当前位置： SCI文献检索 > KIDNEY INTERNATIONAL期刊下所有文献 > Differing regulation and function of ICAM-1 and class II antigens on renal tubular cells.

Differing regulation and function of ICAM-1 and class II antigens on renal tubular cells.

Abstract：

:Intercellular adhesion molecule-1 (ICAM-1) and MHC class II (Ia) antigens are increased on proximal tubular epithelial cells (TEC) in autoimmune nephritis and transplant rejection. ICAM-1 is a member of the immunoglobulin gene superfamily that increases the avidity of T cell interactions with antigen-presenting cells bearing Ia antigens. Using an existing mAb and cDNA probe for Ia antigen, and a newly described mAb (YN1/1.7.4) and cDNA probe for murine ICAM-1, we compared mRNA transcript levels, surface expression and function of these molecules in transformed TEC derived from normal (C3H/FeJ) and autoimmune (MRL-lpr) mice. No differences were found on TEC between these strains of mice. Stimulation of TEC with interferon-gamma (IFN-gamma) resulted in the expression of Ia antigens, and a marked increase of ICAM-1 from basal levels. Increases in ICAM-1 levels occurred with concentrations of IFN-gamma 10 to 100 times lower (0.5 to 1.0 U/ml) than those required for Ia expression, and preceded Ia antigen expression by more than 48 hours. Anti-ICAM-1 mAb lowered the binding and antigen-presenting ability of TEC to the A2A2 T cell hybridoma, suggesting a role for ICAM-1 in immune interactions between TEC and T cells. Dexamethasone treatment of MRL-lpr mice abrogated the increase of Ia antigens found in the kidneys of nephritic mice yet did not reduce the expression of ICAM-1 in either kidneys or cultured stimulated TEC. We conclude that elevated ICAM-1 expression on TEC increases the immune accessory cell capability of TEC bearing Ia antigens, and is resistant to down-regulation by some immunosuppressive agents.

journal_name

Kidney Int

journal_title

Kidney international

authors

Jevnikar AM,Wuthrich RP,Takei F,Xu HW,Brennan DC,Glimcher LH,Rubin-Kelley VE

doi

10.1038/ki.1990.221

subject

Has Abstract

pub_date

1990-09-01 00:00:00

pages

417-25

issue

3

eissn

0085-2538

issn

1523-1755

pii

S0085-2538(15)34983-8

journal_volume

38

pub_type

杂志文章

相关文献

KIDNEY INTERNATIONAL文献大全
  • Toward an etiological classification of developmental disorders of the kidney and upper urinary tract.

    abstract：:Toward an etiological classification of developmental disorders of the kidney and upper urinary tract. There are a large number of developmental disorders and syndromes that affect the kidney and upper urinary tract. These have generally been classified according to morphological criteria established decades ago. Alth...

    journal_title：Kidney international

    pub_type： 杂志文章,评审

    doi：10.1046/j.1523-1755.2002.00086.x

    authors： Pohl M,Bhatnagar V,Mendoza SA,Nigam SK

    更新日期：2002-01-01 00:00:00

  • The lipid 5-phoshatase SHIP2 controls renal brush border ultrastructure and function by regulating the activation of ERM proteins.

    abstract：:The microvillus brush border on the renal proximal tubule epithelium allows the controlled reabsorption of solutes that are filtered through the glomerulus and thus participates in general body homeostasis. Here, using the lipid 5-phosphatase Ship2 global knockout mice, proximal tubule-specific Ship2 knockout mice, an...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1016/j.kint.2017.01.008

    authors： Sayyed SG,Jouret F,Vermeersch M,Pérez-Morga D,Schurmans S

    更新日期：2017-07-01 00:00:00

  • Renoprotection with vitamin D: specific for diabetic nephropathy?

    abstract：:Zhang and co-workers report on the renoprotective role of the vitamin D receptor (VDR) in diabetic nephropathy using the method of streptozotocin-induced hyperglycemia in wild-type and VDR(-/-) mice. Also, experiments with cultured mesangial cells and podocytes confirm the effect of the active vitamin D metabolite 1,2...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1038/sj.ki.5002693

    authors： Klaus G

    更新日期：2008-01-01 00:00:00

  • The endothelium as part of the integrative glomerular barrier complex.

    abstract：:A new study by Xu et al. presents compelling evidence for an important role of the glomerular endothelium in acute kidney injury. They show that lipopolysaccharide reduces the endothelial surface layer, resulting in mild albuminuria, reduced glomerular filtration rate, and fewer endothelial fenestrae. Tumor necrosis f...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1038/ki.2013.317

    authors： Haraldsson BS

    更新日期：2014-01-01 00:00:00

  • Clinical and genetic predictors of atypical hemolytic uremic syndrome phenotype and outcome.

    abstract：:Atypical hemolytic uremic syndrome (aHUS) is a rare, genetic, life-threatening disease. The Global aHUS Registry collects real-world data on the natural history of the disease. Here we characterize end-stage renal disease (ESRD)-free survival, the rate of thrombotic microangiopathy, organ involvement and the genetic b...

    journal_title：Kidney international

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.kint.2018.02.029

    authors： Schaefer F,Ardissino G,Ariceta G,Fakhouri F,Scully M,Isbel N,Lommelé Å,Kupelian V,Gasteyger C,Greenbaum LA,Johnson S,Ogawa M,Licht C,Vande Walle J,Frémeaux-Bacchi V,Global aHUS Registry.

    更新日期：2018-08-01 00:00:00

  • The Oxford classification of IgA nephropathy: pathology definitions, correlations, and reproducibility.

    abstract：:Pathological classifications in current use for the assessment of glomerular disease have been typically opinion-based and built on the expert assumptions of renal pathologists about lesions historically thought to be relevant to prognosis. Here we develop a unique approach for the pathological classification of a glo...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2009.168

    authors： Working Group of the International IgA Nephropathy Network and the Renal Pathology Society.,Roberts IS,Cook HT,Troyanov S,Alpers CE,Amore A,Barratt J,Berthoux F,Bonsib S,Bruijn JA,Cattran DC,Coppo R,D'Agati V,D'Amico G,Emanci

    更新日期：2009-09-01 00:00:00

  • Decreased renal α-Klotho expression in early diabetic nephropathy in humans and mice and its possible role in urinary calcium excretion.

    abstract：:Hypercalciuria is one of the early manifestations of diabetic nephropathy. We explored here the role of α-Klotho, a protein expressed predominantly in distal convoluted tubules that has a role in calcium reabsorption. We studied 31 patients with early diabetic nephropathy and compared them with 31 patients with IgA ne...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2011.423

    authors： Asai O,Nakatani K,Tanaka T,Sakan H,Imura A,Yoshimoto S,Samejima K,Yamaguchi Y,Matsui M,Akai Y,Konishi N,Iwano M,Nabeshima Y,Saito Y

    更新日期：2012-03-01 00:00:00

  • Effects of 1,25(OH)2D3 in experimental mesangial proliferative nephritis in rats.

    abstract：BACKGROUND:1,25-Dihydroxyvitamin D3 [1,25(OH)2D3], the active form of vitamin D3, is a potent immunomodulatory agent on several cell types such as monocytes and mesangial cells. Recruitment of inflammatory cells, as well as stimulation of resident cells and mesangial matrix accumulation are key features of various expe...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2001.00775.x

    authors： Panichi V,Migliori M,Taccola D,Filippi C,De Nisco L,Giovannini L,Palla R,Tetta C,Camussi G

    更新日期：2001-07-01 00:00:00

  • Alterations in glomerular RNA in diabetic rats: roles of glucagon and insulin.

    abstract：:Incorporation in vivo of labeled orotate into RNA and total nucleotides was measured in isolated glomeruli and whole renal cortex. In 2-day diabetic animals, glomerular RNA was increased, and there was greater incorporation of orotate into total nucleotides and RNA as compared with controls. Insulin reversed the exagg...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1981.166

    authors： Cortes P,Dumler F,Venkatachalam KK,Goldman J,Sastry KS,Venkatachalam H,Bernstein J,Levin NW

    更新日期：1981-10-01 00:00:00

  • COL4A4 mutation in thin basement membrane disease previously described in Alport syndrome.

    abstract：BACKGROUND:Carriers of autosomal-recessive and X-linked Alport syndrome often have a thinned glomerular basement membrane (GBM) and have mutations in the COL4A3/COL4A4 and COL4A5 genes respectively. Recently, we have shown that many individuals with thin basement membrane disease (TBMD) are also from families where hem...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2001.060002480.x

    authors： Buzza M,Wang YY,Dagher H,Babon JJ,Cotton RG,Powell H,Dowling J,Savige J

    更新日期：2001-08-01 00:00:00

  • Treatment of arterial hypertension in diabetic humans: importance of therapeutic selection.

    abstract：:This study was undertaken to test the hypothesis that, given equal arterial pressure reductions, the combination of an angiotensin converting enzyme (ACE) inhibitor and calcium antagonist slows declines in renal function and yields greater reductions in albuminuria over either agent alone. This hypothesis was evaluate...

    journal_title：Kidney international

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1038/ki.1992.139

    authors： Bakris GL,Barnhill BW,Sadler R

    更新日期：1992-04-01 00:00:00

  • Proteomic analysis of normal human urinary proteins isolated by acetone precipitation or ultracentrifugation.

    abstract：BACKGROUND:Proteomic techniques have recently become available for large-scale protein analysis. The utility of these techniques in identification of urinary proteins is poorly defined. We constructed a proteome map of normal human urine as a reference protein database by using two differential fractionated techniques ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2002.kid565.x

    authors： Thongboonkerd V,McLeish KR,Arthur JM,Klein JB

    更新日期：2002-10-01 00:00:00

  • IL-37 inhibits IL-18-induced tubular epithelial cell expression of pro-inflammatory cytokines and renal ischemia-reperfusion injury.

    abstract：:Cytokines and chemokines produced by tubular epithelial and infiltrating cells are critical to inflammation in renal ischemia-reperfusion injury. IL-37, a newly described IL-1 family member, inhibits IL-18-dependent pro-inflammatory cytokine production by its binding to IL-18 receptors and IL-18 binding protein. The p...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2014.295

    authors： Yang Y,Zhang ZX,Lian D,Haig A,Bhattacharjee RN,Jevnikar AM

    更新日期：2015-02-01 00:00:00

  • Activated extracellular signal-regulated kinase correlates with cyst formation and transforming growth factor-beta expression in fetal obstructive uropathy.

    abstract：:Human renal dysplasia is frequently associated with urinary tract obstruction and the abnormal expression of mitogen-activated protein kinase (MAPK). Here, we determined the renal responses and MAPK expression in developing kidneys that were obstructed in fetal lambs. Kidneys were harvested at various times after obst...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2008.3

    authors： Omori S,Kitagawa H,Koike J,Fujita H,Hida M,Pringle KC,Awazu M

    更新日期：2008-05-01 00:00:00

  • Circulating soluble receptor of advanced glycation end product inversely correlates with atherosclerosis in patients with chronic kidney disease.

    abstract：:The soluble receptor of advanced glycation end product (sRAGE) prevents vascular damage in experimental animal models, and observational studies in the general population support the hypothesis that sRAGE may exert a protective role on the vasculature. To test this in patients with chronic kidney disease, we determine...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2009.419

    authors： Basta G,Leonardis D,Mallamaci F,Cutrupi S,Pizzini P,Gaetano L,Tripepi R,Tripepi G,De Caterina R,Zoccali C

    更新日期：2010-02-01 00:00:00

  • Demographics of blood pressure and hypertension in children on renal replacement therapy in Europe.

    abstract：:Hypertension is a well-known complication in children on renal replacement therapy and an important risk factor for cardiovascular disease in later life. In order to define the prevalence of and risk factors for hypertension among children, we enrolled 3337 pediatric patients from 15 countries in the ESPN/ERA-EDTA Reg...

    journal_title：Kidney international

    pub_type： 杂志文章,多中心研究

    doi：10.1038/ki.2011.232

    authors： Kramer AM,van Stralen KJ,Jager KJ,Schaefer F,Verrina E,Seeman T,Lewis MA,Boehm M,Simonetti GD,Novljan G,Groothoff JW

    更新日期：2011-11-01 00:00:00

  • Acute renal failure independently predicts mortality after myeloablative allogeneic hematopoietic cell transplant.

    abstract：BACKGROUND:Patients undergoing myeloablative allogeneic hematopoietic cell transplantation (HCT) have a high incidence of acute renal failure (ARF). However, it is unclear if ARF is independently associated with mortality after this procedure. METHODS:We performed meta-analysis of published reports on ARF after myeloa...

    journal_title：Kidney international

    pub_type： 杂志文章,meta分析

    doi：10.1111/j.1523-1755.2005.00301.x

    authors： Parikh CR,McSweeney P,Schrier RW

    更新日期：2005-05-01 00:00:00

  • Long-term risk of adverse outcomes after acute kidney injury: a systematic review and meta-analysis of cohort studies using consensus definitions of exposure.

    abstract：:Reliable estimates of the long-term outcomes of acute kidney injury (AKI) are needed to inform clinical practice and guide allocation of health care resources. This systematic review and meta-analysis aimed to quantify the association between AKI and chronic kidney disease (CKD), end-stage kidney disease (ESKD), and d...

    journal_title：Kidney international

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.kint.2018.08.036

    authors： See EJ,Jayasinghe K,Glassford N,Bailey M,Johnson DW,Polkinghorne KR,Toussaint ND,Bellomo R

    更新日期：2019-01-01 00:00:00

  • Sodium thiosulfate improves renal function and oxygenation in L-NNA-induced hypertension in rats.

    abstract：:Sodium thiosulfate, a reversible oxidation product of hydrogen sulfide, has vasodilating and anti-oxidative properties, making it an attractive agent to alleviate damaging effects of hypertension. In experimental settings, inhibition of nitric oxide synthase causes hypertension, renal dysfunction and damage. We hypoth...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1016/j.kint.2020.02.020

    authors： Nguyen ITN,Klooster A,Minnion M,Feelisch M,Verhaar MC,van Goor H,Joles JA

    更新日期：2020-08-01 00:00:00

  • Predominant synthesis of IgA with lambda light chain in IgA nephropathy.

    abstract：:The nature of the light chains in mesangial IgA deposits and serum IgA was studied in patients with IgA nephropathy. Immunofluorescence (IF) studies using murine monoclonal antibodies, rabbit and goat anti-human monospecific antisera were performed in kidney sections from 15 IgA nephritic patients with only IgA isotyp...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1988.37

    authors： Lai KN,Chui SH,Lai FM,Lam CW

    更新日期：1988-02-01 00:00:00

  • Analysis of renal tubular electrolyte transporter genes in seven patients with hypokalemic metabolic alkalosis.

    abstract：BACKGROUND:Disorders that manifest hypokalemic metabolic alkalosis, such as Bartter's syndrome and Gitelman's syndrome, are caused by the malfunction of renal tubular electrolyte transporters. Bartter's syndrome may be linked to dysfunction of Na-K-2Cl cotransporter (NKCC2), renal outer medullary K channel (ROMK), or C...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2003.00163.x

    authors： Fukuyama S,Okudaira S,Yamazato S,Yamazato M,Ohta T

    更新日期：2003-09-01 00:00:00

  • Fetuin-mineral complex: a new potential biomarker for vascular calcification?

    abstract：:Vascular calcification is prevalent in dialysis patients and is associated with a high burden of cardiovascular disease. Fetuin-A is a potent inhibitor of vascular calcification, but the precise mechanism by which it mediates vascular calcification in uremia is unclear. Matsui and colleagues demonstrate that circulati...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1038/ki.2009.52

    authors： Komaba H,Fukagawa M

    更新日期：2009-05-01 00:00:00

  • Regulation of transforming growth factor-beta1 by insulin in prediabetic African Americans.

    abstract：:Insulin resistance has been associated with kidney disease even in the absence of diabetes; however, pathways linking insulin resistance to kidney disease are unclear. The purpose of this study was to determine if transforming growth factor (TGF)-beta1, a key cytokine associated with kidney disease, responds to circul...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2010.109

    authors： Huan Y,DeLoach S,Daskalakis C,Dunn SR,Sharma K,Falkner B

    更新日期：2010-08-01 00:00:00

  • Effect of glycine on prelethal and postlethal increases in calpain activity in rat renal proximal tubules.

    abstract：:The effect of glycine on hypoxia- and ionomycin-induced increases in calpain activity in rat proximal tubules was determined. Calpain activity was determined both in vitro and in the intact cell using the fluorescent substrate N-succinyl-Leu-Leu-Val-Tyr-7-amido-4-methyl coumarin (N-succinyl-Leu-Leu-Val-Tyr-AMC) and We...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1997.452

    authors： Edelstein CL,Ling H,Gengaro PE,Nemenoff RA,Bahr BA,Schrier RW

    更新日期：1997-11-01 00:00:00

  • Cognitive function before and after dialysis initiation in adults with chronic kidney disease-a new perspective on an old problem?

    abstract：:The impact of dialysis on cognitive trends is uncertain. Kurella Tamura et al. evaluated cognitive trajectories in 212 participants from the Chronic Renal Insufficiency Cohort study and found that dialysis initiation was associated with a decline in executive function. This is consistent with a cerebrovascular basis f...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1016/j.kint.2017.01.022

    authors： Iyasere O,Brown EA

    更新日期：2017-04-01 00:00:00

  • Role of cyanate in the induction of vascular dysfunction during uremia: more than protein carbamylation?

    abstract：:Cyanate is a uremic toxin responsible for the carbamylation of proteins, which has been implicated as playing a key role in accelerating the progression of atherosclerosis in patients with chronic kidney disease. El-Gamal et al. report that while cyanate promotes protein carbamylation in vivo, the resulting endothelia...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1038/ki.2014.256

    authors： Hawkins CL

    更新日期：2014-11-01 00:00:00

  • Changes in plasma 1,25 and 24,25-dihydroxyvitamin D after renal transplantation in children.

    abstract：:The purpose of this investigation is to analyze changes in plasma 1,25-(OH)2D and 24,25-(OH)2D after successful renal transplantation in 20 children and young adults. Studies were performed on 8 subjects between the 1st and 10th month and on 12 others between the 20th and 30th to 36th month. Samples were assayed for p...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1981.153

    authors： Garabedian M,Silve C,Levy-Bentolila D,Bourdeau A,Ulmann A,Nguyen TM,Lieberherr M,Broyer M,Balsan S

    更新日期：1981-09-01 00:00:00

  • RenaGel, a nonabsorbed calcium- and aluminum-free phosphate binder, lowers serum phosphorus and parathyroid hormone. The RenaGel Study Group.

    abstract：BACKGROUND:This multicenter, open-label, dose-titration study assessed the safety and efficacy of RenaGel(R), a nonabsorbed calcium- and aluminum-free phosphate binder, in lowering serum phosphorus. Secondary outcomes were its effects on serum intact parathyroid hormone (iPTH) and serum lipids. METHODS:Phosphate binde...

    journal_title：Kidney international

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1046/j.1523-1755.1999.00240.x

    authors： Slatopolsky EA,Burke SK,Dillon MA

    更新日期：1999-01-01 00:00:00

  • Histone deacetylase inhibition attenuates diabetes-associated kidney growth: potential role for epigenetic modification of the epidermal growth factor receptor.

    abstract：:Clinical trials and experimental studies have highlighted the importance of epigenetic processes in the development of diabetic complications. One of the earliest features of diabetic nephropathy is renal enlargement. The epidermal growth factor (EGF) has a pivotal role in the development of diabetic nephromegaly and ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2011.39

    authors： Gilbert RE,Huang Q,Thai K,Advani SL,Lee K,Yuen DA,Connelly KA,Advani A

    更新日期：2011-06-01 00:00:00

  • Tubuloglomerular feedback and glomerular morphology in Goldblatt hypertensive rats on varying protein diets.

    abstract：:The present experiments were performed to examine the effect of variation in protein intake on renal function and morphology in the non-clipped kidneys of Goldblatt hypertensive rats. After renal artery clipping, rats were put on diets containing 5 (LP), 17.5 (NP), or 51% (HP) protein. After 4 to 5 weeks, all rats had...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1986.30

    authors： Schnermann J,Gokel M,Weber PC,Schubert G,Briggs JP

    更新日期：1986-02-01 00:00:00