abstract：:Cardiovascular disease is the leading cause of death in kidney transplant recipients in many transplant registries. An analysis of transplant recipients from the United Kingdom using propensity score matching (PSM) suggests there are limited or no benefits to cardiovascular screening before transplant listing. We sugg...

journal_title：Kidney international

authors： Rankin AJ,Mark PB

更新日期：2021-02-01 00:00:00

abstract：:Early identification of kidney transplant recipients at risk of progressive allograft dysfunction may allow clinicians to provide closer monitoring and more aggressive risk factor modification. In this issue, Raynaud et al. presented a latent class model that clustered kidney transplant recipients into 8 risk categori...

journal_title：Kidney international

authors： Dinh A,McCulloch CE,Ku E

更新日期：2021-01-01 00:00:00

abstract：:Targeted therapies and immune checkpoint inhibitors have advanced the treatment landscape of Renal Cell Carcinoma (RCC) over the last decade. While checkpoint inhibitors have demonstrated survival benefit and are currently approved in the front-line and second-line settings, primary and secondary resistance is common....

journal_title：Kidney international

authors： Wang X,Lopez R,Luchtel RA,Hafizi S,Gartrell B,Shenoy N

更新日期：2021-01-01 00:00:00

abstract：:Acute kidney injury (AKI) increases the risk for chronic kidney disease (CKD). However, there are few tools to detect microstructural changes after AKI. Here, cationic ferritin-enhanced magnetic resonance imaging (CFE-MRI) was applied to examine the heterogeneity of kidney pathology in the transition from AKI to CKD. ...

journal_title：Kidney international

authors： Charlton JR,Xu Y,Wu T,deRonde KA,Hughes JL,Dutta S,Oxley GT,Cwiek A,Cathro HP,Charlton NP,Conaway MR,Baldelomar EJ,Parvin N,Bennett KM

更新日期：2021-01-01 00:00:00

abstract：:We have previously shown that ultrasonography can detect hyperechogenic crystal deposits in the kidney medulla of patients with gout. In this cross-sectional study we investigated the frequency and clinical correlates of hyperechogenic kidney medulla in 502 consecutive primary consultants for gout (ACR/EULAR criteria)...

journal_title：Kidney international

authors： Bardin T,Nguyen QD,Tran KM,Le NH,Do MD,Richette P,Letavernier E,Correas JM,Resche-Rigon M

更新日期：2021-01-01 00:00:00

abstract：:Chronic kidney disease (CKD) promotes development of cardiac abnormalities and is highly prevalent in patients with heart failure, particularly in those with preserved ejection fraction. CKD is associated with endothelial dysfunction, however, whether CKD can induce impairment of endothelium-to-cardiomyocyte crosstalk...

journal_title：Kidney international

authors： Juni RP,Al-Shama R,Kuster DWD,van der Velden J,Hamer HM,Vervloet MG,Eringa EC,Koolwijk P,van Hinsbergh VWM

更新日期：2020-12-22 00:00:00

abstract：:Aminopeptidase A is one of the most potent enzymes within the renin-angiotensin system in terms of angiotensin II degradation. Here, we examined whether there is a kidney phenotype and any compensatory changes in other renin angiotensin system enzymes involved in the metabolism of angiotensin II associated with aminop...

journal_title：Kidney international

authors： Marahrens B,Schulze A,Wysocki J,Lin MH,Ye M,Kanwar YS,Bader M,Velez JCQ,Miner JH,Batlle D

更新日期：2020-12-11 00:00:00

abstract：:A cyclical corticosteroid-cyclophosphamide regimen is recommended for patients with primary membranous nephropathy at high risk of progression. We hypothesized that sequential therapy with tacrolimus and rituximab is superior to cyclical alternating treatment with corticosteroids and cyclophosphamide in inducing persi...

journal_title：Kidney international

authors： Fernández-Juárez G,Rojas-Rivera J,Logt AV,Justino J,Sevillano A,Caravaca-Fontán F,Ávila A,Rabasco C,Cabello V,Varela A,Díez M,Martín-Reyes G,Diezhandino MG,Quintana LF,Agraz I,Gómez-Martino JR,Cao M,Rodríguez-Moreno A,

更新日期：2020-11-07 00:00:00

abstract：:Recipients of kidney transplants have elevated cancer risk compared with the general population. Improvements over time in transplant care and cancer treatment may have affected incidence and outcomes of cancer among recipients of kidney transplant. To evaluate this, we used linked United States transplant and cancer ...

journal_title：Kidney international

authors： Blosser CD,Haber G,Engels EA

更新日期：2020-11-04 00:00:00

abstract：:Gain-of-function variants in CFB encoding factor B (FB), a component of the alternative pathway C3 convertase, have been reported in a minority of patients with aHUS and result in massive C3 activation. Zhang et al. describe the functional characterization of a novel FB variant (p.Ser367Arg) that they identified in 2 ...

journal_title：Kidney international

authors： Noris M,Remuzzi G

更新日期：2020-11-01 00:00:00

abstract：:Kidney fibrosis is the common consequence of chronic kidney diseases that inexorably progresses to end-stage kidney disease with organ failure treatable only with replacement therapy. Since transforming growth factor-β1 is the main player in the pathogenesis of kidney fibrosis, we posed the hypothesis that recombinant...

journal_title：Kidney international

authors： Takeshita A,Yasuma T,Nishihama K,D'Alessandro-Gabazza CN,Toda M,Totoki T,Okano Y,Uchida A,Inoue R,Qin L,Wang S,D'Alessandro VF,Kobayashi T,Takei Y,Mizoguchi A,Yano Y,Gabazza EC

更新日期：2020-11-01 00:00:00

abstract：:Defective cholesterol metabolism primarily linked to reduced ATP-binding cassette transporter A1 (ABCA1) expression is closely associated with the pathogenesis and progression of kidney diseases, including diabetic kidney disease and Alport Syndrome. However, whether the accumulation of free or esterified cholesterol ...

journal_title：Kidney international

authors： Liu X,Ducasa GM,Mallela SK,Kim JJ,Molina J,Mitrofanova A,Wilbon SS,Ge M,Fontanella A,Pedigo C,Santos JV,Nelson RG,Drexler Y,Contreras G,Al-Ali H,Merscher S,Fornoni A

更新日期：2020-11-01 00:00:00

abstract：:Accumulating evidence indicates that asymptomatic hyperuricemia is involved in the development of hypertension and chronic kidney disease. A 2-hit model has been proposed to explain the role of urate in hypertension. The first hit entails activation of the renin-angiotensin system and inhibition of nitric oxide synthe...

journal_title：Kidney international

authors： Ponticelli C,Podestà MA,Moroni G

更新日期：2020-11-01 00:00:00

abstract：:In recent years, a substantial body of experimental and clinical work has been devoted to C3 glomerulopathy and Ig-mediated membranoproliferative glomerulonephritis. Despite the rapid accumulation of data, several uncertainties about these 2 rare forms of nephropathies persist. They concern their pathophysiology, clas...

journal_title：Kidney international

authors： Fakhouri F,Le Quintrec M,Frémeaux-Bacchi V

更新日期：2020-11-01 00:00:00

abstract：:Polycystin-1 (PC1) and -2 (PC2), products of the PKD1 and PKD2 genes, are mutated in autosomal dominant polycystic kidney disease (ADPKD). They localize to the primary cilia; however, their ciliary function is in dispute. Loss of either the primary cilia or PC1 or PC2 causes cyst formation. However, loss of both cilia...

journal_title：Kidney international

authors： Shao L,El-Jouni W,Kong F,Ramesh J,Kumar RS,Shen X,Ren J,Devendra S,Dorschel A,Wu M,Barrera I,Tabari A,Hu K,Haque N,Yambayev I,Li S,Kumar A,Behera TR,McDonough G,Furuichi M,Xifaras M,Lu T,Alhayaza RM,Miyabaya

更新日期：2020-11-01 00:00:00

abstract：:The treatment of hyperphosphatemia remains challenging in patients receiving hemodialysis. This Phase 1b study assessed safety and efficacy of EOS789, a novel pan-inhibitor of phosphate transport (NaPi-2b, PiT-1, PiT-2) on intestinal phosphate absorption in patients receiving intermittent hemodialysis therapy. Two cro...

journal_title：Kidney international

authors： Hill Gallant KM,Stremke ER,Trevino L,Moorthi RN,Doshi S,Wastney ME,Hisada N,Sato J,Ogita Y,Fujii N,Matsuda Y,Kake T,Moe SM

更新日期：2020-10-30 00:00:00

abstract：:Defective recycling of megalin consequent to impaired phosphatidylinositol metabolism has been implicated as a mechanism causing tubular proteinuria in patients with Lowe syndrome. In this issue, Berquez et al. describe an innovative approach using a clinically approved drug to "rebalance" phosphatidylinositols and re...

journal_title：Kidney international

authors： Weisz OA

更新日期：2020-10-01 00:00:00

abstract：:Protein energy wasting is a common feature of patients with chronic kidney disease (CKD) and is associated with poor outcomes. Protein energy wasting and cachexia, a severe form of protein energy wasting, are characterized by increased resting energy expenditure but the underlying mechanisms are unclear. Browning corr...

journal_title：Kidney international

authors： Luce M,Barba C,Yi D,Mey A,Roussel D,Bres E,Benoit B,Pastural M,Granjon S,Szelag JC,Laville M,Arkouche W,Bouchara A,Nyam E,Fouque D,Soulage CO,Koppe L

更新日期：2020-09-01 00:00:00

abstract：:Chronic kidney disease is characterized as impaired renal function along with the imbalance and dysregulation of mineral metabolism; recognized as chronic kidney disease-mineral and bone disorder. Hyperphosphatemia, characterized by altered phosphate homeostasis along with elevated fibroblast growth factor-23 and inta...

journal_title：Kidney international

authors： Tsuboi Y,Ohtomo S,Ichida Y,Hagita H,Ozawa K,Iida M,Nagao S,Ikegami H,Takahashi T,Horiba N

更新日期：2020-08-01 00:00:00

abstract：:Sodium thiosulfate, a reversible oxidation product of hydrogen sulfide, has vasodilating and anti-oxidative properties, making it an attractive agent to alleviate damaging effects of hypertension. In experimental settings, inhibition of nitric oxide synthase causes hypertension, renal dysfunction and damage. We hypoth...

journal_title：Kidney international

authors： Nguyen ITN,Klooster A,Minnion M,Feelisch M,Verhaar MC,van Goor H,Joles JA

更新日期：2020-08-01 00:00:00

abstract：:Rare mutations in the LRP2 gene encoding for the endocytic receptor megalin cause developmental abnormalities and kidney disease. However, the mechanisms governing the dysfunction of mutant megalin remain unclear. A new study utilizing patient-derived induced pluripotent stem cells is now putting the endolysosomal sys...

journal_title：Kidney international

authors： Luciani A,Freedman BS

更新日期：2020-07-01 00:00:00

abstract：:The association between dietary sodium and potassium intake with the development of kidney disease remains unclear, particularly among younger individuals. Here, we determined whether dietary sodium and potassium intake are associated with incident chronic kidney disease (CKD) using data from 1,030 adults (age 23-35 i...

journal_title：Kidney international

authors： Elfassy T,Zhang L,Raij L,Bibbins-Domingo K,Lewis CE,Allen NB,Liu KJ,Peralta CA,Odden MC,Zeki Al Hazzouri A

更新日期：2020-07-01 00:00:00

abstract：:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia emerged in Wuhan, China in December 2019. Unfortunately, there is a lack of evidence about the optimal management of novel coronavirus disease 2019 (COVID-19), and even less is available in patients on maintenance hemodialysis therapy than in the g...

journal_title：Kidney international

authors： Goicoechea M,Sánchez Cámara LA,Macías N,Muñoz de Morales A,Rojas ÁG,Bascuñana A,Arroyo D,Vega A,Abad S,Verde E,García Prieto AM,Verdalles Ú,Barbieri D,Delgado AF,Carbayo J,Mijaylova A,Acosta A,Melero R,Tejedor A,Ben

更新日期：2020-07-01 00:00:00

abstract：:Protein-bound uremic toxins (PBUTs) accumulate in chronic kidney disease (CKD) and are poorly removed by dialysis. Gryp et al. demonstrated that fecal bacteria from patients with CKD do not produce more PBUTs than do those from healthy controls and that the accumulation of PBUTs, as CKD progresses, is mainly due to th...

journal_title：Kidney international

authors： Jourde-Chiche N,Burtey S

更新日期：2020-06-01 00:00:00

abstract：:Alport syndrome is experiencing a remarkable increase in preclinical investigations. To proactively address the needs of the Alport syndrome community, as well as offer clarity for future clinical research sponsors, the Alport Syndrome Foundation hosted a workshop to generate consensus recommendations for prospective ...

journal_title：Kidney international

authors： Weinstock BA,Feldman DL,Fornoni A,Gross O,Kashtan CE,Lagas S,Lennon R,Miner JH,Rheault MN,Simon JF,Workshop Participants.

更新日期：2020-06-01 00:00:00

abstract：:Early graft loss (EGL) is a feared outcome of kidney transplantation. Consequently, kidneys with an anticipated risk of EGL are declined for transplantation. In the most favorable scenario, with optimal use of available donor kidneys, the donor pool size is balanced by the risk of EGL, with a tradeoff dictated by the ...

journal_title：Kidney international

authors： de Kok MJ,Schaapherder AF,Mensink JW,de Vries AP,Reinders ME,Konijn C,Bemelman FJ,van de Wetering J,van Zuilen AD,Christiaans MH,Baas MC,Nurmohamed AS,Berger SP,Ploeg RJ,Alwayn IP,Lindeman JH

更新日期：2020-06-01 00:00:00

abstract：:Ravulizumab is a long-acting C5 inhibitor engineered from eculizumab with increased elimination half-life, allowing an extended dosing interval from two to eight weeks. Here we evaluate the efficacy and safety of ravulizumab in adults with atypical hemolytic uremic syndrome presenting with thrombotic microangiopathy. ...

journal_title：Kidney international

authors： Rondeau E,Scully M,Ariceta G,Barbour T,Cataland S,Heyne N,Miyakawa Y,Ortiz S,Swenson E,Vallee M,Yoon SS,Kavanagh D,Haller H,311 Study Group.

更新日期：2020-06-01 00:00:00

abstract：:The relationship between commonly occurring genetic variants (G1 and G2) in the APOL1 gene in African Americans and different disease traits, such as kidney disease, cardiovascular disease, and pre-eclampsia, remains the subject of controversy. Here we took a genotype-first approach, a phenome-wide association study, ...

journal_title：Kidney international

authors： Bajaj A,Ihegword A,Qiu C,Small AM,Wei WQ,Bastarache L,Feng Q,Kember RL,Risman M,Bloom RD,Birtwell DL,Williams H,Shaffer CM,Chen J,Center RG,Denny JC,Rader DJ,Stein CM,Damrauer SM,Susztak K

更新日期：2020-05-01 00:00:00

abstract：:Tenascin-C is an extracellular matrix glycoprotein that plays a critical role in kidney fibrosis by orchestrating a fibrogenic niche. Here, we demonstrate that tenascin-C is a biomarker and a mediator of kidney fibrogenesis by impairing tubular integrity. Tenascin-C was found to be increased in kidney biopsies from pa...

journal_title：Kidney international

authors： Zhu H,Liao J,Zhou X,Hong X,Song D,Hou FF,Liu Y,Fu H

更新日期：2020-05-01 00:00:00

abstract：:Sustained oliguria during fluid resuscitation represents a perplexing problem in patients undergoing therapy for septic acute kidney injury. Here, we tested whether lipopolysaccharide induces filtrate leakage from the proximal tubular lumen into the interstitium, thus disturbing the recovery of urine output during the...

journal_title：Kidney international

authors： Nakano D,Kitada K,Wan N,Zhang Y,Wiig H,Wararat K,Yanagita M,Lee S,Jia L,Titze JM,Nishiyama A

更新日期：2020-05-01 00:00:00

abstract：:A dose escalation study of adipose-derived human mesenchymal stem cell (MSC) therapy was studied in 21 subjects. This dose escalation study confirmed no significant cellular toxicity, but it showed improvement in renal oxygenation and glomerular filtration rate. No significant renal toxicity from cell therapy was show...

journal_title：Kidney international

authors： Sivanathan KN,Coates PT

更新日期：2020-04-01 00:00:00

abstract：:Autosomal dominant polycystic kidney disease (ADPKD) is an inherited, progressive nephropathy accounting for 4-10% of end stage renal disease worldwide. PKD1 and PKD2 are the most common disease loci, but even accounting for other genetic causes, about 7% of families remain unresolved. Typically, these unsolved cases ...

journal_title：Kidney international

authors： Hopp K,Cornec-Le Gall E,Senum SR,Te Paske IBAW,Raj S,Lavu S,Baheti S,Edwards ME,Madsen CD,Heyer CM,Ong ACM,Bae KT,Fatica R,Steinman TI,Chapman AB,Gitomer B,Perrone RD,Rahbari-Oskoui FF,Torres VE,HALT Progression of

更新日期：2020-02-01 00:00:00

abstract：:The kidneys excrete the daily acid load mainly by generating and excreting ammonia but the underlying molecular mechanisms are not fully understood. Here we evaluated the role of the inwardly rectifying potassium channel subunit Kir4.2 (Kcnj15 gene product) in this process. In mice, Kir4.2 was present exclusively at t...

journal_title：Kidney international

authors： Bignon Y,Pinelli L,Frachon N,Lahuna O,Figueres L,Houillier P,Lourdel S,Teulon J,Paulais M

更新日期：2020-02-01 00:00:00

abstract：:A protective role for sirtuin 6 (Sirt6) in the context of chronic renal injury is reported by Cai et al. in this issue of Kidney International. The mechanism is thought to be mediated by Sirt6's deacetylase activity, specifically on β-catenin target genes. This commentary discusses these results and the interaction be...

journal_title：Kidney international

authors： Gewin LS

更新日期：2020-01-01 00:00:00

abstract：:Membranous nephropathy is characterized by deposition of immune complexes along the glomerular basement membrane. PLA2R and THSD7A are target antigens in 70% and 1-5% of primary membranous nephropathy cases, respectively. In the remaining cases, the target antigen is unknown. Here, laser microdissection of glomeruli f...

journal_title：Kidney international

authors： Sethi S,Debiec H,Madden B,Charlesworth MC,Morelle J,Gross L,Ravindran A,Buob D,Jadoul M,Fervenza FC,Ronco P

更新日期：2020-01-01 00:00:00

abstract：:Innate lymphoid cells are a recently recognized group of immune cells with critical roles in tissue homeostasis and inflammation. Regulatory innate lymphoid cells are a newly identified subset of innate lymphoid cells, which play a suppressive role in the innate immune response, favoring the resolution of intestinal i...

journal_title：Kidney international

authors： Cao Q,Wang R,Wang Y,Niu Z,Chen T,Wang C,Jin L,Huang Q,Li Q,Wang XM,Azmi F,Lee VWS,Wang YM,Zheng G,Alexander SI,Harris DCH

更新日期：2020-01-01 00:00:00

abstract：:Intravascular hemolysis is relatively rare but can lead to acute kidney injury (AKI), from increased destruction of erythrocytes and release of free hemoglobin. Since hemolysis and hemoglobinuria are known causes of acute kidney injury we sought to define clinicopathologic findings and outcomes of patients with hemoly...

journal_title：Kidney international

authors： Dvanajscak Z,Walker PD,Cossey LN,Messias NC,Boils CL,Kuperman MB,Larsen CP

更新日期：2019-12-01 00:00:00

abstract：:Although the pathogenesis of steroid-sensitive nephrotic syndrome (SSNS) remains elusive, multiple epidemiologic, clinical, and experimental studies converge on the common theme of immune dysregulation. Initially, T-cell adaptive immunity was solely emphasized; however, the role of humoral immunity in nephrotic syndro...

journal_title：Kidney international

authors： Chambers ET,Gbadegesin RA

更新日期：2019-10-01 00:00:00

abstract：:A genome-wide association study (GWAS) indicated that myeloperoxidase-ANCA associated vasculitis (AAV) is associated with HLA-DQ. However, susceptibility alleles in these loci have been under-investigated. Here we genotyped 258 Chinese patients with myeloperoxidase-AAV and 597 healthy control individuals at HLA DRB1, ...

journal_title：Kidney international

authors： Wang HY,Cui Z,Pei ZY,Fang SB,Chen SF,Zhu L,Chen M,Chen N,Zhao MH

更新日期：2019-10-01 00:00:00

abstract：:Emerging evidence of crosstalk between glomerular cells in pathological settings provides opportunities for novel therapeutic discovery. Here we investigated underlying mechanisms of early events leading to filtration barrier defects of podocyte and glomerular endothelial cell crosstalk in the mouse models of primary ...

journal_title：Kidney international

authors： Ebefors K,Wiener RJ,Yu L,Azeloglu EU,Yi Z,Jia F,Zhang W,Baron MH,He JC,Haraldsson B,Daehn I

更新日期：2019-10-01 00:00:00