MDM2 (murine double minute-2) links inflammation and tubular cell healing during acute kidney injury in mice.

abstract：:Intestinal regulation of oxalate absorption is a complex mechanism, not exclusively reliant on the oxalate-degrading anaerobe Oxalobacter formigenes. Using metagenomics, Miller et al. were able to describe a network of bacterial taxa co-occurring with Oxalobacter formigenes in fecal samples from non-stone forming cont...

journal_title：Kidney international

authors： Ticinesi A,Nouvenne A,Meschi T

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:The National Kidney Foundation Dialysis Outcomes Quality Initiative (DOQI) clinical practice guidelines have suggested minimal weekly Kt/V urea and creatinine clearance goals for peritoneal dialysis patients maintained on continuous ambulatory peritoneal dialysis (CAPD) and automated peritoneal dialysis (APD...

journal_title：Kidney international

authors： Juergensen PH,Murphy AL,Pherson KA,Kliger AS,Finkelstein FO

更新日期：2000-06-01 00:00:00

abstract：:Rare autosomal dominant tubulointerstitial kidney disease is caused by mutations in the genes encoding uromodulin (UMOD), hepatocyte nuclear factor-1β (HNF1B), renin (REN), and mucin-1 (MUC1). Multiple names have been proposed for these disorders, including 'Medullary Cystic Kidney Disease (MCKD) type 2', 'Familial Ju...

journal_title：Kidney international

authors： Eckardt KU,Alper SL,Antignac C,Bleyer AJ,Chauveau D,Dahan K,Deltas C,Hosking A,Kmoch S,Rampoldi L,Wiesener M,Wolf MT,Devuyst O,Kidney Disease: Improving Global Outcomes.

更新日期：2015-10-01 00:00:00

abstract：:The importance of the relationship between the alteration of podocytic processes (PP) and proteinuria has been controversial for almost 30 years. In spite of several morphometric studies the range of PP alterations in different proteinuric conditions has gone unnoticed. Thus, we studied the distribution of abnormally ...

journal_title：Kidney international

authors： Fries JW,Rumpelt HJ,Thoenes W

更新日期：1987-11-01 00:00:00

abstract：:We reviewed the diagnostic features and clinical course of 140 patients with idiopathic membranous nephropathy who had their index renal biopsies performed at the Mayo Clinic between 1972 and 1984. There were 93 males and 47 females (average age, 50.8 +/- 17 years); 116 patients (83%) had the nephrotic syndrome and 42...

journal_title：Kidney international

authors： Donadio JV Jr,Torres VE,Velosa JA,Wagoner RD,Holley KE,Okamura M,Ilstrup DM,Chu CP

更新日期：1988-03-01 00:00:00

abstract：:PDGF and TGF-beta are known mediators of mesangial cell proliferation and matrix expansion. The presence of these regulatory factors was examined in 30 renal biopsies from patients with IgA glomerulonephritis (IgA-GN) at the mRNA and protein level. Normal renal tissue served as control. The mRNA expression of PDGF A/B...

journal_title：Kidney international

authors： Niemir ZI,Stein H,Noronha IL,Krüger C,Andrassy K,Ritz E,Waldherr R

更新日期：1995-11-01 00:00:00

abstract：:Nonsteroidal anti-inflammatory drugs (NSAIDs) are associated with an increased risk of acute kidney injury (AKI) when used in triple combination with renin-angiotensin system inhibitors and diuretics, but previous research reported that NSAIDs in dual combinations with either renin-angiotensin system inhibitors or diu...

journal_title：Kidney international

authors： Dreischulte T,Morales DR,Bell S,Guthrie B

更新日期：2015-08-01 00:00:00

abstract：:In this mini review, we would like to challenge the well-established 'fact' that lead exposure causes chronic renal failure (CRF). Even though only scarce evidence exists of the relationship between lead and renal failure, a World Health Organization Environmental Health Criteria document summarizes that 'Lead has bee...

journal_title：Kidney international

authors： Evans M,Elinder CG

更新日期：2011-02-01 00:00:00

abstract：:We have previously shown that the activity of the Na-HCO3 cotransporter is stimulated by protein kinase C (PKC) activation, but the mechanism responsible for this effect is not clear. We have shown that cultured proximal tubule cells of the rabbit have DIDS-sensitive Na-HCO3 cotransporter activity as assessed by HCO3-...

journal_title：Kidney international

authors： Ruiz OS,Wang LJ,Qiu YY,Kear F,Bernardo A,Arruda JA

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND:Population-genetic studies investigating genetic polymorphisms of Mendelian inheritance should always test whether the measured genotype frequencies deviate from the expected one. For this purpose Hardy-Weinberg (HW) criteria are generally used. If genotype distribution of control population misses HW equili...

journal_title：Kidney international

authors： Kocsis I,Györffy B,Németh E,Vásárhelyi B

更新日期：2004-05-01 00:00:00

abstract：:The incidence of acute kidney injury (AKI) is high in elderly people, and is difficult to prevent and treat. One of its major causes is renal ischemia-reperfusion injury (IRI). A young systemic environment may prevent the senescence of old organs. However, it is unknown whether a young milieu may reduce renal IRI in t...

journal_title：Kidney international

authors： Liu D,Lun L,Huang Q,Ning Y,Zhang Y,Wang L,Yin Z,Zhang Y,Xia L,Yin Z,Fu B,Cai G,Sun X,Chen X

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Interleukin-6 (IL-6) exerts its actions through a cell-surface receptor system that consists of two transmembrane subunits: the IL-6 binding glycoprotein gp 80 (IL-6R) and the signal-transducing component (gp 130). Soluble forms of the IL-6R (sIL-6R) are generated by shedding of the membrane-associated prote...

journal_title：Kidney international

authors： Memoli B,Postiglione L,Cianciaruso B,Bisesti V,Cimmaruta C,Marzano L,Minutolo R,Cuomo V,Guida B,Andreucci M,Rossi G

更新日期：2000-07-01 00:00:00

abstract：:We designed a study to provide reversibility and comparative injury data for several candidate urinary biomarkers of kidney injury in the United States Food and Drug Administration biomarker qualification process. The nephrotoxin gentamicin was given to rats once on each of three days and the animals were killed durin...

journal_title：Kidney international

authors： Rouse RL,Zhang J,Stewart SR,Rosenzweig BA,Espandiari P,Sadrieh NK

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Chronic inflammation and oxidative stress are highly prevalent in patients with chronic kidney disease and end-stage renal disease (ESRD). These conditions contribute to high mortality rates associated with cardiovascular disease, the leading cause of death in this patient population. To our knowledge, no pr...

journal_title：Kidney international

authors： Pupim LB,Himmelfarb J,McMonagle E,Shyr Y,Ikizler TA

更新日期：2004-06-01 00:00:00

abstract：:Simple life-table analyses have not identified the reasons for the steady improvement over the years in graft survival. The use of more sophisticated multifactorial statistical techniques is indicated to identify prognostic factors and to explore the "center effect" on graft survival. An agenda for retrospective analy...

journal_title：Kidney international

authors： Gore SM

更新日期：1983-10-01 00:00:00

abstract：:To assess the comparative effects of hemodialysis with acetate versus bicarbonate base on left ventricular systolic function, we performed M-mode echocardiography on 36 patients prior to and immediately following 4-hr maintenance hemodialysis. Patients were initially dialyzed against either sodium acetate or sodium bi...

journal_title：Kidney international

authors： Ruder MA,Alpert MA,Van Stone J,Selmon MR,Kelly DL,Haynie JD,Perkins SK

更新日期：1985-05-01 00:00:00

abstract：BACKGROUND:Although renal protective effect of interrupting the inflammatory process is well established, it is still controversial if it also prevents the glomerular hemodynamic disturbances that initiate renal injury. We investigated the effects of suppressing inflammation with mycophenolate mofetil (MMF) on glomerul...

journal_title：Kidney international

authors： Tapia E,Franco M,Sánchez-Lozada LG,Soto V,Avila-Casado C,Santamaría J,Quiroz Y,Rodríguez-Iturbe B,Herrera-Acosta J

更新日期：2003-03-01 00:00:00

abstract：:Lipid abnormalities have been suggested as a major cause of the accelerated atherosclerosis and the high incidence of coronary heart disease in chronic renal failure patients. In the present work the postprandial lipoprotein metabolism was studied in chronic dialysis patients with or without fasting hypertriglyceridem...

journal_title：Kidney international

authors： Weintraub M,Burstein A,Rassin T,Liron M,Ringel Y,Cabili S,Blum M,Peer G,Iaina A

更新日期：1992-11-01 00:00:00

abstract：:Recent studies have shown renoprotective effects of the peroxisome proliferator-activated receptor-α (PPAR-α), but its role in kidney fibrosis is unknown. In order to gain insight into this, we examined the effect of a novel PPAR-α agonist, BAY PP1, in two rat models of renal fibrosis: unilateral ureteral obstruction ...

journal_title：Kidney international

authors： Boor P,Celec P,Martin IV,Villa L,Hodosy J,Klenovicsová K,Esposito C,Schäfer S,Albrecht-Küpper B,Ostendorf T,Heidland A,Šebeková K

更新日期：2011-12-01 00:00:00

abstract：:Atypical hemolytic uremic syndrome (aHUS) is a rare, genetic, life-threatening disease. The Global aHUS Registry collects real-world data on the natural history of the disease. Here we characterize end-stage renal disease (ESRD)-free survival, the rate of thrombotic microangiopathy, organ involvement and the genetic b...

journal_title：Kidney international

authors： Schaefer F,Ardissino G,Ariceta G,Fakhouri F,Scully M,Isbel N,Lommelé Å,Kupelian V,Gasteyger C,Greenbaum LA,Johnson S,Ogawa M,Licht C,Vande Walle J,Frémeaux-Bacchi V,Global aHUS Registry.

更新日期：2018-08-01 00:00:00

abstract：:It has been proposed that one of the primary events in the development of essential hypertension is a growth-related process initiated as early as during fetal development. Differences in kidney size have been observed between most rat models of hypertension and their respective controls. In this study, we analyzed re...

journal_title：Kidney international

authors： Hamet P,Pausova Z,Dumas P,Sun YL,Tremblay J,Pravenec M,Kunes J,Krenova D,Kren V

更新日期：1998-06-01 00:00:00

abstract：:Neutrophil gelatinase-associated lipocalin (Ngal, 24p3, SIP24, lipocalin 2, or siderocalin) was originally purified from neutrophils, but with unknown function. Recently, it was identified that Ngal activates nephron formation in the embryonic kidney, is rapidly and massively induced in renal failure and possesses kid...

journal_title：Kidney international

authors： Mori K,Nakao K

更新日期：2007-05-01 00:00:00

abstract：:Vitamin D receptor activation has been associated with increased serum creatinine and reduced estimated glomerular filtration rates, raising concerns that its use may be detrimental to kidney function. Here we studied the effect of vitamin D receptor activation on serum creatinine, creatinine generation, and its clear...

journal_title：Kidney international

authors： Agarwal R,Hynson JE,Hecht TJ,Light RP,Sinha AD

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:It is not known whether angiotensin-converting-enzyme (ACE) inhibitors slow the progression of polycystic kidney disease (PKD). We performed a patient-level meta-analysis to compare the effect of antihypertensive regimens, including ACE inhibitors, to those without ACE inhibitors (controls) on kidney disease...

journal_title：Kidney international

authors： Jafar TH,Stark PC,Schmid CH,Strandgaard S,Kamper AL,Maschio G,Becker G,Perrone RD,Levey AS,ACE Inhibition in Progressive Renal Disease (AIPRD) Study Group.

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Chronic cyclosporine (CsA) nephrotoxicity is characterized by interstitial fibrosis and afferent arteriolar hyalinosis. L-arginine (L-Arg), the substrate for nitric oxide (NO) synthase and N-nitro-L-arginine-methyl ester (L-NAME), the NO synthase inhibitor, were shown to modulate acute CsA nephrotoxicity. Ho...

journal_title：Kidney international

authors： Shihab FS,Yi H,Bennett WM,Andoh TF

更新日期：2000-09-01 00:00:00

abstract：:Loss of hypoxic vasodilation has been proposed as a causative factor in the development of hypertension in dialysis patients treated with recombinant human erythropoietin (rHuEPO). Venous occlusion plethysmography was therefore performed on 22 dialysis patients (aged 23 to 71 years, dialysis duration 6 to 260 months, ...

journal_title：Kidney international

authors： Roger SD,Grasty MS,Baker LR,Raine AE

更新日期：1992-10-01 00:00:00

abstract：:Hypercalciuria is one of the early manifestations of diabetic nephropathy. We explored here the role of α-Klotho, a protein expressed predominantly in distal convoluted tubules that has a role in calcium reabsorption. We studied 31 patients with early diabetic nephropathy and compared them with 31 patients with IgA ne...

journal_title：Kidney international

authors： Asai O,Nakatani K,Tanaka T,Sakan H,Imura A,Yoshimoto S,Samejima K,Yamaguchi Y,Matsui M,Akai Y,Konishi N,Iwano M,Nabeshima Y,Saito Y

更新日期：2012-03-01 00:00:00

abstract：:IgA nephropathy (IgAN) is the most prevalent primary chronic glomerular disease for which no safe disease-specific therapies currently exist. IgAN is an autoimmune disease involving the production of autoantigenic, aberrantly O-glycosylated IgA1 and ensuing deposition of nephritogenic immune complexes in the kidney. A...

journal_title：Kidney international

authors： Myette JR,Kano T,Suzuki H,Sloan SE,Szretter KJ,Ramakrishnan B,Adari H,Deotale KD,Engler F,Shriver Z,Wollacott AM,Suzuki Y,Pereira BJG

更新日期：2019-07-01 00:00:00

abstract：:The renal effects of a single intravenous dose of two different E. coli lipopolysaccharides (LPS 0111:B4 and LPS 0127:B8), at the same dose of 100 micrograms/kg, were evaluated in euvolemic Munich-Wistar (MW) rats by whole kidney clearance techniques and micropuncture studies. Following LPS infusion, a significant dec...

journal_title：Kidney international

authors： Lugon JR,Boim MA,Ramos OL,Ajzen H,Schor N

更新日期：1989-10-01 00:00:00

abstract：BACKGROUND:The renal 11beta-hydroxysteroid dehydrogenase type 2 (11beta HSD2) enzyme inactivates 11-hydroxy steroids in the kidney, thereby protecting the nonselective mineralocorticoid (MR) receptor from occupation by glucocorticoids. Loss-of-function mutations in the gene encoding 11beta HSD2 (HSD11B2) result in over...

journal_title：Kidney international

authors： Williams TA,Mulatero P,Filigheddu F,Troffa C,Milan A,Argiolas G,Parpaglia PP,Veglio F,Glorioso N

更新日期：2005-02-01 00:00:00