Theophylline prevents the hypoxemia-induced renal hemodynamic changes in rabbits.

Abstract:

:The acute renal effects of hypoxemia and the ability of theophylline to prevent these effects were assessed in anesthetized and mechanically-ventilated newborn and adult rabbits. Renal blood flow (RBF) and glomerular filtration rate (GFR) were determined by the clearance of para-aminohippuric acid and inulin, respectively. Each animal acted as his own control. In 14 newborn rabbits (group 1), hypoxemia was significantly associated with a fall in GFR (-22 +/- 6%) and filtration fraction (-17 +/- 3%) and with an increase in renal vascular resistance (+13 +/- 6%). Hypoxemia also induced a significant decline in GFR (-27 +/- 6%) and RBF (-29 +/- 6%) in 7 adult rabbits (group 3). Intravenous theophylline (0.5 mg/kg) completely prevented the hypoxemia-induced changes in GFR, filtration fraction (FF) and renal vascular resistance (RVR) in 8 newborn rabbits (group 2). An intravenous dose of 2.4 mg theophylline given after the induction of hypoxemia partially reversed the drop in GFR in adult rabbits (group 3). Separate renal functions were studied in 8 additional adult rabbits (group 4). Low-dose theophylline (27 micrograms/min) infused intra-arterially in the left kidney partially prevented the hypoxemia-induced decline in urine flow rate, GFR, RBF, FF as well as the increase in renal vascular resistance. The beneficial effects of theophylline could be mediated by its adenosine antagonistic properties.

journal_name

Kidney Int

journal_title

Kidney international

authors

Gouyon JB,Guignard JP

doi

10.1038/ki.1988.114

subject

Has Abstract

pub_date

1988-06-01 00:00:00

pages

1078-83

issue

6

eissn

0085-2538

issn

1523-1755

pii

S0085-2538(15)34287-3

journal_volume

33

pub_type

杂志文章
  • Mechanisms of altered renal perfusion in the early stage of obstructive jaundice.

    abstract::Mechanisms responsible for renal hemodynamic alterations were studied in jaundiced (by bile-duct ligation) rabbits (BDL) 10 days after ligation of the biliary tract, in comparison with sham-operated rabbits (SO). Arterial hematocrit, plasma volume, blood pressure, abdominal inferior vena cava pressure, and heart rate ...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.1980.25

    authors: Hishida A,Honda N,Sudo M,Nagase M

    更新日期:1980-02-01 00:00:00

  • Efficacy and tolerance of alpha-2b interferon therapy on HCV infection of hemodialyzed patients.

    abstract::A high frequency (25%) of anti-hepatitis C virus (HCV) antibodies is observed in French hemodialyzed patients; this is associated with detectable viremia in 85% and results in chronic hepatitis in more than 90%. We conducted a pilot study to examine the tolerance and efficacy of alpha-2b Interferon therapy upon HCV in...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.1995.198

    authors: Pol S,Thiers V,Carnot F,Zins B,Romeo R,Berthelot P,Bréchot C

    更新日期:1995-05-01 00:00:00

  • TGF-beta-activating kinase-1 inhibits cell cycle and expression of cyclin D1 and A in LLC-PK1 cells.

    abstract:BACKGROUND:Transforming growth factor-beta (TGF-beta) is known to play an important role in the pathophysiology of renal tubular disease. Researchers have recently identified a novel mitogen-activated protein kinase kinase kinase (MAPKKK), TAK (TGF-beta activated kinase)1, which stimulates the MKK3/6-p38K pathway. The ...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1046/j.1523-1755.1999.00665.x

    authors: Terada Y,Nakashima O,Inoshita S,Kuwahara M,Sasaki S,Marumo F

    更新日期:1999-10-01 00:00:00

  • Predicting renal survival in primary focal glomerulosclerosis from the time of presentation.

    abstract:UNLABELLED:Predicting renal survival in primary focal glomerulosclerosis from the time of presentation. BACKGROUND:To predict the risk of developing chronic renal failure in patients with primary focal glomerulosclerosis (FGS) using predictors available at the time of presentation, a retrospective analysis was perform...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/sj.ki.4491164

    authors: Chitalia VC,Wells JE,Robson RA,Searle M,Lynn KL

    更新日期:1999-12-01 00:00:00

  • Renoprotective effects of vitamin D analogs.

    abstract::Recent decades have witnessed the revelation of expanding roles of the vitamin D endocrine system beyond calcium and phosphorus metabolism. Along with these non-calcemic or non-classic actions of vitamin D are newly discovered therapeutic actions of vitamin D analogs in a number of pathological conditions, including k...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.2009.175

    authors: Li YC

    更新日期:2010-07-01 00:00:00

  • Thrombomodulin ameliorates transforming growth factor-β1-mediated chronic kidney disease via the G-protein coupled receptor 15/Akt signal pathway.

    abstract::Kidney fibrosis is the common consequence of chronic kidney diseases that inexorably progresses to end-stage kidney disease with organ failure treatable only with replacement therapy. Since transforming growth factor-β1 is the main player in the pathogenesis of kidney fibrosis, we posed the hypothesis that recombinant...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1016/j.kint.2020.05.041

    authors: Takeshita A,Yasuma T,Nishihama K,D'Alessandro-Gabazza CN,Toda M,Totoki T,Okano Y,Uchida A,Inoue R,Qin L,Wang S,D'Alessandro VF,Kobayashi T,Takei Y,Mizoguchi A,Yano Y,Gabazza EC

    更新日期:2020-11-01 00:00:00

  • Metabolomic study of cisplatin-induced nephrotoxicity.

    abstract::We have shown that cisplatin inhibits fatty acid oxidation, and that fibrate treatment ameliorates renal function by preventing the inhibition of fatty acid oxidation and proximal tubule cell death. Urine samples of mice treated with single injection of cisplatin (20 mg/kg body weight) were collected for 3 days and an...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/sj.ki.5000433

    authors: Portilla D,Li S,Nagothu KK,Megyesi J,Kaissling B,Schnackenberg L,Safirstein RL,Beger RD

    更新日期:2006-06-01 00:00:00

  • The prognosis of segmental glomerulonephritis in systemic lupus erythematosus.

    abstract::Severe segmental glomerulonephritis (Seg GN) (greater than or equal to 50% involvement) in systemic lupus erythematosus (SLE) is classified as diffuse GN (DPGN) in the WHO classification. We tested the validity of the assumption that severe Seg GN and DPGN have the same prognosis by determining the proportion of glome...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.1987.203

    authors: Schwartz MM,Kawala KS,Corwin HL,Lewis EJ

    更新日期:1987-08-01 00:00:00

  • Perioperative dexmedetomidine reduces the incidence and severity of acute kidney injury following valvular heart surgery.

    abstract::Acute kidney injury (AKI) following cardiac surgery is closely interrelated with hemodynamic instability and sympathetic activity, and adversely influences prognosis. Here, we investigated in a randomized placebo-controlled trial whether dexmedetomidine, an α2 adrenoreceptor agonist, could prevent AKI after valvular h...

    journal_title:Kidney international

    pub_type: 杂志文章,随机对照试验

    doi:10.1038/ki.2015.306

    authors: Cho JS,Shim JK,Soh S,Kim MK,Kwak YL

    更新日期:2016-03-01 00:00:00

  • Glomerular expression of neuronal activity-regulated pentraxin precedes the development of anti-Thy-1-induced progressive glomerulosclerosis.

    abstract::Although it is clear that genetic predispositions play a role in progressive glomerulosclerosis, identification of specific genes is difficult because of natural genetic heterogeneity among individuals. We have reported a differential susceptibility to progressive glomerulosclerosis after induction of experimental glo...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/sj.ki.5001757

    authors: Aben JA,Ijpelaar DH,Baelde H,Worley P,Noble N,Bruijn JA,de Heer E

    更新日期:2006-10-01 00:00:00

  • Association of short sleep duration and rapid decline in renal function.

    abstract::The kidney is influenced by circadian rhythms and is entrained to the sleep-wake cycle allowing anticipation of the metabolic and physiological demands of the kidney throughout a 24-hour cycle. Although sleep disruption has been studied extensively in cardiovascular and metabolic disease, its association with chronic ...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1016/j.kint.2015.12.048

    authors: McMullan CJ,Curhan GC,Forman JP

    更新日期:2016-06-01 00:00:00

  • Clinical trial recommendations for potential Alport syndrome therapies.

    abstract::Alport syndrome is experiencing a remarkable increase in preclinical investigations. To proactively address the needs of the Alport syndrome community, as well as offer clarity for future clinical research sponsors, the Alport Syndrome Foundation hosted a workshop to generate consensus recommendations for prospective ...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1016/j.kint.2020.02.029

    authors: Weinstock BA,Feldman DL,Fornoni A,Gross O,Kashtan CE,Lagas S,Lennon R,Miner JH,Rheault MN,Simon JF,Workshop Participants.

    更新日期:2020-06-01 00:00:00

  • High-dose erythropoietin has no effect on short- or long-term graft function following deceased donor kidney transplantation.

    abstract::We evaluated short- and long-term effects of high-dose recombinant human erythropoietin (rHuEPO) in kidney transplantation in a prospective double-blind, placebo-controlled study. Patients with chronic kidney disease following receipt of a deceased donor kidney allograft were randomized to 3 doses of 40,000 units rHuE...

    journal_title:Kidney international

    pub_type: 杂志文章,随机对照试验

    doi:10.1038/ki.2011.349

    authors: Hafer C,Becker T,Kielstein JT,Bahlmann E,Schwarz A,Grinzoff N,Drzymala D,Bonnard I,Richter N,Lehner F,Klempnauer J,Haller H,Traeder J,Fliser D

    更新日期:2012-02-01 00:00:00

  • Selective decrease of mRNAs encoding plasma membrane calcium pump isoforms 2 and 3 in rat kidney.

    abstract:BACKGROUND:Although the existence of multiple isoforms of plasma membrane calcium ATPase (PMCA) is now well documented, their biological functions are not yet known. In this study, we set out to investigate the potential role of PMCA isoforms, previously identified in renal cortical tissue, in tubular reabsorption of c...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1046/j.1523-1755.1999.00736.x

    authors: Caride AJ,Chini EN,Penniston JT,Dousa TP

    更新日期:1999-11-01 00:00:00

  • Hypoxia-inducible factor prolyl-4-hydroxylation in FOXD1 lineage cells is essential for normal kidney development.

    abstract::Hypoxia in the embryo is a frequent cause of intra-uterine growth retardation, low birth weight, and multiple organ defects. In the kidney, this can lead to low nephron endowment, predisposing to chronic kidney disease and arterial hypertension. A key component in cellular adaptation to hypoxia is the hypoxia-inducibl...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1016/j.kint.2017.06.015

    authors: Kobayashi H,Liu J,Urrutia AA,Burmakin M,Ishii K,Rajan M,Davidoff O,Saifudeen Z,Haase VH

    更新日期:2017-12-01 00:00:00

  • The SAM domain of ANKS6 has different interacting partners and mutations can induce different cystic phenotypes.

    abstract::The ankyrin repeat and sterile α motif (SAM) domain-containing six gene (Anks6) is a candidate for polycystic kidney disease (PKD). Originally identified in the PKD/Mhm(cy/+) rat model of PKD, the disease is caused by a mutation (R823W) in the SAM domain of the encoded protein. Recent studies support the etiological r...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.2015.122

    authors: Bakey Z,Bihoreau MT,Piedagnel R,Delestré L,Arnould C,de Villiers Ad,Devuyst O,Hoffmann S,Ronco P,Gauguier D,Lelongt B

    更新日期:2015-08-01 00:00:00

  • Renal vascular sclerosis is associated with inherited thrombophilias.

    abstract::Vascular sclerosis is often seen in renal biopsies. It is usually associated with diabetes mellitus, hypertension, smoking, etc. However, whether inherited thrombophilic states such as factor V gene mutation, prothrombin gene mutation, and methylenetetrahydrofolate reductase (MTHFR) gene mutation are associated with t...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/sj.ki.5001551

    authors: Goforth RL,Rennke H,Sethi S

    更新日期:2006-08-01 00:00:00

  • Adiponectin in renal disease: relationship to phenotype and genetic variation in the gene encoding adiponectin.

    abstract:BACKGROUND:The prevalence of cardiovascular disease (CVD) and inflammation is high in patients with end-stage renal disease (ESRD). Adiponectin is an adipocytokine that may have significant anti-inflammatory and anti-atherosclerotic effects. Low adiponectin levels have previously been found in patients with high risk f...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1111/j.1523-1755.2004.00370.x

    authors: Stenvinkel P,Marchlewska A,Pecoits-Filho R,Heimbürger O,Zhang Z,Hoff C,Holmes C,Axelsson J,Arvidsson S,Schalling M,Barany P,Lindholm B,Nordfors L

    更新日期:2004-01-01 00:00:00

  • Targeted proximal tubule injury triggers interstitial fibrosis and glomerulosclerosis.

    abstract::Chronic kidney disease (CKD) remains one of the leading causes of death in the developed world, and acute kidney injury (AKI) is now recognized as a major risk factor in its development. Understanding the factors leading to CKD after acute injury are limited by current animal models of AKI, which concurrently target v...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.2012.20

    authors: Grgic I,Campanholle G,Bijol V,Wang C,Sabbisetti VS,Ichimura T,Humphreys BD,Bonventre JV

    更新日期:2012-07-01 00:00:00

  • Leukocyte and serum S100A8/S100A9 expression reflects disease activity in ANCA-associated vasculitis and glomerulonephritis.

    abstract::Antineutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) commonly results in glomerulonephritis, in which neutrophils and monocytes have important roles. The heterodimer calprotectin (S100A8/S100A9, mrp8/14) is a Toll-like receptor-4 ligand found in neutrophils and monocytes and is elevated in inflammatory...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.2013.2

    authors: Pepper RJ,Hamour S,Chavele KM,Todd SK,Rasmussen N,Flint S,Lyons PA,Smith KG,Pusey CD,Cook HT,Salama AD

    更新日期:2013-06-01 00:00:00

  • Subtotal nephrectomy alters tubular function: effect of phosphorus restriction.

    abstract::Few studies have examined tubular function after subtotal nephrectomy (Nx) and conservative treatments. The effects of 70% and 80% Nx (associated with dietary phosphate restriction in the latter case) on the apical brush border membrane (BBM) enzymes 5'-nucleotidase, gamma glutamyl-transferase and alkaline-phosphatase...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.1997.485

    authors: Laouari D,Friedlander G,Burtin M,Silve C,Dechaux M,Garabedian M,Kleinknecht C

    更新日期:1997-12-01 00:00:00

  • Low parathyroid hormone status induced by high dialysate calcium is an independent risk factor for cardiovascular death in hemodialysis patients.

    abstract::Here we studied a possible association between low parathyroid hormone (PTH) status and mortality in incident patients undergoing hemodialysis . A total of 1983 patients were included at baseline and prospectively followed for 24 months. Patients were classified according to their Kidney Disease: Improving Global Outc...

    journal_title:Kidney international

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.kint.2015.12.001

    authors: Merle E,Roth H,London GM,Jean G,Hannedouche T,Bouchet JL,Drüeke T,Fouque D,Daugas E,French Calcium and Phosphate Observatory.

    更新日期:2016-03-01 00:00:00

  • A micropuncture study of renal sodium retention in nephrotic syndrome in rats: evidence for increased resistance to tubular fluid flow.

    abstract::Micropuncture studies were carried out in surface nephrons of rats with nephrotoxic-serum (NTS)-induced nephrotic syndrome during a period of active sodium and water retention. It was found that hydrostatic pressure and tubular diameter were increased in the proximal tubules (13.4 +/- 0.2 vs. 10.4 +/- 0.2 mm Hg; 31.3 ...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.1979.166

    authors: Kuroda S,Aynedjian HS,Bank N

    更新日期:1979-11-01 00:00:00

  • Identification of a clinically relevant immunodominant region of collagen IV in Goodpasture disease.

    abstract:BACKGROUND:The characteristic feature of Goodpasture disease is the occurrence of an autoantibody response to the noncollagenous domain of the alpha3 chain of type IV collagen [alpha3(IV)NC1] in the alveolar and glomerular basement membrane. These antibodies are associated with the development of a rapidly progressive ...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1046/j.1523-1755.1999.055003936.x

    authors: Hellmark T,Segelmark M,Unger C,Burkhardt H,Saus J,Wieslander J

    更新日期:1999-03-01 00:00:00

  • High glucose can induce lipid peroxidation in the isolated rat glomeruli.

    abstract::The present study examined the effect of elevated glucose on glomerular cell membrane lipid peroxidation. Glomeruli were isolated from male Sprague-Dawley rat kidneys utilizing a standard sieving method and incubated in medium containing different concentrations of glucose at 37 degrees C for one and 48 hours. The lev...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.1994.461

    authors: Ha H,Yoon SJ,Kim KH

    更新日期:1994-12-01 00:00:00

  • A role for novel cell-cycle proteins in podocyte biology.

    abstract::Cell-cycle proteins influence almost all aspects of embryogenesis and differentiation. In adults, these proteins control cell division and regeneration after injury. During the past several years, their roles in controlling reaction to stress have been demonstrated in several organ systems. In the kidney, the cell typ...

    journal_title:Kidney international

    pub_type: 杂志文章,评审

    doi:10.1038/ki.2009.562

    authors: Price PM

    更新日期:2010-04-01 00:00:00

  • Rapid, enhanced, and persistent protection of patients with renal insufficiency by AS02(V)-adjuvanted hepatitis B vaccine.

    abstract::The adjuvanted hepatitis B vaccine, HB-AS04, elicits more rapid and persistent protective antibody concentrations than double doses of conventional recombinant vaccines in patients with renal insufficiency. We compared the immunogenicity, reactogenicity, and safety of the AS02(V)-adjuvanted hepatitis B vaccine HB-AS02...

    journal_title:Kidney international

    pub_type: 杂志文章,随机对照试验

    doi:10.1038/ki.2009.454

    authors: Surquin M,Tielemans CL,Kulcsár I,Ryba M,Vörös P,Mat O,Treille S,Dhaene M,Stolear JC,Kuriyakose SO,Leyssen MX,Houard SA

    更新日期:2010-02-01 00:00:00

  • Severe defect in clearing postprandial chylomicron remnants in dialysis patients.

    abstract::Lipid abnormalities have been suggested as a major cause of the accelerated atherosclerosis and the high incidence of coronary heart disease in chronic renal failure patients. In the present work the postprandial lipoprotein metabolism was studied in chronic dialysis patients with or without fasting hypertriglyceridem...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.1992.411

    authors: Weintraub M,Burstein A,Rassin T,Liron M,Ringel Y,Cabili S,Blum M,Peer G,Iaina A

    更新日期:1992-11-01 00:00:00

  • The Oxford classification of IgA nephropathy: pathology definitions, correlations, and reproducibility.

    abstract::Pathological classifications in current use for the assessment of glomerular disease have been typically opinion-based and built on the expert assumptions of renal pathologists about lesions historically thought to be relevant to prognosis. Here we develop a unique approach for the pathological classification of a glo...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.2009.168

    authors: Working Group of the International IgA Nephropathy Network and the Renal Pathology Society.,Roberts IS,Cook HT,Troyanov S,Alpers CE,Amore A,Barratt J,Berthoux F,Bonsib S,Bruijn JA,Cattran DC,Coppo R,D'Agati V,D'Amico G,Emanci

    更新日期:2009-09-01 00:00:00

  • Modulation of salt transport rate affects DNA synthesis in vivo in rat renal tubules.

    abstract::In adult male Wistar rats we investigated whether cell proliferation contributes to salt load-induced hypertrophy of distal tubules. In one treatment group salt transport in the thick ascending limb (TAL) was inhibited by furosemide (7.5 mg/100 g body wt/24 hr, via osmotic minipump) and stimulated in the successive di...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.1995.225

    authors: Loffing J,Le Hir M,Kaissling B

    更新日期:1995-06-01 00:00:00