Oxalate ions and calcium oxalate crystals stimulate MCP-1 expression by renal epithelial cells.

abstract：:Organomercurial diuretics stimulate renin secretion although the underlying cellular mechanisms remain undefined. Since organomercurials are also known to react with sulfhydryl groups, the present studies determined the effects of sulfhydryl reagents on renin secretion. The effects of the non-diuretic mercurial agent,...

journal_title：Kidney international

authors： Lee DY,Cho KW,Lee JS,Honeyman TW,Park CS

更新日期：1989-03-01 00:00:00

abstract：BACKGROUND:Gap junctional intercellular communication (GJIC) plays an important role in the regulation of cell growth, migration, and differentiation. Ultrastructural and histochemical studies indicate the existence of a high density of gap junctions among mesangial cells (MCs), but little is known about their regulati...

journal_title：Kidney international

authors： Yao J,Morioka T,Oite T

更新日期：2000-05-01 00:00:00

abstract：:The association between dietary sodium and potassium intake with the development of kidney disease remains unclear, particularly among younger individuals. Here, we determined whether dietary sodium and potassium intake are associated with incident chronic kidney disease (CKD) using data from 1,030 adults (age 23-35 i...

journal_title：Kidney international

authors： Elfassy T,Zhang L,Raij L,Bibbins-Domingo K,Lewis CE,Allen NB,Liu KJ,Peralta CA,Odden MC,Zeki Al Hazzouri A

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Hyperuricemia has been linked to cardiovascular and renal diseases, possibly through the generation of reactive oxygen species (ROS) and subsequent endothelial dysfunction. The enzymatic effect of xanthine oxidase is the production of ROS and uric acid. Studies have shown that inhibiting xanthine oxidase wit...

journal_title：Kidney international

authors： Khosla UM,Zharikov S,Finch JL,Nakagawa T,Roncal C,Mu W,Krotova K,Block ER,Prabhakar S,Johnson RJ

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:We have recently demonstrated an increase in apoptosis in Han:SPRD rat kidneys with autosomal-dominant polycystic kidney disease (ADPKD). Caspase-3 and caspase-7 are major mediators of apoptosis. There are two pathways of caspase-3 and caspase-7-mediated apoptosis: (1) the "extrinsic" pathway involving the d...

journal_title：Kidney international

authors： Tao Y,Kim J,Stanley M,He Z,Faubel S,Schrier RW,Edelstein CL

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:Cadaveric renal transplantation is associated with a survival advantage compared with dialysis patients remaining on the renal transplantation waiting list, but this advantage has not been confirmed in obese end-stage renal disease (ESRD) patients. METHODS:Using data from the USRDS, we studied 7521 patients...

journal_title：Kidney international

authors： Glanton CW,Kao TC,Cruess D,Agodoa LY,Abbott KC

更新日期：2003-02-01 00:00:00

abstract：:We examined the effect of daily cyclosporin A administration on the development and extent of tubulointerstitial nephritis produced in rats immunized with tubular basement membranes in adjuvant. Six mg/kg/day of cyclosporin A, given from the time of immunization, completely blocked the development of interstitial lesi...

journal_title：Kidney international

authors： Shih W,Hines WH,Neilson EG

更新日期：1988-06-01 00:00:00

abstract：:Cyclosporine A (CsA) is a potent immunosuppressive drug that inhibits the transcription of several proinflammatory cytokines including interleukin-2. In contrast, CsA stimulates transcription of the pleuripotent cytokine, transforming growth factor-beta (TGF beta). Since the effect of CsA in transplant recipients is u...

journal_title：Kidney international

authors： Pankewycz OG,Miao L,Isaacs R,Guan J,Pruett T,Haussmann G,Sturgill BC

更新日期：1996-11-01 00:00:00

abstract：:Because of differences in case-mix across states, state-level case-mix-adjusted end-stage renal disease (ESRD) incident rates are reported in each United States Renal Data System Annual Data Report to make the across-state comparisons valid. The adjusted rates were estimated by the direct adjustment method, a widely u...

journal_title：Kidney international

authors： Liu J,Louis TA,Pan W,Ma JZ,Collins AJ

更新日期：2006-04-01 00:00:00

abstract：:Accumulating evidence indicates that asymptomatic hyperuricemia is involved in the development of hypertension and chronic kidney disease. A 2-hit model has been proposed to explain the role of urate in hypertension. The first hit entails activation of the renin-angiotensin system and inhibition of nitric oxide synthe...

journal_title：Kidney international

authors： Ponticelli C,Podestà MA,Moroni G

更新日期：2020-11-01 00:00:00

abstract：:Recent reports indicate a decreased mortality risk for patients on chronic peritoneal dialysis in the United States. We sought to determine whether a higher use of automated versus continuous ambulatory peritoneal dialysis was associated with this improvement. Analyses were carried out using data from the United State...

journal_title：Kidney international

authors： Mehrotra R,Chiu YW,Kalantar-Zadeh K,Vonesh E

更新日期：2009-07-01 00:00:00

abstract：:We examined the role of the plasminogen activator/plasmin system in extracellular matrix (ECM) degradation by human mesangial cells cultured on thin films of 125I-labeled ECM (Matrigel). ECM degradation (release of 125I into the medium) was dependent on exogenous plasminogen, proportional to the number of mesangial ce...

journal_title：Kidney international

authors： Baricos WH,Cortez SL,el-Dahr SS,Schnaper HW

更新日期：1995-04-01 00:00:00

abstract：BACKGROUND:Human mesothelial cells (HMCs) have an important role in maintaining an adequately functioning fibrinolytic system in the peritoneal cavity by secreting the fibrinolytic enzymes tissue-type and urokinase-type plasminogen activator (t-PA and u-PA), as well as a specific PA inhibitor, PA inhibitor type 1 (PAI-...

journal_title：Kidney international

authors： Sitter T,Toet K,Quax P,Kooistra T

更新日期：1999-01-01 00:00:00

abstract：:Females across their lifespan and certain male populations are susceptible to urinary tract infections (UTI). The influence of female vs. male sex on UTI is incompletely understood, in part because preclinical modeling has been performed almost exclusively in female mice. Here, we employed established and new mouse mo...

journal_title：Kidney international

authors： Olson PD,McLellan LK,Hreha TN,Liu A,Briden KE,Hruska KA,Hunstad DA

更新日期：2018-09-01 00:00:00

abstract：:In uremic patients resistance to the action of insulin has been documented, but it is not known at what stage of renal disease it appears. We therefore examined 29 patients with IgA glomerulonephritis (IgAGN) and 21 patients with adult polycystic kidney disease (ADPKD) in different stages of renal failure, and in addi...

journal_title：Kidney international

authors： Fliser D,Pacini G,Engelleiter R,Kautzky-Willer A,Prager R,Franek E,Ritz E

更新日期：1998-05-01 00:00:00

abstract：:Cell-cycle proteins influence almost all aspects of embryogenesis and differentiation. In adults, these proteins control cell division and regeneration after injury. During the past several years, their roles in controlling reaction to stress have been demonstrated in several organ systems. In the kidney, the cell typ...

journal_title：Kidney international

authors： Price PM

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:Patients on continuous ambulatory peritoneal dialysis (CAPD) are dependent on residual renal function for solute and water clearances, and this declines with time on dialysis. Loop diuretics have been postulated to slow this decline. METHODS:Sixty-one patients new to dialysis were randomly assigned to eithe...

journal_title：Kidney international

authors： Medcalf JF,Harris KP,Walls J

更新日期：2001-03-01 00:00:00

abstract：:Dysregulated production of adipocytokines may be involved in the development of atherosclerotic cardiovascular disease in metabolic syndrome and chronic kidney disease (CKD) associated with metabolic syndrome. The aim of this study was to determine the effects of treatment with angiotensin II (Ang II) type-1 receptor ...

journal_title：Kidney international

authors： Kurata A,Nishizawa H,Kihara S,Maeda N,Sonoda M,Okada T,Ohashi K,Hibuse T,Fujita K,Yasui A,Hiuge A,Kumada M,Kuriyama H,Shimomura I,Funahashi T

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:Idiopathic nephrotic syndrome is a proteinuric disease secondary to the release of a nonidentified circulating glomerular permeability factor by T cells. Because specificities of T-cell activation in idiopathic nephrotic syndrome remain unknown, we evaluated transcriptional activation of T cells in nephrotic...

journal_title：Kidney international

authors： Mansour H,Cheval L,Elalouf JM,Aude JC,Alyanakian MA,Mougenot B,Doucet A,Deschênes G

更新日期：2005-06-01 00:00:00

abstract：:Since 1992 and the discovery of an MIP (major intrinsic protein of lens fiber cell) homologue protein that selectively permeates water, aquaporin (AQP), there has been an explosion of research in this field. Early research speculated that aquaporins played indispensible physiological roles in bacteria and plants, as w...

journal_title：Kidney international

authors： Yamamoto T,Sasaki S

更新日期：1998-10-01 00:00:00

abstract：:A model of glomerular dynamics has been developed by using network thermodynamics and the SPICE 2 computer program to further explore the determinants of glomerular filtration. The model is designed to be holistic and self-adjusting, taking cognizance of and permitting quantitation of the secondary alterations in indi...

journal_title：Kidney international

authors： Oken DE,Thomas SR,Mikulecky DC

更新日期：1981-02-01 00:00:00

abstract：BACKGROUND:Cardiovascular death continues to be a major problem in renal failure. Structural abnormalities of the heart and the vasculature contribute to the increased cardiovascular risk. They are ameliorated by angiotensin-converting enzyme (ACE) inhibitors, but because of the nonspecifity of ACE inhibition, it is un...

journal_title：Kidney international

authors： Amann K,Gassmann P,Buzello M,Orth SR,Törnig J,Gross ML,Magener A,Mall G,Ritz E

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND:Mice overexpressing thymic stromal lymphopoietin (TSLP) develop mixed cryoglobulinemia with renal disease closely resembling human cryoglobulin-associated membranoproliferative glomerulonephritis (MPGN), including glomerular deposits of immunoglobulins and complement. We assessed the effect of complement inh...

journal_title：Kidney international

authors： Mühlfeld AS,Segerer S,Hudkins K,Farr AG,Bao L,Kraus D,Holers VM,Quigg RJ,Alpers CE

更新日期：2004-04-01 00:00:00

abstract：BACKGROUND:We hypothesized that increasing small solute clearance in peritoneal dialysis (PD) would lead to improvements in patient health-related quality of life (HRQOL). METHODS:Patients were randomized to a control group [standard 4 x 2 L continuous ambulatory peritoneal dialysis (CAPD)] and an intervention group (...

journal_title：Kidney international

authors： Paniagua R,Amato D,Vonesh E,Guo A,Mujais S,Mexican Nephrology Collaborative Study Group.

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:The long-term prognostic associations of pre- and post-dialysis blood pressures, interdialytic weight gain, and antihypertensive use in hemodialysis patients are unclear. METHODS:The United States Renal Data System (USRDS) Dialysis Morbidity and Mortality Waves 3 and 4 Study, a randomly generated sample of ...

journal_title：Kidney international

authors： Foley RN,Herzog CA,Collins AJ,United States Renal Data System.

更新日期：2002-11-01 00:00:00

abstract：:The effect of intravenous infusion of angiotensin II on microvascular parameters of the renal microcirculation of rats was studied. With the aid of fluorescence microscopy and a high sensitivity video system we observed the passage of fluorescence-labeled erythrocytes through single glomerular capillaries on the surfa...

journal_title：Kidney international

authors： Zimmerhackl B,Parekh N,Kücherer H,Steinhausen M

更新日期：1985-01-01 00:00:00

abstract：:Many subjects nowadays present with end-stage renal failure and its attendant cardiovascular complications without known prior renal damage. In this report we review the evidence available to strongly suggest that the present practice of secondary prevention in those with known prior renal disease should be extended t...

journal_title：Kidney international

authors： de Jong PE,Brenner BM

更新日期：2004-12-01 00:00:00

abstract：BACKGROUND:In uremic patients with secondary hyperparathyroidism (2HPT), nodular hyperplasia of parathyroid gland shows a monoclonal pattern of cell proliferation, in which a decreased density of vitamin D receptor (VDR) also is demonstrated. The present study aimed at elucidating the mechanism of parathyroid cell prol...

journal_title：Kidney international

authors： Tokumoto M,Tsuruya K,Fukuda K,Kanai H,Kuroki S,Hirakata H

更新日期：2002-10-01 00:00:00

abstract：BACKGROUND:Primary collapsing glomerulopathy recurs postransplant, raising the possibility of circulating factors implicated in the pathogenesis of the disease. METHODS:To determine the presence of circulating factors in collapsing glomerulopathy patients, we tested serum from those patients in an in vivo assay. Eleve...

journal_title：Kidney international

authors： Avila-Casado Mdel C,Perez-Torres I,Auron A,Soto V,Fortoul TI,Herrera-Acosta J

更新日期：2004-07-01 00:00:00

abstract：:Changes in tissue oxygen levels trigger molecular signaling pathways that regulate cellular proliferation and differentiation in multiple cell types. The functional role of oxygen signaling in the immune system is not well understood. Rama and colleagues demonstrate that hypoxia induces dendritic-cell maturation; thus...

journal_title：Kidney international

authors： Maltzman JS,Haase VH

更新日期：2008-04-01 00:00:00