin PH,Doraiswamy PM,Burke J,Kraus W,Hinderliter A,Sherwood A

更新日期：2013-01-01 00:00:00

abstract：PURPOSE:African-American women (AAW) are more likely to be metabolically unhealthy than White women (WW). Metabolic syndrome (MetS) is associated with increased breast cancer risk and mortality from breast cancer is greater in AAW compared to WW. Data show MetS affects health-related quality of life (HRQoL). Exercise s...

journal_title：Contemporary clinical trials

authors： Taylor TR,Dash C,Sheppard V,Makambi K,Ma X,Adams-Campbell LL

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Postmenopausal Latinas are a growing population group in the US who are at high risk for cardiovascular disease. Epidemiological studies have shown that excessive sitting is related to cardiovascular disease risk. Older women sit for prolonged periods and most individuals do not meet physical activity guidel...

journal_title：Contemporary clinical trials

authors： Takemoto M,Schechtman M,Villa N,Talavera G,Sears DD,Natarajan L,Owen N,Rosenberg DE,Dunstan D,Allison M,Kerr J

更新日期：2019-04-01 00:00:00

abstract：:The Medication Adherence and BP Control Trial (ABC Trial) is a randomized, controlled, multi-site, medication adherence and blood pressure (BP) control trial in an economically disadvantaged and multi-cultural population of hypertensive patients followed in primary care practices. To date, no other such trial has been...

journal_title：Contemporary clinical trials

authors： Gerin W,Tobin JN,Schwartz JE,Chaplin W,Rieckmann N,Davidson KW,Goyal TM,Jhalani J,Cassells A,Feliz K,Khalida C,Diaz-Gloster M,Ogedegbe G

更新日期：2007-07-01 00:00:00