Predicting long-term kidney allograft outcomes: pitfalls and progress.


:Early identification of kidney transplant recipients at risk of progressive allograft dysfunction may allow clinicians to provide closer monitoring and more aggressive risk factor modification. In this issue, Raynaud et al. presented a latent class model that clustered kidney transplant recipients into 8 risk categories of post-transplant kidney function loss. This commentary discusses some of the advantages, but also challenges, of the use of latent class analyses, including the clinical applicability of models that are often derived from such approaches.


Kidney Int


Kidney international


Dinh A,McCulloch CE,Ku E




Has Abstract


2021-01-01 00:00:00














  • A clinical study of anti-NDP in the sera of patients in a large repetitive hemodialysis program.

    abstract::Anti-NDP has been detected in the sera of 38 of 430 patients on regular hemodialysis at the Regional Kidney Disease Program in Minneapolis. It developed in these patients from 7 to 58 months after commencement of dialysis. Bacterial infection appeared temporally related to the development of anti-NDP in 12 patients. H...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Crosson JT,Moulds J,Comty CM,Polesky HF

    更新日期:1976-12-01 00:00:00

  • Stress protein activation by the cyclopentenone prostaglandin 15-deoxy-delta12,14-prostaglandin J2 in human mesangial cells.

    abstract:BACKGROUND:The cyclopentenone prostaglandin 15-deoxy-delta12,14-prostaglandin J2 (15dPGJ2) affects mesangial proliferation, survival and production of proinflammatory proteins. During a survey of the mesangial cell proteome after treatment with 15dPGJ2, heat shock protein 70 (HSP70) was found to be the most conspicuous...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Zhang X,Lu L,Dixon C,Wilmer W,Song H,Chen X,Rovin BH

    更新日期:2004-03-01 00:00:00

  • The duodenal mucosa in patients with renal failure: response to 1,25(OH)2D3.

    abstract::The structure of the duodenal mucosa was evaluated in duodenal biopsy samples obtained from patients with moderate renal failure (MRF) and in dialysis patients (HD) in an effort to examine the possibility that changes in duodenal mucosa may contribute to the impaired calcium absorption in renal failure (RF). The effec...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Goldstein DA,Horowitz RE,Petit S,Haldimann B,Massry SG

    更新日期:1981-02-01 00:00:00

  • Glomerulosclerosis in mice transgenic for human insulin-like growth factor-binding protein-1.

    abstract:BACKGROUND:The growth hormone (GH)/insulin-like growth factor (IGF) system is thought to participate in the glomerulosclerosis process. Because IGF-binding proteins (IGFBPs) modulate IGF actions and hence GH secretion, this study assessed whether mice transgenic for human IGFBP-1 have altered susceptibility to glomerul...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Doublier S,Seurin D,Fouqueray B,Verpont MC,Callard P,Striker LJ,Striker GE,Binoux M,Baud L

    更新日期:2000-06-01 00:00:00

  • Gelatinase A is a glomerular mesangial cell growth and differentiation factor.

    abstract::The members of the matrix metalloproteinase gene family play critical roles in numerous physiologic events, including cellular migration, tissue remodeling in wound healing and development, as well as in the evolution of the inflammatory process. The 72 kDa gelatinase A (formerly denoted 72 kDa Type IV collagenase) is...

    journal_title:Kidney international

    pub_type: 杂志文章,评审


    authors: Turck J,Pollock AS,Lovett DH

    更新日期:1997-05-01 00:00:00

  • First responders: understanding monocyte-lineage traffic in the acutely injured kidney.

    abstract::Interstitial monocytic infiltration of the kidney occurs within hours of acute kidney injury and is an important determinant of functional decline and fibrosis. Li et al. used several surface markers to distinguish between dendritic cells and inflammatory monocytes following acute kidney injury and to identify two che...

    journal_title:Kidney international

    pub_type: 评论,杂志文章


    authors: Swaminathan S,Griffin MD

    更新日期:2008-12-01 00:00:00

  • Familial, hemodynamic and metabolic factors in the predisposition to diabetic kidney disease.

    abstract::Proteinuric diabetic patients have an increased risk of cardiovascular disease and almost always have hypertension. In the early stages of diabetic renal disease (microalbuminuria) when renal function is well preserved, systemic arterial blood pressure is already elevated compared to insulin-dependent diabetic patient...

    journal_title:Kidney international

    pub_type: 杂志文章,评审


    authors: Earle K,Viberti GC

    更新日期:1994-02-01 00:00:00

  • Mitochondrial dysfunction is a primary event in renal cell oxalate toxicity.

    abstract:BACKGROUND:In cultured renal epithelial cells, exposure to oxalate, a constituent of many kidney stones, elicits a cascade of responses that often leads to cell death. Oxalate toxicity is mediated via generation of reactive oxygen species (ROS) in a process that depends at least in part upon lipid signaling molecules t...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Cao LC,Honeyman TW,Cooney R,Kennington L,Scheid CR,Jonassen JA

    更新日期:2004-11-01 00:00:00

  • Treatment of arterial hypertension in diabetic humans: importance of therapeutic selection.

    abstract::This study was undertaken to test the hypothesis that, given equal arterial pressure reductions, the combination of an angiotensin converting enzyme (ACE) inhibitor and calcium antagonist slows declines in renal function and yields greater reductions in albuminuria over either agent alone. This hypothesis was evaluate...

    journal_title:Kidney international

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Bakris GL,Barnhill BW,Sadler R

    更新日期:1992-04-01 00:00:00

  • Renal injury in the extremely obese patients with normal renal function.

    abstract::We studied the glomerular architecture in renal biopsies of 95 patients undergoing bariatric surgery for extreme obesity but whose renal function was normal. The comparison group was 40 control patients having protocol biopsies. These latter patients had normal weight and renal function, were non-diabetic, non-hyperte...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Serra A,Romero R,Lopez D,Navarro M,Esteve A,Perez N,Alastrue A,Ariza A

    更新日期:2008-04-01 00:00:00

  • Update on renal blood oxygenation level-dependent MRI to assess intrarenal oxygenation in chronic kidney disease.

    abstract::Identifying subjects with progressive chronic kidney disease will be important both in clinical practice and in conducting clinical trials. Pruijm et al. (in this issue) demonstrate for the first time that cortical oxygenation as evaluated by blood oxygenation level-dependent magnetic resonance imaging can predict fut...

    journal_title:Kidney international

    pub_type: 评论,杂志文章


    authors: Prasad PV

    更新日期:2018-04-01 00:00:00

  • Clinical trial of focal segmental glomerulosclerosis in children and young adults.

    abstract::This NIH-funded multicenter randomized study of focal segmental glomerulosclerosis (FSGS) treatment compared the efficacy of a 12-month course of cyclosporine to a combination of oral pulse dexamethasone and mycophenolate mofetil in children and adults with steroid-resistant primary FSGS. Of the 192 patients enrolled,...

    journal_title:Kidney international

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Gipson DS,Trachtman H,Kaskel FJ,Greene TH,Radeva MK,Gassman JJ,Moxey-Mims MM,Hogg RJ,Watkins SL,Fine RN,Hogan SL,Middleton JP,Vehaskari VM,Flynn PA,Powell LM,Vento SM,McMahan JL,Siegel N,D'Agati VD,Friedman AL

    更新日期:2011-10-01 00:00:00

  • Factors leading to the discard of deceased donor kidneys in the United States.

    abstract::The proportion of deceased donor kidneys procured for transplant but subsequently discarded has been growing steadily in the United States, but factors contributing to the rising discard rate remain unclear. To assess the reasons for and probability of organ discard we assembled a cohort of 212,305 deceased donor kidn...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Mohan S,Chiles MC,Patzer RE,Pastan SO,Husain SA,Carpenter DJ,Dube GK,Crew RJ,Ratner LE,Cohen DJ

    更新日期:2018-07-01 00:00:00

  • Acute renal failure in hemorrhagic hypotension: cellular energetics and renal function.

    abstract::In male Wistar rats, renal adenosine triphosphate (ATP), inorganic phosphate (Pi) and intracellular pH were measured by 31phosphorus nuclear magnetic resonance (31P NMR) and correlated with renal function before, during, and for one hour after a period of 30 to 40 minutes hemorrhagic hypotension. In animals which suff...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Ratcliffe PJ,Moonen CT,Holloway PA,Ledingham JG,Radda GK

    更新日期:1986-09-01 00:00:00

  • Expression and role of connexins in the rat renal vasculature.

    abstract::Gap junctions are present in the juxtaglomerular apparatus enabling intercellular communication. Our study determined the location of different connexin subtypes within the juxtaglomerular apparatus of the rat, and the role of these subtypes in renal hemodynamics through the use of specific mimetic peptides. Immunohis...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Takenaka T,Inoue T,Kanno Y,Okada H,Meaney KR,Hill CE,Suzuki H

    更新日期:2008-02-01 00:00:00

  • Calcitriol deficiency with retained synthetic reserve in chronic renal failure.

    abstract::Serum calcitriol and the free calcitriol index together with factors considered to regulate calcitriol production were measured in eleven patients with moderate chronic renal failure (MCRF) and eleven age- and sex-matched normal subjects. Although the serum dialysable calcium levels were similar in the two groups, the...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Prince RL,Hutchison BG,Kent JC,Kent GN,Retallack RW

    更新日期:1988-03-01 00:00:00

  • Presence of an anti-viral factor in peritoneal dialysis effluent.

    abstract::Viral peritonitis is an exceptionally rare occurrence in peritoneal dialysis. In fact, up to now, only one case report has been documented in the literature. In a prospective study, peritoneal dialysis effluent (PDE) was specifically cultured for the following viruses: the herpes group of viruses, including herpes sim...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Pomeranz A,Korzets Z,Smetana O,Yuhas Y,Elan I,Bernheim J

    更新日期:1989-08-01 00:00:00

  • CD14(++)CD16+ monocytes but not total monocyte numbers predict cardiovascular events in dialysis patients.

    abstract::Migration of monocytes into the vessel wall contributes to the onset and progression of atherosclerosis. Because monocytes are a heterogeneous population, we determined potential associations between monocyte subsets and cardiovascular events in a prospective cohort of 94 dialysis patients followed for 35 months. The ...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Heine GH,Ulrich C,Seibert E,Seiler S,Marell J,Reichart B,Krause M,Schlitt A,Köhler H,Girndt M

    更新日期:2008-03-01 00:00:00

  • Ontogeny of aromatic L-amino acid decarboxylase-containing tubule cells in rat kidney.

    abstract::Dopamine plays an important role in regulation of renal sodium transport. Proximal tubule cells produce dopamine after decarboxylation of L-DOPA via the enzyme aromatic L-amino acid decarboxylase (AADC). The presence and cellular localization of AADC-like immunoreactivity (-LI) and AADC mRNA were examined during pre- ...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Meister B,Fried G,Holgert H,Aperia A,Hökfelt T

    更新日期:1992-09-01 00:00:00

  • Polycystic kidney and liver disease in Springbok: I. Morphology of the lesions.

    abstract::Spontaneous polycystic kidney and liver disease in an inbred herd of Springbok (Antidorcas marsupialis) was studied by light microscopy, transmission electron microscopy, and microdissection. Springbok are a small species of gazelle of the family Bovidae native to South Africa. Since 1976, 18% of all live calves born ...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Iverson WO,Fetterman GH,Jacobson ER,Olsen JH,Senior DF,Schobert EE

    更新日期:1982-08-01 00:00:00

  • Prevention of crescentic glomerulonephritis by immunoneutralization of the fractalkine receptor CX3CR1 rapid communication.

    abstract:BACKGROUND:Fractalkine is a newly identified T-cell and monocyte/macrophage (Mphi) chemokine with a transmembrane domain and is a cell-surface protein on activated endothelium. It can mediate adhesion of cells expressing the fractalkine receptor CX3CR1. These unique features make fractalkine well suited for leukocyte r...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Feng L,Chen S,Garcia GE,Xia Y,Siani MA,Botti P,Wilson CB,Harrison JK,Bacon KB

    更新日期:1999-08-01 00:00:00

  • The role of mitochondria in ischemia/reperfusion injury in organ transplantation.

    abstract::In organ transplantation, ischemia/reperfusion (I/R) results in damage that may affect cell viability and lead to organ failure. I/R injury involves a complex cascade of events, including loss of energy, derangement of the ionic hemostasis, production of reactive oxygen species, and cell death. In this context, mitoch...

    journal_title:Kidney international

    pub_type: 杂志文章,评审


    authors: Jassem W,Heaton ND

    更新日期:2004-08-01 00:00:00

  • Leukocyte and serum S100A8/S100A9 expression reflects disease activity in ANCA-associated vasculitis and glomerulonephritis.

    abstract::Antineutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) commonly results in glomerulonephritis, in which neutrophils and monocytes have important roles. The heterodimer calprotectin (S100A8/S100A9, mrp8/14) is a Toll-like receptor-4 ligand found in neutrophils and monocytes and is elevated in inflammatory...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Pepper RJ,Hamour S,Chavele KM,Todd SK,Rasmussen N,Flint S,Lyons PA,Smith KG,Pusey CD,Cook HT,Salama AD

    更新日期:2013-06-01 00:00:00

  • Stimulation of renin secretion by non-diuretic sulfhydryl reagents.

    abstract::Organomercurial diuretics stimulate renin secretion although the underlying cellular mechanisms remain undefined. Since organomercurials are also known to react with sulfhydryl groups, the present studies determined the effects of sulfhydryl reagents on renin secretion. The effects of the non-diuretic mercurial agent,...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Lee DY,Cho KW,Lee JS,Honeyman TW,Park CS

    更新日期:1989-03-01 00:00:00

  • The use of contrast media in deceased kidney donors does not affect initial graft function or graft survival.

    abstract::Patients receiving cadaveric kidney transplants often experience delayed graft function. As iodinated contrast media injection (ICMI), necessary for cerebral angiography, which is often used to diagnose brain death, can be nephrotoxic, we compared renal function recovery (RFR) and 1-year and long-term graft survival a...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Vigneau C,Fulgencio JP,Godier A,Chalem Y,El Metaoua S,Rondeau E,Tuppin P,Bonnet F

    更新日期:2006-09-01 00:00:00

  • Increased mitochondrial activity in renal proximal tubule cells from young spontaneously hypertensive rats.

    abstract::Renal proximal tubule cells from spontaneously hypertensive rats (SHR), compared with normotensive Wistar-Kyoto rats (WKY), have increased oxidative stress. The contribution of mitochondrial oxidative phosphorylation to the subsequent hypertensive phenotype remains unclear. We found that renal proximal tubule cells fr...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Lee H,Abe Y,Lee I,Shrivastav S,Crusan AP,Hüttemann M,Hopfer U,Felder RA,Asico LD,Armando I,Jose PA,Kopp JB

    更新日期:2014-03-01 00:00:00

  • National trends in acute kidney injury requiring dialysis in England between 1998 and 2013.

    abstract::Acute kidney injury (AKI) severe enough to require dialysis is increasing and associated with high mortality, yet robust information about temporal epidemiology of AKI requiring dialysis in England is lacking. In this retrospective observational study of the Hospital Episode Statistics (HES) data set covering the enti...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Kolhe NV,Muirhead AW,Wilkes SR,Fluck RJ,Taal MW

    更新日期:2015-11-01 00:00:00

  • Two channels for one job.

    abstract::The study by Rieg et al. is the first to examine potassium handling in BK(-/-) mice, thereby addressing many unanswered questions regarding the separate roles of BK and ROMK channels in renal potassium secretion. This Commentary is an interpretation and opinion of their results, by two researchers who have been studyi...

    journal_title:Kidney international

    pub_type: 评论,杂志文章


    authors: Sansom SC,Welling PA

    更新日期:2007-09-01 00:00:00

  • Effect of serum phosphate on parathyroid hormone secretion during hemodialysis.

    abstract:BACKGROUND:Recent studies have demonstrated that a high concentration of phosphate directly stimulates parathyroid hormone (PTH) secretion. High serum levels of phosphate are usually observed in patients with end-stage renal disease. The aim of the present study was to evaluate whether serum phosphate concentration had...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: de Francisco AL,Cobo MA,Setien MA,Rodrigo E,Fresnedo GF,Unzueta MT,Amado JA,Ruiz JC,Arias M,Rodriguez M

    更新日期:1998-12-01 00:00:00

  • Surgical salvage of failed radiocephalic arteriovenous fistulae: techniques and results in 29 patients.

    abstract::From August 1987 through February 1995 we performed 42 surgical procedures in 29 patients with occluded or stenotic radiocephalic arteriovenous fistulae. Operations were designed to preserve native veins for cannulation (Group I) or to preserve access in the same forearm, bypassing the failed fistula (Group II). For 2...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Oakes DD,Sherck JP,Cobb LF

    更新日期:1998-02-01 00:00:00