Prognostic value of inducible myocardial ischemia in predicting cardiovascular events after renal transplantation.


BACKGROUND:The aims of the present study were to determine the prevalence of inducible myocardial ischemia (IMI) in renal transplant recipients (RTR) more than 50 years old, to identify predictors of IMI, and to search for its prognostic value. METHODS:Among the 377 renal transplantations performed between 1989 and 1998 in a single institution, 120 were done in patients > or =50 years old, and 97 were recruited for the study. During the last quarter of 1998, all of them underwent an exercise test (EST), an exercise-thallium 201 single photon emission computed tomography coupled with dipyridamole (SPECT), and 81% of them had a dobutamine stress echocardiography (DSE). Patients with IMI subsequently underwent coronary angiography to detect coronary stenosis. RESULTS:IMI was present in 12 of the 97 patients (10%). The diagnosis was evidenced by EST in four cases, by SPECT in 11 cases, and DSE in three cases. Five of these 12 patients (42%) had significant coronary artery stenosis (> or =50%). Multivariate analysis of several pre- and post-transplant variables evidenced acute rejection and left ventricular hypertrophy as significant correlates of IMI (both P < 0.03). Patients were prospectively followed-up for 48 months for the occurrence of major cardiovascular events. Kaplan-Meier analysis revealed a significant increase in cardiovascular events in the IMI group (P < 0.0001). In addition, the Cox proportional hazards model revealed that IMI and diabetes mellitus had an independent significant effect on the occurrence of major cardiovascular events. CONCLUSION:IMI was present in 10% of RTR aged > or =50 years, and was predicted by acute rejection and left ventricular hypertrophy. IMI had a strong effect on major cardiovascular events in this population.


Kidney Int


Kidney international


Dussol B,Bonnet JL,Sampol J,Savin B,De La Forte C,Mundler O,Habib G,Morange S,Barrau K,Loundoun A,Vacher-Coponat H,Berland Y




Has Abstract


2004-10-01 00:00:00














  • Patients double-seropositive for ANCA and anti-GBM antibodies have varied renal survival, frequency of relapse, and outcomes compared to single-seropositive patients.

    abstract::Co-presentation with both ANCA and anti-GBM antibodies is thought to be relatively rare. Current studies of such 'double-positive' cases report small numbers and variable outcomes. To study this further we retrospectively analyzed clinical features and long-term outcomes of a large cohort of 568 contemporary patients ...

    journal_title:Kidney international

    pub_type: 杂志文章,多中心研究


    authors: McAdoo SP,Tanna A,Hrušková Z,Holm L,Weiner M,Arulkumaran N,Kang A,Satrapová V,Levy J,Ohlsson S,Tesar V,Segelmark M,Pusey CD

    更新日期:2017-09-01 00:00:00

  • A GAP in our knowledge of vascular signaling in acute kidney injury.

    abstract::Injury resulting from ischemia-reperfusion injury is a multifactorial process involving compromised function in both the tubular and the vascular compartments. Multiple vasoactive compounds have been implicated in the profound vasoconstriction that occurs in response to ischemia-reperfusion injury, and many of these f...

    journal_title:Kidney international

    pub_type: 评论,杂志文章


    authors: Basile DP

    更新日期:2011-08-01 00:00:00

  • Impaired kidney growth in low-birth-weight children: distinct effects of maturity and weight for gestational age.

    abstract:BACKGROUND:Low birth weight is an important risk factor for hypertension and unfavorable prognoses of a number of renal diseases. It is also associated with reduced kidney size and nephron number. A differentiation between the effects of low birth weight versus being born premature or small for gestational age has, how...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Schmidt IM,Chellakooty M,Boisen KA,Damgaard IN,Mau Kai C,Olgaard K,Main KM

    更新日期:2005-08-01 00:00:00

  • Potential mechanisms of marked hyperoxaluria not due to primary hyperoxaluria I or II.

    abstract:BACKGROUND:Hyperoxaluria may be idiopathic, secondary, or due to primary hyperoxaluria (PH). Hepatic alanine:glyoxylate aminotransferase (AGT) or glyoxylate/hydroxypyruvate reductase (GR/HPR) deficiency causes PHI or PHII, respectively. Hepatic glycolate oxidase (GO) is a candidate enzyme for a third form of inherited ...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Monico CG,Persson M,Ford GC,Rumsby G,Milliner DS

    更新日期:2002-08-01 00:00:00

  • Lead chelation therapy and urate excretion in patients with chronic renal diseases and gout.

    abstract:BACKGROUND:It is known that chronic renal insufficiency (CRI) patients with gout may have subtle lead poisoning. In addition, gout episodes frequently aggravate progressive renal insufficiency because of the use of nephrotoxic drugs and urate deposition. Our study was arranged to evaluate the causal effect of environme...

    journal_title:Kidney international

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Lin JL,Yu CC,Lin-Tan DT,Ho HH

    更新日期:2001-07-01 00:00:00

  • Incidence of latent mesangial IgA deposition in renal allograft donors in Japan.

    abstract:BACKGROUND:Mesangial immunoglobulin A (IgA) deposition is incidentally encountered in asymptomatic individuals, but its precise frequency and significance had not been clarified. The background of the latent IgA deposition is related to the epidemiology and pathogenesis of IgA nephropathy. METHODS:Zero-hour allograft ...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Suzuki K,Honda K,Tanabe K,Toma H,Nihei H,Yamaguchi Y

    更新日期:2003-06-01 00:00:00

  • Effects of sex hormones on fluid and solute transport in Madin-Darby canine kidney cells.

    abstract::Polycystic kidney disease progresses more rapidly in men than in women. To investigate the basis for this sexual dimorphism, we exposed Madin-Darby canine kidney (MDCK) cells grown on collagen-coated cell culture inserts to control media, or to estradiol or testosterone (1 nM-1 microM). Compared to control and estradi...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Sandhu S,Silbiger SR,Lei J,Neugarten J

    更新日期:1997-05-01 00:00:00

  • Small proteoglycans of normal adult human kidney: distinct expression patterns of decorin, biglycan, fibromodulin, and lumican.

    abstract:BACKGROUND:Among the members of the small leucine-rich proteoglycan family, decorin, biglycan, and fibromodulin have been proposed to be potent modulators of transforming growth factor-beta (TGF-beta) activity, thereby playing an important role in the pathogenesis of fibrotic kidney diseases. Furthermore, decorin expre...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Schaefer L,Gröne HJ,Raslik I,Robenek H,Ugorcakova J,Budny S,Schaefer RM,Kresse H

    更新日期:2000-10-01 00:00:00

  • The growth of acute kidney injury: a rising tide or just closer attention to detail?

    abstract::Acute kidney injury (AKI), previously termed acute renal failure, is associated with increased mortality, prolonged hospital stay, and accelerated chronic kidney disease (CKD). Over the past 2 decades, dramatic rises in the incidences of AKI have been reported, particularly within the United States. The question arise...

    journal_title:Kidney international

    pub_type: 杂志文章,评审


    authors: Siew ED,Davenport A

    更新日期:2015-01-01 00:00:00

  • What is the place of peritoneal dialysis in the integrated treatment of renal failure?

    abstract::The role of peritoneal dialysis (PD) in renal replacement therapy (RRT) remains unclear. There are no controlled trials to provide hard evidence of its efficacy. Comparative studies with haemodialysis from different centres and countries have given conflicting results even when allowing for case mix. Data from the Uni...

    journal_title:Kidney international

    pub_type: 杂志文章,评审


    authors: Coles GA,Williams JD

    更新日期:1998-12-01 00:00:00

  • Comparative effectiveness of incident oral antidiabetic drugs on kidney function.

    abstract::Diabetes is a major cause of chronic kidney disease, and oral antidiabetic drugs are the mainstay of therapy for most patients with Type 2 diabetes. Here we evaluated their role on renal outcomes by using a national Veterans Administration database to assemble a retrospective cohort of 93,577 diabetic patients who fil...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Hung AM,Roumie CL,Greevy RA,Liu X,Grijalva CG,Murff HJ,Ikizler TA,Griffin MR

    更新日期:2012-04-01 00:00:00

  • Long-term risk of adverse outcomes after acute kidney injury: a systematic review and meta-analysis of cohort studies using consensus definitions of exposure.

    abstract::Reliable estimates of the long-term outcomes of acute kidney injury (AKI) are needed to inform clinical practice and guide allocation of health care resources. This systematic review and meta-analysis aimed to quantify the association between AKI and chronic kidney disease (CKD), end-stage kidney disease (ESKD), and d...

    journal_title:Kidney international

    pub_type: 杂志文章,meta分析


    authors: See EJ,Jayasinghe K,Glassford N,Bailey M,Johnson DW,Polkinghorne KR,Toussaint ND,Bellomo R

    更新日期:2019-01-01 00:00:00

  • CD154-CD40 T-cell co-stimulation pathway is a key mechanism in kidney ischemia-reperfusion injury.

    abstract::Ischemia-reperfusion occurs in a great many clinical settings and contributes to organ failure or dysfunction. CD154-CD40 signaling in leukocyte-endothelial cell interactions or T-cell activation facilitates tissue inflammation and injury. Here we tested a siRNA anti-CD40 in rodent warm and cold ischemia models to che...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: de Ramon L,Ripoll E,Merino A,Lúcia M,Aran JM,Pérez-Rentero S,Lloberas N,Cruzado JM,Grinyó JM,Torras J

    更新日期:2015-09-01 00:00:00

  • First responders: understanding monocyte-lineage traffic in the acutely injured kidney.

    abstract::Interstitial monocytic infiltration of the kidney occurs within hours of acute kidney injury and is an important determinant of functional decline and fibrosis. Li et al. used several surface markers to distinguish between dendritic cells and inflammatory monocytes following acute kidney injury and to identify two che...

    journal_title:Kidney international

    pub_type: 评论,杂志文章


    authors: Swaminathan S,Griffin MD

    更新日期:2008-12-01 00:00:00

  • Gene delivery using human cord blood-derived CD34+cells into inflamed glomeruli in NOD/SCID mice.

    abstract:BACKGROUND:Bone marrow reconstitution using genetically-modified hematopoietic stem cells has been reported to confer resistance to inflammation and prevent renal injury in glomerulonephritis. Although this strategy has potentials for clinical use, taking hematopoietic stem cells from bone marrow is highly stressful fo...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Yokoo T,Ohashi T,Utsunomiya Y,Okamoto A,Suzuki T,Shen JS,Tanaka T,Kawamura T,Hosoya T

    更新日期:2003-07-01 00:00:00

  • Glycated and carboxy-methylated proteins do not directly activate human vascular smooth muscle cells.

    abstract:BACKGROUND:Advanced glycation end products (AGEs) accumulate in patients with diabetes, particularly at sites of vascular damage and within atherosclerotic lesions, but whether they have direct actions on vascular smooth muscle cells (VSMCs) is controversial. METHODS:AGEs were constructed and characterized by protein ...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Ballinger ML,Thomas MC,Nigro J,Ivey ME,Dilley RJ,Little PJ

    更新日期:2005-12-01 00:00:00

  • Differences in tolerance for health risk to the living donor among potential donors, recipients, and transplant professionals.

    abstract::In organ donation, the donor, recipient, and transplant team must all accept potential health risks to the donor and any uncertainties. To gauge these risks, we surveyed general altruism and risk-taking behaviors in 112 potential donors, 111 potential recipients, and 51 transplant professionals. Next, participants ind...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Young A,Karpinski M,Treleaven D,Waterman A,Parikh CR,Thiessen-Philbrook H,Yang RC,Garg AX

    更新日期:2008-05-01 00:00:00

  • The cystic fibrosis transmembrane conductance regulator mediates transepithelial fluid secretion by human autosomal dominant polycystic kidney disease epithelium in vitro.

    abstract::Transepithelial fluid secretion promotes the progressive enlargement of cysts in autosomal dominant polycystic kidney disease (ADPKD). Recent indirect evidence indicated that active chloride transport may drive net fluid secretion in cultures of epithelia derived from ADPKD cysts. We now report that forskolin, which s...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Davidow CJ,Maser RL,Rome LA,Calvet JP,Grantham JJ

    更新日期:1996-07-01 00:00:00

  • Inverted formin 2 mutations with variable expression in patients with sporadic and hereditary focal and segmental glomerulosclerosis.

    abstract::Focal and segmental glomerulosclerosis (FSGS) is a major cause of end-stage kidney disease. Recent advances in molecular genetics show that defects in the podocyte play a major role in its pathogenesis and mutations in inverted formin 2 (INF2) cause autosomal dominant FSGS. In order to delineate the role of INF2 mutat...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Gbadegesin RA,Lavin PJ,Hall G,Bartkowiak B,Homstad A,Jiang R,Wu G,Byrd A,Lynn K,Wolfish N,Ottati C,Stevens P,Howell D,Conlon P,Winn MP

    更新日期:2012-01-01 00:00:00

  • Similar patient survival following kidney allograft failure compared with non-transplanted patients.

    abstract::Data from the national French Renal Epidemiology and Information Network (REIN) registry were used to compare survival between transplant recipients under age 65 who resumed dialysis after graft failure during 2007-2009 and transplant-naïve incident dialysis patients matched for age, gender, diabetes mellitus, and yea...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Mourad G,Minguet J,Pernin V,Garrigue V,Peraldi MN,Kessler M,Jacquelinet C,Couchoud C,Duny Y,Daurès JP

    更新日期:2014-07-01 00:00:00

  • Genotype-based changes in serum uric acid affect blood pressure.

    abstract::Elevated serum levels of uric acid consistently correlate with hypertension, but the directionality of the association remains debated. To help define this relationship, we used a controlled setting within a homogeneous Amish community and the Mendelian randomization of a nonsynonymous coding single-nucleotide polymor...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Parsa A,Brown E,Weir MR,Fink JC,Shuldiner AR,Mitchell BD,McArdle PF

    更新日期:2012-03-01 00:00:00

  • Differential proteomic analysis of proteins induced by glucocorticoids in cultured murine podocytes.

    abstract:BACKGROUND:The glomerular podocyte is the kidney cell most affected during the development of nephrotic syndrome, and mutations in podocyte proteins are responsible for a variety of inherited forms of nephrotic syndrome. Although glucocorticoids are a primary treatment for nephrotic syndrome, neither their target cell ...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Ransom RF,Vega-Warner V,Smoyer WE,Klein J

    更新日期:2005-04-01 00:00:00

  • The severity of acute kidney injury predicts progression to chronic kidney disease.

    abstract::Acute kidney injury (AKI) is associated with progression to advanced chronic kidney disease (CKD). We tested whether patients who survive AKI and are at higher risk for CKD progression can be identified during their hospital admission, thus providing opportunities to intervene. This was assessed in patients in the Dep...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Chawla LS,Amdur RL,Amodeo S,Kimmel PL,Palant CE

    更新日期:2011-06-01 00:00:00

  • TNF-alpha and IL-1beta-mediated regulation of MMP-9 and TIMP-1 in renal proximal tubular cells.

    abstract:BACKGROUND:Tubulointerstitial fibrosis is a morphologic hallmark of chronic kidney disease and is a key factor in the prediction of progression to end-stage renal failure. Disruption of tubular basement membrane and interstitial extracellular matrix (ECM) via cytokine-induced alterations in matrix metalloproteinases (M...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Nee LE,McMorrow T,Campbell E,Slattery C,Ryan MP

    更新日期:2004-10-01 00:00:00

  • Circulating luteinizing hormone receptor inhibitor(s) in boys with chronic renal failure.

    abstract::Patients with chronic renal failure frequently have hypogonadism. To elucidate the molecular mechanisms involved, we tested the ability of serum from these patients to inhibit recombinant human luteinizing hormone receptors. Using a cell line expressing functional human luteinizing hormone receptors, we found that ade...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Dunkel L,Raivio T,Laine J,Holmberg C

    更新日期:1997-03-01 00:00:00

  • Immune evasion in renal cell carcinoma: biology, clinical translation, future directions.

    abstract::Targeted therapies and immune checkpoint inhibitors have advanced the treatment landscape of Renal Cell Carcinoma (RCC) over the last decade. While checkpoint inhibitors have demonstrated survival benefit and are currently approved in the front-line and second-line settings, primary and secondary resistance is common....

    journal_title:Kidney international

    pub_type: 杂志文章,评审


    authors: Wang X,Lopez R,Luchtel RA,Hafizi S,Gartrell B,Shenoy N

    更新日期:2021-01-01 00:00:00

  • Lipopolysaccharide-induced MCP-1 gene expression in rat tubular epithelial cells is nuclear factor-kappaB dependent.

    abstract:BACKGROUND:Endotoxin is an important factor in the development of acute renal failure related to infection and in acceleration of chronic nephritis. Lipopolysaccharide (LPS; the major component of endotoxin) is one of the most potent triggers for renal cells to produce monocyte chemoattractant protein-1 (MCP-1), a key ...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Wang Y,Rangan GK,Goodwin B,Tay YC,Harris DC

    更新日期:2000-05-01 00:00:00

  • Nitric oxide enhances paracellular permeability of opossum kidney cells.

    abstract:BACKGROUND:Nitric oxide (NO) has been shown to be a paracrine/autocrine regulator of proximal tubular transport. In this study, we investigated the effect of NO on the paracellular permeability of opossum kidney (OK) cells, a proximal tubule cell line that possesses a leaky paracellular pathway resembling that of the i...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Liang M,Knox FG

    更新日期:1999-06-01 00:00:00

  • Deletion of scavenger receptor A protects mice from progressive nephropathy independent of lipid control during diet-induced hyperlipidemia.

    abstract::Scavenger receptor A (SR-A) is a key transmembrane receptor in the endocytosis of lipids and contributes to the pathogenesis of atherosclerosis. To assess its role in hyperlipidemic chronic kidney disease, wild-type and SR-A-deficient (knockout) mice underwent uninephrectomy followed by either normal or high-fat diet....

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Wang W,He B,Shi W,Liang X,Ma J,Shan Z,Hu Z,Danesh FR

    更新日期:2012-05-01 00:00:00

  • Apolipoproteins and lipoprotein receptors in glomeruli in human kidney diseases.

    abstract::This study offers morphological evidence of the involvement of lipid abnormalities in human glomerular injury. Renal biopsy tissues from patients with several types of glomerular diseases were immunocytochemically examined using antibodies to apolipoproteins (apo) A-I, B-100, and E, and antibodies to low density lipop...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Takemura T,Yoshioka K,Aya N,Murakami K,Matumoto A,Itakura H,Kodama T,Suzuki H,Maki S

    更新日期:1993-04-01 00:00:00