Tenascin-C promotes acute kidney injury to chronic kidney disease progression by impairing tubular integrity via αvβ6 integrin signaling.

abstract：:Lipid abnormalities have been suggested as a major cause of the accelerated atherosclerosis and the high incidence of coronary heart disease in chronic renal failure patients. In the present work the postprandial lipoprotein metabolism was studied in chronic dialysis patients with or without fasting hypertriglyceridem...

journal_title：Kidney international

authors： Weintraub M,Burstein A,Rassin T,Liron M,Ringel Y,Cabili S,Blum M,Peer G,Iaina A

更新日期：1992-11-01 00:00:00

abstract：:Plasma lipid and lipoprotein concentration and high density lipoprotein (HDL) kinetics were determined in control subjects and patients with chronic renal failure (CRF). Results demonstrated that plasma triglyceride (TG) concentration was significantly higher (P less than 0.001) in patients with CRF, associated with a...

journal_title：Kidney international

authors： Fuh MM,Lee CM,Jeng CY,Shen DC,Shieh SM,Reaven GM,Chen YD

更新日期：1990-05-01 00:00:00

abstract：:Albuminuria and a reduced glomerular filtration rate are conventional predictors of a future decline in kidney function in patients with type 2 diabetes mellitus. Using a nested case-control study we assessed whether circulating transforming growth factor-β1 (TGF-β1) and bone morphogenetic protein-7 (BMP-7) levels mor...

journal_title：Kidney international

authors： Wong MG,Perkovic V,Woodward M,Chalmers J,Li Q,Hillis GS,Yaghobian Azari D,Jun M,Poulter N,Hamet P,Williams B,Neal B,Mancia G,Cooper M,Pollock CA

更新日期：2013-02-01 00:00:00

abstract：:The content of platelet activating factor (PAF) in glomeruli isolated from rats with nephrotoxic serum glomerulonephritis (NSGN) was quantified at various stages of the disease and the role of complement, platelets and neutrophils in mediating changes in glomerular PAF levels was evaluated. PAF content was assessed fo...

journal_title：Kidney international

authors： Lianos EA,Zanglis A

更新日期：1990-02-01 00:00:00

abstract：:Phagocyte-derived interleukin-12 (IL-12) is a key cytokine that induces the development of an effective Th1 type immune response in various inflammatory and infectious disorders. To determine the importance of IL-12 in the pathogenesis of autoimmune renal injury we examined the renal production of this heterodimeric c...

journal_title：Kidney international

authors： Fan X,Oertli B,Wüthrich RP

更新日期：1997-01-01 00:00:00

abstract：:The transforming growth factor-beta (TGF-beta) plays a central role in the progression of renal fibrosis. TGF-beta transduces its signal through the activin receptor-like kinase (ALK)5. IN-1130, a novel small molecule ALK5 inhibitor, inhibited the purified kinase domain of ALK5-mediated Smad3 phosphorylation with an I...

journal_title：Kidney international

authors： Moon JA,Kim HT,Cho IS,Sheen YY,Kim DK

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND:Cold ischemia and reperfusion during kidney transplantation are associated with release of free oxygen radicals and damage of renal tubular cells. Bioflavonoids may diminish cold storage-induced injury due to antioxidant and iron chelating activities. This study was designed to delineate the renoprotective m...

journal_title：Kidney international

authors： Ahlenstiel T,Burkhardt G,Köhler H,Kuhlmann MK

更新日期：2003-02-01 00:00:00

abstract：BACKGROUND:Wegener's granulomatosis (WG) is a rare systemic autoimmune disease characterized by small-vessel vasculitis leading to organ damage and the presence of antineutrophil cytoplasmic autoantibodies (ANCAs). ANCAs were shown to be involved in the pathogenesis of the disease by increasing adhesion of polymorphonu...

journal_title：Kidney international

authors： Gencik M,Meller S,Borgmann S,Fricke H

更新日期：2000-12-01 00:00:00

abstract：:The microcirculation is regulated by oxygen gradients and by endothelial release of nitric oxide, which can react with hemoglobin to form S-nitroso derivatives. Here we induced flow-mediated dilatation of the brachial artery in response to ischemia in 141 non-diabetic patients with stage 3-4 chronic kidney disease who...

journal_title：Kidney international

authors： Yilmaz MI,Sonmez A,Saglam M,Gulec M,Kilic S,Eyileten T,Caglar K,Oguz Y,Vural A,Yenicesu M,Zoccali C

更新日期：2009-06-01 00:00:00

abstract：:In contrast to other nonsteroidal anti-inflammatory drugs (NSAIDs), sulindac has been reported to inhibit systemic prostaglandins (PGs) while not affecting renal PGs. We studied 11 normal volunteers who received placebo, ibuprofen, naproxen, or sulindac in a randomized, double-blind fashion. After control periods asse...

journal_title：Kidney international

authors： Brater DC,Anderson S,Baird B,Campbell WB

更新日期：1985-01-01 00:00:00

abstract：:A major factor contributing to failure of arteriovenous fistulas (AVFs) is migration of smooth muscle cells into the forming neointima. To identify the source of smooth muscle cells in neointima, we created end-to-end AVFs by anastomosing the common carotid artery to the jugular vein and studied neural crest-derived s...

journal_title：Kidney international

authors： Liang M,Wang Y,Liang A,Mitch WE,Roy-Chaudhury P,Han G,Cheng J

更新日期：2015-09-01 00:00:00

abstract：:The defect in urinary acidification induced by amphotericin B (AMB) was further characterized in turtle bladder. Since AMB has been shown to increase the hydrogen ion (H+) permeability of this epithelium in the absence of exogenous bicarbonate ions (HCO3-), we explored the permeability characteristics in the presence ...

journal_title：Kidney international

authors： Finn JT,Cohen LH,Steinmetz PR

更新日期：1977-04-01 00:00:00

abstract：:Protein and mRNA expression of TGF-beta isoforms, TGF-beta 1, -beta 2 and -beta 3, and deposition of fibronectin containing extra domain A (fibronectin EDA+) and plasminogen activator inhibitor-1 (PAI-1) were studied in human chronic glomerulonephritis and diabetic nephropathy. Normal kidneys showed similar, weak immu...

journal_title：Kidney international

authors： Yamamoto T,Noble NA,Cohen AH,Nast CC,Hishida A,Gold LI,Border WA

更新日期：1996-02-01 00:00:00

abstract：BACKGROUND:Decay accelerating factor (DAF), a product of mesangial cells in vitro, is expressed on the surface of cells and is a candidate for the focal suppression of complement activation. It is not clear at present whether the levels of expression of DAF and intrarenal C3 synthesis correlate with the level of tissue...

journal_title：Kidney international

authors： Abe K,Miyazaki M,Koji T,Furusu A,Ozono Y,Harada T,Sakai H,Nakane PK,Kohno S

更新日期：1998-07-01 00:00:00

abstract：:Class II gene products of the major histocompatibility complex (MHC) are not expressed usually in abundance on normal epithelium. The cell surface visibility of such proteins for the immune system is thought to be limited protectively in order to minimize inflammation consequent to the recognition of self-antigens in ...

journal_title：Kidney international

authors： Albert SE,Shelton K,Sun MJ,Neilson EG

更新日期：1991-07-01 00:00:00

abstract：:It has been shown that somatostatin inhibits the antidiuretic action of vasopressin in toad urinary bladder in vitro and in dogs and rats in vivo. The presence of somatostatin-like immunoreactivity (SLI) in the urinary bladder and kidney of the toad has suggested the possibility that somatostatin may act as a local pa...

journal_title：Kidney international

authors： Kurokawa K,Aponte GW,Fujibayashi S,Yamada T

更新日期：1983-12-01 00:00:00

abstract：BACKGROUND:The "intact" parathyroid hormone (PTH) assay recognizes PTH-(1-84) as well as amino terminally truncated PTH fragments, that is, large carboxyterminal PTH fragments (C-PTH fragments). The present study investigated whether the use of the plasma PTH-(1-84)/C-PTH fragment ratio enhances the noninvasive assessm...

journal_title：Kidney international

authors： Monier-Faugere MC,Geng Z,Mawad H,Friedler RM,Gao P,Cantor TL,Malluche HH

更新日期：2001-10-01 00:00:00

abstract：:Disasters result in a substantial number of renal challenges, either by the creation of crush injury in victims trapped in collapsed buildings or by the destruction of existing dialysis facilities, leaving chronic dialysis patients without access to their dialysis units, medications, or medical care. Over the past two...

journal_title：Kidney international

authors： Gibney RT,Sever MS,Vanholder RC

更新日期：2014-05-01 00:00:00

abstract：:We have developed an immunological procedure for measuring advanced glycosylation end-products (AGEs) in serum. Using this method, we measured AGEs in healthy volunteers, patients with diabetes, renal failure without treatment and in patients with renal failure, treated with hemodialysis (HD) or continuous ambulatory ...

journal_title：Kidney international

authors： Papanastasiou P,Grass L,Rodela H,Patrikarea A,Oreopoulos D,Diamandis EP

更新日期：1994-07-01 00:00:00

abstract：:Familial aggregation of non-diabetic end-stage renal disease (ESRD) is found in African Americans and variants in the apolipoprotein L1 gene (APOL1) contribute to this risk. To detect genetic associations with milder forms of nephropathy in the high-risk families, analyses were performed using generalized estimating e...

journal_title：Kidney international

authors： Freedman BI,Langefeld CD,Turner J,Núñez M,High KP,Spainhour M,Hicks PJ,Bowden DW,Reeves-Daniel AM,Murea M,Rocco MV,Divers J

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Tubulointerstitial fibrosis is a morphologic hallmark of chronic kidney disease and is a key factor in the prediction of progression to end-stage renal failure. Disruption of tubular basement membrane and interstitial extracellular matrix (ECM) via cytokine-induced alterations in matrix metalloproteinases (M...

journal_title：Kidney international

authors： Nee LE,McMorrow T,Campbell E,Slattery C,Ryan MP

更新日期：2004-10-01 00:00:00

abstract：:Efficacy and safety of antibiotic 'locks', in prevention of thrombotic and infectious complication-related morbidity and mortality, among diabetics dialyzed through tunneled-cuffed catheters (TCCs) has not been effectively investigated. This trial was designed to investigate the outcome of TCCs (n = 109), inserted amo...

journal_title：Kidney international

authors： Saxena AK,Panhotra BR,Sundaram DS,Al-Hafiz A,Naguib M,Venkateshappa CK,Abu-Oun BA,Hussain SM,Al-Ghamdi AA

更新日期：2006-11-01 00:00:00

abstract：:Angiotensinase A (aminopeptidase A; ATA) is an angiotensin II splitting exopeptidase, which is localized in endothelial and epithelial cells of the glomerular tuft. In order to investigate the influence of a reduction in renal mass on enzyme activity, ATA activity was measured in isolated rat glomeruli five and 14 wee...

journal_title：Kidney international

authors： Wolf G,Thaiss F,Scherberich JE,Schoeppe W,Stahl RA

更新日期：1990-11-01 00:00:00

abstract：:Injury resulting from ischemia-reperfusion injury is a multifactorial process involving compromised function in both the tubular and the vascular compartments. Multiple vasoactive compounds have been implicated in the profound vasoconstriction that occurs in response to ischemia-reperfusion injury, and many of these f...

journal_title：Kidney international

authors： Basile DP

更新日期：2011-08-01 00:00:00

abstract：:Previous studies have shown a number of different associations between major histocompatibility complex (MHC) alleles and primary systemic vasculitis. Disease heterogeneity and the lack of specificity of certain MHC typing techniques may have contributed to the lack of consistency in those studies. We therefore studie...

journal_title：Kidney international

authors： Zhang L,Jayne DR,Zhao MH,Lockwood CM,Oliveira DB

更新日期：1995-01-01 00:00:00

abstract：:The purpose of this investigation is to analyze changes in plasma 1,25-(OH)2D and 24,25-(OH)2D after successful renal transplantation in 20 children and young adults. Studies were performed on 8 subjects between the 1st and 10th month and on 12 others between the 20th and 30th to 36th month. Samples were assayed for p...

journal_title：Kidney international

authors： Garabedian M,Silve C,Levy-Bentolila D,Bourdeau A,Ulmann A,Nguyen TM,Lieberherr M,Broyer M,Balsan S

更新日期：1981-09-01 00:00:00

abstract：:Since the kidney medulla was reported to generate platelet activating factor (PAF), we investigated a possible effect of this agent on the reabsorptive function of in vitro microperfused medullary thick ascending limbs from mouse kidney (mTAL). PAF, 10(-7) M in the bath, significantly decreased the net chloride flux (...

journal_title：Kidney international

authors： Bailly C,Barlet-Bas C,Amiel C

更新日期：1992-02-01 00:00:00

abstract：BACKGROUND:Redox-active iron can promote oxidative stress and tissue injury by catalyzing hydroxyl radical generation and lipid peroxidation. Intravenous iron preparations are routinely administered in conjunction with erythropoietin to treat anemia in patients with chronic renal failure (CRF), a condition that is mark...

journal_title：Kidney international

authors： Lim CS,Vaziri ND

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:The renal 11beta-hydroxysteroid dehydrogenase type 2 (11beta HSD2) enzyme inactivates 11-hydroxy steroids in the kidney, thereby protecting the nonselective mineralocorticoid (MR) receptor from occupation by glucocorticoids. Loss-of-function mutations in the gene encoding 11beta HSD2 (HSD11B2) result in over...

journal_title：Kidney international

authors： Williams TA,Mulatero P,Filigheddu F,Troffa C,Milan A,Argiolas G,Parpaglia PP,Veglio F,Glorioso N

更新日期：2005-02-01 00:00:00

abstract：:In adults on chronic hemodialysis, achieving a hemoglobin concentration of 12g/dl and above with erythropoiesis stimulating agents leads to increased cardiovascular events and mortality, but this may not be true in children. Therefore, we conducted a retrospective cohort study of pediatric patients (under 18) from the...

journal_title：Kidney international

authors： Rheault MN,Molony JT,Nevins T,Herzog CA,Chavers BM

更新日期：2017-01-01 00:00:00