Roscovitine blocks collecting duct cyst growth in Cep164-deficient kidneys.

abstract：:The Diabetes Control and Complications Trial (DCCT) has demonstrated that intensive diabetes treatment delays the onset and slows the progression of retinopathy, nephropathy, and neuropathy in patients with IDDM. A detailed description of the effects of this treatment on diabetic nephropathy is presented here. In the ...

journal_title：Kidney international

authors：

更新日期：1995-06-01 00:00:00

abstract：:From August 1987 through February 1995 we performed 42 surgical procedures in 29 patients with occluded or stenotic radiocephalic arteriovenous fistulae. Operations were designed to preserve native veins for cannulation (Group I) or to preserve access in the same forearm, bypassing the failed fistula (Group II). For 2...

journal_title：Kidney international

authors： Oakes DD,Sherck JP,Cobb LF

更新日期：1998-02-01 00:00:00

abstract：:The development of effective therapies for acute kidney injury (AKI) has been hindered by delayed diagnosis in the clinical setting, varying definitions of AKI, and limited prognostic information. In a study by Portilla et al., elevations in liver fatty acid-binding protein (L-FABP) were found to predict AKI in childr...

journal_title：Kidney international

authors： Thurman JM,Parikh CR

更新日期：2008-02-01 00:00:00

abstract：:Glomerular podocytes are terminally differentiated cells, and podocyte loss is a common feature of progressive renal pathologies. In this issue, Romoli et al. focus on podocyte progenitors that were proposed to reside in the Bowman's capsule. They demonstrate that suppression of CXCL12/CXCR4 signaling activates pariet...

journal_title：Kidney international

authors： Massa F,Schedl A

更新日期：2018-12-01 00:00:00

abstract：:Many transgenic and knockout mice with increased urine flow have structural abnormalities of the renal pelvis and inner medulla. Here, we used high resolution contrast enhanced T1-weighted magnetic resonance imaging of mice whose urea transporters UT-A1 and UT-A3 were deleted (UT-A1/3(-/-) mice) as a model for the in ...

journal_title：Kidney international

authors： Jacob VA,Harbaugh CM,Dietz JR,Fenton RA,Kim SM,Castrop H,Schnermann J,Knepper MA,Chou CL,Anderson SA

更新日期：2008-11-01 00:00:00

abstract：:The soluble receptor of advanced glycation end product (sRAGE) prevents vascular damage in experimental animal models, and observational studies in the general population support the hypothesis that sRAGE may exert a protective role on the vasculature. To test this in patients with chronic kidney disease, we determine...

journal_title：Kidney international

authors： Basta G,Leonardis D,Mallamaci F,Cutrupi S,Pizzini P,Gaetano L,Tripepi R,Tripepi G,De Caterina R,Zoccali C

更新日期：2010-02-01 00:00:00

abstract：:Angiotensin converting enzyme (ACE) inhibitors are known to lower urinary protein excretion in human renal disease. This proteinuria lowering effect of ACE inhibition has been hypothesized to be a result of renal hemodynamic changes due to the inhibition of angiotensin II (Ang II) production. To test this hypothesis w...

journal_title：Kidney international

authors： Heeg JE,de Jong PE,van der Hem GK,de Zeeuw D

更新日期：1991-10-01 00:00:00

abstract：BACKGROUND:Cardiovascular disease is known to be the most important complication among patients with renal failure, and oxidative stress has been proposed to play a major role as the source of such complications. Human serum albumin (HSA) is composed of human mercaptoalbumin (HMA) with cysteine residues having reducing...

journal_title：Kidney international

authors： Terawaki H,Yoshimura K,Hasegawa T,Matsuyama Y,Negawa T,Yamada K,Matsushima M,Nakayama M,Hosoya T,Era S

更新日期：2004-11-01 00:00:00

abstract：:To investigate mechanisms underlying GFR control in diabetes mellitus, renal hemodynamics and segmental tubular handling of sodium, using lithium clearance, were assessed in 41 insulin-dependent diabetics (IDD) treated by insulin for 11 +/- 8 days, and in 19 normal controls. Average GFR and effective renal plasma flow...

journal_title：Kidney international

authors： Hannedouche TP,Delgado AG,Gnionsahe DA,Boitard C,Lacour B,Grünfeld JP

更新日期：1990-04-01 00:00:00

abstract：:In adults on chronic hemodialysis, achieving a hemoglobin concentration of 12g/dl and above with erythropoiesis stimulating agents leads to increased cardiovascular events and mortality, but this may not be true in children. Therefore, we conducted a retrospective cohort study of pediatric patients (under 18) from the...

journal_title：Kidney international

authors： Rheault MN,Molony JT,Nevins T,Herzog CA,Chavers BM

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Previous reports have shown the presence of erythrogenic toxin type B (ETB), apoptosis, proliferation, and leukocyte infiltration in biopsies from patients with acute poststreptococcal glomerulonephritis (APSGN). METHODS:Attempting to correlate the apoptotic and proliferative events with the interaction of ...

journal_title：Kidney international

authors： Viera NT,Romero MJ,Montero MK,Rincon J,Mosquera JA

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND:The clinical use of cyclosporine (CsA) is limited by its nephrotoxicity. Apoptosis, perhaps instigated by increased nitric oxide synthase (NOS) activity, may play a role in such toxicity. METHODS:Human mesangial cells, human tubular cells, human umbilical vein endothelial cells, or murine endothelial cells ...

journal_title：Kidney international

authors： Amore A,Emancipator SN,Cirina P,Conti G,Ricotti E,Bagheri N,Coppo R

更新日期：2000-04-01 00:00:00

abstract：:The importance of the relationship between the alteration of podocytic processes (PP) and proteinuria has been controversial for almost 30 years. In spite of several morphometric studies the range of PP alterations in different proteinuric conditions has gone unnoticed. Thus, we studied the distribution of abnormally ...

journal_title：Kidney international

authors： Fries JW,Rumpelt HJ,Thoenes W

更新日期：1987-11-01 00:00:00

abstract：BACKGROUND:High-efficiency hemodialysis may induce a deficiency in hydrosoluble vitamins. Supplementation with B-complex vitamins has been shown to lower serum homocysteine concentrations in several groups, but relatively few studies have concerned hemodialysis patients. Our objectives were to determine the status in B...

journal_title：Kidney international

authors： Tremblay R,Bonnardeaux A,Geadah D,Busque L,Lebrun M,Ouimet D,Leblanc M

更新日期：2000-08-01 00:00:00

abstract：:The impact of dialysis on cognitive trends is uncertain. Kurella Tamura et al. evaluated cognitive trajectories in 212 participants from the Chronic Renal Insufficiency Cohort study and found that dialysis initiation was associated with a decline in executive function. This is consistent with a cerebrovascular basis f...

journal_title：Kidney international

authors： Iyasere O,Brown EA

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Vascular access failure is the main cause of morbidity in hemodialysis. Venous stenosis and subsequent thrombosis, as the result of intimal hyperplasia, is the major cause of vascular access failure. Intimal hyperplasia of the arteriovenous fistula (AVF) closely resembles the main histopathologic feature of ...

journal_title：Kidney international

authors： Grandaliano G,Teutonico A,Allegretti A,Losappio R,Mancini A,Gesualdo L,Schena FP,Pertosa G

更新日期：2003-08-01 00:00:00

abstract：BACKGROUND:The measurement of many parameters of human blood is usually performed in plasma or serum. Since lipoproteins or apolipoproteins, for example, are found almost exclusively in the plasma fraction after low-speed centrifugation, these parameters can be expected to be distributed in a different plasma volume de...

journal_title：Kidney international

authors： Kronenberg F,Trenkwalder E,Kronenberg MF,König P,Utermann G,Dieplinger H

更新日期：1998-10-01 00:00:00

abstract：:It is unknown whether the association between body mass index (BMI) and chronic kidney disease (CKD) is mediated by genetic confounding or obesity-associated diabetes. We investigated the association between BMI and incident CKD in 29,136 Swedish twins with no history of CKD or diabetes, first using traditional Cox re...

journal_title：Kidney international

authors： Xu H,Kuja-Halkola R,Chen X,Magnusson PKE,Svensson P,Carrero JJ

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Although peritoneal dialysis (PD) is a widely accepted form of renal replacement therapy (RRT), concerns remain regarding the bioincompatible nature of standard PD fluid. In order to evaluate whether a newly formulated fluid of neutral pH, and containing low levels of glucose degradation products (GDP), resu...

journal_title：Kidney international

authors： Williams JD,Topley N,Craig KJ,Mackenzie RK,Pischetsrieder M,Lage C,Passlick-Deetjen J,Euro Balance Trial Group.

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND:Bicarbonate reabsorption in the kidney proximal tubule is predominantly mediated via the apical Na+/H+ exchanger (NHE-3) and basolateral Na+: HCO(-3) cotransporter (NBC-1). The purpose of these studies was to examine the effects of Na+ load and altered acid-base status on the expression of NHE-3 and NBC-1 in...

journal_title：Kidney international

authors： Amlal H,Chen Q,Greeley T,Pavelic L,Soleimani M

更新日期：2001-11-01 00:00:00

abstract：BACKGROUND:Although apoptosis has been linked to the renal cell deletion and ensuing renal fibrosis, its regulating mechanisms remain obscure. Of the known regulators of apoptosis, the best characterized is the Bax to Bcl-2 ratio. However, its importance in controlling apoptosis in glomerulonephritis is unclear. Here, ...

journal_title：Kidney international

authors： Yang B,Johnson TS,Thomas GL,Watson PF,Wagner B,Furness PN,El Nahas AM

更新日期：2002-10-01 00:00:00

abstract：:Podocytes are highly differentiated cells that play an important role in maintaining glomerular filtration barrier integrity; a function regulated by small GTPase proteins of the Rho family. To investigate the role of Rho A in podocyte biology, we created transgenic mice expressing doxycycline-inducible constitutively...

journal_title：Kidney international

authors： Wang L,Ellis MJ,Gomez JA,Eisner W,Fennell W,Howell DN,Ruiz P,Fields TA,Spurney RF

更新日期：2012-06-01 00:00:00

abstract：:Prostaglandin E2 (PGE2) may be an important negative feedback modulator of endothelin-1 (ET-1)-stimulated mesangial cell proliferation and contraction. Recent studies suggest that ET-1 may induce prolonged mesangial cell PGE2 production, however the mechanism of this effect is unknown. The current study was undertaken...

journal_title：Kidney international

authors： Hughes AK,Padilla E,Kutchera WA,Michael JR,Kohan DE

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:It is not known whether angiotensin-converting-enzyme (ACE) inhibitors slow the progression of polycystic kidney disease (PKD). We performed a patient-level meta-analysis to compare the effect of antihypertensive regimens, including ACE inhibitors, to those without ACE inhibitors (controls) on kidney disease...

journal_title：Kidney international

authors： Jafar TH,Stark PC,Schmid CH,Strandgaard S,Kamper AL,Maschio G,Becker G,Perrone RD,Levey AS,ACE Inhibition in Progressive Renal Disease (AIPRD) Study Group.

更新日期：2005-01-01 00:00:00

abstract：:The impact of high-flux hemodialysis on clinical outcomes remains controversial. We have previously shown that in vivo transmigrated leukocytes from patients with low-flux bioincompatible hemodialysis have an impaired capacity to upregulate CD11b at the site of interstitial inflammation. In the present study, we inves...

journal_title：Kidney international

authors： Olsson J,Dadfar E,Paulsson J,Lundahl J,Moshfegh A,Jacobson SH

更新日期：2007-03-01 00:00:00

abstract：:In previous studies from this laboratory it has been shown that ATP-ase activity in situ in the glomerular basement membrane (GBM) is clearly reduced in rats rendered nephrotic after treatment with adriamycin (ADR). The question was raised whether this reduction of ATP-ase activity in the GBM is due to toxic activity ...

journal_title：Kidney international

authors： Bakker WW,Kalicharan D,Donga J,Hulstaert CE,Hardonk MJ

更新日期：1987-03-01 00:00:00

abstract：:Osteocytes within the mineralized bone matrix control bone remodeling by regulating osteoblast and osteoclast activity. Osteocytes express the aging suppressor Klotho, but the functional role of this protein in skeletal homeostasis is unknown. Here we identify Klotho expression in osteocytes as a potent regulator of b...

journal_title：Kidney international

authors： Komaba H,Kaludjerovic J,Hu DZ,Nagano K,Amano K,Ide N,Sato T,Densmore MJ,Hanai JI,Olauson H,Bellido T,Larsson TE,Baron R,Lanske B

更新日期：2017-09-01 00:00:00

abstract：:To test the hypothesis that systemic administration of immunoglobulin might reduce glomerular injury in membranous nephropathy through mechanisms involving inhibition of complement activation, we studied the passive Heymann nephritis (PHN) model of membranous nephropathy in rats. The daily administration of immunoglob...

journal_title：Kidney international

authors： Nangaku M,Pippin J,Richardson CA,Schulze M,Young BA,Alpers CE,Gordon KL,Johnson RJ,Couser WG

更新日期：1996-12-01 00:00:00

abstract：:Renal iron handling was characterized in three experimental models of the nephrotic syndrome: puromycin aminonucleoside, adriamycin and nephrotoxic serum. In adriamycin-induced nephrotic syndrome, which has previously been shown to result from alterations in pore size of the filtration barrier, the transferrin leak wa...

journal_title：Kidney international

authors： Alfrey AC,Hammond WS

更新日期：1990-06-01 00:00:00

abstract：BACKGROUND:Dialysis efficiency has a great influence on the outcome of patients. Few data are available on the removal of solutes with molecular weights higher than urea and creatinine. The aim of our study was to assess the transport and the removal of substances with molecular weights up to 15 kD and to evaluate the ...

journal_title：Kidney international

authors： Montini G,Amici G,Milan S,Mussap M,Naturale M,Rätsch IM,Ammenti A,Sorino P,Verrina E,Andreetta B,Zacchello G,Italian Registry of Pediatric Peritoneal Dialysis.

更新日期：2002-03-01 00:00:00