Angiotensin II does not acutely reverse the reduction of proteinuria by long-term ACE inhibition.

abstract：:We studied the adaptation to early (72 hr) and late (20 days) K loading (400 mmol/day, 4 equal meals every 6 hour) in six healthy humans. Throughout the study, each single K meal was followed by an acute transient rise in plasma K, aldosterone and kaliuresis. "K balance" (urinary K excretion approximately 80% of intak...

journal_title：Kidney international

authors： Rabelink TJ,Koomans HA,Hené RJ,Dorhout Mees EJ

更新日期：1990-11-01 00:00:00

abstract：:Calcitonin secretion is stimulated by acute hypercalcemia. Furthermore, in the rat, the calcemic response to parathyroid hormone (PTH) is decreased by calcitonin stimulation. However, in renal failure, it is not known if an increase in the serum calcium concentration within the physiologic range of serum calcium stimu...

journal_title：Kidney international

authors： Torres A,Rodriguez M,Felsenfeld A,Martin-Malo A,Llach F

更新日期：1991-10-01 00:00:00

abstract：BACKGROUND:Chemokine receptor 5 (CCR5) plays an important role in the recruitment of monocytes and T cells in inflammation and experimental studies suggest that CCR5 might be involved in the pathogenesis of IgA nephropathy. A mutation in the CCR5 gene (CCR5 Delta32), leading to a nonfunctional receptor, was recently de...

journal_title：Kidney international

authors： Panzer U,Schneider A,Steinmetz OM,Wenzel U,Barth P,Reinking R,Becker JU,Harendza S,Zahner G,Fischereder M,Krämer BK,Schlöndorff D,Ostendorf T,Floege J,Helmchen U,Stahl RA

更新日期：2005-01-01 00:00:00

abstract：:A second generation hepatitis C virus recombinant immunoblot assay (RIBA) was used to screen stored perioperative serum from 641 renal allograft recipients. One hundred and nine (17%) were anti-HCV positive at the time of transplant. RIBA positivity was found to be an independent predictor of post-transplant liver dis...

journal_title：Kidney international

authors： Roth D,Zucker K,Cirocco R,DeMattos A,Burke GW,Nery J,Esquenazi V,Babischkin S,Miller J

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:Hemodialysis access thrombosis is a significant cause of morbidity for hemodialysis patients and results from decreased access flow caused by venous outflow tract stenosis. Ultrasound dilution (UD) is a practical, noninvasive, and reliable indicator of access flow and is effective in predicting venous stenos...

journal_title：Kidney international

authors： Goldstein SL,Allsteadt A

更新日期：2001-06-01 00:00:00

abstract：:This study examined the consequences of nephrectomy in United States Army personnel who lost a kidney due to trauma during World War II (WWII). Records of 62 servicemen who underwent nephrectomy at an average age of 25 years were obtained. Mortality was compared with that of WWII servicemen of the same age. Medical re...

journal_title：Kidney international

authors： Narkun-Burgess DM,Nolan CR,Norman JE,Page WF,Miller PL,Meyer TW

更新日期：1993-05-01 00:00:00

abstract：:Kinetic parameters were studied to determine the effectiveness of hemoperfusion in removing ethychlorvynol from the plasma and red blood cells (RBC) of intoxicated dogs. Perfusion columns contained polystyrene/divinyl benzene resin (XAD-4 Amberlite. Column clearances of ethchlorvynol averaged 96.5 +/- 0.4% of the plas...

journal_title：Kidney international

authors： Zmuda MJ

更新日期：1980-03-01 00:00:00

abstract：:Experiments in rodents have demonstrated an important role for selectins in kidney ischemia-reperfusion injury (IRI). However, the relevance of this in larger mammals, as well as the impact on long-term structure and function is unknown. We tested the hypothesis that small molecule selectin ligand inhibition attenuate...

journal_title：Kidney international

authors： Jayle C,Milinkevitch S,Favreau F,Doucet C,Richer JP,Deretz S,Mauco G,Rabb H,Hauet T

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND:Population-genetic studies investigating genetic polymorphisms of Mendelian inheritance should always test whether the measured genotype frequencies deviate from the expected one. For this purpose Hardy-Weinberg (HW) criteria are generally used. If genotype distribution of control population misses HW equili...

journal_title：Kidney international

authors： Kocsis I,Györffy B,Németh E,Vásárhelyi B

更新日期：2004-05-01 00:00:00

abstract：:The relationship between commonly occurring genetic variants (G1 and G2) in the APOL1 gene in African Americans and different disease traits, such as kidney disease, cardiovascular disease, and pre-eclampsia, remains the subject of controversy. Here we took a genotype-first approach, a phenome-wide association study, ...

journal_title：Kidney international

authors： Bajaj A,Ihegword A,Qiu C,Small AM,Wei WQ,Bastarache L,Feng Q,Kember RL,Risman M,Bloom RD,Birtwell DL,Williams H,Shaffer CM,Chen J,Center RG,Denny JC,Rader DJ,Stein CM,Damrauer SM,Susztak K

更新日期：2020-05-01 00:00:00

abstract：:In adults on chronic hemodialysis, achieving a hemoglobin concentration of 12g/dl and above with erythropoiesis stimulating agents leads to increased cardiovascular events and mortality, but this may not be true in children. Therefore, we conducted a retrospective cohort study of pediatric patients (under 18) from the...

journal_title：Kidney international

authors： Rheault MN,Molony JT,Nevins T,Herzog CA,Chavers BM

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Crystals of calcium oxalate monohydrate (COM) and excess oxalate ions (OX) stimulate an array of responses inducing localized injury and inflammation in the kidneys. These inflammatory responses are key regulators of development of nephrolithiasis. We propose that monocyte chemoattractant protein-1 (MCP-1), ...

journal_title：Kidney international

authors： Umekawa T,Chegini N,Khan SR

更新日期：2002-01-01 00:00:00

abstract：:Previous studies in living animals have suggested that variations in the serum concentrations of calcium and phosphate directly affect renal tubular bicarbonate transport. To examine this area more directly, we measured the bicarbonate and the fluid transport in isolated rabbit proximal convoluted and straight tubules...

journal_title：Kidney international

authors： McKinney TD,Myers P

更新日期：1982-03-01 00:00:00

abstract：:Chronic kidney disease (CKD) promotes development of cardiac abnormalities and is highly prevalent in patients with heart failure, particularly in those with preserved ejection fraction. CKD is associated with endothelial dysfunction, however, whether CKD can induce impairment of endothelium-to-cardiomyocyte crosstalk...

journal_title：Kidney international

authors： Juni RP,Al-Shama R,Kuster DWD,van der Velden J,Hamer HM,Vervloet MG,Eringa EC,Koolwijk P,van Hinsbergh VWM

更新日期：2020-12-22 00:00:00

abstract：:Mitochondria are critical in determining a cell's energy homeostasis and fate, and mitochondrial dysfunction has been implicated in the pathogenesis of chronic kidney disease (CKD). We sought to identify causative mitochondrial microRNAs. A microarray screen of kidney tissue from healthy mice identified 97 microRNAs t...

journal_title：Kidney international

authors： Bai M,Chen H,Ding D,Song R,Lin J,Zhang Y,Guo Y,Chen S,Ding G,Zhang Y,Jia Z,Huang S,He JC,Yang L,Zhang A

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Increased venous pressure (VP) and decreased access flow (Qa) are predictors of dialysis access graft thrombosis. VP is easily obtainable. Qa assessment requires a special device and takes more time. The aims of our randomized multicenter studies were to compare outcome in patients with grafts monitored by V...

journal_title：Kidney international

authors： Smits JH,van der Linden J,Hagen EC,Modderkolk-Cammeraat EC,Feith GW,Koomans HA,van den Dorpel MA,Blankestijn PJ

更新日期：2001-04-01 00:00:00

abstract：:Current practice recommends metabolic evaluation of patients who have formed multiple renal stones, but not those with one stone or temporally remote stones. This presumes that recentness and recurrence imply greater risk of new future stones. We hypothesize that number of stones reflects how long patients are permitt...

journal_title：Kidney international

authors： Parks JH,Coe FL

更新日期：1994-06-01 00:00:00

abstract：:Management of idiopathic glomerular disease associated with nephrotic syndrome (INS) remains controversial and one of the most complex areas relates to utilization of the drug cyclosporin. This is despite its demonstrated effectiveness in several histologic types of the INS in randomized controlled trials. Cyclosporin...

journal_title：Kidney international

authors： Cattran DC,Alexopoulos E,Heering P,Hoyer PF,Johnston A,Meyrier A,Ponticelli C,Saito T,Choukroun G,Nachman P,Praga M,Yoshikawa N

更新日期：2007-12-01 00:00:00

abstract：:Aldosterone exerts its biological effects through binding to mineralocorticoid receptor (MR). Ligand binding induces a receptor transconformation within the ligand-binding domain and dissociation of associated proteins from the receptor. The ligand-activated receptor binds as a dimer to the response elements present i...

journal_title：Kidney international

authors： Hellal-Levy C,Fagart J,Souque A,Rafestin-Oblin ME

更新日期：2000-04-01 00:00:00

abstract：:The effects of chronic respiratory alkalosis on divalent ion homeostasis have not been reported in any species. We studied four normal male subjects during a four-day control period (residence at 500 m), during six days of chronic respiratory alkalosis induced by hypobaric hypoxia (residence at 3450 m), followed by a ...

journal_title：Kidney international

authors： Krapf R,Jaeger P,Hulter HN

更新日期：1992-09-01 00:00:00

abstract：BACKGROUND:Human immunodeficiency virus-associated nephropathy (HIVAN) has become the third leading cause of end-stage renal disease (ESRD) in African Americans, and is expected to grow exponentially. Highly active antiretroviral therapy (HAART) has significantly prolonged the survival of patients with HIV infection. D...

journal_title：Kidney international

authors： Kumar MS,Sierka DR,Damask AM,Fyfe B,McAlack RF,Heifets M,Moritz MJ,Alvarez D,Kumar A

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND:Transplantation of developing metanephroi into adult hosts has been proposed as a means to augment host renal function. METHODS:We implanted whole metanephroi from embryonic day 15 (E15) rats subcapsularly in kidneys or into the omentum of non-immunosupressed adult rat hosts. At the time of implantation, so...

journal_title：Kidney international

authors： Rogers SA,Lowell JA,Hammerman NA,Hammerman MR

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND:The aim of this study was to establish whether there is a differential effect of mode of dialysis, hemodialysis (HD), or continuous ambulatory peritoneal dialysis (CAPD) on the dyslipidemia of renal failure. METHODS:The lipoprotein profile was determined in 61 non-diabetic patients on chronic HD (N = 30) an...

journal_title：Kidney international

authors： Attman PO,Samuelsson OG,Moberly J,Johansson AC,Ljungman S,Weiss LG,Knight-Gibson C,Alaupovic P

更新日期：1999-04-01 00:00:00

abstract：:Kidney fibrosis is one of the most promising treatment targets in nephrology. To design effective treatment approaches, a detailed understanding of the initiating mechanisms is of great importance. Kim and Pandanilam now find that renal nerves are a major trigger for renal fibrosis. Both afferent and efferent nerve fi...

journal_title：Kidney international

authors： Boor P,Papasotiriou ME

更新日期：2015-02-01 00:00:00

abstract：:Murine double minute (MDM)-2, an E3 ubiquitin ligase, promotes cancer cell survival and growth, by degrading the cell cycle regulator p53. Antagonism of MDM2 by the small-molecule cis-imidazoline nutlin analogs is under current study for cancer therapy. To test whether MDM2 also promotes regenerative cell growth, we d...

journal_title：Kidney international

authors： Mulay SR,Thomasova D,Ryu M,Anders HJ

更新日期：2012-06-01 00:00:00

abstract：:Chronic inflammation is a complication of conventional hemodialysis that induces progressive cardiovascular damage. An apparently straightforward manipulation to treat this-removal of a large amount of uremic toxins by convection-has proven that the relationships between inflammation and convective techniques such as ...

journal_title：Kidney international

authors： Santoro A,Mancini E

更新日期：2014-08-01 00:00:00

abstract：:Determination of serum oxalate concentration is important for the diagnosis and monitoring of hyperoxalurias, and extends to patients with all types of renal disease. Approximately 5 to 10 ml of blood is required for each test by conventional methods, and the test is not adapted for use in children. We developed a hig...

journal_title：Kidney international

authors： Gaulier JM,Cochat P,Lardet G,Vallon JJ

更新日期：1997-12-01 00:00:00

abstract：:The renal handling of gentamicin in the rat was examined by clearance, microinjection, and renal cortical-slice techniques. The steady-state renal clearance of 14C-gentamicin, when corrected for the 7.5% binding to plasma protein, was not significantly different from that of 3H-inulin. At the end of the renal clearanc...

journal_title：Kidney international

authors： Pastoriza-Munoz E,Bowman RL,Kaloyanides GJ

更新日期：1979-10-01 00:00:00

abstract：INTRODUCTION:Monocyte chemoattractant protein-1 (MCP-1) promotes renal inflammation, thereby contributing to acute and chronic nephropathies. Its production is stimulated by oxidative stress. Thus, this study tested whether pro-oxidant iron/carbohydrate complexes, used to treat iron deficiency, induce MCP-1 in renal/ex...

journal_title：Kidney international

authors： Zager RA

更新日期：2005-10-01 00:00:00

abstract：:Hypertension is a well-known complication in children on renal replacement therapy and an important risk factor for cardiovascular disease in later life. In order to define the prevalence of and risk factors for hypertension among children, we enrolled 3337 pediatric patients from 15 countries in the ESPN/ERA-EDTA Reg...

journal_title：Kidney international

authors： Kramer AM,van Stralen KJ,Jager KJ,Schaefer F,Verrina E,Seeman T,Lewis MA,Boehm M,Simonetti GD,Novljan G,Groothoff JW

更新日期：2011-11-01 00:00:00