Predicting long-term kidney allograft outcomes: pitfalls and progress.


:Early identification of kidney transplant recipients at risk of progressive allograft dysfunction may allow clinicians to provide closer monitoring and more aggressive risk factor modification. In this issue, Raynaud et al. presented a latent class model that clustered kidney transplant recipients into 8 risk categories of post-transplant kidney function loss. This commentary discusses some of the advantages, but also challenges, of the use of latent class analyses, including the clinical applicability of models that are often derived from such approaches.


Kidney Int


Kidney international


Dinh A,McCulloch CE,Ku E




Has Abstract


2021-01-01 00:00:00














  • Higher hemoglobin levels and quality of life in patients with advanced chronic kidney disease: no longer a moving target?

    abstract::International clinical practice guidelines for the management of anemia in chronic kidney disease suggest target hemoglobin levels ≤ 11.5 g/dl (115 g/l), with individualized consideration of slightly higher hemoglobin targets to improve quality of life. An updated meta-analysis of randomized trials demonstrates no sig...

    journal_title:Kidney international

    pub_type: 评论,杂志文章


    authors: Wyatt CM,Drueke TB

    更新日期:2016-05-01 00:00:00

  • IN-1130, a novel transforming growth factor-beta type I receptor kinase (ALK5) inhibitor, suppresses renal fibrosis in obstructive nephropathy.

    abstract::The transforming growth factor-beta (TGF-beta) plays a central role in the progression of renal fibrosis. TGF-beta transduces its signal through the activin receptor-like kinase (ALK)5. IN-1130, a novel small molecule ALK5 inhibitor, inhibited the purified kinase domain of ALK5-mediated Smad3 phosphorylation with an I...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Moon JA,Kim HT,Cho IS,Sheen YY,Kim DK

    更新日期:2006-10-01 00:00:00

  • Thrombospondin 1 precedes and predicts the development of tubulointerstitial fibrosis in glomerular disease in the rat.

    abstract::Tubulointerstitial fibrosis is one of the most important histologic features that predicts progression in kidney disease. Thrombospondin 1 is an extracellular matrix protein that can activate latent TGF-beta, a cytokine implicated in the pathogenesis of tubulointerstitial fibrosis. We examined the expression of thromb...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Hugo C,Shankland SJ,Pichler RH,Couser WG,Johnson RJ

    更新日期:1998-02-01 00:00:00

  • Pre-existing renal disease promotes sepsis-induced acute kidney injury and worsens outcome.

    abstract::While it is known that risk of death from sepsis is higher in patients with pre-existing chronic kidney disease its mechanism is unknown. To study this we established a two-stage mouse model where renal disease was first induced by folic acid injection followed by sub-lethal cecal ligation and puncture to induce sepsi...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Doi K,Leelahavanichkul A,Hu X,Sidransky KL,Zhou H,Qin Y,Eisner C,Schnermann J,Yuen PS,Star RA

    更新日期:2008-10-01 00:00:00

  • Dietary NaCl-restriction prevents the calciuria of KCl-deprivation and blunts the calciuria of KHCO3-deprivation in healthy adults.

    abstract::Previous studies have demonstrated that dietary potassium deprivation in healthy human subjects eating diets otherwise containing normal quantities of NaCl is accompanied by an increase in urinary calcium excretion. This increase in urinary Ca excretion occurs in association with reductions in urinary Na and Cl excret...

    journal_title:Kidney international

    pub_type: 临床试验,杂志文章


    authors: Lemann J Jr,Pleuss JA,Hornick L,Hoffman RG

    更新日期:1995-03-01 00:00:00

  • Comprehensive suppression of the renin-angiotensin-aldosterone system in chronic kidney disease: covering all of the bases.

    abstract::Reducing proteinuria and blood pressure in chronic kidney disease (CKD) decreases rate of progression. Inhibition of the renin-angiotensin system by angiotensin-converting enzyme inhibitors and/or angiotensin receptor blockers is beneficial in reducing proteinuria but incomplete in suppressing aldosterone production a...

    journal_title:Kidney international

    pub_type: 评论,杂志文章,评审


    authors: Weinberger MH,Luft FC

    更新日期:2006-12-01 00:00:00

  • Renal hemodynamics during separate and combined infusion of amino acids and dopamine.

    abstract::Healthy volunteers (N = 9) and patients with varying degrees of renal insufficiency (N = 36) were given a low dose of dopamine and/or amino acids intravenously during a simultaneous measurement of the glomerular filtration rate and the effective renal plasma flow. Dopamine infusion led to a rise in the glomerular filt...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: ter Wee PM,Rosman JB,van der Geest S,Sluiter WJ,Donker AJ

    更新日期:1986-04-01 00:00:00

  • Cell surface aminopeptidase A and N activities in human glomerular epithelial cells.

    abstract::Cell surface aminopeptidases N (APN) and A (APA) have been characterized on cultured human glomerular epithelial cells and a SV40-transformed cell line derived from them. APN had a wide substrate specificity whereas APA only attacked peptides with an acidic N terminal amino acid. Both enzymes also differed by their se...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Stefanovic V,Vlahovic P,Ardaillou N,Ronco P,Ardaillou R

    更新日期:1992-06-01 00:00:00

  • Hypertension, glomerular number, and birth weight in African Americans and white subjects in the southeastern United States.

    abstract::Low nephron number has been related to low birth weight and hypertension. In the southeastern United States, the estimated prevalence of chronic kidney disease due to hypertension is five times greater for African Americans than white subjects. This study investigates the relationships between total glomerular number ...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Hughson MD,Douglas-Denton R,Bertram JF,Hoy WE

    更新日期:2006-02-01 00:00:00

  • What is the place of peritoneal dialysis in the integrated treatment of renal failure?

    abstract::The role of peritoneal dialysis (PD) in renal replacement therapy (RRT) remains unclear. There are no controlled trials to provide hard evidence of its efficacy. Comparative studies with haemodialysis from different centres and countries have given conflicting results even when allowing for case mix. Data from the Uni...

    journal_title:Kidney international

    pub_type: 杂志文章,评审


    authors: Coles GA,Williams JD

    更新日期:1998-12-01 00:00:00

  • Drug use and nephrotoxicity in the intensive care unit.

    abstract::Patients cared for in the intensive care unit (ICU) undergo multiple interventions to treat serious medical conditions. In addition to the acute illness being treated, underlying chronic conditions require ongoing drug therapy. As a result, these patients are exposed to numerous pharmaceutical agents, many of which ha...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Perazella MA

    更新日期:2012-06-01 00:00:00

  • High-dose erythropoietin has no effect on short- or long-term graft function following deceased donor kidney transplantation.

    abstract::We evaluated short- and long-term effects of high-dose recombinant human erythropoietin (rHuEPO) in kidney transplantation in a prospective double-blind, placebo-controlled study. Patients with chronic kidney disease following receipt of a deceased donor kidney allograft were randomized to 3 doses of 40,000 units rHuE...

    journal_title:Kidney international

    pub_type: 杂志文章,随机对照试验


    authors: Hafer C,Becker T,Kielstein JT,Bahlmann E,Schwarz A,Grinzoff N,Drzymala D,Bonnard I,Richter N,Lehner F,Klempnauer J,Haller H,Traeder J,Fliser D

    更新日期:2012-02-01 00:00:00

  • The Euro-Balance Trial: the effect of a new biocompatible peritoneal dialysis fluid (balance) on the peritoneal membrane.

    abstract:BACKGROUND:Although peritoneal dialysis (PD) is a widely accepted form of renal replacement therapy (RRT), concerns remain regarding the bioincompatible nature of standard PD fluid. In order to evaluate whether a newly formulated fluid of neutral pH, and containing low levels of glucose degradation products (GDP), resu...

    journal_title:Kidney international

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Williams JD,Topley N,Craig KJ,Mackenzie RK,Pischetsrieder M,Lage C,Passlick-Deetjen J,Euro Balance Trial Group.

    更新日期:2004-07-01 00:00:00

  • Accumulation of natriuretic peptides is associated with protein energy wasting and activation of browning in white adipose tissue in chronic kidney disease.

    abstract::Protein energy wasting is a common feature of patients with chronic kidney disease (CKD) and is associated with poor outcomes. Protein energy wasting and cachexia, a severe form of protein energy wasting, are characterized by increased resting energy expenditure but the underlying mechanisms are unclear. Browning corr...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Luce M,Barba C,Yi D,Mey A,Roussel D,Bres E,Benoit B,Pastural M,Granjon S,Szelag JC,Laville M,Arkouche W,Bouchara A,Nyam E,Fouque D,Soulage CO,Koppe L

    更新日期:2020-09-01 00:00:00

  • Tubuloglomerular feedback and glomerular morphology in Goldblatt hypertensive rats on varying protein diets.

    abstract::The present experiments were performed to examine the effect of variation in protein intake on renal function and morphology in the non-clipped kidneys of Goldblatt hypertensive rats. After renal artery clipping, rats were put on diets containing 5 (LP), 17.5 (NP), or 51% (HP) protein. After 4 to 5 weeks, all rats had...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Schnermann J,Gokel M,Weber PC,Schubert G,Briggs JP

    更新日期:1986-02-01 00:00:00

  • Preservation of residual kidney function in hemodialysis patients: reviving an old concept.

    abstract::Residual kidney function (RKF) may confer a variety of benefits to patients on maintenance dialysis. RKF provides continuous clearance of middle molecules and protein-bound solutes. Whereas the definition of RKF varies across studies, interdialytic urine volume may emerge as a pragmatic alternative to more cumbersome ...

    journal_title:Kidney international

    pub_type: 杂志文章,评审


    authors: Mathew AT,Fishbane S,Obi Y,Kalantar-Zadeh K

    更新日期:2016-08-01 00:00:00

  • Role of cGMP as second messenger of adenosine in the inhibition of renin release.

    abstract::Adenosine is known to be a potent inhibitor of renin release from the kidneys. The aim of this study was to investigate the transmembrane signalling avenue that the second messenger of adenosine causes inhibition of renal renin release. Using short term cultures of juxtaglomerular cells isolated from rat kidneys, we f...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Kurtz A,Della Bruna R,Pfeilschifter J,Bauer C

    更新日期:1988-04-01 00:00:00

  • Micropuncture studies of the transport of individual amino acids by the Necturus proximal tubule.

    abstract::Absorption of amino acids by the necturus proximal tubules was measured under free-flow conditions The coexistence of proximal tubular amino acid influx was determined by infusing saline into tubular lumens by the stopped-flow microperfusion technique. Under free-flow conditions, fractional absorption of individual am...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Oken DE,Weise M

    更新日期:1978-06-01 00:00:00

  • The cell cycle and acute kidney injury.

    abstract::Acute kidney injury (AKI) activates pathways of cell death and cell proliferation. Although seemingly discrete and unrelated mechanisms, these pathways can now be shown to be connected and even to be controlled by similar pathways. The dependence of the severity of renal-cell injury on cell cycle pathways can be used ...

    journal_title:Kidney international

    pub_type: 杂志文章,评审


    authors: Price PM,Safirstein RL,Megyesi J

    更新日期:2009-09-01 00:00:00

  • IgG4-related tubulointerstitial nephritis.

    abstract::Tubulointerstitial nephritis (TIN) is a disease pattern with heterogeneous causes. Recently a specific subtype of autoimmune TIN, IgG4-related TIN, has been identified that is part of systemic IgG4-related disease/ autoimmune pancreatitis. On biopsy, this TIN shows an IgG4+ plasma cell-rich infiltrate, akin to the pan...

    journal_title:Kidney international

    pub_type: 评论,杂志文章


    authors: Cornell LD

    更新日期:2010-11-01 00:00:00

  • Polyamines in the anemia of end-stage renal disease.

    abstract::The improvement in the anemia in patients with end-stage renal disease (ESRD) on continuous ambulatory peritoneal dialysis (CAPD) suggests that dialyzable substances present in the sera of uremic patients either inhibit erythropoiesis directly or inactivate erythropoietin (EPO). In the present study predialysis sera f...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Kushner D,Beckman B,Nguyen L,Chen S,Della Santina C,Husserl F,Rice J,Fisher JW

    更新日期:1991-04-01 00:00:00

  • Microangiographic evaluation of the effects of heparin on progressive Masugi nephritis.

    abstract::Unilateral progressive Masugi nephritis was produced in rabbits and studied by microangiography as well as light and immunofluorescence microscopy. The following five groups were studied: Group 1. Heparin was started simultaneously with nephrotoxic serum (NTS) and was given for one week. The animals were then sacrific...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Nakamoto Y,Dohi K,Fujike H,Yuri T,Shinoda A,Takeuchi J

    更新日期:1978-04-01 00:00:00

  • Inhibition of nuclear uptake of calcitriol receptor by uremic ultrafiltrate.

    abstract::The biological action of calcitriol is mediated through a hormone-receptor complex interacting with nuclear chromatin. Interaction of the calcitriol receptor (VDR) with VDR response elements produces bioactive proteins which carry out the physiological actions of calcitriol. Since biological response to calcitriol app...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Patel SR,Ke HQ,Vanholder R,Hsu CH

    更新日期:1994-07-01 00:00:00

  • A controlled trial of cyclosporine in patients with progressive membranous nephropathy. Canadian Glomerulonephritis Study Group.

    abstract::A controlled trial of cyclosporine in patients diagnosed with progressive membranous nephropathy (MGN) was carried out to determine whether cyclosporine (D) would be more effective than placebo (P) in reducing the rate of deterioration in renal function. Patients (N = 64) with MGN were placed on a restricted protein d...

    journal_title:Kidney international

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Cattran DC,Greenwood C,Ritchie S,Bernstein K,Churchill DN,Clark WF,Morrin PA,Lavoie S

    更新日期:1995-04-01 00:00:00

  • Risk factors in idiopathic renal vasculitis and glomerulonephritis.

    abstract::In this retrospective study, we analyzed clinical laboratory, and pathologic variables to determine their value in predicting survival and survival free of renal failure for 170 consecutive patients with idiopathic renal vasculitis and glomerulonephritis evaluated during a 15 year period. Of the 170 patients, 108 had ...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Wilkowski MJ,Velosa JA,Holley KE,Offord KP,Chu CP,Torres VE,McCarthy JT,Donadio JV Jr,Wagoner RD

    更新日期:1989-12-01 00:00:00

  • Disposition of total and unbound prednisolone in renal transplant patients receiving anticonvulsants.

    abstract::Kidney transplant patients receiving phenytoin or phenobarbital may have decreased graft survival. These drugs have been shown to enhance the metabolism of glucocorticoids. We determined the disposition of total and unbound prednisolone in six stable kidney transplant patients receiving prednisone for immunosuppressio...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Gambertoglio JG,Holford NH,Kapusnik JE,Nishikawa R,Saltiel M,Stanik-Lizak P,Birnbaum JL,Hau T,Amend WJ Jr

    更新日期:1984-01-01 00:00:00

  • A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.

    abstract::Urinary exosomes have received considerable attention as a potential biomarker source for the diagnosis of renal diseases. Notwithstanding, their use in protein biomarker research is hampered by the lack of efficient methods for vesicle isolation, lysis, and protein quantification. Here we report an improved ultracent...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Raj DA,Fiume I,Capasso G,Pocsfalvi G

    更新日期:2012-06-01 00:00:00

  • Transcription factor FoxO1, the dominant mediator of muscle wasting in chronic kidney disease, is inhibited by microRNA-486.

    abstract::Chronic kidney disease (CKD) accelerates muscle protein degradation by stimulating the ubiquitin proteasome system through activation of the E3 ligases, Atrogin-1/MAFbx and MuRF-1. Forkhead transcription factors (FoxOs) can control the expression of these E3 ligases, but the contribution of individual FoxOs to muscle ...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Xu J,Li R,Workeneh B,Dong Y,Wang X,Hu Z

    更新日期:2012-08-01 00:00:00

  • Membrane proteinase 3 expression and ANCA-induced neutrophil activation.

    abstract:BACKGROUND:Proteinase 3 is the major autoantigen in Wegener's granulomatosis (WG). Membrane PR3 expression is bimodal; low expressing cells (mPR3(low)) can be distinguished from cells with high expression (mPR3(high)) within a given individual. High mPR3 expression is a WG risk factor and is associated with relapse. Ho...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Schreiber A,Luft FC,Kettritz R

    更新日期:2004-06-01 00:00:00

  • Metabolic support of collecting duct transport.

    abstract::The present studies address the metabolic processes that support the reabsorption of sodium and the secretion of bicarbonate in the interspersed but distinct principal and intercalated cells of the cortical collecting duct (CCD). In microperfused rabbit CCD, sodium reabsorption was measured by lumen-to-bath 22Na flux,...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Hering-Smith KS,Hamm LL

    更新日期:1998-02-01 00:00:00