Hyperuricemia induces endothelial dysfunction.

abstract：:Among patients with proteinuric chronic kidney disease (CKD), current guideline recommendations mandate the use of agents blocking the renin angiotensin aldosterone system (RAAS) as first-line antihypertensive therapy based on randomized trials demonstrating that RAAS inhibitors are superior to other antihypertensive ...

journal_title：Kidney international

authors： Georgianos PI,Agarwal R

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Tumor necrosis factor (TNF) receptor family members, such as Fas and TNF receptor 1 (TNFR1), are thought to induce apoptosis in a variety of cells and organs. Although a number of potential scenarios have been postulated for the involvement of these receptors in the pathogenesis of acute renal failure (ARF),...

journal_title：Kidney international

authors： Tsuruya K,Ninomiya T,Tokumoto M,Hirakawa M,Masutani K,Taniguchi M,Fukuda K,Kanai H,Kishihara K,Hirakata H,Iida M

更新日期：2003-01-01 00:00:00

abstract：:The following bone density measurements have limited utility in determining bone strength because they do not include bone quality: microarchitecture, mineralization, ability to repair damage, collagen structure, crystal size, or marrow composition. Patients with kidney disease have poor bone quality. Newman et al. no...

journal_title：Kidney international

authors： Ott SM

更新日期：2016-01-01 00:00:00

abstract：:Utilizing [5-15N] and [2-15N]-labeled glutamine and gas chromatography mass spectrometry methodology, we examined the pathways of ammoniagenesis under basal and acute acidotic conditions of pH 7.0 and pH 6.8, respectively. LLC-PK1 cultures were incubated for one hour with gentle rocking in a bicarbonate buffer of pH 7...

journal_title：Kidney international

authors： Nissim I,Sahai A,Sandler RS,Tannen RL

更新日期：1994-04-01 00:00:00

abstract：:Class II gene products of the major histocompatibility complex (MHC) are not expressed usually in abundance on normal epithelium. The cell surface visibility of such proteins for the immune system is thought to be limited protectively in order to minimize inflammation consequent to the recognition of self-antigens in ...

journal_title：Kidney international

authors： Albert SE,Shelton K,Sun MJ,Neilson EG

更新日期：1991-07-01 00:00:00

abstract：:The members of the matrix metalloproteinase gene family play critical roles in numerous physiologic events, including cellular migration, tissue remodeling in wound healing and development, as well as in the evolution of the inflammatory process. The 72 kDa gelatinase A (formerly denoted 72 kDa Type IV collagenase) is...

journal_title：Kidney international

authors： Turck J,Pollock AS,Lovett DH

更新日期：1997-05-01 00:00:00

abstract：BACKGROUND:We hypothesized that increasing small solute clearance in peritoneal dialysis (PD) would lead to improvements in patient health-related quality of life (HRQOL). METHODS:Patients were randomized to a control group [standard 4 x 2 L continuous ambulatory peritoneal dialysis (CAPD)] and an intervention group (...

journal_title：Kidney international

authors： Paniagua R,Amato D,Vonesh E,Guo A,Mujais S,Mexican Nephrology Collaborative Study Group.

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:The aims of the present study were to determine the prevalence of inducible myocardial ischemia (IMI) in renal transplant recipients (RTR) more than 50 years old, to identify predictors of IMI, and to search for its prognostic value. METHODS:Among the 377 renal transplantations performed between 1989 and 19...

journal_title：Kidney international

authors： Dussol B,Bonnet JL,Sampol J,Savin B,De La Forte C,Mundler O,Habib G,Morange S,Barrau K,Loundoun A,Vacher-Coponat H,Berland Y

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND:Proteomic techniques have recently become available for large-scale protein analysis. The utility of these techniques in identification of urinary proteins is poorly defined. We constructed a proteome map of normal human urine as a reference protein database by using two differential fractionated techniques ...

journal_title：Kidney international

authors： Thongboonkerd V,McLeish KR,Arthur JM,Klein JB

更新日期：2002-10-01 00:00:00

abstract：BACKGROUND:High-efficiency hemodialysis may induce a deficiency in hydrosoluble vitamins. Supplementation with B-complex vitamins has been shown to lower serum homocysteine concentrations in several groups, but relatively few studies have concerned hemodialysis patients. Our objectives were to determine the status in B...

journal_title：Kidney international

authors： Tremblay R,Bonnardeaux A,Geadah D,Busque L,Lebrun M,Ouimet D,Leblanc M

更新日期：2000-08-01 00:00:00

abstract：:Intercellular adhesion molecule-1 (ICAM-1) and MHC class II (Ia) antigens are increased on proximal tubular epithelial cells (TEC) in autoimmune nephritis and transplant rejection. ICAM-1 is a member of the immunoglobulin gene superfamily that increases the avidity of T cell interactions with antigen-presenting cells ...

journal_title：Kidney international

authors： Jevnikar AM,Wuthrich RP,Takei F,Xu HW,Brennan DC,Glimcher LH,Rubin-Kelley VE

更新日期：1990-09-01 00:00:00

abstract：:Problems with vascular access are an important cause of morbidity and mortality in hemodialysis patients. We established a rodent model of arteriovenous fistula by anastomosing the end of a lateral vein to the side of the ventral artery of the rat tail. All operations were technically successful and in all animals the...

journal_title：Kidney international

authors： Lin T,Horsfield C,Robson MG

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:Cux-1 is a murine homeobox gene that is highly expressed in the nephrogenic zone of the developing kidney. Transgenic mice ectopically expressing Cux-1 develop renal hyperplasia associated with down-regulation of the cyclin kinase inhibitor p27. Because the reduction of p27 has been associated with mesangial...

journal_title：Kidney international

authors： Brantley JG,Sharma M,Alcalay NI,Heuvel GB

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND:Phenylalanine is converted to para- and ortho-tyrosine by hydroxyl free radical, or to para-tyrosine by the phenylalanine hydroxylase enzyme. The aim of this study was to measure para- and ortho-tyrosine in the urine and plasma of patients with chronic renal disease and/or diabetes, to obtain information on ...

journal_title：Kidney international

authors： Molnár GA,Wagner Z,Markó L,Kó Szegi T,Mohás M,Kocsis B,Matus Z,Wagner L,Tamaskó M,Mazák I,Laczy B,Nagy J,Wittmann I

更新日期：2005-11-01 00:00:00

abstract：:Chronic kidney disease (CKD) has received increased attention as a leading public health problem worldwide. Globally surveillance systems for kidney disease are still lacking, especially in developing countries like China, which constitutes an obstacle to develop effective preventive strategies. China Kidney Disease N...

journal_title：Kidney international

authors： Wang F,Yang C,Long J,Zhao X,Tang W,Zhang D,Bai K,Su Z,Gao B,Chu H,Wang J,Sun X,Wang S,Zuo L,Wang Y,Yu F,Wang H,Zhang L,Zhao MH

更新日期：2019-03-01 00:00:00

abstract：:Cystinosis as a clinical entity is a progressive dysfunction of multiple organs caused by the accumulation of cystine in the tissues, leading, for example, to end-stage renal failure, diabetes, hypothyroidism, myopathy, and central nervous system deterioration. Brodin-Sartorius and colleagues present a long-term study...

journal_title：Kidney international

authors： Cherqui S

更新日期：2012-01-01 00:00:00

abstract：:We previously reported that oxidative stress and renal tubular damage occur in chronic hyperoxaluric rats. However, the in vivo responses of renal epithelial cells after vitamin E administration and their correlations with calcium oxalate (CaOx) crystal formation have not been evaluated. Male Wistar rats received 0.75...

journal_title：Kidney international

authors： Huang HS,Chen J,Chen CF,Ma MC

更新日期：2006-08-01 00:00:00

abstract：:In rodents, mercuric chloride (HgCl2) causes an autoimmune disorder with glomerulonephritis (GN), and represents an animal model for the pathogenesis of GN. We have tested the hypothesis that HgCl2 induces major histocompatibility complex (MHC) expression in renal parenchymal cells, and studied the kinetics of this in...

journal_title：Kidney international

authors： Madrenas J,Parfrey NA,Halloran PF

更新日期：1991-02-01 00:00:00

abstract：:Progressive renal vascular sclerosis is a key feature of chronic kidney disease (CKD). Adiponectin, an adipokine with potent anti-inflammatory and antiatherosclerotic properties, is associated with insulin resistance, type II diabetes and cardiovascular disease. In this study, we evaluated the predictive value of adip...

journal_title：Kidney international

authors： Kollerits B,Fliser D,Heid IM,Ritz E,Kronenberg F,MMKD Study Group.

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND:Mesangial immunoglobulin A (IgA) deposition is incidentally encountered in asymptomatic individuals, but its precise frequency and significance had not been clarified. The background of the latent IgA deposition is related to the epidemiology and pathogenesis of IgA nephropathy. METHODS:Zero-hour allograft ...

journal_title：Kidney international

authors： Suzuki K,Honda K,Tanabe K,Toma H,Nihei H,Yamaguchi Y

更新日期：2003-06-01 00:00:00

abstract：:Large epidemiological studies clearly demonstrate that multiple episodes of acute kidney injury contribute to the development and progression of kidney fibrosis. Although our understanding of kidney fibrosis has improved in the past two decades, we have limited therapeutic strategies to halt its progression. Myofibrob...

journal_title：Kidney international

authors： Gu X,Mallipattu SK,Guo Y,Revelo MP,Pace J,Miller T,Gao X,Jain MK,Bialkowska AB,Yang VW,He JC,Mei C

更新日期：2017-11-01 00:00:00

abstract：:The in vitro heparin sensitivity of 18 nephrotic children was compared with that of 10 normal children and 13 children with other renal diseases. The influence of age on the heparin sensitivity of 52 normal subjects (aged 12 to 85 years) was also studied. The heparin sensitivity was calculated from the dose-response c...

journal_title：Kidney international

authors： Vermylen CG,Levin M,Lanham JG,Hardisty RM,Barratt TM

更新日期：1987-06-01 00:00:00

abstract：:Risk factors for disease states are rigorously defined. This analysis considers the definition of a risk factor as applied to the question of whether the serum phosphorus level is a risk factor for cardiovascular disease. Observational studies strongly suggest that phosphorus is associated with cardiovascular risk, an...

journal_title：Kidney international

authors： Hruska K,Mathew S,Lund R,Fang Y,Sugatani T

更新日期：2011-04-01 00:00:00

abstract：:Acute kidney injury (AKI) is a critical condition with a mortality rate as high as 50% and significantly contributes to the burden of end-stage renal disease (ESRD) requiring renal replacement therapy. The incidence and prognosis of AKI have been shown to vary with patient age, with younger individuals being more resi...

journal_title：Kidney international

authors： Fan H,Yang HC,You L,Wang YY,He WJ,Hao CM

更新日期：2013-03-01 00:00:00

abstract：:Measures related to red cell oxygen transport were evaluated in 17 hemodialysis patients receiving androgen therapy, 15 untreated hemodialysis patients and 15 normal subjects. Hemoglobin levels were higher in androgen-treated patients than in the untreated population and were directly related to the reticulocyte index...

journal_title：Kidney international

authors： Hendler ED,Solomon L

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:Atherogenic lipoproteins cause injury to the vascular wall in the early phase of atherogenesis. We assessed the effects of native (nLDL) and oxidized (oxLDL) low-density lipoprotein (LDL) and lipoprotein (a) [Lp(a)] on O2- formation and cell death in cultured human umbilical vein endothelial cells (HUVECs) a...

journal_title：Kidney international

authors： Galle J,Schneider R,Heinloth A,Wanner C,Galle PR,Conzelmann E,Dimmeler S,Heermeier K

更新日期：1999-04-01 00:00:00

abstract：:The effects of two models of chronic hypercalcemia on renal acid-base metabolism were studied in rats. In the first series of experiments, rats were rendered hyperparathyroid by the autologous grafting of 20 to 24 parathyroid glands into a single recipient. Hypercalcemia (5.48 +/- 0.03 mEq/liter in high PTH animals, 4...

journal_title：Kidney international

authors： Mitnick P,Greenberg A,Coffman T,Kelepouris E,Wolf CJ,Goldfarb S

更新日期：1982-04-01 00:00:00

abstract：BACKGROUND:Since the cloning of the gene for autosomal dominant polycystic kidney disease type 2 (PKD2), approximately 40 different mutations of that gene have been reported to be associated with the disease. The relationship between the PKD2 genotype and phenotype, however, remains unclear. METHODS:Detailed clinical ...

journal_title：Kidney international

authors： Hateboer N,Veldhuisen B,Peters D,Breuning MH,San-Millán JL,Bogdanova N,Coto E,van Dijk MA,Afzal AR,Jeffery S,Saggar-Malik AK,Torra R,Dimitrakov D,Martinez I,de Castro SS,Krawczak M,Ravine D

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:Among the members of the small leucine-rich proteoglycan family, decorin, biglycan, and fibromodulin have been proposed to be potent modulators of transforming growth factor-beta (TGF-beta) activity, thereby playing an important role in the pathogenesis of fibrotic kidney diseases. Furthermore, decorin expre...

journal_title：Kidney international

authors： Schaefer L,Gröne HJ,Raslik I,Robenek H,Ugorcakova J,Budny S,Schaefer RM,Kresse H

更新日期：2000-10-01 00:00:00

abstract：:In recent years, a substantial body of experimental and clinical work has been devoted to C3 glomerulopathy and Ig-mediated membranoproliferative glomerulonephritis. Despite the rapid accumulation of data, several uncertainties about these 2 rare forms of nephropathies persist. They concern their pathophysiology, clas...

journal_title：Kidney international

authors： Fakhouri F,Le Quintrec M,Frémeaux-Bacchi V

更新日期：2020-11-01 00:00:00